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低温与超导 1982年第2期 72-74+79页

作者： N.Gauthier p.rochon 景桂兰大连光明化工所

本文提出了处于居间态的 S;（第Ⅰ类超导体）动态电阻特性线性扰动理论的计算方法。我们采用广泛伦敦模型,对长直导线情况提出了该方法的求解,并介绍此方法获得的若干结果。

关键词：居间态超导态临界电流导线动态电阻函数电阻特性瞬时电压方程趋肤深度动态阻抗线性扰动伦敦表达式

Clostridium paraputrificum septicemia and liver abscess

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World Journal of Hepatology 2018年第3期10卷 388-395页

作者： Yong K Kwon Faiqa A Cheema Bejon T Maneckshana Caroline rochon patricia A Sheiner Department of Transplant Hartford HospitalHartfordCT 06106United States

We report the first case of a healthy 23-year-old female who underwent an interventional radiology-guided embolization of a hepatic adenoma, which resulted in a gas forming hepatic liver abscess and septicemia by Clostridium paraputrificum. A retrospective review of Clostridial liver abscesses was performed using a pub Med literature search, and we found 57 clostridial hepatic abscess cases. The two most commonly reported clostridial species are C. perfringens and C. septicum(64.9% and 17.5% respectively). C. perfringens cases carried a mortality of 67.6% with median survival of 11 h, and 70.2% of the C. perfringens cases experienced hemolysis. All C. septicum cases were found to have underlying liver malignancy at the time of the presentation with a mortality of only 30%. The remaining cases were caused by various Clostridium species, and this cohort's clinical course was significantly milder when compared to the above C. perfringens and C. septicum cohorts.

关键词： Clostridium Hemolysis Liver cell adenoma Morbidity Mortality pyogenic liver abscess

Glyoxylate Reductase Isoform 1 is Localized in the Cytosol and Not peroxisomes in plant Cells

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Journal of Integrative plant Biology 2012年第3期54卷 152-168页

作者： Steven L. K. Ching Satinder K. Gidda Amanda rochon Owen R. van Cauwenberghe Barry J. Shelp Robert T. Mullen Department of Molecular and Cellular Biology University of Guelph Guelph Ontario N1G 2W1 Canada Department of plant Agriculture University of Guelph Guelph Ontario N1G 2W1 Canada

Glyoxylate reductase （GLYR） is a key enzyme in plant metabolism which catalyzes the detoxification of both photorespiratory glyoxylate and succinic semialdehdye, an intermediate of the γ-aminobutyrate （GABA） pathway. Two isoforms of GLYR exist in plants, GLYR1 and GLYR2, and while GLYR2 is known to be localized in plastids, GLYR1 has been reported to be localized in either peroxisomes or the cytosol. Here, we reappraised the intracellular localization of GLYR1 in Arabidopsis thaliana L. Heynh （ecotype Lansberg erecta） using both transiently-transformed suspension cells and stably-transformed plants, in combination with fluorescence microscopy. The results indicate that GLYR1 is localized exclusively to the cytosol regardless of the species, tissue and/or cell type, or exposure of plants to environmental stresses that would increase flux through the GABA pathway. Moreover, the C-terminal tripeptide sequence of GLYR1, -SRE, despite its resemblance to a type 1 peroxisomal targeting signal, is not sufficient for targeting to peroxisomes. Collectively, these results define the cytosol as the intracellular location of GLYR1 and provide not only important insight to the metabolic roles of GLYR1 and the compartmentation of the GABA and photorespiratory pathways in plant cells, but also serve as a useful reference for future studies of proteins proposed to be localized to peroxisomes and/or the cytosol.

关键词： Arabidopsis GABA GLYR1 cytosol photobleaching peroxisome pTS stress tobacco BY-2.

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Implementing uterine balloon tamponade(UBT)device for immediate postpartum hemorrhage management:Leveraging resource allocation and highlighting noteworthy experiences

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Gynecology and Obstetrics Clinical Medicine 2023年第3期3卷 175-180页

作者： Mian Dehi Boston Guie privat Apollinaire Horo Aka Edele Kouakou Konan Virginie Aholoupke Bruno KonéSeydou rochon Sarah Boni Serge Burke Thomas F Felix Houphouet Boigny University Cote d’Ivoire Division of Global Health and Human Rights Department of Emergency MedicineCote d’Ivoire National Mother and Child Health program Côte d'Ivoire Cote d’Ivoire Massachusetts General Hospital Division of Global Health and Human Rights BostonMAUSA Harvard T.H.Chan School of public Health BostonMAUSA Harvard Medical School BostonMAUSA

Background The use of uterine balloon tamponade(UBT)devices for intrauterine packing and management of vaginal bleeding by uterine atony has shown promising results in improving the quality of care and reducing maternal *** This report aims to provide an overview of progress made in implementing UBT devices in northern Cote d'*** and methods A four-year retrospective study was conducted in the North-East(163,645),North-Center(351,909),and North-West(57,983).In 2017,UBT was adopted by members of the healthcare ***,5 national and 32 regional trainers have been *** training session was a theoretical and practical program with a low *** is a male condom tied to a urinary catheter,filled with *** outcomes included stopping bleeding,avoiding the need for surgery,and preventing maternal deaths(MD).In 2018,3,515 UBT devices were *** 2019,monitoring tools and transmission circuits of the data were *** 2020,the collection of data and local manufacturing was *** During the process,978 health workers,mainly midwife(52.0%)and nurses(32.2%)out of the 1,295 assigned were *** number of trained individuals decreased from 209 in 2019 to 160 in 2020.A total of 1,715 UBT devices were locally manufactured,adding to the existing gift of 5,080 devices,with total availability of 6,*** distribution of devices increased from 2017 to 2019 but decreased in *** rates increased from 87.3%in 2017(365/418)to 95.0%in 2019(556/585)and slightly decreased in 2020 to 98.0%(681/695).Adverse outcomes(144/2,193),included MD(35/2,193)and medical evacuation to the surgical center(109/2,193).Conclusion The implementation of UBT in northern Cote d'Ivoire successfully reduced maternal death rates caused by immediate post-partum hemorrhage(IppH).However,to ensure sustainability,further improvements are needed,including increased monitoring,ongoing training,and device availability.

关键词： Implementation Uterine balloon tamponade post-partum hemorrhage Health providers Health regions

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使用临床流程图鉴别处方瀑布

英国医学杂志中文版 2020年第11期23卷 672-676页

作者： Katrina L piggott Nishila Mehta Camilla L Wong paula A rochon 闫雪莲(译) Department of Medicine and the Institute for Health policy Management and Evaluation(IHPME)University of TorontoTorontoCanada Undergraduate Medicine Faculty of MedicineUniversity of TorontoTorontoCanada Division of Geriatric Medicine St Michael′s HospitalUniversity of TorontoTorontoCanada Women′s College Research Institute Women′s College HospitalUniversity of TorontoTorontoCanada 中国医学科学院北京协和医院药剂科

药物的不良反应可能"隐藏"于常见症状中。如1997年rochon和Gurwitz在The BMJ所阐述,处方瀑布即医务人员将药物不良事件误认为是新出现的医疗状况,而开具新的药物来处理这个不良事件。这个概念已扩展至不必要的诊断性检查、使用医疗设备... 详细信息

药物的不良反应可能"隐藏"于常见症状中。如1997年rochon和Gurwitz在The BMJ所阐述,处方瀑布即医务人员将药物不良事件误认为是新出现的医疗状况,而开具新的药物来处理这个不良事件。这个概念已扩展至不必要的诊断性检查、使用医疗设备和非处方药治疗等可能使患者暴露于风险和伤害的情况。目前还没有公认的方法来确定某一症状是否由一种药物所致,但是通过核查处方瀑布,临床医师可以减少不必要的药物、检查、会诊和伤害。

关键词：诊断性检查药物不良事件医疗状况临床医师常见症状医疗设备非处方药流程图

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临床试验报告的透明性理清各自职责

英国医学杂志中文版 2019年第2期22卷 69-70页

作者： rochon paula A Nathan M Stall Rachel D Savage An-Wen Chan 陈立敏(译) Women′s College Research Institute Women′s College HospitalTorontoONCanada Division of Geriatric Medicine Department of MedicineUniversity of TorontoONCanada Division of Dermatology Department of MedicineUniversity of TorontoTorontoONCanada 中华医学杂志英文版编辑部

患者、医生、监管者和决策者依靠临床试验来评估新药、疫苗和设备的有效性和安全性。自20世纪90年代以来,大多数临床试验都有产业赞助,这些赞助者与学术界合作,以得到临床和方法学专家的意见、招募受试者并参与学术出版。最近,为了有效... 详细信息

患者、医生、监管者和决策者依靠临床试验来评估新药、疫苗和设备的有效性和安全性。自20世纪90年代以来,大多数临床试验都有产业赞助,这些赞助者与学术界合作,以得到临床和方法学专家的意见、招募受试者并参与学术出版。最近,为了有效地监视临床试验,产业赞助越来越多地转向与研究机构签订合同。这些营利性实体雇用临床医师科学家、药剂师、生物统计学家、管理人员和医学论文写手,而这些人控制着试验的设计、实施、分析和报告。这种对临床试验的商业化监视,使试验中学术型医师的作用变得相对不那么重要了。

关键词：临床试验报告职责透明临床医师生物统计学学术型研究机构医学论文

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回到旧时光英国伦敦柏宁四季酒店

室内设计与装修 2015年第2期 110-113页

作者： pierre-Yves rochon 小麦

可以在阳台上鸟瞰海德公园的美景，又充满精致的古典主义风格，是画廊，亦是酒吧、餐厅，这便是坐落于英国伦敦，新近改造完成的柏宁四季酒店。自上世纪70年代开业以来，酒店一直受到游客的喜爱。随着酒店内外部装修与陈设的日益老旧，... 详细信息

可以在阳台上鸟瞰海德公园的美景，又充满精致的古典主义风格，是画廊，亦是酒吧、餐厅，这便是坐落于英国伦敦，新近改造完成的柏宁四季酒店。自上世纪70年代开业以来，酒店一直受到游客的喜爱。随着酒店内外部装修与陈设的日益老旧，业主希望通过改造可以使这座历史悠久的酒店重现昔日的辉煌。

关键词：酒店伦敦英国柏古典主义改造公园阳台

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Manual aspiration thrombectomy in acute ST elevation myocardial infarction:New gold standard?

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World Journal of Cardiology 2011年第2期3卷 43-47页

作者： Brent rochon Youssef Chami Rajesh Sachdeva Joe K Bissett Nick Willis Barry F Uretsky Department of Medicine Central Arkansas Veterans Health SystemUniversity of Arkansas for Medical SciencesLittle RockAR 72205United States

percutaneous coronary intervention(pCI) is the preferred method to treat ST segment myocardial infarction(STEMI).The use of thrombus aspiration(TA) may be particularly helpful as part of the pCI process,insofar as the presence of thrombus is essentially a universal component of the STEMI *** article reviews evidence favoring the routine use of TA,and the limitations of these *** on current evidence,we consider TA to be an important maneuver during STEMI pCI,even in the absence of visible angiographic thrombus,and recommend it whenever the presence of thrombus is likely.

关键词： Aspiration thrombectomy Myocardial infarction Guidelines Thrombus

接种彩色豆马勃对杨树插穗根系和枝条生长的促进

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林业科技通讯 1983年第3期 31-32页

作者： S. Navratil G. C. rochon 郑世锴

杨树插干造林以及苗圃和温室的扦插繁殖,要依靠良好和稳定的生根力。提高生根力使杨树初期生长旺盛,保证全苗,以充分发挥栽培措施的潜力。人们一直在寻找提高和稳定插穗生根力的方法,使有前途的杨树无性系的生产潜力能发挥出来,给集约... 详细信息

杨树插干造林以及苗圃和温室的扦插繁殖,要依靠良好和稳定的生根力。提高生根力使杨树初期生长旺盛,保证全苗,以充分发挥栽培措施的潜力。人们一直在寻找提高和稳定插穗生根力的方法,使有前途的杨树无性系的生产潜力能发挥出来,给集约栽培带来好处(Zsuffa等1977,1979)。天然或人工接种的真菌共生体在植物根上形成菌根,能改善寄主的生长和发育状况。彩色豆马勃pisolithus tinctorius (pers.)Cokerand Couch是许多树种上的一种外生菌根共生体。在苗圃和造林地它对松树和其它树种的成活率和生长有促进作用,已被证实。很多事实

关键词：插穗彩色豆马勃枝条生长杨树绿荫林木

对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究

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英国医学杂志中文版 2003年第3期6卷 147-151页

作者： Muhammad Mamdani paula A rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie peter C Austin Andreas Laupacis 邓瑞雪 Institute for Clinial Evaluative Sciences 2075 Bayview Avenue-G215 Toronto Ontario Canada scientist Alex Kopp analyst peter C Austin scientist Andreas Laupacis chief executive officer Kunin Lunenfeld Applied Research Unit Baycrest Centre for Geriatric CareToronto scientist and assistant director Sunnybrook and Women' s College Health Sciences Center Toronto clinical pharmacologist Department of health policy management and evaluation Faculty of Medicine University oU University of Toronto Mary Trimmer chair in geriatric medicine research

目的对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。设计观察性队列研究。设置利用来自加拿大安大略2000年4月17日～2001年3月31日的官方数据,以确认基于人群的、初... 详细信息

目的对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。设计观察性队列研究。设置利用来自加拿大安大略2000年4月17日～2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。对象年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。衡量结局的主要指标每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。结果与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95％,可信区间为2.3～6.9,)、双氯芬酸加米索前列醇(3.0,1.7～5.6)以及罗非昔布(1.9,1.3～2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7～1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3～8.5)、双氯芬酸加米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2～2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0～3.5)。结论选择性COX

关键词：选择性环氧酶2抑制剂非甾体类抗炎药物老年上消化道出血临床观察双氯芬酸

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