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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto paola pramaggiore Laura Cornaggia Guglielmo patelli Ali Mohamed Margherita piccolella Mariarita Galbiati paola Rusmini Barbara Tedesco Angelo poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSpB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSpB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSpB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSpB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSpB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSpB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSpB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSpB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSpB8 neuroinflammation neuromuscular diseases therapy

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非法体内藏毒的筛查:腹部X线摄影是否足够准确?与低剂量CT的对照研究

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国际医学放射学杂志 2013年第1期 74-74页

作者： p.poletti L.Canel C.D.Becker H.Wolff B.Elger E.Lock 王雪杰 Department of Radiology University Hospital of Geneva4 rue Gabrielle Perret-Gentil1211 Geneva 14Switzerland

目的评价腹部X线在检测体内非法藏毒中的诊断效能,以低剂量CT为参考标准。材料与方法本研究通过单位伦理委员会批准,并签署知情同意书。从2007年7月—2010年7月对怀疑吞入包装毒品的330人(男296人,女34人;年龄18～55岁,平均32岁)进行仰... 详细信息

目的评价腹部X线在检测体内非法藏毒中的诊断效能,以低剂量CT为参考标准。材料与方法本研究通过单位伦理委员会批准,并签署知情同意书。从2007年7月—2010年7月对怀疑吞入包装毒品的330人(男296人,女34人;年龄18～55岁,平均32岁)进行仰卧位腹部X线摄影和低剂量CT检查。报告腹部X线摄影是否发现体内毒品包,以低剂量CT为参考标准。记录低剂量CT中毒品包的密度和数量(≤12或>12),分析确定这些因素是否会对腹部X线的结果有影响。结果低剂量CT在53个(16%)嫌疑人的体内发现了毒品包。腹部X线摄影对于检测毒品包的敏感度是0.77(41/53),特异度是0.96(267/277)。53例毒品包中,低剂量CT发现16例(30%)与肠内容物呈等密度;19例(36%)的毒品包数量小于12个。低剂量CT中的等密度毒品包和较少的毒品包数量(≤12)均与腹部X线摄影的假阴性结果存在明显相关性(p值分别为0.004和0.016)。结论与低剂量CT相比,腹部X线摄影筛查体内藏毒嫌疑人的敏感度有限。低剂量CT是一种腹部X线摄影的有效替代方法。原文载于Radiology,2012,265(3):772-779.

关键词：体内藏毒低剂量腹部躯干摄影美术 CT 筛查

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A NEW AppROACH TO SOLVE SYSTEMS OF LINEAR EQUATIONS

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Journal of Computational Mathematics 2001年第4期19卷 445-448页

作者： V á squez, Luis V á squez-poletti, Jos é L. Universidad Complutense 西班牙 E-28040 Universidad pontificia Comillas 西班牙 E-28015

presents a study which proposed an iterative approach to solve systems of linear equations. Definition of two families of convergent iterative methods; Features of the iterative method; Application of the method to a ... 详细信息

关键词： Iterative method Linear systems Classical dynamics.

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Low-loss microwave photonics links using hollow core fibres

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Light(Science & Applications) 2022年第8期11卷 1891-1902页

作者： Xi Zhang Zitong Feng David Marpaung Eric Numkam Fokoua Hesham Sakr John Richard Hayes Francesco poletti David John Richardson Radan Slavík Optoelectronics Research Centre University of SouthamptonSouthamptonSO171BJUK Laser physics and Nonlinear Optics Group Faculty of Science and TechnologyMESA+Institute for NanotechnologyUniversity of TwenteEnschede7500 AEThe Netherlands

There are a host of applications in communications, sensing, and science, in which analogue signal transmission is preferred over today’s dominant digital transmission. In some of these applications, the advantage is in lower cost, while in others, it lies in superior performance. However, especially for longer analogue photonics links (up to 10 s of km), the performance is strongly limited by the impairments arising from using standard single-mode fibres (SSMF). Firstly, the three key metrics of analogue links (loss, noise figure, and dynamic range) tend to improve with received power, but this is limited by stimulated Brillouin scattering in SSMF. Further degradation is due to the chromatic dispersion of SSMF, which induces radio-frequency (RF) signal fading, increases even-order distortions, and causes phase-to-intensity-noise conversion. Further distortions still, are caused by the Kerr nonlinearity of SSMF. We propose to address all of these shortcomings by replacing SSMFs with hollow-core optical fibres, which have simultaneously six times lower chromatic dispersion and several orders of magnitude lower nonlinearity (Brillouin, Kerr). We demonstrate the advantages in this application using a 7.7 km long hollow-core fibre sample, significantly surpassing the performance of an SSMF link in virtually every metric, including 15 dB higher link gain and 6 dB lower noise figure.

关键词： nonlinearity microwave shortcomings

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Epidural anesthesia improves pancreatic perfusion and decreases the severity of acute pancreatitis

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World Journal of Gastroenterology 2015年第43期21卷 12448-12456页

作者： Samira M Sadowski Axel Andres philippe Morel Eduardo Schiffer Jean-Louis Frossard Alexandra platon pierre-Alexandre poletti Leo Bühler Department of Visceral and Transplantation Surgery University Hospitals of Geneva Department of Anesthesiology University Hospital Geneva Department of Gastroenterology University Hospital Geneva Department of Radiology University Hospital Geneva

AIM: To study the safety of epidural anesthesia(EA),its effect on pancreatic perfusion and the outcome of patients with acute pancreatitis(Ap).METHODS: From 2005 to August 2010,patients with predicted severe Ap [Ranson score ≥ 2,C-reactive protein > 100 or necrosis on computed tomography(CT)] were prospectively randomized to either a group receiving EA or a control group treated by patientcontrolled intravenous analgesia. pain management was evaluated in the two groups every eight hours using the visual analog pain scale(VAS). parameters for clinical severity such as length of hospital stay,use of antibiotics,admission to the intensive care unit,radiological/clinical complications and the need for surgical necrosectomy including biochemical data were recorded. A CT scan using a perfusion protocol was performed on admission and at 72 h to evaluate pancreatic blood flow. A significant variation in blood flow was defined as a 20% difference in pancreatic perfusion between admission and 72 h and was measured in the head,body and tail of the ***: We enrolled 35 patients. Thirteen were randomized to the EA group and 22 to the control group. There were no differences in demographic characteristics between the two groups. The Balthazar radiological severity score on admission was higher in the EA group than in the control group(mean score 4.15 ± 2.54 vs 3.38 ± 1.75,respectively,p = 0.347) and the median Ranson scores were 3.4 and 2.7 respectively(p = NS). The median duration of EA was 5.7 d,and no complications of the epidural procedure were reported. An improvement in perfusion of the pancreas was observed in 13/30(43%) of measurements in the EA group vs 2/27(7%) in the control group(p = 0.0025). Necrosectomy was performed in 1/13 patients in the EA group vs 4/22 patients in the control group(p = 0.63). The VAS improved during the first ten days in the EA group compared to the control group(0.2 vs 2.33,p = 0.034 at 10 d). Length of stay and mortality were not

关键词： Severe acute pancreatitis Epidural anes thesia pan

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Cognitive Demand and Reminders Effect on Time-Based prospective Memory in Amnesic Mild Cognitive Impairment (AMCI) and in Healthy Elderly

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Open Journal of Medical psychology 2013年第1期2卷 35-46页

作者： Olimpia pino Francesca poletti paolo Caffarra Department of Neurosciences University of Parma Parma Italy

Individuals with-Mild Cognitive Impairment (MCI) often complain of difficulty remembering to carry out intended actions. We investigated the relative efficacy of a different reminder in performing a time-based prospective Memory (pM) task. The pM performance of 24 participants with amnesic Mild Cognitive Impairment (AMCI) has been compared with that of 24 healthy controls. As ongoing task, samples of the Attentive Matrices Test were used. In the pM task subjects were requested to write an “X” every three minutes during a 9 minutes period. participants received the task consisting either in a low demand condition (checking number “5”) or in a high demand condition (checking numbers “1”, “4”, “9”). In order to be as punctual as possible, participants were asked to simultaneously write the “X” at task time expiration, using a digital clock. Time monitoring was recorded. Reminder occurring was manipulated in that participants could receive critical, accidental or completely absent reminder. As expected, high cognitive demand was negatively correlated with pM performance and time monitoring. Unexpectedly, all the participants did not benefit from the critical reminder. These findings demonstrated, from a behavioral perspective, that Working Memory (WM) and pM processes are not based on the same memory system and pM may require WM resources at high demand.

关键词： AMCI prospective Memory Time Monitoring Memory Reminder

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public "Cloud" provisioning for Venus Express VMC Image processing

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Communications on Applied Mathematics and Computation 2019年第2期1卷 253-261页

作者： J.L.Vazquez-poletti M.p.Velasco S.Jimenez D.Usero I.M.Llorente L.Vazquez O.Korablev D.Belyaev M.V.patsaeva I.V.Khatuntsev Instituto de Matematica Interdisdiciplinar (IMI) Universidad Complutense de Madrid28040 MadridSpain Universidad politdcnica de Madrid 28040 MadridSpain Space Research Institute of Russian Academy of Sciences (IKI) 117997 MoscowRussia

In this paper,we consider the implementation of the “cloud" computing strategy to study data sets associated to the atmospheric exploration of the planet Venus. More concretely,the Venus Monitoring Camera (VMC) onboard Venus Express orbiter provided the largest and the longest so far set of ultraviolet (UV),visible and near-IR images for investigation of the atmospheric circulation. To our best knowledge,this is the first time where the analysis of data from missions to Venus is integrated in the context of the "cloud" computing. The followed path and protocols can be extended to more general cases of space data analysis,and to the general framework of the big data analysis.

关键词： Retrieval Data integration Cloud computing Big data

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Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management

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World Journal of Gastroenterology 2010年第7期16卷 818-831页

作者： Nicolas C Buchs Michael Chilcott pierre-Alexandre poletti Leo H Buhler philippe Morel Clinic for Visceral and Transplantation Surgery Department of SurgeryUniversity Hospitals of GenevaGeneva1211Switzerland Department of Radiology University Hospitals of GenevaGeneva1211Switzerland

pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative *** the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major ***,surgical exploration with pathological examination remains the"gold standard"in terms of evaluation of resectability,especially from the point of view of vascular ***,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively ***,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular *** the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a *** of vascular invasion remains one of the most important challenges in pancreatic *** aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer.

关键词： Vascular invasion Cancer pancreas Management

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少儿法语学生用书 2

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2008年

作者：由权（法）Marie-Laure poletti Clelia paccagnino

这套教材分两级，每级需要六十课时左右。每级教材包括学生用书、练习册、教师用书和两张配套的CD。学生用书以听说训练为主，练习册则以读写训练为主。学完二级至少可以会说600个词，会写332个词，掌握一些基本的句法结构、重要的时态... 详细信息

ISBN: (纸本)9787560080376

这套教材分两级，每级需要六十课时左右。每级教材包括学生用书、练习册、教师用书和两张配套的CD。学生用书以听说训练为主，练习册则以读写训练为主。学完二级至少可以会说600个词，会写332个词，掌握一些基本的句法结构、重要的时态、日常的口语表达和简单句子的书写。

关键词：儿童教育法语教材

来源：畅想之星图书光盘版（南... 评论

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A body-packer with a cocaine bag stuck in the stomach

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World Journal of Radiology 2011年第6期3卷 155-158页

作者： Yan Beauverd pierre-Alexandre poletti Hans Wolff Frédéric Ris Jean-Marc Dumonceau Bernice S Elger Department of General Internal Medicine University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland Department of Radiology University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland Department of Community Medicine Primary Care and Emergency medicineUniversity Hospitals of Geneva and Faculty of Medicine University of GenevaRue Michel-Servet 11211 Geneva 4Switzerland Department of visceral surgery University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland Department of Gastroenterology University Hospital of GenevaRue Gabrielle-Perret-Gentil 41211 Geneva 14Switzerland University of Geneva Center for legal medicineCMURue Michel-Servet 11211 Geneva 4Switzerland

Management of patients carrying packets of drugs in the digestive tract is a frequent medical *** on a patient who was referred by the police after ingestion of packets of *** spontaneous elimination of 81 drug packets,the patient had three unremarkable stools.A plain abdominal X-ray disclosed no residual packet but computed tomography(CT) scan showed one in the *** this was not eliminated during the 10 d following ingestion,it was removed through *** case stresses the usefulness of the CT scan to ensure that no residual packet is present before hospital discharge.

关键词： Body-packing Cocaine Management Surgery Gastroscopy

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