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The Rising Burden of hepatocellular Carcinoma: Is the Gender Gap Narrowing?

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Journal of Clinical and Translational hepatology 2024年第9期12卷 763-764页

作者： James K.h.ho prem h.Thurairajah Daniel Q.huang Kristie h.Fan Division of Gastroenterology and hepatology National University HospitalNational University Health SystemSingaporeSingapore

Dear Editors,The landscape of hepatocellular carcinoma(hCC)is continuously *** global trends indicate a significant shift in the epidemiology of hCC from viral-related to non-viral-related ***-associated fatty liver disease has emerged as the fastest-growing contributor to hCC in recent years,due to the increased prevalence of obesity and metabolic risk factors.

关键词： Carcinoma epidemiology obesity

The great catastrophe: causes of the permo-Triassic marine mass extinction

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National Science Review 2024年第1期11卷 37-50页

作者： paul B.Wignall David p.G.Bond School of Earth & Environment University of Leeds School of Environmental Sciences University of Hull

The marine losses during the permo-Triassic mass extinction were the worst ever experienced. All groups were badly affected, especially amongst the benthos(e.g. brachiopods, corals, bryozoans, foraminifers,ostracods). planktonic populations underwent a fundamental change with eukaryotic algae being replaced by nitrogen-fixing bacteria, green-sulphur bacteria, sulphate-reducing bacteria and prasinophytes. Detailed studies of boundary sections, especially those in South China, have resolved the crisis to a ～55 kyr interval straddling the permo-Triassic boundary. Many of the losses occur at the beginning and end of this interval painting a picture of a two-phase extinction. Improved knowledge of the extinction has been supported by numerous geochemical studies that allow diverse proposed extinction mechanisms to be studied. A transition from oxygenated to anoxic-euxinic conditions is seen in most sections globally, although the intensity and timing shows regional variability. Decreased ocean ventilation coincides with rapidly rising temperatures and many extinction scenarios attribute the losses to both anoxia and high *** kill mechanisms include ocean acidification for which there is conflicting support from geochemical proxies and, even less likely, siltation(burial under a massive influx of terrigenous sediment) which lacks substantive sedimentological evidence. The ultimate driver of the catastrophic changes at the end of the permian was likely Siberian Trap eruptions and their associated carbon dioxide emissions with consequences such as warming, ocean stagnation and acidification. Volcanic winter episodes stemming from Siberian volcanism have also been linked to the crisis, but the short-term nature of these episodes(he overwhelming evidence for rapid warming during the crisis makes this an unlikely cause. Finally, whilst the extinction is well studied in equatorial latitudes, a different history is found in northern Boreal latitudes

关键词： ocean anoxia ocean acidification siltation productivity collapse volcanic winter

Experimental investigation of radiative heat propagation in a simplified generic packed bed

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particuology 2024年第5期88卷 149-160页

作者： Matthias Tyslik Lukas pörtner Siegmar Wirtz Martin Schiemann Institute of Energy plant Technology Ruhr-University Bochum44780 BochumGermany

A novel test rig for the investigation of radiative heat transfer in packed beds has been developed and is introduced with representative experimental *** individual components and the calibration are *** generic packed bed is realized in a simplified way by an arrangement of parallel rods,which represent particles in *** this arrangement,electrically heated rods provide the radiation propagating through the rod array to heat the passive counterparts.A sophisticated temperature-control scheme with a large number of thermocouples and infrared-imaging provides in-depth information about heat transfer in the *** radiation intensities are determined with a Fourier-transform infrared spectroscopy,which has been modified and validated for this specific *** order to compare the influence of different surface properties of particles on the heat propagation and surface reflections,rod samples made of stainless steel and magnesium oxide are *** influence of material properties becomes clearly visible by comparing the high radiation intensities resulting from a stainless steel rod array to the same geometry built from magnesium oxide *** addition,the influence of the surface properties is particularly evident in the infrared images since the reflections are significantly higher for the stainless steel samples than for the magnesium oxide *** experimental results in the current work demonstrate the ability of the test rig to provide data with a well-defined accuracy as a validation base for numerical radiation simulations in packed beds.

关键词： Thermal radiation Spectral reflections Fourier-transform infrared spectroscopy

Constraining the variable generalized Chaplygin gas model in matter creation cosmology

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Communications in Theoretical physics 2024年第10期76卷 121-136页

作者： Yogesh Bhardwaj C p Singh Department of Applied Mathematics Delhi Technological University

We explore the variable generalized Chaplygin gas（VGCG） model in the theory of matter creation cosmology within the framework of a spatially homogeneous and isotropic flat Friedmann—Lemai tre—Robertson—Walker space-time. Matter creation cosmology is based on reinterpretation of the energy–momentum tensor in Einstein's field equations. This creation corresponds to an irreversible energy flow from the gravitational field to the created matter constituents. The variable Chaplygin gas（VCG） is also studied as a particular solution. We use the Markov chain Monte Carlo method to constrain the free parameters of three models, namely,Lambda-Cold-Dark matter（ΛCDM）, VGCG and VCG models with and without matter creation from the latest observational data from baryon acoustic oscillations, cosmic chronometer, type Ia supernovae（pantheon） including gamma-ray bursts, quasars and the local measurement of h0from R21 data. Two different combinations of dataset provide a fairly tight constraint on the parameters of the ΛCDM, VGCG and VCG models. The present values of various cosmological parameters are obtained, which are very close to the ΛCDM model. Furthermore, we perform stability analysis, Bayesian evidence analysis and information criteria analysis for these models through studying the sound speed, Bayes factor, and Akaike information criteria（AIC） and Bayesian information criteria（BIC） selection criteria. The values of sound speed for VGCG and VCG models shows that both the models are stable. According to AIC, it is observed that VGCG and VCG models with matter creation are supported considerably less by current observations,while BIC shows that these models are not favoured by observational data.

关键词： Chaplygin gas model cosmological model dark energy matter creation

RARRES2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi T.h.shubhra Institute of Chemistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(pC)and triacylglycerols(TAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(pTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBp1)signaling *** commentary aims to elaborate on the key findings and their relevance to the field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism Cancer pTEN-mTOR-SREBp1 signaling Metabolic reprogramming Brain metastasis

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Combining GLp-1 receptor agonists and SGLT-2 inhibitors for cardiovascular disease prevention in type 2 diabetes:A systematic review with multiple network meta-regressions

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World Journal of Diabetes 2024年第10期15卷 2135-2146页

作者： Jing-Jing Zhu John p h Wilding Xiao-Song Gu Department of Endocrinology and Metabolic Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of Cardiovascular and Metabolic Medicine University of LiverpoolLiverpool L697ZXUnited Kingdom Clinical Sciences Centre Liverpool University Hospitals NHS Foundation TrustLiverpool L97ALUnited Kingdom Department of Cardiovascular Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina

BACKGROUND Glucagon-like peptide-1 receptor agonists(GLp-1RA)and sodium-glucose co-transporter-2 inhibitors(SGLT-2I)are associated with significant cardiovascular benefit in type 2 diabetes(T2D).however,GLp-1RA or SGLT-2I alone may not improve some cardiovascular outcomes in patients with prior cardiovascular *** To explore whether combining GLp-1RA and SGLT-2I can achieve additional benefit in preventing cardiovascular diseases in *** The systematic review was conducted according to pRISMA *** protocol was registered on pROSpERO(ID:42022385007).A total of 107049 participants from eligible cardiovascular outcomes trials of GLp-1RA and SGLT-2I were included in network meta-regressions to estimate cardiovascular benefit of the combination *** modification of prior myocardial infarction(MI)and heart failure(hF)was also explored to provide clinical insight as to when the INTRODUCTION The macro-and micro-vascular benefits of glucagon-like peptide-1 receptor agonists(GLp-1RA)and sodium-glucose co-transporter-2 inhibitors(SGLT-2I)are independent of their glucose-lowering effects[1].In patients with type 2 diabetes(T2D),the major cardiovascular outcome trials(CVOT)showed that dipeptidyl peptidase-4 inhibitors(Dpp-4I)did not improve cardiovascular outcomes[2],whereas cardiovascular benefit of GLp-1RA or SGLT-2I was significant[3,4].Further subgroup analyses indicated that the background cardiovascular risk should be considered when examining the cardiovascular outcomes of these newer glucose-lowering *** instance,prevention of major adverse cardiovascular events(MACE)was only seen in those patients with baseline atherosclerotic cardiovascular disease[3,4].Moreover,a series of CVOT conducted in patients with heart failure(hF)have demonstrated that(compared with placebo)SGLT-2I significantly reduced risk of hospitalization for hF or cardiovascular death,irrespective of their history of T2D[5-8].however,similar car

关键词： Type 2 diabetes Glucagon-like peptide-1 receptor agonist Sodium-glucose co-transporter-2 inhibitor Combination treatment Cardiovascular outcome Systematic review Network meta-regression

Exploring the potential of drill cuttings for reservoir characterization:A case study from the Volga-Ural basin,Russia

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petroleum Research 2024年第2期9卷 193-205页

作者： Ibrahem Yousef V.p.Morozov Kazan Federal University Institute of Geology and Petroleum Technologies420008Russian Federation

The research objectives are to assess the possibility of using drill cutting analysis to obtain information about the mineralogical and geochemical properties of the reservoir *** cutting samples were collected from a vertical well that penetrated the Domanik sediments(Semiluksk Formation)in one of the oil fields in the Volga-Ural petroleum *** sections from drill cuttings were examined using an optical polarizing microscope(Axio Imager A2).X-ray diffraction(XRD)analyses were performed using a Brucker D2 phaser X-ray powder *** properties were studied using an STA 449 F3 Jupiter *** pyrolytic studies were performed using the Rock-Eval *** inspection showed that the studied sediments are alternations of carbonates and siliceous-carbonate *** section examinations revealed that the carbonates are mainly limestone(mudstone and wackestone)and are characterized by a dense texture and up to 30%organic *** siliceous-carbonate rocks are dominated by siliceous mudstones and are characterized by dark colours,layered structure,and an enrichment in organic *** analyses showed that the carbonate rocks are mainly composed of calcite,dolomite,quartz,feldspar,and mica,which are minor *** siliceous-carbonate rocks are dominated by quartz,followed by calcite,although they also contain feldspars,mica,dolomite,and pyrite as *** to the simultaneous thermal analysis,the average total hydrocarbon in the carbonate and siliceous-carbonate rocks is 13.6%(for the core samples)and 11.5%(for the drill cutting samples).The content of heavy hydrocarbons in the rocks is higher than the content of light hydrocarbons,indicating the immature nature of organic *** is found sporadically in siliceous-carbonate *** to the pyrolytic studies,average S1 is 4.4 mg/g and average S2 is 19.8 mg/g(for the core samples);average S1 is 2.1 mg/g and average S2 is 17.8 mg/g(for the

关键词： Drill cuttings Reservoir characterization Domanik Semiluksk Volga-Ural Russia

Discrete Boltzmann model with split collision for nonequilibrium reactive flows

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Communications in Theoretical physics 2024年第8期76卷 164-186页

作者： Chuandong Lin Kai h Luo huilin Lai Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Key Laboratory for Thermal Science and power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical Engineering National University of Singapore10 Kent Ridge Crescent119260Singapore Department of Mechanical Engineering University College LondonTorrington PlaceLondon WC1E 7JEUnited Kingdom School of Mathematics and Statistics Key Laboratory of Analytical Mathematics and Applications(Ministry of Education)Fujian Key Laboratory of Analytical Mathematics and Applications(FJKLAMA)Center for Applied Mathematics of Fujian Province(FJNU)Fujian Normal University350117 FuzhouChina

A multi-relaxation-time discrete Boltzmann model(DBM) with split collision is proposed for both subsonic and supersonic compressible reacting flows, where chemical reactions take place among various components. The physical model is based on a unified set of discrete Boltzmann equations that describes the evolution of each chemical species with adjustable acceleration, specific heat ratio, and prandtl number. On the right-hand side of discrete Boltzmann equations, the collision,force, and reaction terms denote the change rates of distribution functions due to self-and crosscollisions, external forces, and chemical reactions, respectively. The source terms can be calculated in three ways, among which the matrix inversion method possesses the highest physical accuracy and computational efficiency. Through Chapman-Enskog analysis, it is proved that the DBM is consistent with the reactive Navier-Stokes equations, Fick's law and the Stefan-Maxwell diffusion equation in the hydrodynamic limit. Compared with the one-step-relaxation model, the split collision model offers a detailed and precise description of hydrodynamic, thermodynamic, and chemical nonequilibrium effects. Finally, the model is validated by six benchmarks, including multicomponent diffusion, mixture in the force field, Kelvin-helmholtz instability, flame at constant pressure, opposing chemical reaction, and steady detonation.

关键词： discrete Boltzmann method reactive flow detonation nonequilibrium effect

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hepatitis B virus genotypes in precision medicine of hepatitis Brelated hepatocellular carcinoma:Where we are now

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1097-1103页

作者： Caecilia h C Sukowati Sri Jayanti Turyadi Turyadi David h Muljono Claudio Tiribelli Eijkman Research Center for Molecular Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver Cancer Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Faculty of Medicine Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Faculty of Medicine and health University of SydneySydney 2050Australia

hepatitis B virus(hBV)infection is a major player in chronic hepatitis B that may lead to the development of hepatocellular carcinoma(hCC).hBV genetics are diverse where it is classified into at least 9 genotypes(A to I)and 1 putative genotype(J),each with specific geographical distribution and possible different clinical outcomes in the *** diversity may be associated with the precision medicine for hBV-related hCC and the success of therapeutical approaches against hCC,related to different pathogenicity of the virus and host *** Editorial discusses recent updates on whether the classification of hBV genetic diversity is still valid in terms of viral oncogenicity to the hCC and its precision medicine,in addition to the recent advances in cellular and molecular biology technologies.

关键词： hepatitis B virus hepatocellular carcinoma Genotypes pathogenesis precision medicine