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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.w.So Konstantin Feinberg marina manoraj Jenny Cheung Jennifer Zhang Kaveh mirmoeini Jpaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of medicine IndianapolisINUSA Division of plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications

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中国有色金属学会会刊：英文版 2006年第B01期16卷 209-216页

作者： XU w HU w Y LI m H mA Q Q p. D. HODGSON wEN C E Department of Applied physics Hunan University Changsha 410082 China Centre for material and Fibre Innovation Deakin University Geelong Vic 3217 Australia

Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEm) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEm observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic

关键词：钛支架溶胶-凝胶法羟基磷灰石/二氧化钛涂层医学整形外科应用

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Less is more： Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD~ homeostasis and contributes to longevity

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Frontiers in Biology 2015年第4期10卷 333-357页

作者： Felicia tsang Su-Ju Lin Department of microbiology and molecular Genetics College of Biological Sciences University of California Davis CA 95616 USA

Nutrient sensing pathways and their regulation grant cells control over their metabolism and growth in response to changing nutrients. Factors that regulate nutrient sensing can also modulate longevity. Reduced activity of nutrient sensing pathways such as glucose-sensing pKA, nitrogen-sensing TOR and S6 kinase homolog Sch9 have been linked to increased life span in the yeast, Saccharomyces cerevisiae, and higher eukaryotes. Recently, reduced activity of amino acid sensing SpS pathway was also shown to increase yeast life span. Life span extension by reduced SpS activity requires enhanced NAD＋（nicotinamide adenine dinucleotide, oxidized form） and nicotinamide riboside （NR, a NAD＋ precursor） homeostasis. maintaining adequate NAD＋ pools has been shown to play key roles in life span extension, but factors regulating NAD＋ metabolism and homeostasis are not completely understood. Recently, NAD＋ metabolism was also linked to the phosphate （pi）-sensing pHO pathway in yeast. Canonical pHO activation requires pi-starvation. Interestingly, NAD＋ depletion without pi-starvation was sufficient to induce pHO activation, increasing NR production and mobilization. moreover, SpS signaling appears to function in parallel with pHO signaling components to regulate NR/NAD＋ homeostasis. These studies suggest that NAD＋ metabolism is likely controlled by and/or coordinated with multiple nutrient sensing pathways. Indeed, cross-regulation of pHO, pKA, TOR and Sch9 pathways was reported to potentially affect NAD＋ metabolism; though detailed mechanisms remain unclear. This review discusses yeast longevity- related nutrient sensing pathways and possible mechanisms of life span extension, regulation of NAD＋ homeostasis, and cross-talk among nutrient sensing pathways and NAD＋ homeostasis.

关键词： nutrient sensing NAD+ homeostasis yeast longevity

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Strong-coupling superconductivity induced by calcium intercalation in bilayer transition-metal dichalcogenides

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Frontiers of physics 2018年第2期13卷 185-191页

作者： R. Szczesniak A. p. Durajski m. w. Jarosik Institute of physics Czestochowa University of Technology Ave. Armii Krajowej 19 42-200 Czestochowa Poland

we theoretically investigate the possibility of achieving a superconducting state in transition-metal dichalcogenide bilayers through intercalation, a process previously and widely used to achieve metal- lization and superconducting states in novel superconductors. For the Ca-intercalated bilayers moSs and wS2, we find that the superconducting state is characterized by an electron-phonon coupling constant larger than 1.0 and a superconducting critical temperature of 13.3 and 9.3 K, respectively. These results are superior to other predicted or experimentally observed two-dimensional conventional ＇superconductors and suggest that the investigated materials may be good candidates for nanoscale su- perconductors. more interestingly, we proved that the obtained thermodynamic properties go beyond the predictions of the mean-field Bardeen-Cooper-Schrieffer approximation and that the calculations conducted within the framework of the strong-coupling Eliashberg theory should be treated as those that yield quantitative results.

关键词： 2D superconductivity effect of intercalation transition-metal dichalcogenides,thermodynamic properties

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Nuclear magnetic resonance studies of vortices in high temperature superconductors

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Frontiers of physics 2011年第4期6卷 450-462页

作者： A. m. mounce S. Oh w. p. Halperin Department of physics and Astronomy Northwestern University Evanston IL 60208 USA

The distinct distribution of local magnetic fields due to superconducting vortices can be detected with nuclear magnetic resonance （NmR） and used to investigate vortices and related physical properties of extreme type II superconductivity. This review summarizes work on high temperature superconductors （HTS） including cuprates and pnictide materials. Recent experimental results are presented which reveal the nature of vortex matter and novel electronic states. For example, the NmR spectrum has been found to provide a sharp indication of the vortex melting transition. In the vortex solid a frequency dependent spin-lattice relaxation has been reported in cuprates, including YBa2Cu3OT-x, Bi2SrCa2Cu2O8＋δ, and T12Ba2CuO6＋5. These results have initiated a new spectroscopy via Doppler shifted nodal quasiparticles for the investigation of vortices. At very high magnetic fields this approach is a promising method for the study of vortex core excitations. These measurements have been used to quantify an induced spin density wave near the vortex cores in Bi2SrCa2Cu2Os＋δ. Although the cuprates have a different superconducting order parameter than the iron arsenide superconductors there are, nonetheless, some striking similarities between them regarding vortex dynamics and frequency dependent relaxation.

关键词： nuclear magnetic resonance (NmR) superconductor vortex Doppler effect

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Carbon storage potential of avenue trees:a comparison of Barringtonia racemosa,Cyclobalanopsis glauca,and Alnus formosana

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Journal of Forestry Research 2015年第2期26卷 307-314页

作者： Jyh-Shyan Tsay pei-Hsin Ko pai-tsang Chang Department of Horticultural Science National Chiayi University

Trees in cities play a valuable public health role for they are able to use photosynthesis to absorb atmospheric carbon dioxide（CO2）,which is then stored as tree *** present study compared the potential for carbon storage in the aboveground tree biomass of 3-year-old specimens of Barringtonia racemosa,Cyclobalanopsis glauca,and Alnus formosana grown in Chiayi City,*** of the carbon storage of avenue trees was based on measurement of the photosynthetic rate and leaf area,as well as the biomass of timbers,from October 2008 to *** on photosynthetic rates and leaf area,the estimated carbon stocks of ***,***,and *** are 756,615,and2738 kg Cha-1a-1,*** addition,carbon storage can be estimated based on timber volume,and these results are 1170,720,and 1995 kg Cha-1a-1for ***,***,and ***,*** on these findings,*** has the highest carbon fixation potential of these three *** the photosynthetic rate measurements can provide detailed data on the diurnal changes in carbon stocks,this requires more time and *** contrast,timber volume measurements provide a rapid and convenient way to estimate carbon stocks.

关键词： Carbon dioxide Carbon stock Greenhouse gas Leaf area Timber volume

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machine learning applications in healthcare clinical practice and research

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world Journal of Clinical Cases 2025年第1期13卷 16-21页

作者： Nikolaos-Achilleas Arkoudis Stavros p papadakos Research Unit of Radiology and medical Imaging School of MedicineNational and Kapodistrian University of AthensAthens 11528Greece 2^(nd)Department of Radiology “Attikon”General University HospitalMedical SchoolNational and Kapodistrian University of AthensChaidari 12462Greece Department of Gastroenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece

machine learning(mL)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human *** its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and *** this editorial,we succinctly introduce mL applications and present a study,featured in the latest issue of the world Journal of Clinical *** authors of this study conducted an analysis using both multiple linear regression(mLR)and mL methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and *** addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+***,the study's distinctive contribution lies in its adoption of mL methodologies,showcasing their superiority over traditional statistical approaches(herein mLR),thereby highlighting the potential of mL to represent an invaluable advanced adjunct tool in clinical practice and research.

关键词： machine Learning Artificial Intelligence Clinical practice Research Glomerular filtration rate Non-alcoholic fatty liver disease medicine

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Deformation Strength of Nanocrystalline Thin Films

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Journal of materials Science & Technology 2017年第7期33卷 718-722页

作者： w.Blum p.Eisenlohr Department of Chemical Engineering and materials Science Michigan State University East Lansing M148824 USA

The data of deformation strength and microstructure of thin films of nanocrystalline pd recently provided by Colla et al. have been analysed. It is shown that the properties of the films with cylindrical grains of30 nm diameter extending over a significant portion of the film thickness（≈90 nm） are quantitatively comparable to what is known from nanocrystalline bulk material. This is explained in terms of boundarymediated processes governing emission, storage, and recovery of dislocations.

关键词： Stress relaxation Thin Film Nanocrystalline pd In situ Dislocations

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Reflective graphene oxide absorber for passively mode-locked laser operating at nearly 1μm

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Chinese physics B 2013年第9期22卷 442-445页

作者：杨济民杨琦刘杰王勇刚 Yuen H.tsang College of physics and Electronics Shandong Normal University State Key laboratory of Crystal material Shandong University Department of Applied physics and materials Research Center The Hong Kong Polytechnic University

A low cost and simply fabricated reflective graphene oxide is successfully made. By using this absorber, as well as an end reflector, we obtain a passively mode-locked Yb：LuYSiO5 laser operating at nearly 1 p,m. when the pump power is increased up to 5.73 w, stable mode locking is achieved. The central wavelength of the laser spectrum is 1043.2 nm with a pulse duration of 5.0 ps. when the pump power reaches 8.16 w, dual-wavelength mode locking laser pulses at 1036.3 nm and 1043.5 nm are simultaneously detected.

关键词： passively mode-locked dual-wavelength laser graphene oxide Yb:LuYSi05 crystal

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Improving the wind and temperature measurements of an airborne meteorological measuring system

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Journal of Zhejiang University-Science A(Applied physics & Engineering) 2012年第10期13卷 723-746页

作者： Stephen FOSTER p.w.CHAN Aventech Research Inc. BarrieON L4N 2E3Canada Hong Kong Observatory KowloonHong KongChina

The Aircraft Integrated meteorological measuring System 20 Hz(AImmS-20) has been used by the Hong Kong Observatory(HKO),China in data collection for tropical cyclone situations over the South China Sea and windshear and turbulence measurement at the Hong Kong International Airport(HKIA).This paper discusses possible methods for further enhancing the quality of the wind and temperature measurements from the *** wind measurement,the enhancement methods include:error modelling of the accelerometer(e.g.,bias offset and cross-axis rate sensitivity),global positioning system(GpS) phase lag consideration,better representation of the inertial measurement unit(ImU) velocity based on the GpS velocities and considering their location differences,consideration of the slower update of GpS velocity,and wing *** temperature measurement,the methods include the consideration of the temperature sensor response and the sensor housing *** results of typical flights using AImmS-20 show that the accuracy of the wind and temperature data could be improved by 20%-30%.Though the discussion in the present paper is related mainly to a specific meteorological measuring system on a particular aircraft,the techniques so employed should be a useful reference for similar systems installed on other aircraft.

关键词： Airborne meteorological measurements Kalman filter Comparison with radiosonde measurement

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