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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

DEpICT:A High-level Formal Language for modeling Constraint Satisfaction problems

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International Journal of Automation and computing 2008年第2期5卷 208-216页

作者： Abdulwahed m.Abbas Edward p.K.tsang Ahmad H.Nasri Department of Computer Science The University of Balamand Department of Computing and Electronic SystemsThe University of EssexDepartment of Computer ScienceThe American University of BeirutP.O.Box 100TripoliLebanonWivenhoe ParkColchester CO4 3SQUKP.O.Box:11-0236Riad EI-SolhBeirutLebanon

The past decade witnessed rapid development of constraint satisfaction technologies, where algorithms are now able to cope with larger and harder problems. However, owing to the fact that constraints are inherently declarative, attention is quickly turning toward developing high-level programming languages within which such problems can be modeled and also solved. Along these lines, this paper presents DEpICT, the language. Its use is illustrated through modeling a number of benchmark examples. The paper continues with a description of a prototype system within which such models may be interpreted. The paper concludes with a description of a sample run of this interpreter showing how a problem modeled as such is typically solved.

关键词： Constraint satisfaction problems (CSps) and languages formal specifications typed predicate calculus language interpreter

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis pharma plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Review on theory and applications of wavefront recording plane framework in generation and processing of digital holograms

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Chinese Optics Letters 2013年第1期11卷 18-24页

作者： p. w. m. tsang T.-C. poon Department of Electronic Engineering City University of Hong Kong Bradley Department of Electrical and Computer Engineering

The wavefront recording plane （wRp）, subsequently generalized to be known as the virtual diffraction plane （VDp）, is a recent concept that has been successfully deployed in fast generation and processing of digital holograms. In brief, the wRp and its extension, the VDp, is a hypothetical plane that is located between the hologram and the object scene, and which is at close proximity to the latter. As such, the fringe patterns on the hypothetical plane are carrying the holistic information of the hologram, as well as the local optical properties of the object scene. This important property enables a hologram to be processed with classical image processing techniques that are normally unsuitable for handling holographic information. In this paper we shall review a number of works, that have been developed based on the framework of the wRp and the VDp.

关键词： Review on theory and applications of wavefront recording plane framework in generation and processing of digital holograms

Adding new dimension to non-directed C（sp3）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Aliphatic C–H groups are among the most abundant yet least reactive functional groups in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p450 superfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp3）–H bonds in complex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic applications [2].

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SpAST spastin

Data-embedded-error-diffusion hologram(Invited paper)

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Chinese Optics Letters 2014年第6期12卷 76-79页

作者： p. w. m. tsang T.-C. poon Department of Electronic Engineering City University of Hong KongHong Kong SAR China Bradley Department of Electrical and Computer Engineering Virginia TechBlacksburg VA 24061 USA Shanghai Institute of Optics and Fine mechanics Chinese Academy of SciencesShanghai 201800 China

This paper describes a method for converting a complex Fresnel hologram into a phase-only hologram that can be embedded with large amount of data. Briefly, each row of pixels in the hologram is scanned sequentially in a left-to-right direction. The magnitude of each visited pixel is set to a constant, and its phase is embedded with the data. Subsequently, the error is diffused to the neighborhood pixels. The phase hologram realized with such means, which is referred to as the data-embedded-error-diffusion （DEED） hologram, is capable of preserving high fidelity on the content of the hologram and the embedded data.

关键词： Data-embedded-error-diffusion hologram

Evolving Decision Rules to predict Investment Opportunities

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International Journal of Automation and computing 2008年第1期5卷 22-31页

作者： Alma Lilia Garcia-Almanza Edward p.K.tsang Department of Computer Science University of EssexWivenhoe ParkColchester CO4 3SQUK

This paper is motivated by the interest in finding significant movements in financial stock prices. However, when the number of profitable opportunities is scarce, the prediction of these cases is difficult. In a previous work, we have introduced evolving decision rules （EDR） to detect financial opportunities. The objective of EDR is to classify the minority class （positive eases） in imbalaneed environments. EDR provides a range of classifications to find the best balance between not making mistakes and not missing opportunities. The goals of this paper are： 1） to show that EDR produces a range of solutions to suit the investor＇s preferences and 2） to analyze the factors that benefit the performance of EDR. A series of experiments was performed. EDR was tested using a data set from the London Financial market. To analyze the EDR behaviour, another experiment was carried out using three artificial data sets, whose solutions have different levels of complexity. Finally, an illustrative example was provided to show how a bigger collection of rules is able to classify more positive eases in imbalanced data sets. Experimental results show that： 1） EDR offers a range of solutions to fit the risk guidelines of different types of investors, and 2） a bigger collection of rules is able to classify more positive eases in imbalanced environments.

关键词： machine learning genetic programming (Gp) classification imbalanced classes evolution of rules

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death