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plasma electrolytic oxidation of magnesium and its alloys:Mechanism,properties and applications

Journal of Magnesium and Alloys 2017年第1期5卷 74-132页

作者： Gh.Barati Darband M.Aliofkhazraei p.Hamghalam N.Valizade Department of Materials Engineering Faculty of EngineeringTarbiat Modares UniversityP.O.Box:14115-143TehranIran

plasma Electrolyte Oxidation(pEO)process has increasingly been employed to improve magnesium surface properties by fabrication of an MgO-based *** from conventional anodizing procedures,this high-voltage process produces an adhesive ceramic film on the *** present article provides a comprehensive review around mechanisms of pEO coatings fabrication and their different *** to complexity of pEO coatings formation,a complete explanation regarding fabrication mechanisms of pEO coatings has not yet been proposed;however,the most important advancements in the field of fabrication mechanisms of pEO coatings were gathered in this *** of pEO coatings fabrication on magnesium were reviewed considering voltage–time plots,optical spectrometry,acoustic emission spectrometry and electronic properties of the ceramic ***,the coatings properties,affecting parameters and improvement strategies were *** addition,corrosion resistance of coatings,important factors in corrosion resistance and methods for corrosion resistance improvement were *** properties(important factors and improvement methods)of coatings were also *** magnesium and its alloys are broadly used in biological applications,the biological properties of pEO coatings,important factors in their biological performance and existing methods for improvement of coatings were *** of ceramic based nanoparticles and formation of nanocomposite coatings may considerably influence properties of plasma electrolyte oxidation *** coatings properties and nanoparticles adsorption mechanisms were included in a separate *** method to improve coatings properties is formation of hybrid coatings on pEO coatings which was discussed in the end.

关键词： plasma electrolytic oxidation Magnesium Tribological properties Biomedical properties Nanocomposite coatings

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具有多体效应的胶体聚团的特征

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物理化学学报 1997年第1期13卷 28-35页

作者：李敬生 p.MarkRodger 西安建筑科技大学冶金系西安710055

考察了多体效应（用Stutton－Chen势，SC．）对胶体聚团的影响并与双体（Lennard－Jones，LJ）势下的结果作了比较,研究表明，SC和LJ势下簇团的性质有其相似的一面，如，随着剪应力的增加，系统里颗粒的平均势能增加，而每个簇团的颗粒... 详细信息

考察了多体效应（用Stutton－Chen势，SC．）对胶体聚团的影响并与双体（Lennard－Jones，LJ）势下的结果作了比较,研究表明，SC和LJ势下簇团的性质有其相似的一面，如，随着剪应力的增加，系统里颗粒的平均势能增加，而每个簇团的颗粒数减少；在较强的剪应力场里，簇团沿剪应力方向（X轴）被明显拉长且其主轴偏离X轴等.但它们间的差异也是明显的，在剪应力下SC系统内颗粒排列得更合理，从而使得平均位能比LJ系统低约1－3个对比能量单位，因而簇团较致密，分形维数较高；颗粒的平均位能，平均簇团大小和分形维数对剪应力的依赖均比LJ系统减弱．在某些条件下簇团的形貌特征也发生了一定程度的改变．

关键词：多体效应胶体计算机模拟

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New Findings of Latest Early Olenekian(Early Triassic)Fossils in South primorye,Russian Far East,and their Stratigraphical Significance

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Journal of Earth Science 2021年第3期32卷 554-572页

作者： Yuri D.Zakharov Liana G.Bondarenko Alexander M.popov Olga p.Smyshlyaeva Far Eastern Geological Institute Far Eastern BranchRussian Academy of SciencesVladivostok 690022Russia

Information on latest early Olenekian(latest Smithian)ammonoids is available apparently from only seven regions of the world,including South *** Smithian evidences on this topic are recorded from the West SMID(abbreviation from the Russian name of the quarry:"Building Materials and Details"),East SMID and Golyj Cape areas in South *** provides additional information on systematic composition of latest Smithian ammonoid,as well as conodont and brachiopod assemblages from the recently identified Shimanskyites shimanskyi Zone,located between lower Olenekian Anasibirites nevolini Zone and upper Olenekian Tirolites subcassianus *** are many common ammonoid species in the Shimanskyites shimanskyi Zone and the underlying Anasibirites nevolini Zone,e.g.,prosphingitoides sp.,Arctoceras septentrionale(Diener),Churkites syskoi Zakharov et Shigeta,Submeekoceras?subhhydaspis(Kiparisova),prionites markevichi Zakharov et Smyshlyaeva,?Anasibirites?simanenkoi Zakharov et Smyshlyaeva,Xenoceltites?subvariocostatus Zakharov et Smyshlyaeva,and Mianwaliites zimini Zakharov et *** base of the Shimanskyites shimanskyi Zone,marked by a negativeδ13Corg excursion in the Kamenushka-2 Section by our previous study,coincides with the FO(first occurrence)of ammonoids Shimanskyites shimanskyi Zakharov et Smyshlyaeva and Glyptophiceras ***(Waagen)and conodont Hindeodella budurovi *** zone is characterized additionally by some fossils common for the overlying upper Olenekian Tirolites subcassianus Zone:ammonoids of the genus Kamenushkaites,brachiopods Bittnerihyris margaritovi(Bittner)and Lepismatina *** conodont?Neogondolella?(=?Borinella)jubata *** latest Smithian ammonoids recorded from the Shimanskyites shimanskyi Zone totally consist of 30 taxa belonging to 11 families(Sageceratidae,Ussuiriidae,Aspenitidae,paranannitidae,Arctoceratidae,proptychitidae,?Galfetitidae,prionitidae,?Kashmiritidae,Xenoceltitidae and palaeophyllitidae).th

关键词： ammonoids conodonts brachiopods biostratigraphy Smithian Russia

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Horizontal transfer and evolution of the biosynthetic gene cluster for benzoxazinoids in plants

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plant Communications 2022年第3期3卷 102-115页

作者： Dongya Wu Bowen Jiang Chu-Yu Ye Michael p.Timko Longjiang Fan Hainan Institute of Zhejiang University Yonyou Industrial ParkSanya 572025China Institute of Crop Science&Institute of Bioinformatics Zhejiang UniversityHangzhou 310058China Department of Biology University of VirginiaCharlottesvilleVA 22904USA

Benzoxazinoids are a class of protective and allelop.thic plant secondary metabolites that have been identified in multiple grass species and are encoded by the Bx biosynthetic gene cluster(BGC)in *** mining of 41 high-quality grass genomes identified complete Bx clusters(containing genes Bx1–Bx5 and Bx8)in three genera(Zea,Echinochloa,and Dichanthelium)of panicoideae and partial clusters in *** Bx cluster probably originated from gene duplication and chromosomal translocation of native homologs of Bx *** ancient Bx cluster that included additional Bx genes(e.g.,Bx6)is presumed to have been present in ancestral *** ancient Bx cluster was putatively gained by the Triticeae ancestor via horizontal transfer(HT)from the ancestral panicoideae and later separated into multiple segments on different ***6 appears to have been under less constrained selection compared with the Bx cluster during the evolution of panicoideae,as evidenced by the fact that it was translocated away from the Bx cluster in Zea mays,moved to other chromosomes in Echinochloa,and even lost in *** investigations indicate that purifying selection and polyploidization have shaped the evolutionary trajectory of Bx clusters in the grass *** study provides the first candidate case of HT of a BGC between plants and sheds new light on the evolution of BGCs.

关键词： biosynthetic gene cluster horizontal transfer benzoxazinoid grass purifying selection

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CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation

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Journal of Molecular Cell Biology 2022年第7期14卷 49-61页

作者： Yan Zhang Emily A.Daniel July Metcalf Yuqiao Dai Gail A.Reif Darren p.Wallace Department of Internal Medicine University of Kansas Medical CenterKansas CityKS 66160-3018USA Jared Grantham Kidney Institute University of Kansas Medical CenterKansas CityKS 66160-3018USA Department of Molecular and Integrative physiology University of Kansas Medical CenterKansas CityKS 66160-3018USA

Autosomal dominant polycystic kidney disease(ADpKD)is characterized by progressive enlargement of fluid-filled cysts,causing nephron loss and a decline in renal *** target of rapamycin(mTOR)is overactive in cyst-lining cells and contributes to abnormal cell proliferation and cyst enlargement;however,the mechanism for mTOR stimulation remains *** discovered that calcium/calmodulin(CaM)dependent kinase IV(CaMK4),a multifunctional kinase,is overexpressed in the kidneys of ADpKD patients and pKD mouse *** human ADpKD cells,CaMK4 knockdown reduced mTOR abundance and the phosphorylation of ribosomal protein S6 kinase(S6K),a downstream target of *** inhibition of CaMK4 with KN-93 reduced phosphorylated S6K and S6 levels and inhibited cell proliferation and in vitro cyst formation of ADpKD ***,inhibition of calcium/CaM-dependent protein kinase kinase-βand CaM,two key upstream regulators of CaMK4,also decreased mTOR *** effects of KN-93 were independent of the liver kinase B1-adenosine monophosphate-activated protein kinase(AMpK)p.thway,and the combination of KN-93 and metformin,an AMpK activator,had additive inhibitory effects on mTOR signaling and in vitro cyst *** data suggest that increased CaMK4 expression and activity contribute to mTOR signaling and the proliferation of cystic cells of ADpKD kidneys.

关键词： ADpKD CaMK4 CaMKKβ calmodulin LKB1 AMpK

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Reply:Is the evolution of tumors Darwinian or non-Darwinian?

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National Science Review 2018年第1期5卷 17-19页

作者： Marc J Williams Benjamin Werner Chris p Barnes Trevor A Graham Andrea Sottoriva Evolution and Cancer Laboratory Barts CancerInstitute Queen Marry University of London Department of Cell and Developmental Biology University College London Centre for Mathematics and physics in the Life Sciences and Experimental Biology (CoMpLEX) University College London Centre for Evolution and Cancer The Institute of Cancer Research Department of Genetics Evolution and EnvironmentUniversity College London

Wu and colleagues’letter discusses the limitations of the use of a single sample per tumor to investigate neutral evolution in human *** evolution describes the situation in which there is no differential clonal selection amongst the population of cells within a cancer:all mutations thataccrue during growth are passengers and all drivers were already present in the

关键词： Reply:Is the evolution of tumors Darwinian or non-Darwinian VAF

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Upper Gastrointestinal Endoscopy and Children Digestive p.thology in Abidjan

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Open Journal of Gastroenterology 2016年第10期6卷 265-274页

作者： Aboubacar Demba Bangoura Henriette Ya Anzouan Kissi-Kacou Stanislas Doffou Constant A ssi Mamert Fulgence Yao Bathaix Alain Koffi Attia Aya thérèse Ndri-Yoman Hepatogastroenterology Unit Yopougon Teaching Hospital Yopougon Ivory Coast Hepatogastroenterology Unit Cocody Teaching Hospital Cocody Ivory Coast

the aim of our study is to determine the demographic data, indications, performance, and security of gastroscopy in children in Ivory Coast. patients and Methods: this is a retrospective analytical study based on reports of upper digestive endoscopy per-formed in children (from 1 day to 15 years included) in 2 university hospitals in Abid-jan from March 2009 to March 2016. Results: 276 upper gastrointestinal endoscopies (UGIE) were performed in children during the study period. UGIE was performed with a diagnostic purpose in most cases (99%). the indications of UGIE were abdominal pains (38.95%), ingestion of caustic substances (29.82%), upper gastrointestinal bleeding (10.87%) and vomiting (10.17%). UGIE was normal in 39.49% of cases for all ages. the main anomalies observed in upper gastrointestinal (GI) endoscopy for all ages were gastrop.thies (29%);caustic lesions (13.02%) and bile reflux (10.45%). Ul-cers were rarely found (2.54%). Histological examination of biopsies revealed chronic H. pylori gastritis in 67% of gastric samples examined. All endoscopic examinations were performed without incident. Conclusion: Gastroscopy is a harmless examination with a great diagnostic and therapeutic utility in digestive p.thology of children in Ivory Coast.

关键词： Upper Gastrointestinal Endoscopy Children Abidjan Ivory Coast

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Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review

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World Journal of Gastroenterology 2015年第6期21卷 1945-1955页

作者： Michael S Broder David Beenhouwer Jonathan R Strosberg Maureen p Neary Dasha Cherepanov partnership for Health Analytic Research LLC Beverly Hills H. Lee Moffitt Cancer Center and Research Institute Novartis pharmaceuticals Corporation

AIM:To review literature on efficacy and safety of octreotide-long-acting repeatable(LAR)used at doses higher than the Food and Drug Administration(FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors(NETs).MEthODS:We searched pub Med and Cochrane Library from 1998-2012,5 conferences(American Society of Clinical Oncology,Endocrine Society,European Neuroendocrine Tumor Society,European Society for Medical Oncology,North American Neuroendocrine Tumor Society)from 2000-2013 using Me SH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and *** of accepted articles were also *** reviewers reviewed titles,abstracts,and full-length *** that reported data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,published in any language were included in the ***:the search identified 1086 publications,of which 238 underwent full-text review(20 were translated into English);17 were included in the *** varied in designs,subjects,octreotide-LAR regimens,and definition of *** studies reported use of higher doses to control symptoms and tumor progression,although symptom severity and formal quality-of-life analysis were not quantitatively *** studies reported efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/*** studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor *** studies reported safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/***:As reported in this review,octreotide-LAR at doses>30 mg/mo is being prescribed for symptom and tumor control in NET ***,expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal sy

关键词： Carcinoma Neuroendocrine Carcinoid syndrome Carcin

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纳米压痕硬度尺寸效应的残余面积最大压深模型

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硅酸盐学报 2005年第7期33卷 817-821页

作者：周亮姚英学 SHAHJADA A p 哈尔滨工业大学机电学院哈尔滨150001

针对材料在纳米压痕硬度测试实验中出现的压痕尺寸效应,通过对单晶硅的纳米压痕实验,得到压痕的真实最大压深,再利用原子力显微镜获得压痕的三维形貌,并结合Matlab软件得到压痕的真实残余面积。以残余面积和最大压深为变量,提出了一种... 详细信息

针对材料在纳米压痕硬度测试实验中出现的压痕尺寸效应,通过对单晶硅的纳米压痕实验,得到压痕的真实最大压深,再利用原子力显微镜获得压痕的三维形貌,并结合Matlab软件得到压痕的真实残余面积。以残余面积和最大压深为变量,提出了一种新的描述硬度压痕尺寸效应的模型———残余面积最大压深模型,此模型能更好地描述和理解纳米压痕硬度的尺寸效应。

关键词：压痕尺寸效应残余面积最大压深模型原子力显微镜硬度单晶硅

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Cerebral aneurysm treatment: modern neurovascular techniques

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Stroke & Vascular Neurology 2016年第3期1卷 93-100页

作者： Bowen Jiang Michelle paff Geoffrey p Colby Alexander L Coon Li-Mei Lin Department of Neurosurgery Johns Hopkins University School of MedicineThe Johns Hopkins HospitalBaltimoreMarylandUSA Department of Neurosurgery University of CaliforniaIrvine School of MedicineUC Irvine Medical CenterOrangeCaliforniaUSA

Endovascular treatment of cerebral aneurysm continues to evolve with the development of new *** review provides an overview of the recent major innovations in the neurointerventional space in recent years.

关键词： treatment cerebral neu

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