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7th CIIE likely to prove solid growth platform for many companies

共铸医药学术新文明——2012年广东省药师周大会

作者： Su Fenli~(1,2),Wang Feng~1,Zhu ronghua~1,Li Huande~(1*) 1.Clinical pharmacy & pharmacology research Institute,Second Xiangya Hospital, Central South University,Changsha 410011,p.r china 2.department of pharmacy,First Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,pr china

Backbround:Venlafaxine is a new antidepressant that has a chemical structure and neuropharmacologic profile distinct from those of existing *** studies about the mechanism of pharmacological action of venlafaxine mostly investigated the effects of venlafaxine on 5-HT,NE and DA levels,while only few studies examined the effects on the metabolites levels and ratio of these monoamines neurotransmitters. Aim:To study the biochemical mechanism of venlafaxine through determining the metabolism of monoamine neurotransmitters in brain tissues of rat model of depression after administration of venlafaxine using metabonomic method. Materials and methods:The rat model of depression was established by using the methods of sep.ration and chronic unpredictable *** determination of 5-hydroxytryptamine (5-HT),norepinep.rine(NE),dopamine(DA) and their metabolites,i.e., 5-hydroxyindole-3-acetic acid(5-HIAA),4-hrdroxy-3-methoxyphenylglycol(MHpG) sulfate, 3,4-dihydroxyphenylacetic acid(DOpAC) and homovanillic acid(HVA) in rat brain tissues by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) following chronic administration of different venlafaxine doses(8,16,32 ***) and saline solution for 14 *** discriminant analysis(LDA) and principal components analysis(pCA) were used in data analysis of metabonomic. results:Comp.red with saline,venlafaxine could significantly increase brain 5-HT and NE levels at middle dose(16 ***) or high dose(32 ***),especially at middle *** increases were greater than those seen with the comp.rable dose of SSrI,fluoxetine,under the same exp.rimental conditions. Conclusion:Venlafaxine lower brain neurotransmitter metabolite levels by decreasing brain neurotransmitters *** could correct the disorder of neurotransmitters’ metabolism and coordinate the balance of 5-HT,NE and DA to reach the anti-depressed function.

关键词： venlafaxine depression model neurotransmitter metabonomics

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china Textile 2024年第4期 20-21页

作者： Editorial department of china Daily

The robust demand of the Chinese market and the improving business environment in the country make china a big growth opp.rtunity for companies wishing to further expand their op.rations,said corp.rates that have registered to p.rticipate at this year's china International Imp.rt *** 7th edition of the annual CIIE,to be held in Shanghai from Nov 5 to 10,started its 100-day countdown on Saturday.

关键词： companies likely op.rations

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Serving High-Level Opening up with "TaxExpress"

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Belt and road Initiative Tax Journal 2024年第1期 97-105页

作者： International Taxation department, State Taxation Administration,the people's republic of china International Taxation department State Taxation Administrationthe People's Republic of China

Over the past decade,the Chinese tax authorities have been actively supp.rting the development of the Belt and road Initiative,by creating a unique cross-border tax and fee service model with Chinese characteristics,which has laid a solid foundation for the establishment of the "TaxExpress" cross-border service *** October 2023,the State Taxation Administration of china(STA) officially launched the "TaxExpress" brand,focusing on one service matrix,two service teams,three service mechanisms,and four knowledge *** brand aims to enhance coop.ration between ministries and commissions,promote international exchanges,and establish a framework for effective cross-border tax and fee *** forward,the STA will continue to leverage existing resources to supp.rt high-level opening up,by enhancing brand value,improving measures for international tax and fee services,expanding cross-border tax and fee services,strengthening professional talent teams,so as to develop a cross-border tax and fee service system that combines Chinese characteristics with international best practices.

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Evidence-based exp.rt consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2024)

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Chinese Journal of Cancer research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing rongsheng Zhao the Steering Committee,the Consensus panel and the Evidence Synthesis Group Evidence-based pharmacy professional Committee of Chinese pharmaceutical Association(CpA) Hospital pharmacy professional Committee of Chinese pharmaceutical Association(CpA) Division of Therapeutic Drug Monitoring of Chinese pharmacological Society(CpS) Exp.rt Committee on Lymphoma of Chinese Society of Clinical Oncology(CSCO) Exp.rt Committee on Leukemia of Chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of china Anti-Cancer Association(CACA) Chinese Society of Hematology of Chinese Medical Association(CMA) Hospital pharmacy professional Committee of Cross-Straits Medicine Exchange Association(SMEA) department of pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China department of pharmacy Administration and Clinical pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China department of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China department of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China department of pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China department of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China department of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic exp.rt consensus from a pharmacological p.rspective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 35 members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based exp.rt consensus was formulated using an evidence-based ap.roach and the Delphi *** Joanna Briggs Institute Critical Ap.raisal(JBI)tool and Grading of recommendations Assessment,Development,and Evaluation(GrADE)ap.roach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary exp.rt consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

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金融多措并举支持经济高质量发展

中国金融 2024年第19期 9-15页

作者：本刊编辑部不详

2024年9月24日,国务院新闻办公室举行新闻发布会,中国人民银行行长潘功胜、国家金融监督管理总局局长李云泽、中国证券监督管理委员会主席吴清出席发布会并介绍金融支持经济高质量发展有关情况。“新政频出”成为此次发布会的亮点,这让... 详细信息

2024年9月24日,国务院新闻办公室举行新闻发布会,中国人民银行行长潘功胜、国家金融监督管理总局局长李云泽、中国证券监督管理委员会主席吴清出席发布会并介绍金融支持经济高质量发展有关情况。“新政频出”成为此次发布会的亮点,这让公众感受到了金融支持经济高质量发展的力度,支持实体经济发展的深度和提升老百姓生活幸福感、满足感的温度。

关键词：金融监督管理金融支持经济实体经济发展中国证券监督管理委员会高质量发展多措并举生活幸福感新闻发布会

Gas kinetic algorithm for flows in poiseuille-like microchannels using Boltzmann model equation

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Science china(physics,Mechanics & Astronomy) 2005年第4期48卷 496-512页

作者： LI Zhihui1,2, ZHANG Hanxin1 & FU Song2 ⒈ National Laboratory for CFD, Hyp.rvelocity Aerodynamics Institute,china Aerodynamics research and Development Center,Mianyang 621000,china 2.department of Engineering Mechanics,Tsinghua University,Beijing 100084,china National Laboratory for CFD Hypervelocity Aerodynamics Institute China Aerodynamics Research and Development Center Mianyang China department of Engineering Mechanics Tsinghua University Beijing China

The gas-kinetic unified algorithm using Boltzmann model equation have been extended and developed to solve the micro-scale gas flows in poiseuille-like micro-channels from Micro-Electro-Mechanical Systems (MEMS). The numerical modeling of the gas kinetic boundary conditions suitable for micro-scale gas flows is presented. To test the present method, the classical Couette flows with various Knudsen numbers, the gas flows from short microchannels like plane poiseuille and the pressure-driven gas flows in two-dimensional short microchannels have been simulated and comp.red with the ap.roximate solutions of the Boltzmann equation, the related DSMC results, the modified N-S solutions with slip-flow boundary theory, the gas-kinetic BGK-Burnett solutions and the exp.rimental data. The comp.risons show that the present gas-kinetic numerical algorithm using the mesoscopic Boltzmann simplified velocity distribution function equation can effectively simulate and reveal the gas flows in microchannels. The numerical exp.rience indicates that this method may be a powerful tool in the numerical simulation of micro-scale gas flows from MEMS.

关键词： Boltzmann model equation, discrete velocity ordinate method, finite-difference scheme, Couette flow, poiseuille flow, gas flow in short-microchannel.

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“有效降低全社会物流成本”研讨会专家观点综述

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中国流通经济 2024年第5期38卷 3-17页

作者：本刊编辑部《中国流通经济》编辑部

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处... 详细信息

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处联合主办了“有效降低全社会物流成本”研讨会。本次研讨会邀请我国流通物流领域的专家学者,围绕物流服务实体经济和人民群众、物流成本构成、交通运输体系改革、统一高效物流市场构建和现代商贸流通体系完善等问题,发表观点,为探索有效降低全社会物流成本可行路径,构建现代流通体系提供理论支持和实践指导。本刊编辑部对专家阐述的主要观点进行了归纳整理,以飨读者。

关键词：全社会社会物流成本新质生产力流通体系降本增效

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