检索结果-南通市图书馆

Revisiting cerebral endothelial cells in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisp.s.d by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine program and Department of pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been prop.s.d for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in parkinson’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of parkinson’s disease(pD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes pD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Grobner-shirshov Bases for Replicated Algebras

在线全文

学校读者我要写书评

暂无评论

Algebra Colloquium 2017年第4期24卷 563-576页

作者： p.s. Kolesnikov sobolev Institute of Mathematics Akad. Koptyug prosp. 4 630090 Novosibirsk Russia

We establish a universal approach to solutions of the word problem in the varieties of di- and tri-algebras. This approach, for example, allows us to apply Grobner-shirshov bases method for Lie algebras to solve the ideal membership problem in free Leibniz algebras （Lie di-algebras）. As another application, we prove an analogue of the poincare-Birkhoff-Witt Theorem for universal enveloping associative tri-algebra of a Lie tri-algebra （CTD!-algebra）.

关键词： di-algebra tri-algebra Grobner-shirshov basis

Effects of Vortex Generator on Cylindrical protrusion Aerodynamics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal science 2016年第1期25卷 7-12页

作者： Vignesh Ram p.s. Toshiaki setoguchi Heuy Dong Kim school of Mechanical Engineering Andong National University Department of Mechanical Engineering Saga University

Experimental and numerical studies were carried out to evaluate the effect of vortex generator on a small cylindrical protrusion at Mach number 2.0. The experiments were performed using the supersonic blow down wind tunnel on different heights of cylindrical protrusion with vortex generator placed ahead of them. The upstream and downstream flow around the cylindrical protrusion is influenced by vortex generator as is observed using both visualization and pressure measurement techniques. Numerical studies using three dimensional steady implicit formulations with standard k-ω turbulence model was performed. Results obtained through the present computation are compared with the experimental results at Mach 2.0. Good agreements between computation and experimental results have been achieved. The results indicate that the aerodynamic drag acting on cylindrical protrusion can be reduced by adopting vortex generator.

关键词： Cylindrical protrusion Vortex generator shock wave boundary layer interaction Drag control

structural Tuning of Low Band Gap Intermolecular p.s./pull side-chain polymers for Organic photovoltaic Applications

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of polymer science 2017年第9期35卷 1073-1085页

作者： Ansuman Nayak p.s. Rama sreekanth santosh Kumar sahu Duryodhan sahu Department of Chemistry National Institute of Science and Technology Palur Hills Berhampur Odisha India 761008 Department of Chemistry Gandhi Institute of Engineering and Technology Gunpur Odisha India Department of Mechanical Engineering National Institute of Science and Technology Palur Hills Berhampur Odisha India 761008

A series of novel low band gap donor-acceptor （D-A） type organic co-polymers （BT-F-TpA, BT-CZ-TpA and BT-sI-TpA） consisting of electron-deficient acceptor blocks both in main chains （M1） and at the pendant （M2） were polymerized with different electron rich donor （M3-M5） blocks, i.e., 9,9-dihexyl-9H-fluorene, N-alkyl-2,7-carbazole, and 2,6-dithinosilole, respectively, via suzuki method. These polymers exhibited relatively low band gaps （1.65-1.88 eV） and broad absorption ranges （680-740 nm）. Bulk heterojunction （BHJ） solar cells incorporating these polymers as electron donors, blended with [6,6]-phenyl-C61-butyric acid methyl ester （pC61BM） or [6,6]-phenyl-Cvl-butyric acid methyl ester （pC71BM） as electron-acceptors in different weight ratios were fabricated and tested under 100 mW/cm2 of AM 1.5 with white-light illumination. The photovoltaic device containing donor BT-sI-TpA and acceptor pC71BM in 1：2 weight ratio showed the best power conversion efficiency （pCE） value of 1.88%, with open circuit voltage （Voc） = 0.75 V, short circuit current density （Jsc） = 7.60 mA/cm2, and fill factor （FF） = 33.0%.

关键词： polymer solar cells Low band gap Conducting polymers Charge transfer Donor-acceptor Bulk heterojunctionsolar cell

A novel approach to correlate heat transfer and pressure fluctuation in gas-solid spouted bed

在线全文

学校读者我要写书评

暂无评论

particuology 2019年第1期17卷 26-34页

作者： p.K. Mollick p.s. Goswamib M. Krishnana p.K. Vijayanc A.B. panditd Mechanical Metallurgy Division Bhabha Atomic Research CentreMumbai 400085India Deptartmenr of Chemical Engineering Indian Institute ofTechnology-BombayMumbai 400076India Reactor Engineering Division Bhabha Atomic Research CentreMumbai 400085India Deptartment of Chemical Engineering Institute of Chemical TechnologyMumbai 400019India

statistical analysis of pressure fluctuations in spouted beds has been used as a well-established diagnostic tool to determine bed and flow characteristics because of its smooth operation. However, in many recent and conventional applications of spouted beds such as drying, coal gasification, catalytic conversion, biomass treatment, and chemical vapor dep.s.tion, direct estimation of the heat transfer rate from the solid bed to the gas or vice versa has proven to be difficult. A variance and spectral analysis of pressure fluctuation is extended here to characterize the heat transfer phenomena in a spouted bed. In the present study, zirconia and alumina were used as the bed materials, and argon and nitrogen were used as the spouting gases. Experiments were conducted at various heating rates for different superficial gas velocities for a range of temperatures up to 300 °C. significant changes in the gas density and viscosity with different extents of heat transfer were observed to affect the momentum diffusivity and gas–particle interaction, which in turn led to local pressure fluctuations, causing the bed to behave differently. In the present work, a novel approach is prop.s.d to establish a link between local pressure fluctuation and the extent of heat transfer in the bed. This method shows potential for correlation of the statistics of pressure fluctuation with the thermal properties of individual solids and gases. Thus, the technique can be extended to many industrial applications for the indirect estimation of the extent of heat transfer and prediction of unknown thermal properties of products in solids or gases.

关键词： spouted bed Heat transfer pressure fluctuation statistical analysis power spectral density analysis Thermal properties

An Artificial Neural Network-Based snow Cover predictive Modeling in the Higher Himalayas

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain science 2014年第4期11卷 825-837页

作者： Bhogendra MIsHRA Nitin K.TRIpATHI muk s.BABEL Remote sensing and Geographical Information systems Asian Institute of Technology P.O. Box 4 Klong LuangPathumthani 12120 Thailand Water Engineering and Management Asian Institute of Technology P.O. Box 4 Klong Luang Pathumthani 12120 Thailand

With trends indicating increase in temperature and decrease in winter precipitation, a significant negative trend in snow-covered areas has been identified in the last decade in the Himalayas. This requires a quantitative analysis of the snow cover in the higher Himalayas. In this study, a nonlinear autoregressive exogenous model, an artificial neural network （ANN）, was deployed to predict the snow cover in the Kaligandaki river basin for the next 30 years. Observed climatic data, and snow covered area was used to train and test the model that captures the gross features of snow under the current climate scenario. The range of the likely effects of climate change on seasonal snow was assessed in the Himalayas using downscaled temperature and precipitation change projection from - HadCM3, a global circulation model to project future climate scenario, under the AIB emission scenario, which describes a future world of very rapid economic growth with balance use between fossil and non-fossil energy sources. The results show that there is a reduction of 9% to 46% of snow cover in different elevation zones during the considered time period, i.e., 2Oll to 2040. The 4700 m to 52oo m elevation zone is the most affected area and the area higher than 5200 m is the least affected. Overall, however, it is clear from the analysis that seasonal snow in the Kaligandaki basin is likely to be subject to substantialchanges due to the impact of climate change.

关键词： snow cover Kaligandai river Himalayas Artificial neural network Global warming Climatechange

A systematic review of progenitor survival and maturation in parkinsonian models

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of parkinson's disease.A defined systematic search of the pubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells parkinson's disease survival transplant