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Adriamycin-induced cardiomyopathy can serve as a model for diabetic cardiomyopathy ——a hypothesis

Asian pacific Journal of Tropical biomedicine 2017年第11期7卷 1041-1045页

作者： Kaviyarasi Renu V.G.Abilash p.b.tirupathi pichiah Thabassum Akthar Syeda Sankarganesh Arunachalam School of biosciences and Technology VIT University Department of Animal Science School of Life Sciences Bharathidasan University Department of biotechnology Kalasalingam University

Diabetic cardiomyopathy is one of the life threatening complications of diabetes. A number of animal models are being used for studying diabetic cardiomyopathy. In laboratory animal models, induction of cardiomyopathy happens in two stages: first being the induction of diabetic condition and the second being the induction of cardiomyopathy by prolonging diabetic condition. It takes a longer time to develop diabetes with the limited success rate for development of cardiomyopathy. Adriamycin is an effective anticancer drug limited by its major side-effect cardiomyopathy. A number of features of Adriamycin treatment mimics diabetes. We postulate that Adriamycin-induced cardiomyopathy might be used as a model system to study diabetic cardiomyopathy in rodents since a number of features of both the cardiomyopathies overlap. Left ventricular hypertrophy, systolic and diastolic dysfunction, myofibrillar loss, and fibrosis are hallmarks of both of the cardiomyopathies. At the molecular level, calcium signaling, endoplasmic reticulum stress, advance glycation endproduct activation, mitochondrial dysfunction,inflammation, lipotoxicity and oxidative stress are similar in both the *** signature profile of both the cardiomyopathies shares commonalities. In conclusion,we suggest that Adriamycin induced cardiomyopathic animal model can be used for studying diabetic cardiomyopathy and would save time for researchers working on cardiomyopathy developed in rodent using the traditional method.

关键词： Cardiomyopathy Diabetes Animal model for cardiomyopathy Adriamycin Diabetic cardiomyopathy

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Origin of giant dielectric permittivity and weak ferromagnetic behavior in(1−x)LaFeO_(3−x)baTiO_(3)(0.0≤x≤0.25)solid solutions

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Journal of Advanced Dielectrics 2016年第4期6卷 45-52页

作者： T.Sreenivasu p.tirupathi K.prabahar b.Suryanarayana K.Chandra Mouli Department of Engineering physics Andhra University College of Engineering Visakhapatnam-530003India Department of physics Rajiv Gandhi University of Knowledge Technologies(Ap-IIIT)RK Valley-516330 India Advanced Magnetic Group Defense Metallurgical Research Laboratory Hyderabad-500058 India

The solid solutions of(1-x)LaFeO_(3–x)baTiO_(3)(0.0≤x≤0.25)have been synthesized successfully by the conventional solid-state reaction *** temperature(RT)X-ray diffraction studies reveal the stabilization of orthorhombic phase with pbnm space *** solubility in the perovskite series was demonstrated up to x=*** dielectric permittivity shows colossal dielectric constant(CDC)at *** doping of baTiO_(3)in LaFeO_(3)exhibit pronounced CDC up to a composition x=0.15,further it starts to *** frequency-dependent dielectric loss exhibits polaronic conduction,which can attribute to presence of multiple valence of *** relaxation frequency and polaronic conduction mechanism was shifted towards RT as function of ***,large magnetic moment with weak ferromagnetic behavior is observed in doped LaFeO_(3) solid solution,which might be the destruction of spin cycloid structure due to insertion of Ti in Fe–O–Fe network of LaFeO_(3).

关键词： Multiferroic ferromagnetic ceramics.

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Manpower Systems Operating under Heavy and Light Tailed Inter-Exit Time Distributions

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Applied Mathematics 2014年第2期5卷 285-291页

作者： R. Sivasamy p. tirupathi Rao K. Thaga Department of Statistics Pondicherry University Puducherry India Statistics Department University of Botswana Gaborone Botswana

This paper considers a Manpower system where “exits” of employed personnel produce some wastage or loss. This system monitors these wastages over the sequence of exit epochs {t0 = 0 and tk;k = 1, 2,…} that form a recurrent process and admit recruitment when the cumulative loss of man hours crosses a threshold level Y, which is also called the breakdown level. It is assumed that the inter-exit times Tk = tk-1 - tk, k = 1, 2,… are independent and identically distributed random variables with a common cumulative distribution function (CDF) b(t) = p(Tk t) which has a tail 1 – b(t) behaving like t-v with 1 v as t → ∞. The amounts {Xk} of wastages incurred during these inter-exit times {Tk} are independent and identically distributed random variables with CDF p(Xk X) = G(x) and Y is distributed, independently of {Xk} and {tk}, as an exponentiated exponential law with CDF H(y) = p(Y y) = (1 - e-λy)n. The mean waiting time to break down of the system has been obtained assuming b(t) to be heavy tailed and as well as light tailed. For the exponential case of G(x), a comparative study has also been made between heavy tailed mean waiting time to break down and light tailed mean waiting time to break down values. The recruitment policy operating under the heavy tailed case is shown to be more economical in all types of manpower systems.

关键词： Manpower System Recruitment policy Inter-Exit Time Wastage Waiting Time to breakdown Heavy Tailed Inter-Exit Time Distribution and Light Tailed Distribution

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Optimization Concepts and Applications in Engineering 2

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2011年

作者： Ashok D. belegundu tirupathi R. Chandrupatla

ISBN: (纸本)9780521878463

It is vitally important to meet or exceed previous quality and reliability standards while at the same time reducing resource consumption. This textbook addresses this critical imperative integrating theory, modeling, the development of numerical methods and problem solving, thus preparing the student to apply optimization to real-world problems. This text covers a broad variety of optimization problems using: unconstrained, constrained, gradient and non-gradient techniques; duality concepts; multiobjective optimization; linear, integer, geometric and dynamic programming with applications; and finite element based optimization. In this revised and enhanced second edition of Optimization Concepts and Applications in Engineering, the already robust pedagogy has been enhanced with more detailed explanations, an increased number of solved examples and end-of-chapter problems. The source codes are now available free on multiple platforms. It is ideal for advanced undergraduate or graduate courses and for practising engineers in all engineering disciplines, as well as in applied mathematics.

关键词： Engineering Engineering design Mathematical optimization. Engineering models

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