检索结果-南通市图书馆

Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme:a systematic review going beyond pathologic implications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第8期32卷 1239-1256页

作者： dIMITRA p.VAGELI pANAGIOTIS G.dOUKAS KERASIA GOUpOU ANTONIOS d.BENOS KYRIAKI ASTARA KONSTANTINA ZACHAROULI SOTIRIS SOTIRIOU MARIA IOANNOU department of Surgery Yale UniversityNew HavenCT 06510USA department of pathology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece department of Medicine Rutgers/Saint Peter’s University HospitalNew BrunswickNJ 08901USA department of Neurology Army Share Fund Hospital(NIMTS)Athens11521Greece Laboratory of Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece

Glioblastoma multiforme(GBM)is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular *** conditions in the tissue microenvironment are considered a pivotal player leading tumor ***,hypoxia is known to activate inducible factors,such as hypoxia-inducible factor 1alpha(HIF-1α),which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators,such as the vascular endothelial growth factor(VEGF).Here,we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data,as potential biomarkers of GBM prognosis and treatment *** performed a systematic review(Medline/Embase,and pubmed database search was completed by 16th of April 2024 by two independent teams;pRISMA 2020).We evaluated methods of immunoassays,cell viability,or animal or patient survival methods of the retrieved studies to assess unbiased *** used inclusion criteria,such as the evaluation of GBM prognosis based on HIF-1α/VEGF expression,other biomarkers or clinical and imaging manifestations in GBM related to HIF-1α/VEGF expression,application of immunoassays for protein expression,and evaluation of the effectiveness of GBM therapeutic strategies based on HIF-1α/VEGF *** used exclusion criteria,such as data not reporting both HIF-1αand VEGF or *** included 50 studies investigating in total 1319 GBM human specimens,18 different cell lines or GBM-derived stem cells,and 6 different animal models,to identify the association of HIF-1α/VEGF immunophenotypes,and with other prognostic factors,clinical and macroscopic data in GBM prognosis and therapeutic *** found that increased HIF-1α/VEGF expression in GBM correlates with oncogenic factors,such as miR-210-3p,Oct4,AKT,COX-2,pdGF-C,pLdO3,M2 polarization,or ALK,leading to unfavorable *** HIF-1α/VEGF expression correlates with F

关键词： Glioblastoma multiforme(GBM) Astrocytoma Grade III Astrocytoma Grade IV Hypoxia-inducible factor 1alpha(HIF-1α) Vascular endothelial growth factor(VEGF)

Influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 563-580页

作者： N.HUMNEKAR d.SRINIVASACHARYA department of Mathematics National Institute of TechnologyWarangal 506004TelanganaIndia

The influence of variable viscosity and double diffusion on the convective stability of a nanofluid flow in an inclined porous channel is *** darcyBrinkman model is used to characterize the fluid flow dynamics in porous *** analytical solutions are obtained for the unidirectional and completely developed *** on a normal mode analysis,the generalized eigenvalue problem under a perturbed state is *** eigenvalue problem is then solved by the spectral ***,the critical Rayleigh number with the corresponding wavenumber is evaluated at the assigned values of the other flow-governing *** results show that increasing the darcy number,the Lewis number,the dufour parameter,or the Soret parameter increases the stability of the system,whereas increasing the inclination angle of the channel destabilizes the ***,the flow is the most unstable when the channel is vertically oriented.

关键词： nanofluid inclined channel variable viscosity linear stability double dif-fusion porous medium

Study of boundary layer characteristics during the landfalling of a Nisarga cyclone

在线全文

学校读者我要写书评

暂无评论

Tropical Cyclone Research and Review 2024年第2期13卷 55-71页

作者： Rani p.pawar prajna priyadarshini T.dharmaraj dada p.Nade Mahendra N.patil Omkar M.patil N.Jeni Victor Sambhaji M.pawar d.G.Kanase Sunil d.pawar Indian Institute of Tropical Meteorology Ministry of Earth SciencesPuneIndia department of physics Bharati Vidyapeeth’s Dr.Patangrao Kadam Mahavidyalaya(Shivaji University Kolhapur)SangliIndia KSK Geomagnetic Research Laboratory IIGPrayagrajAllahabadIndia department of physics Sanjay Ghodawat University KolhapurIndia

One of the most important parameters in meteorology is the mean wind proﬁle in the tropical cyclone boundary *** vertical proﬁle of wind speed and wind direction were measured during the period of the Nisarga cyclone from May 31st,2020,to June 5th,2020,using the newly installed phased Array doppler Sodar system at the Center for Space and Atmospheric Science(CSAS),Sanjay Ghodawat University,Kolhapur(16.74◦N,74.37◦E;near India's western coast).Our analysis revealed that the maximum mean wind speed was 17 m/s on June 3,2020,at 10:00 *** also shows the change in wind direction from southwest to southeast on June 2 and 3,*** high-resolution reanalysis data in the domain,0–25◦N,65–110◦E,during the period from May 31st to June 5th,2020,revealed the variation of the atmospheric pressure of the Nisarga cyclone from 1000 to 1008 hpa,sea surface temperature(SST)between 30◦C and 31◦C,outgoing longwave radiation(OLR)between 100 and 240 Wm-2,wind speed between 3 and 15 m/s,and low values of vertical wind shear(VWS)were observed to the north of Nisarga *** observations may provide more insights for the study of boundary layer turbulence during cyclonic activities.

关键词： doppler Sodar Tropical cyclone Atmospheric boundary layer Vertical turbulence intensity

Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： M.p.SALAIMANIMAGUdAM J.JAYApRAKASH department of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

digital fabrication techniques,in recent decades,have provided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a complex *** paper presents alternatives and criteria for selection of digital fabrication techniques by adopting the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3d)printing,shotcrete,smart dynamic casting,material intrusion,mesh molding,injection concrete 3d printing,and thin forming *** criteria include formwork utilization,reinforcement incorporation,geometrical complexity,material enhancement,assembly complexity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subjective and objective weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorporation,build area,and geometrical complexity play a pivotal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3d printing emerged as the best performer,however the shotcrete and mesh molding techniques in the second and third positions.

关键词： digital fabrication multicriteria decision-making concrete 3d printing

The Effect of External Magnetic Field on Electron Scale Kelvin–Helmholtz Instability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第9期24卷 236-247页

作者： d.Tsiklauri Joule physics Laboratory School of ScienceEngineering and EnvironmentUniversity of SalfordManchesterM54WTUK

We use particle-in-cell,fully electromagnetic,plasma kinetic simulation to study the effect of external magnetic field on electron scale Kelvin–Helmholtz instability(ESKHI).The results are applicable to collisionless plasmas when,e.g.,solar wind interacts with planetary magnetospheres or a magnetic field is generated in AGN *** find that as in the case of magnetohydrodynamic(MHd)KHI,in the kinetic regime,the presence of an external magnetic field reduces the growth rate of the *** the MHd case,there is a known threshold magnetic field for KHI stabilization,while for ESKHI this is to be analytically *** a kinetic analytical expression,we use several numerical simulation runs to establish an empirical dependence of ESKHI growth rate,Γ(B_(0))ω_(pe),on the strength of the applied external magnetic *** find the best fit is hyperbolic,Γ(B_(0))ω_(pe)=Γ_(0)ω_(pe)/(A+BB_(0)),where Γ_(0) is the ESKHI growth rate without an external magnetic field and B_(0)=B_(0)/B_(MHd)is the ratio of external and two-fluid MHd stability threshold magnetic field,derived *** analytical theory to back up this growth rate dependence on the external magnetic field is *** results suggest that in astrophysical settings where a strong magnetic field pre-exists,the generation of an additional magnetic field by the ESKHI is suppressed,which implies that nature provides a“safety valve”—natural protection not to“over-generate”magnetic field by the ESKHI ***,we find that our two-fluid MHd threshold magnetic field is the same(up to a factor √γ_(0))as the dC saturation magnetic field,previously predicted by fully kinetic theory.

关键词： instabilities magnetic fields plasmas Sun:heliosphere ISM:magnetic fields

Improved Leap-frog Method for Time-domain Fault Location

在线全文

学校读者我要写书评

暂无评论

Journal of Modern power Systems and Clean Energy 2024年第2期12卷 670-674页

作者： Izudin džafić Rabih A.Jabr Faculty of Electrical Engineering University of SarajevoSarajevo 71000Bosnia and Herzegovina department of Electrical and Computer Engineering American University of BeirutBeirut 11072020Lebanon IEEE

The partial differential equation(pdE)solution of the telegrapher is a promising fault location method among time-domain and model-based *** research works have shown that the leap-frog process is superior to other explicit methods for the pdE ***,its implementation is challenged by determining the initial conditions in time and the boundary conditions in *** letter proposes two implicit solution methods for determining the initial conditions and an analytical way to obtain the boundary conditions founded on the signal *** results show that the proposal gives fault location accuracy superior to the existing leap-frog scheme,particularly in the presence of harmonics.

关键词： Fault location leap-frog partial differential equation time-domain analysis transmission line

CL2ES-KdBC:A Novel Covariance Embedded Selection Based on Kernel distributed Bayes Classifier for detection of Cyber-Attacks in IoT Systems

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第3期78卷 3511-3528页

作者： Talal Albalawi p.Ganeshkumar Computer Science department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless ***,IoT systems are vulnerable to cyberattacks due to its opennes The proposed work intends to implement a new security framework for detecting the most specific and harmful intrusions in IoT *** this framework,a Covariance Linear Learning Embedding Selection(CL2ES)methodology is used at first to extract the features highly associated with the IoT ***,the Kernel distributed Bayes Classifier(KdBC)is created to forecast attacks based on the probability distribution value *** addition,a unique Mongolian Gazellas Optimization(MGO)algorithm is used to optimize the weight value for the learning of the *** effectiveness of the proposed CL2ES-KdBC framework has been assessed using several IoT cyber-attack datasets,The obtained results are then compared with current classification methods regarding accuracy(97%),precision(96.5%),and other *** analysis of the CL2ES-KdBC system on IoT intrusion datasets is performed,which provides valuable insight into its performance,efficiency,and suitability for securing IoT networks.

关键词： IoT security attack detection covariance linear learning embedding selection kernel distributed bayes classifier mongolian gazellas optimization

Comparative analysis of microstructure,mechanical,and corrosion properties of biodegradable Mg-3Y alloy prepared by selective laser melting and spark plasma sintering

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第4期12卷 1496-1510页

作者： p.Minárik M.Zemková S.Šašek J.dittrich M.Knapek F.Lukáˇc d.Koutný J.Jaroš R.Král Faculty of Mathematics and physics Charles UniversityKe Karlovu 5Praha 12116Czech Republic Research Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Institute of plasma physics of the Czech Academy of Sciences Za Slovankou 1782/318200 Praha 8Czech Republic Institute of Machine and Industrial design Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This work explored possibilities of biodegradable magnesium alloy Mg-3Y preparation by two modern powder metallurgy techniques–spark plasma sintering(SpS)and selective laser melting(SLM).The powder material was consolidated by both methods utilising optimised parameters,which led to very low porosity(∼0.3%)in the SLM material and unmeasurably low porosity in the SpS *** main aim of the study was the thorough microstructure characterisation and interrelation between the microstructure and the functional properties,such as mechanical strength,deformability,and corrosion *** materials showed comparable strength of∼110 Mpa in tension and compression and relatively good deformability of∼9%and∼21%for the SLM and SpS materials,*** corrosion resistance of the SpS material in 0.1 M NaCl solution was superior to the SLM one and comparable to the conventional extruded *** digital image correlation during loading and the cross-section analysis of the corrosion layers revealed that the residual porosity and large strained grains have the dominant negative effect on the functional properties of the SLM *** the other hand,one of the primary outcomes of this study is that the SpS consolidation method is very effective in the preparation of the W3 biodegradable alloy,resulting in material with convenient mechanical and degradation properties that might find practical applications.

关键词： Magnesium Yttrium powder metallurgy Microstructure Mechanical strength Corrosion resistance

presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan Josépérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSp)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSp,encompassing various cellular components,although mutations in genes encoding endoplasmic reticulum(ER)-shaping proteins are the most prevalent(parodi et al.,2017).ER-shaping proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSp.

关键词： reticulum endoplasmic