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国际医学放射学杂志 2020年第1期 114-115页

作者： A.Roux p.roca M.Edjlali K.Sato M.Zanello E.Dezamis 黄娟 Department of Neurosurgery Sainte -Anne Hospital

肿瘤部位是胶质母细胞瘤病人的主要预后参数。对于异柠檬酸脱氢酶(IDH)野生型胶质母细胞瘤来说,目前未见有MRI脑图谱可以详细说明特定肿瘤发生部位与重要

关键词：胶质母细胞瘤野生型 IDH 治疗和预后 MRI 概率图

电源按钮征:2型局灶性皮质发育不良的表面重现MR影像上一种新的描述中央沟的形式

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国际医学放射学杂志 2015年第2期 180-181页

作者： C.Mellerio p.roca F.Chassoux F.Danière A.Cachia S.Lion 庞国栋 Department of Radiology Centre Hospitalier Sainte AnneUniversité Paris Descartes Sorbonne Paris Cité1 rue Cabanis75014 Paris

摘要目的比较几种中央沟变异的发生情况及评估中央沟电源按钮征(pBS)在2型局灶性皮质发育不良(FCD2)病人和健康对照组中的可重复性。材料与方法本研究获当

关键词：中央沟 FCD 对照组局灶性皮质发育不良 MR

MR选择性血流示踪成像技术:一种用于完整显示颅脑硬膜动静脉瘘的4D血流MR后处理技术

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国际医学放射学杂志 2014年第2期 167-168页

作者： M.Edjlali p.roca C.Rabrait D.Trystram C.Rodriguez-Régent K.M.Johnson 朱晓明 Department of Morphologic and Functional Imaging Universite Paris Descartes INSERM UMR 894 Hopital Sainte Anne 1 rueCabanis 75014 Paris France

目的评估选择性血流示踪成像技术在4D血流成像中应用的可行性,并对其显示硬脑膜动静脉瘘(DAVF)的实用性进行论证。材料与方法本研究得到机构伦理委员会

关键词：成像技术 MR 血流示踪颅脑

关注颅内动静脉畸形的HYpR血流动力学MRA特征:与TRICKS MRA和DSA的比较

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国际医学放射学杂志 2016年第1期 87-87页

作者： R.Dautry M.Edjlali p.roca C.Rabrait Y.Wu K.Johnson 牡丹 Department of Radiology Centre de Psychiatrie et Neuroscience INSERM S894 Centre Hospitalier Sainte -AnneUniversité Paris Descartes Sorbonne Paris Cité

摘要目的HYpR流成像是一种三维动态对比增强MRA技术,它可以在0.5 s时间分辨率的情况下提供各向同性亚毫米级的空间分辨率。以DSA作为标准,比较HYpR流成像和对比剂动态时间分辨成像(TRICKS)MRA在显示颅内动静脉畸形(c AVM)特征中的表现... 详细信息

摘要目的HYpR流成像是一种三维动态对比增强MRA技术,它可以在0.5 s时间分辨率的情况下提供各向同性亚毫米级的空间分辨率。以DSA作为标准,比较HYpR流成像和对比剂动态时间分辨成像(TRICKS)MRA在显示颅内动静脉畸形(c AVM)特征中的表现。方法 22例颅内动静脉畸形病人在行DSA后的15 d内行HYpR流成像和TRICKS MRA检查。数据分别由2名医生进行分析,包括评估影像质量、Spetzler-Martin评分、静脉扩张及深静脉引流情况评价。结果 HYpR流成像的影像质量优于TRICKS(较窄

关键词： DSA HYpR 颅内动静脉畸形 TRICKS MRA

The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health

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Journal of Environmental Sciences 2025年第1期147卷 294-309页

作者： Juan p.Munoz Laboratorio de Bioquímica Departamento de QuímicaFacultad de CienciasUniversidad de TarapacáArica 1000007Chile

Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interferewith the normal functioning of the endocrine *** is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction,metabolic disorders,neurological alterations,and increased risk of hormone-dependent *** cells(SCs)are integral to these pathological processes,and it is therefore crucial to understand how EDCs may influence SC *** review examines the literature on different types of EDCs and their effects on various types of SCs,including embryonic,adult,and cancer *** mechanisms through which EDCs may influence the phenotype of SCs are also ***,the possible implications of these effects on human health are *** available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal pathways,DNA damage,epigenetic changes,reactive oxygen species production and alterations in the gene expression *** disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders,obesity,infertility,reproductive abnormalities,and ***,the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.

关键词： Endocrine-disrupting chemicals Stem cells Cancer stem cells Epigenetic Hormones

The role of energetic flow structures on the aeolian transport of sediment and plastic debris

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Acta Mechanica Sinica 2025年第1期41卷 67-81页

作者： Manousos Valyrakis Xiaohu Zhao Thomas pähtz Zhenshan Li Department of Civil Engineering Aristotle University of ThessalonikiThessaloniki 54124Greece School of Engineering University of GlasgowGlasgow G128QQUK Division of Environmental Management and policy School of EnvironmentTsinghua UniversityBeijing 100084China Institute of port Coastal and Offshore EngineeringZhejiang UniversityZhoushan 316021China Donghai Laboratory Zhoushan 316021China College of Environmental Science and Engineering Peking UniversityBeijing 100871China Key Laboratory of Water and Sediment Sciences Ministry of EducationPeking UniversityBeijing 100871China

Recently,significant progress has been made in conceptually describing the dynamic aspects of coarse particle entrainment,which has been explored experimentally for open channel *** aim of this study is to extend the application of energy criterion to the low mobility aeolian transport of solids(including both natural sediment and anthropogenic debris such as plastics),ranging from incomplete(rocking)to full(rolling)*** is achieved by linking particle movements to energetic flow events,which are defined as flow structures with the ability to work on particles,setting them into *** is hypothesized that such events should impart sufficient energy to the particles,above a certain threshold *** concept’s validity is demonstrated experimentally,using a wind tunnel and laser distance sensor to capture the dynamics of an individual target particle,exposed on a rough bed *** are acquired at a high spatiotemporal resolution,and synchronously with the instantaneous air velocity at an appropriate distance upwind of the target particle,using a hot film *** enables the association of flow events with rocking and rolling ***,it is shown that rocking and rolling may have distinct energy *** of the energy transfer efficiency,normalized by the drag coefficient,range over an order of magnitude(from about 0.001 to 0.0048 for rocking,up to about 0.01,for incipient rolling).The proposed event-based theoretical framework is a novel approach to characterizing the energy imparted from the wind to the soil surface and could have potential implications for modelling intermittent creep transport of coarse particles and related aeolian bedforms.

关键词： particle rocking Incipient rolling Wind tunnel experiments Threshold flow energy Aeolian transport plastics plastic debris

Synergistic effects of constituents in rare earth-based composites:Enhanced structural,electrical and magnetic properties for water splitting applications

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Journal of Rare Earths 2025年第1期43卷 105-114,I0005页

作者： Chitralekha S.Shankar A.p.Singh Functional Materials Research Laboratory Department of PhysicsARSD CollegeUniversity of Delhi1021India Department of physics Multanimal Modi CollegeCh.Charan Singh UniversityMeerutU.PIndia

Rare earth-based Bi_(0.85)La_(0.15)FeO_(3)(BLFO)and NdMnO_(3)(NMO)particles were synthesised using the solidstate route,and their roles affecting structural,electrical,magnetic properties along with hydroelectric application in different concentrations i.e.,(1-x)BLFO:xNMO(where x=0,0.10,0.20,0.30 and 1.0)ceramics composites were investigated.X-ray diffraction analyses confirm the pure-phase formation of BLFO:NMO composites,featuring micrometer-scale crystallite *** transform infrared(FT-IR)spectra of BLFO:NMO composites reveal peak shifts with rising NMO content,indicating composite *** composites exhibit robust Maxwell-Wagner polarization and a pronounced composition-dependent *** addition of NMO to BLFO results in a rise in dielectric permittivity at lower frequencies,confirming relaxor behavior and indicating success in achieving the transition *** spectroscopy facilitates a clearer understanding of how charge carriers contribute to these composites and the impact of grain/grain *** saturation magnetization maximum value(i.e.,0.807 emu/g)was attained in *** coercivity decreases with the addition of NMO in *** results suggest the composite's enhanced suitability for microelectronics and hydropower cells,showing improved hydroelectric cell performance with increased NMO in BLFO,highlighting a notable ion diffusion mechanism.

关键词： Composites X-ray diffraction Relative permittivity Hydroelectric cell Rare earths

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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

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Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

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