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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAps).

关键词： function supporting

Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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world Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis Calzadilla-Bertot Briohny w Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry C MacQuillan George Garas Gary p Jeffrey Michael C wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of HCC recurrence is generally reported as 8%-20%in the *** predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of HCC recurrence in a contemporary western Australian LT *** we performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate cox regression was used to determine predictors of HCC recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(p=0.001),vascular invasion(p=0.003)and poorly differentiated HCC(p=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank pwas low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma predictors post-transplant survival Australian data

CHARACTERIZATION OF NANOSTRUCTURES:TOOLS AND CHALLENGES

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Chinese Journal of polymer Science 2009年第1期27卷 77-83页

作者： G.cox w.wohlleben w.Schrepp polymer physics Dept. BASF SE67056 LudwigshafenGermany

Apart from long-known and applied nanostructures like carbon black for tyres or pigments for coatings nanotechnology has created highly sophisticated structures used for nano/molecular electronics,diagnostics,drug delivery, UV-absorbers *** the main question to be solved analytically is the local determination of tiny amounts of chemicals resulting in an ever increasing need for highly sensitive as well as locally resolved *** of techniques like mass spectroscopy,transmission elect...

关键词： Analytical ultracentrifugation Fuel cells Inorganic particles Nanostructures Surface energy

On the Base point Locus of Surface parametrizations:Formulas and Consequences

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Communications in Mathematics and Statistics 2022年第4期10卷 757-783页

作者： David A.cox Sonia pérez-Díaz J.Rafael Sendra Department of Mathematics and Statistics Amherst CollegeAmherstMA 01002USA Universidad de Alcalá Dpto.de Física y Matemáticas28871 MadridSpain

This paper shows that the multiplicity of the base point locus of a projective rational surface parametrization can be expressed as the degree of the content of a univariate *** a consequence,we get a new proof of the degree formula relating the degree of the surface,the degree of the parametrization,the base point multiplicity and the degree of the rational map induced by the *** addition,we extend both formulas to the case of dominant rational maps of the projective plane and describe how the base point loci of a parametrization and its reparametrizations are *** an application of these results,we explore how the degree of a surface reparametrization is affected by the presence of base points.

关键词： Base point Hilbert-Samuel multiplicity Surface parametrization Reparametrization parametrization degree Surface degree

phosphorus Dynamics in Two poultry-Litter Amended Soils of Mississippi Under Three Management Systems

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pedosphere 2010年第2期20卷 217-228页

作者： B. w. BEAVERS Z. LIU M. S. cox w. L. KINGERY G. E. BRINK p. D. GERARD K. C. MCGREGOR Department of plant and Soil Sciences Mississippi State University Mississippi State Mississippi 39762 (USA) Dairy Forage Research Center of Agricultural Research Service at the U.S. Department of Agriculture Madison Wi-sconsin 53706 (USA) Experimental Statistics Unit Mississippi State University Mississippi State Mississippi 39762 (USA) National Sedimentation Laboratory of Agricultural Research Service at the U.S. Department of Agriculture OxfordMississippi 38655 (USA) Dynamic Solutions LLC Knoxville Tennessee 37919 (USA)

An experiment arranged in a randomized complete block design with three replications was conducted on a Lexington soil (fine-silty,mixed,active,thermic,Ultic Hapludalfs) and a Loring soil (fine-silty,mixed,active,thermic,Oxyaquic Fragiudalfs) in Mississippi from September 1997 to September 2000 on 18 runoff plots under natural rainfall condition to study the phosphorus (p) dynamics in poultry litter amended soils under three management systems combining tillage and planting date treatments to identify effective management practices in southern *** management systems in the study were:1) tillage in the fall prior to litter application followed by a delayed planting of fall forages (CT-Dp);2) tillage followed by immediate planting of the fall forage with subsequent litter application (CT-Ip);and 3) no-till with planting prior to litter application (NT-Ip).The results indicated that there was significant increase in soil p after 3 years of poultry litter application for both Lexington and Loring soils (p p budget analysis,the majority of p from poultry litter application (> 90%),was accumulated in both *** Loring soil,soluble p mass in the runoff was significantly higher from NT-Ip than from CT-Dp and CT-Ip over the entire study period (p were no significant differences in sediment p mass between management *** Loring soil,CT-Dp and CT-Ip were effective management practices to mitigate negative effects due to poultry litter application.

关键词： conventional tillage no-till sediment phosphorus soluble phosphorus

T lymphocyte apoptosis induced by CD8ε chimera

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Chinese Science Bulletin 1997年第3期42卷 222-227页

作者： David perkins cox Terhorst Harvard Medical School BostonMAUSAHarvard Medical SchoolBostonMAUSA

THE T cell repertoire is characterized by an extremely diverse population of different surface receptors (TCR) which participates in highly specific responses to a large number of different antigens and mediate antigen stimulation signals. Variable heterodimers of TCR α/β and γ/δ receptors are associated with invariable CD3γ, δ, ε and ζ proteins, thus forming the TCR/CD3 complex. CD3ε plays an important role in the initiation of TCR resembling and signfal transduction among the octopeptide chains. Stimulation by anti-CD3ε monoclonal

关键词： T lymphocyte apoptosis CD8ε chimera.

Equal Sex Ratios of a Marine Green Alga, Bryopsis plumosa

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Journal of Integrative plant Biology 2008年第6期50卷 648-652页

作者： Tatsuya Togashi paul Alan cox Marine Biosystems Research Center Chiba University Institute for Ethnomedicine Box 3464 Jackson Hole Wyoming 83001 USA Institute for Ethnomedicine Box 3464 Jackson Hole

By finding some important culture conditions as below, we succeeded in experimentally controlling the whole life history of a dioecious marine green alga, Bryopsis plumosa （Hudson） C. Agardh. In this study, we focused on the primary and secondary sex ratios （i.e. at inception and maturity） using these culture techniques. Gametogenesis was induced by culturing haploid gametophytes with provasoli＇s enriched seawater （pES） medium under a 14：10 h light： dark cycle at 14 ℃. Formed zygotes grew into diploid sporophytes, which were cultured for 3 months with pES medium under a 14：10 h light ： nbsp;dark cycle at 18℃. Then they were transferred into Schreiber medium and cultured under a 10：14 h light： dark cycle at 22℃. within 1 week, zoosporogenesis was observed. Zoospores were released within a couple of days. Each zoospore soon germinated and grew into a unisexual gametophyte. The primary sex ratio was examined in gametophytes that originated from a single sporophyte. The secondary sex ratio was studied in the field. Both were estimated as 1：1. Synchronized meiotic cell divisions might occur during zoosporogenesis dividing each sex-determining factor evenly among zoospores. Given the equal sex ratio at maturity, there seems to be no environmental factor that differentially affects the survival of male or female gametophytes in nature.

关键词： algal culture Bryopsis green algae life history sex ratio.

why are pandas so obsessed with horse manure?

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Science China(Life Sciences) 2021年第3期64卷 492-493页

作者： Li Zhang Biao Yang Neil cox Key Laboratory for Biodiversity and Ecological Engineering of Ministry of Education College of Life SciencesBeijing Normal UniversityBeijing 100875China Key Laboratory of Southwest China wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchong 637002China IUCN-CI Biodiversity Assessment Unit Global Species ProgramNW Washington DC 20009USA

Giant pandas are commonly perceived as clean and cuddly *** the wild,the bamboo-eating giant pandas(Huang et al.,2021)are dirty,and perhaps worse,field observations have shown that giant pandas are so attracted to horse manure that they cannot resist rolling in it(Zhou et al.,2020).This strange behavior requires further study to *** the natural environment,feces are like an identification card;Animals can learn about the sex and mating status of other individuals of their species(Zhou et al.,2019)and identify the presence of predators nearby by smelling the feces(Linklater et al.,2013;Brodie et al.,2016).After a decade of field observation,Chinese scientists have determined that horse manure strongly attracts wild giant pandas in the Qinling region,a behavior that appears rare among other animals.A video taken by the research team in Shaanxi’s Foping National Nature Reserve showed a wild giant panda sniffing,rolling,rubbing its cheek against,and coating the manure all over its body after encountering the fresh horse manure.

关键词： horse giant rolling

A likely role for the pH-domain containing protein, pEpp2/ pLEKHA5, at the membrane-microtubule cytoskeleton interface

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BIOCELL 2013年第3期37卷 55-61页

作者： Yi ZOU Timothy C cox School of Molecular Biosciences University of AdelaideAdelaideSouth Australia and Department of Anatomy&Developmental BiologyMonash UniversityClaytonVictoriaAustralia

pH(pleckstrin homology)domains are well known to bind membrane phosphoinositides with different specificities and direct pH domain-containing proteins to discrete subcellular compartments with assistances of alternative binding *** domain-containing proteins have been found to be involved in a wide range of cellular events,including signalling,cytoskeleton rearrangement and vesicular *** we showed that a novel pH domain-containing protein,pEpp2(also known as pLEKHA5),displays moderate phosphoinositide binding *** length pEpp2 was observed to variably associate with both the plasma membrane and *** membrane-associated pEpp2 nucleated at cell-cell contacts and the leading edge of migrating *** of pEpp2 increased membrane microviscosity,indicating a potential role for pEpp2 in regulating function of microtubule-dependent membrane functions.

关键词： microtubule membrane phosphoinositide microviscosity pH domain