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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay vincentÉmond Martine Saint-pierre Clémence Rouxel Line Berthiaume pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOpAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration parkinson’s disease polyunsaturated fatty acids omega-3

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Scattering and diffraction of plane p-waves in a 2-D elastic half-space Ⅱ：shallow arbitrary shaped canyon

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 459-485页

作者： Heather p.Brandow vincent Lee Civil and Environmental Engineering University of Southern California Los Angeles 90089 United States

Scattering and Diffraction of elastic in-plane p-and SV-waves by a surface topography such as an elastic canyon at the surface of a half-space is a classical problem which has been studied by earthquake engineers and strong-motion seismologists for over forty years. The case of out-of-plane SH waves on the same elastic canyon that is semi-circular in shape on the half-space surface is the first such problem that was solved by analytic closed form solutions over forty years ago by Trifunac. The corresponding case of in-plane p-and SV-waves on the same circular canyon is a much more complicated problem because, the in-plane p-and SV-scattered waves have different wave speeds and together they must have zero normal and shear stresses at the half-space surface. It is not until recently in 2014 that analytic solution for such problem is found by the author in the work of Lee and Liu. This paper uses the technique of Lee and Liu of defining these stress-free scattered waves to solve the problem of the scattered and diffraction of these in-plane waves on an almost-circular surface canyon that is arbitrary in shape.

关键词： diffraction elastic p-waves SV-waves weighted-residual method arbitrary-shaped canyon

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Weighted residual method for diffraction of plane p-waves in a 2-D elastic half-spaceⅢ:on an almost circular arbitrary-shaped alluvial valley

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Earthquake Science 2018年第1期31卷 19-34页

作者： Heather p.Brandow vincent Lee Brandow&Nastar Inc. Rancho Santa MargaritaCA 92688USA Asanti Civil Environmental Engineering University of Southern CaliforniaLos AngelesCA 90089-2531USA

Scattering and diffraction of elastic in-plane p- and SV-waves by a surface topography such as an elastic canyon at the surface of a half-space is a classical problem which has been studied by earthquake engineers and strong motion seismologists for over forty years. The case of out-of- plane SH-waves on the same elastic canyon that is semicircular in shape on the half-space surface is the first such problem that was solved by analytic closed-form solutions over forty years ago by Trifunac. The corresponding case of in-plane p- and SV- waves on the same circular canyon is a much more complicated problem because the in-plane p- and SV- scattered waves have different wave speeds and together they must have zero normal and shear stresses at the half-space surface. It is not until recently in 2014 that analytic solution for such problem is found by Lee and Liu. This paper uses their technique of defining these stress-free scattered waves, which Brandow and Lee previously used to solve the problem of the scattering and diffraction of these in-plane waves on an almost-circular surface canyon that is arbitrary in shape, to the study of the scattering and diffraction of these in-plane waves on an almost circular arbitrary-shaped alluvial valley.

关键词： Scattering Diffraction Alluvial valley Arbitrary shaped Weighted-residues Amplification

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Assembly of peptide nanostructures with controllable sizes

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Nano Research 2024年第1期17卷 151-161页

作者： Dan Cheng Fan Jia Yun-Bao Jiang vincent p.Conticello Tao Jiang The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian province(IKKEM) Xiamen 361005China Department of Chemistry Emory UniversityAtlanta 30033USA

Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in *** the progress in forming peptide nanostructures of various morphology,there exists a distinct gap between natural and synthetic assembly systems in terms of size *** nanostructures with a narrow size distribution that can be tuned over a wide range of length-scales is essential for applications that require precise spacing between *** approach provides the opportunity to correlate materials and biological properties of interest with assembly *** this review,we discuss representative endeavors over the past two decades for design of size-controllable peptide nanostructures using tunable building *** mechanisms for size control,e.g.,molecular frustration,template-directed peptide assembly,and multi-component peptide co-assembly,will also be *** also demonstrate the applicable scopes of these strategies and suggest potential future avenues for scientific advances in this field.

关键词： peptide assembly controllable size template multi-component

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Tourism Developments Increase Tsunami Disaster Risk in pangandaran, West Java, Indonesia

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International Journal of Disaster Risk Science 2021年第5期12卷 764-769页

作者： vincent Nijman Department of Social Sciences Oxford Brookes UniversityOxford OX30BP.United Kingdom

On 17 July 2006,the tourist resort of pangandaran on Java’s south coast was hit by a tsunami,resulting in 413 fatalities and severe damage to *** tsunami resulted in major rebuilds with a focus on mass *** of the impact of a future tsunami focussed on building development and suggest limited change since *** article presents a case study on the development of(largely domestic)tourism in pangandaran and how this has increased the tsunami disaster *** numbers were stable at about 900,000 visitors a year prior to the tsunami,down to slightly over 250,000 visitors a year in its aftermath,and from 2007 onwards numbers are doubling every three years to about 4 million visitors in *** increase has been most pronounced during *** to 2006,pangandaran was characterized by wooden structures and one-and two-story buildings of clay-brick masonry;by 2019,14 three to sixstory hotels have been erected along the *** many more visitors,most of whom are unfamiliar with tsunami risks,and shelter facilities for less than a quarter of visitors during peak times,future impacts and the potential cost to life are considerably higher now than in 2006,especially if a tsunami were to hit over a *** tourists upon arrival and throughout their stay should be better informed about the risks of tsunamis,and of the location of tsunami shelters and evacuation routes.

关键词： Disaster resilience Effective warning Indonesia Risk mitigation Tourism Tsunami

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Strain and stress analysis on Zn multicrystal film by XRD method

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中国有色金属学会会刊：英文版 2006年第B02期16卷 735-738页

作者： vincent JI LIM UMR CNRS8006ENSAM 151Boulevard de I'Hopital75013 ParisFrance

A new method was denonstrated to determine stress in a single crystal for multicrystal material and this new method could be specially applied for any symmetric crystalline systems. The strain tensor e was determined by the change of the metric tensor G before the initial state and after the deformed state in the crystal reference system. Then stress tensor at grain scale was calculated by the HOOK's law. The stress evaluations were carried out in coarse grains of a thin galvanized coating on a steel substrate during tensile loading. This makes it possible to link the microstructure evolution to the elastic heterogeneity at grain scale or between the grains.

关键词：锌多晶膜单晶应力应变分析 XRD法锌镀层

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Investigation of blood pulse ppG signal regulation on toe effect of body posture and lower limb height

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Journal of Zhejiang University-Science A(Applied physics & Engineering) 2007年第6期8卷 916-920页

作者： XIN Shang-zhi HU Sijung CRABTREE vincent p. ZHENG Jia AZORIN-pERIS vincent ECHIADIS Angelos SMITH peter R. College of Electrical Engineering University of Shanghai for Science and Technology Shanghai 200093 China Department of Electronic and Electrical Engineering Loughborough University Leicestershire LE11 3TU UK

Objective: To study the regulation of blood pulse volume via photoplethysmography (ppG) signal detected from toe, while the lower limb is passively raised in different height positions. Methods: Use a modified non-invasive ppG technique to detect the blood pulse signal on toe with infrared (IR) photo sensor. A protocol consisting of two postures, i.e., supine and 45° reclining, was designed to conduct laboratory trial in this study. During the period of performing the protocol of these postures, the lower limb was passively raised from the heights of 10 cm to 60 cm randomly and individually with sponge blocks underneath the foot. Results: In the supine posture, the higher the foot was passively raised, the more the blood ppG signal decreased. In the 45° reclining posture, the blood ppG signal increased at the beginning and then decreased in the foot height position from 10 cm to 60 cm. In both postures the normalized AC signal changes significantly while the normalized DC signal changes little. Conclusion: The toe ppG signals can obviously indicate the regulated blood volume change with the designated postural procedures due to the heart level position.

关键词： photoplethysmographv (ppG) Non-invasive Body posture Blood pulse volume signal Lower limb

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Multicomponent flow modeling

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Science China Mathematics 2012年第1期55卷 285-308页

作者： GIOVANGIGLI vincent CMAp-CNRS Ecole

We present multicomponent flow models derived from the kinetic theory of gases and investigate the symmetric hyperbolic-parabolic structure of the resulting system of partial differential *** address the Cauchy problem for smooth solutions as well as the existence of deflagration waves,also termed anchored *** further discuss related models which have a similar hyperbolic-parabolic structure,notably the SaintVenant system with a temperature equation as well as the equations governing chemical equilibrium *** next investigate multicomponent ionized and magnetized flow models with anisotropic transport fluxes which have a different mathematical *** finally discuss numerical algorithms specifically devoted to complex chemistry flows,in particular the evaluation of multicomponent transport properties,as well as the impact of multicomponent transport.

关键词： multicomponent reactive flow Cauchy problem deflagration wave multicomponent transport

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Experimental study of path planning problem using EMCOA for a holonomic mobile robot

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Journal of Systems Engineering and Electronics 2021年第6期32卷 1450-1462页

作者： MOHSENI Alireza DUCHAINE vincent WONG Tony Department of System Engineering École de Technologie SupérieureMontreal QC H3C 1K3Canada

In this paper,a comparative study of the path planning problem using evolutionary algorithms,in comparison with classical methods such as the A*algorithm,is presented for a holonomic mobile *** configured navigation system,which consists of the integration of sensors sources,map formatting,global and local path planners,and the base controller,aims to enable the robot to follow the shortest smooth path ***-based mapping is used for scoring paths efficiently,allowing the determination of collision-free trajectories from the initial to the target *** work considers the evolutionary algorithms,the mutated cuckoo optimization algorithm(MCOA)and the genetic algorithm(GA),as a global planner to find the shortest safe path among others.A non-uniform motion coefficient is introduced for MCOA in order to increase the performance of this algorithm.A series of experiments are accomplished and analyzed to confirm the performance of the global planner implemented on a holonomic mobile *** results of the experiments show the capacity of the planner framework with respect to the path planning problem under various obstacle layouts.

关键词： holonomic robot path planning evolutionary algorithm(EA)

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Cropping leads to loss of soil organic matter: How can we prevent it?

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pedosphere 2023年第1期33卷 8-10页

作者： vincent CHApLOT pete SMITH Institut de Recherche pour le Développement(IRD) Laboratoire d’Océanographie et du ClimatExpérimentations et Approches NumériquesUMR 7159IRD-CNRS-UPMC-MNHNCedex 05Paris 75252France Institute of Biological and Environmental Sciences School of Biological SciencesUniversity of AberdeenAberdeen AB243UUUK

Soil organic matter(SOM),which associates carbon(C)to key plant nutrients,has been stored in soil for thousands of *** have long recognised its positive impact on key environmental functions such as food production and climate *** soon as a virgin land(forest or grassland)is cultivated,there is a tendency for the soil to lose its SOM,and we still largely misunderstand the underlying mechanisms,leading to inappropriate decisions being taken to fight soil,climate,and overall ecosystem degradation.

关键词： soil grassland forest

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