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Comparison of conventional and supported liquid extraction methods for the determination of sitagliptin and simvastatin in rat plasma by LC-ESI-MS/MS

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Journal of pharmaceutical Analysis 2015年第3期5卷 161-168页

作者： B.ramesh N.Manjula S.r.Bijargi V.U.M.Sarma p.Sita Devi Natural products Chemistry Division Indian Institute of Chemical Technology Medicinal Chemistry & pharmacology Division Indian Institute of Chemical Technology

Three extraction methods were compared for their efficiency to analyze sitagliptin and simvastatin in rat plasma by LC-MS/MS, including （1） liquid-liquid extraction （LLE）, （2） solid phase extraction （SpE） and （3） supported liquid extraction （SLE）. Comparison of recoveries of analytes with different extraction methods revealed that SLE was the best extraction method. The detection was facilitated with ion trap-mass spectrometer by multiple reactions monitoring （MrM） in a positive ion mode with ESI. The transitions monitored were m./z 441.1→325.2 for simvastatin, 408.2→235.1 for sitagliptin and 278.1→260.1 for the IS. The lower limit of quantification （LLOQ） was 0.2 ng/mL for sitagliptin and 0.1 ng/mL for simvastatin. The effective SLE offers enhanced chromatographic selectivity, thus facilitating the potential utility of the method for routine analysis of biological samples along with pharmacokinetic studies.

关键词： rat plasma Simvastatin Sita#'ptin Supported liquid extraction

Barut-Girardello and Gilmore-perelomov coherent states for pseudoharmonic oscillators and their nonclassical properties: Factorization method

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Chinese physics B 2013年第8期22卷 421-428页

作者： M K Tavassoly H r Jalali Atomic and Molecular Group Faculty of Physics Yazd UniversityYazd Iran photonics research Group Engineering Research Center Yazd UniversityYazd Iran The Laboratory of Quantum Information processing Yazd UniversityYazd Iran

In this paper we try to introduce the ladder operators associated with the pseudoharmonic oscillator, after solving the corresponding Schrrdinger equation by using the factorization method. The obtained generalized raising and lowering operators naturally lead us to the Dirac representation space of the system which is much easier to work with, in comparison to the functional Hilbert space. The SU（1, 1） dynamical symmetry group associated with the considered system is exactly established through investigating the fact that the deduced operators satisfy appropriate commutation relations. This result enables us to construct two important and distinct classes of Barut-Girardello and Gilmore-perelomov coherent states associated with the system. Finally, their identities as the most important task are exactly resolved and some of their nonclassical properties are illustrated, numerically.

关键词： pseudoharmonic oscillator factorization method Barut-Girardello coherent states Gilmore-perelomov coherent states nonclassical properties

Three-Dimensional Numerical Modeling of an Ar-N_2 plasma Arc Inside a Non-Transferred Torch

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plasma Science and Technology 2009年第6期11卷 679-687页

作者： B.SELVAN K.rAMACHANDrAN K.p.SrEEKUMAr T.K.THIYAGArAJAN p.V.ANANTHApADMANABHAN School of Mechanical and Building Sciences Vellore Institute of Technology UniversityVellore 632014India Laser and plasma Technology Division Bhabha Atomic Research CentreMumbai 400085India

A three-dimensional numerical model is developed to study the behaviour of an argon-nitrogen plasma arc inside a non-transferred torch. In this model, both the entire cathode and anode nozzle are considered to simulate the plasma arc. The argon-nitrogen plasma arc is simulated for different arc currents and gas flow rates of argon. Various combinations of arc core radius and arc length, which correspond to a given torch power, are predicted. A most feasible combination of the same, which corresponds to an actual physical situation of the arc inside the torch, is identified using the thermodynamic principle of minimum entropy production for a particular torch power. The effect of the arc current and gas flow rate on the plasma arc characteristics and torch efficiency is explained. The effect of the nitrogen content in the plasma gas on the torch power and efficiency is clearly detected. predicted torch efficiencies are comparable to the measured ones and the effect of the arc current and gas flow rate on predicted and measured efficiencies is almost similar. The efficiency of the torch, cathode and anode losses and core temperature and velocity at the nozzle exit are reported for five different cases.

关键词： plasma arc numerical modeling plasma torch minimum entropy production electro-thermal efficiency

Mechanism of soft x-ray continuum radiation from low-energy pinch discharges of hydrogen and ultra-low field ignition of solid fuels

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plasma Science and Technology 2017年第9期19卷 7-34页

作者： r MILLS J LOTOSKI Y LU Brilliant Light power Inc.493 Old Trenton RoadCranburyNJ 08512United States of America

EUV continuum radiation（10–30 nm） arising only from very low energy pulsed pinch gas discharges comprising some hydrogen was first observed at Black Light power, Inc. and reproduced at the Harvard Center for Astrophysics（Cf A）. The source was determined to be due to the transition of H to the lower-energy hydrogen or hydrino state H（1/4） whose emission matches that observed wherein alternative sources were eliminated. The identity of the catalyst that accepts 3 · 27.2 eV from the H to cause the H to H（1/4） transition was determined to HOH versus 3H. The mechanism was elucidated using different oxide-coated electrodes that were selective in forming HOH versus plasma forming metal atoms as well as from the intensity profile that was a mismatch for the multi-body reaction required during 3H catalysis. The HOH catalyst was further shown to give EUV radiation of the same nature by igniting a solid fuel comprising a source of H and HOH catalyst by passing a low voltage, high current through the fuel to produce explosive plasma. No chemical reaction can release such high-energy light. No high field existed to form highly ionized ions that could give radiation in this EUV region that persisted even without power input. This plasma source serves as strong evidence for the existence of the transition of H to hydrino H（1/4） by HOH as the catalyst and a corresponding new power source wherein initial extraordinarily brilliant light-emitting prototypes are already producing photovoltaic generated electrical power. The hydrino product of a catalyst reaction of atomic hydrogen was analyzed by multiple spectroscopic techniques. Moreover, the m H catalyst was identified to be active in astronomical sources such as the Sun, stars and interstellar medium wherein the characteristics of hydrino match those of the dark matter of the Universe.

关键词： ignition continuum brilliant catalysis matches elucidated reproduced spectroscopic figure helium

Central place Theory and Distribution of post Offices in Cities

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The Journal of China Universities of posts and Telecommunications 2000年第Z1期 89-93页

作者： WANG Wei-min, WANG Wei-ning (1 Department of postal Communication Management Shijiazhuang postal College, Shijiazhuang 050021, p.r.China 2 The Management and Humanities Institute, Beijing University of posts and Telecommunications, Beijing 100876, p.r.

The feasibility of application of the Central place Theory in the distribution of post offices in cities is analysed, the grade scale structure and space distribution structure Shijiazhauang of post offices in city are studied, the research results prove the actual value of the Central place Theory, and the suggestion of adjustment in the space distribution Shijiazhuang of post offices in city is put forward.

关键词： post office, center grade scale structure space distribution structure service district central place theory

D-N认知评估系统在AD／HD儿童认知评估中的应用

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心理学 2009年第11期 77-82页

作者：邓赐平傅丽萍李其维 Jagannath p.das

研究采用基于pASS理论建构的D-N认知评估系统（CAS）作为主要评估工具，以临床推介的18名AD／HD儿童和18名在性别、年龄及智力水平与临床样本相匹配的正常儿童为被试，对其pASS认知过程特征开展比较研究，探查临床组儿童潜在的认知过程... 详细信息

研究采用基于pASS理论建构的D-N认知评估系统（CAS）作为主要评估工具，以临床推介的18名AD／HD儿童和18名在性别、年龄及智力水平与临床样本相匹配的正常儿童为被试，对其pASS认知过程特征开展比较研究，探查临床组儿童潜在的认知过程异常，研究结果表明：（1）临床AD／HD儿童在CAS总量表分上显著低于正常对照组儿童；（2）临床AD／HD儿童与正常对照组儿童在计划和注意过程分数上存在显著差异，且临床AD／HD儿童的计划和注意分量表分数可很好地预测其在DSM-IV上的注意涣散评估分数；（3）临床AD／HD组儿童与正常对照组儿童在同时性加工和继时性加工水平上则没有显著差异。

关键词：注意缺陷/多动障碍(AD/HD) pASS理论 D-N认知评估系统(CAS) 注意计划

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高温高比刚度快速凝固铝合金

兵器材料科学与工程 1990年第11期13卷 66-72页

作者： paul S.Gilman Santosh K.das 王茂林

在过去十年中,花费了很大的精力用来研究在500K(450°F)到615K(650°F)温度范围内比强度可与钛合金相竞争的高温铝合金。这是一种典型的用过渡族金属的金属间化合物强化的合金,大的溶解10～15％过渡族元素。联合信号公司(Allied Signal ... 详细信息

在过去十年中,花费了很大的精力用来研究在500K(450°F)到615K(650°F)温度范围内比强度可与钛合金相竞争的高温铝合金。这是一种典型的用过渡族金属的金属间化合物强化的合金,大的溶解10～15％过渡族元素。联合信号公司(Allied Signal Inc.)

关键词：铝合金高温

Biochemical Liver Functions and Molecular Identification of Fasciola hepatica from Experimentally Infected rat Model

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Open Journal of Animal Sciences 2024年第2期14卷 88-100页

作者： Omnia M. Kandil Emad B. Ata Margarita p. Gabrashanska Hatem A. Shalaby Tamer H. Abd El-Aziz Noha M. F. Hassan Soad M. Nasr Mohamed A. Helal Ebtesam M. Al-Olayan Department of parasitology & Animal Diseases Veterinary Research Institute National Research Centre Giza Egypt Institute of Experimental Morphology Pathology and Anthropology with Museum Bulgarian Academy of Sciences Sofia Bulgaria Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The current study was performed to evaluate the liver function status as well as molecular characterization of the recovered worms in rats experimentally infected with F. hepatica. Sixteen male Wister rats aged 30 days were randomly allocated into two groups (n = 8). The first group was infected orally with 15 viable encysted metacercaria of F. hepatica per animal. The other group was kept non-infected (control group). At zero time (before infection), the 2p>ndp>, 4p>thp>, 6p>thp>, 8p>thp>, 10p>thp>, 12p>thp> and 14p>thp> weeks post-infection (WpI), blood and serum samples were collected via puncture of retro-orbital plexus of veins from each rat. Serum enzyme level (AST and ALT) and total protein were measured, and the serum protein profile was carried out using agarose gel electrophoresis. During the period of the experiment, serum ALT and AST activities and serum total globulins significantly increased while serum total proteins and albumin markedly decreased in the infected group. On the 14p>thp> WpI, the data of the electropherogram showed that globulin fractions (α1-, β- and γ-globulin) levels were significantly increased while α2-globulin was markedly decreased in the infected group. The molecular analysis confirmed the amplification of the ITS1, ITS2 and NDI genes of F. hepatica recovered from the infected liver of rats with amplicon sizes of 630, 510 and 560 bp, respectively. Sequencing of the amplified ITS gene resulted in the determination of 3 strains (pp108836, pp108837, and pp108838). Also, analysis of the ITS2 gene resulted in obtaining 3 isolates under the accession numbers (pp109065, pp109066, and pp109067). In conclusion, fasciolosis in the rat model is suitable for routine experimental infections and caused a pronounced liver dysfunction with discharging of the Fasciola eggs in the faeces and the development of adult stages in the bile ducts. Furthermore, molecular techniques are a sensitive

关键词： Fasciola hepatica Liver Functions Serum Enzymes Serum protein Electrophoresis Molecular Characterization

Eastern Asian endemic seed plant genera and their paleogeographic history throughout the Northern Hemisphere

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Journal of Systematics and Evolution 2009年第1期47卷 1-42页

作者： Steven r.MANCHESTEr Kazuhiko UEMUrA Florida Museum of Natural History University of Florida National Museum of Nature and Science

We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably kn... 详细信息

ract>We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the "eastern Asian endemic" genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions al- lowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Ketel-eeria, Metasequoia, Nothotsuga, pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Em-menopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, paulownia, phellodendron, platycarya, pteroceltis, rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, pteroceltis, and Toricellia.

关键词： Cretaceous eastern Asia endemic paleobotany phytogeography Tertiary