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Oral microbiome and pancreatic cancer

World Journal of Gastroenterology 2020年第48期26卷 7679-7692页

作者： Ai-Lin Wei Mao Li Guo-Qing Li Xuan Wang Wei-Ming Hu zhen-Lu Li Jue Yuan Hong-Ying Liu Li-Li zhou Ka Li ang Li Mei Rosemary Fu Department of pancreatic Surgery West China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina Key Laboratory of Transplant Engineering and Immunology Regenerative Medicine Research CenterWest China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina West China School of public Health/West China fourth Hospital Sichuan UniversityChengdu 610000Sichuan ProvinceChina West China Hospital/West China School of Nursing Sichuan UniversityChengdu 610000Sichuan ProvinceChina Boston College William F.Connell School of Nursing Boston College William F.Connell SchoolMA02467United States

BACKGROUND Microbiota profiles differ between patients with pancreatic cancer and healthy people,and understanding these differences may help in early detection of pancreatic *** sampling is an easy and cost-effective way to determine microbiota profiles compared to fecal and tissue sample *** To investigate the saliva microbiome distribution in patients with pancreatic adenocarcinoma(pDAC)and the role of oral microbiota profiles in detection and risk prediction of pancreatic *** We conducted a prospective study of patients with pancreatic cancer(n=41)and healthy individuals(n=69).Bacterial taxa were identified by 16S ribosomal ribonucleic acid gene sequencing,and a linear discriminant analysis effect size algorithm was used to identify differences in *** taxonomic unit values of all selected taxa were converted into a normalized z-score,and logistic regressions were used to calculate risk prediction of pancreatic *** Compared with the healthy control group,carriage of Streptococcus and Leptotrichina(z-score)was associated with a higher risk of pDAC[odds ratio(OR)=5.344,95%confidence interval(CI):1.282-22.282,p=0.021 and OR=6.886,95%CI:1.423-33.337,p=0.016,respectively].Veillonella and Neisseria(z-score)were considered a protective microbe that decreased the risk of pDAC(OR=0.187,95%CI:0.055-0.631,p=0.007 and OR=0.309,95%CI:0.100-0.952,p=0.041,respectively).Among the patients with pDAC,patients reporting bloating have a higher abundance of porphyromonas(p=0.039),Fusobacterium(p=0.024),and Alloprevotella(p=0.041);while patients reporting jaundice had a higher amount of prevotella(p=0.008);patients reporting dark brown urine had a higher amount of Veillonella(p=0.035).patients reporting diarrhea had a lower amount of Neisseria and Campylobacter(p=0.024 and p=0.034),and patients reporting vomiting had decreased Alloprevotella(p=0.036).CONCLUSION Saliva microbiome was able to distinguish patients with pancreatic ca

关键词： Oral microbiota Dysbiosis pancreatic cancer Cancer detection 16s rRNA High-throughput sequencing

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Summarization and comparison of dermoscopic features on different subtypes of rosacea

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Chinese Medical Journal 2022年第12期135卷 1444-1450页

作者： Wenmin Fei Yang Han ang Li Keke Li Xiaoli Ning Chengxu Li Wenju Wang Rusong Meng Yong Cui Department of Dermatology China-Japan Friendship HospitalBejing 100029China Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBejng 100730China Graduate School of peking University Health Science Center Bejing 100191China Department of Dermatology Chengdu Second People's HospitalChengduSichuan 610017China Department of Dermatology Specialty Medical Center of the Air ForceChinese People's Liberation ArmyBeijing 100142China

Background:The dermoscopic features of rosacea have already been ***,the current findings are incomplete,and little is known about phymatous ***,this study aimed to summarize and compare the dermoscopic features and patterns of three rosacea subtypes(erythematotelangiectatic[ETR],papulopustular[ppR],and phymatous[pHR])in the Chinese Han population and to evaluate whether these features differ with patients’genders,ages,and ***:Dermoscopic images of 87 rosacea patients were collected in non-polarized and polarized dermoscopy contact modes at 20-fold *** features,including vessels,scales,follicular findings,and other structures,were summarized and ***::The reticular linear vessels and red diffuse structureless areas of ETR were *** ppR,red diffuse structureless areas,reticular linear vessels,yellow scales,follicular plugs,and follicular pustules were typical dermoscopic *** common dermoscopic features of pHR were:orange diffuse structureless areas,linear vessels with branches,perifollicular white color,orange focal structureless areas,and white *** following features statistically differed among the three rosacea subtypes:reticular linear vessels(ppecific linear vessels(p=0.005),linear vessels with branches(pp=0.001),follicular plugs(pperifollicular white color(pp=0.022),orange diffuse structureless areas(pp=0.002),orange focal structureless areas(p=0.003),white lines(ppustules(pppic patterns of ETR are red diffuse structureless areas and reticular linear *** ppR,the pattern comprehends combinations of red diffuse structureless areas,reticular linear vessels,yellow scales,follicular plugs,and follicular ***,pHR is characterized by remarkable orange d

关键词： Rosacea Dermoscopic features patterns Summarizations Comparisons

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Nitrogen addition amplified water effects on species composition shift and productivity increase

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Journal of plant Ecology 2021年第5期14卷 816-828页

作者： Xiaolin zhang Muqier Hasi ang Li Yulian Tan Stefani Daryanto Lixin Wang Xueyao zhang Shiping Chen Jianhui Huang State Key Laboratory of Vegetation and Environmental Change Institute of Botanythe Chinese Academy of SciencesBeijing 100093China College of Grassland Science Shanxi Agricultural UniversityTdigu 030801China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Departmcnt of Earth Sciences Indiana University Purdue University IndianapolisIndianapolisIN 46202USA

Aims Water and nitrogen(N)are two key resources in dryland ecosystems,but they may have complex interactive effects on the community structure and ecosystem *** future precipitation(rainfall vs snowfall)change will impact aboveground net primary production(ANpp)is far from clear,especially when combined with increasing N *** In this study,we investigated changes in community productivity,abundance and aboveground biomass of two dominant plant functional groups(pFGs),*** rhizome grasses(pR)and perennial bunchgrasses(pB)under the impacts of increased precipitation(rainfall vs snowfall)combined with N addition in a semiarid temperate *** Findings Summer rainfall augmentation marginally increased community ANpp,whereas it significantly increased the abundance and aboveground biomass of pR,but not those of *** rainfall addition increased the fraction of pR biomass(fpR)while decreased that of pB(fpB).Spring snow addition had no effect on aboveground biomass of either compositional pFG although it marginally increased community *** addition significantly increased community ANpp with greater increase in pR under summer rainfall addition,indicating strong interactive effects on community ANpp largely by enhancing pR *** also found a nonlinear increase in the positive effect of nitrogen addition on productivity with the increased precipitation *** findings indicate an amplified impact of precipitation increase on grassland productivity under the accelerated atmospheric N deposition in the future.

关键词： aboveground net primary production community structure temperate steppe nitrogen addition snow and water addition

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Genome-wide CRISpR activation screen identifies candidate receptors for SARS-CoV-2 entry

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Science China(Life Sciences) 2022年第4期65卷 701-717页

作者： Shiyou zhu Ying Liu zhuo zhou zhiying zhang Xia Xiao zhiheng Liu ang Chen Xiaojing Dong Feng Tian Shihua Chen Yiyuan Xu Chunhui Wang Qiheng Li Xuran Niu Qian pan Shuo Du Junyu Xiao Jianwei Wang Wensheng Wei Biomedical pioneering Innovation Center Beijing Advanced Innovation Center for GenomicsPeking-Tsinghua Center for Life SciencesPeking University Genome Editing Research CenterState Key Laboratory of Protein and Plant Gene ResearchSchool of Life SciencesPeking UniversityBeijing100871China State Key Laboratory of protein and plant Gene Research School of Life SciencesPeking UniversityPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing Advanced Innovation Center for GenomicsPeking UniversityBeijing 100871China NHC Key Laboratory of Systems Biology of pathogens and Christophe Merieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Respiratory Disease PathogenomicsChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China

The outbreak of coronavirus disease 2019(COVID-19) caused by SARS-CoV-2 has created a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor ACE2 is low or almost absent, suggesting the existence of alternative viral entry pathways. Here, we performed a genome-wide barcoded-CRISpRa screen to identify novel host factors that enable SARS-CoV-2 infection. Beyond known host proteins, i.e., ACE2, TMpRSS2, and NRp1, we identified multiple host components,among which LDLRAD3, TMEM30A, and CLEC4G were confirmed as functional receptors for SARS-CoV-2. All these membrane proteins bind directly to spike’s N-terminal domain(NTD). Their essential and physiological roles have been confirmed in either neuron or liver cells. In particular, LDLRAD3 and CLEC4G mediate SARS-CoV-2 entry and infection in an ACE2-independent fashion. The identification of the novel receptors and entry mechanisms could advance our understanding of the multiorgan tropism of SARS-CoV-2, and may shed light on the development of COVID-19 countermeasures.

关键词： CRISpRa screen SARS-CoV-2 novel receptors

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preparation and Thermal/fast Neutron Shielding properties of Novel Boron Containing Ore Composites

Preparation and Thermal/fast Neutron Shielding Properties of...

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中国材料大会2012

作者： zhefu Li Xiangxin Xue peining Duan ang Tian Shuxian Li zhengshuai Yin School of Materials & Metallurgy Northeastern University Liaoning key laboratory for ecologically comprehensive utilization of boron resources and materials

ISBN: (纸本)9783037856062;3037856068

Four novel boron containing ores/epoxy composites were prepared by using nature ludwigite green ore （NLGO）, artificial ores including boron containing iron ore concentrate （BCIOC）, boron rich slag （BRS） and boron mud （BM） as neutron absorbers, which were obtained by dressing from NLGO, blast furnace separation from BCIOC and borax production, respectively. The microstructure of the composites was investigated by X-ray diffraction （XRD）, scanning electron microscope （SEM） and Fourier transform infrared spectroscopy （FT-IR）. Shielding properties of the composites against thermal and Cf-252 fast neutron were measured. Factors affecting the shielding properties were investigated. Energy deposition, absorbed dose and half value layers of the composites against neutron penetration were simulated by Monte Carlo method, and a simulated function was obtained. The results showed that the composites were compact and the particles of ores were homogeneous. Ascending boron mole numbers per unit volume （nB ） in the composites can obviously enhance the macroscopic absorbing cross section （Σthermal ） and improve the shielding properties for thermal neutron. The relationship of Σthermal and n B follows the equation of Σthermal =0.218+450.490n B . And the relationship of average atomic number （z） of boron containing ores composites and the macroscopic removal cross section for fast neutron follows the equation of Σremoval =0.042exp （-z/5.70）+0.032. Enhancement of the shielding abilities against Cf-252 fast neutron can be achieved by using the composites with low average atomic number.

关键词： Boron containing ores composite Monte Carlo method Macroscopic cross section Boron mole number Average atomic number

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超声引导下国产纳秒刀消融治疗甲状腺微小乳头状癌

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中国介入影像与治疗学 2023年第11期20卷 641-644页

作者：岳文文董刚任志刚张雨昂郑州大学第一附属医院超声科河南郑州450052 郑州大学第一附属医院感染科河南郑州450052

目的观察超声引导下国产纳秒刀消融治疗甲状腺微小乳头状癌(pTMC)的效果及安全性。方法前瞻性纳入12例pTMC患者行超声引导下国产纳秒刀消融治疗,计算术后第1、3、6个月病灶体积缩小率(VRR病灶)以及消融灶体积缩小率(VRR消融灶);观察围... 详细信息

目的观察超声引导下国产纳秒刀消融治疗甲状腺微小乳头状癌(pTMC)的效果及安全性。方法前瞻性纳入12例pTMC患者行超声引导下国产纳秒刀消融治疗,计算术后第1、3、6个月病灶体积缩小率(VRR病灶)以及消融灶体积缩小率(VRR消融灶);观察围手术期并发症及随访期间复发、转移情况。结果12例pTMC均一次完全消融成功。术后第1、3、6个月,VRR病灶分别为-14.43%、81.79%及100%,VRR消融灶分别为92.46%、98.56%及100%。1例术后颈部疼痛,3天后自行缓解。未见出血、喉返神经损伤、心律失常等严重并发症。随访期间无复发、转移。结论超声引导下国产纳秒刀消融治疗pTMC有效且安全。

关键词：甲状腺癌,乳头状消融技术纳秒刀

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Unified neutron star EOSs and neutron star structures in RMF models

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Communications in Theoretical physics 2022年第9期74卷 105-119页

作者： Cheng-Jun Xia Toshiki Maruyama ang Li Bao Yuan Sun Wen-Hui Long Ying-Xun zhang Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China School of Information Science and Engineering NingboTech UniversityNingbo 315100China Advanced Science Research Center Japan Atomic Energy AgencyShirakata 2-4TokaiIbaraki 319-1195Japan Department of Astronomy Xiamen UniversityXiamen 361005China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China China Institute of Atomic Energy Beijing 102413China Guangxi Key Laboratory Breeding Base of Nuclear physics and Technology Guilin 541004China

In the framework of the Thomas-Fermi approximation,we systematically study the EOSs and microscopic structures of neutron star matter in a vast density range with n_(b)≈10^(-10)-2 fm^(-3),where various covariant density functionals are adopted,i.e.,those with nonlinear self couplings(NL3,pK1,TM1,GM1,MTVTC)and density-dependent couplings(DD-Lz1,DDME-X,pKDD,DDME2,DD2,TW99).It is found that the EOSs generally coincide with each other at nb■10^(-4)fm^(-3)and 0.1 fm^(-3)■n_(b)■0.3 fm^(-3),while in other density regions they are sensitive to the effective interactions between *** adopting functionals with a larger slope of symmetry energy L,the curvature parameter K_(sym)and neutron drip density generally increases,while the droplet size,proton number of nucleus,core-crust transition density,and onset density of non-spherical nuclei,*** functionals predict neutron stars with maximum masses exceeding the two-solar-mass limit,while those of DD2,DD-Lz1,DD-ME2,and DDME-X predict optimum neutron star radii according to the observational ***,the corresponding skewness coefficients J are much larger than expected,while only the functionals MTVTC and TW99 meet the start-of-art constraints on *** accurate measurements on the radius of pSR J0740+6620 and the maximum mass of neutron stars are thus essential to identify the functional that satisfies all constraints from nuclear physics and astrophysical *** linear correlations between neutron stars’radii at M=1.4M⊙and 2M⊙,the slope L and curvature parameter K_(sym)of symmetry energy are observed as well,which are mainly attributed to the curvature-slope correlations in the functionals adopted *** results presented here are applicable for investigations of the structures and evolutions of compact stars in a unified manner.

关键词： neutron star EOS nuclear pasta covariant density functionals

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准分子激光辅助回收嵌入型下腔静脉滤器的应用价值

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中华实用诊断与治疗杂志 2024年第4期38卷 392-395页

作者：杨海鹏张克伟邢哲诚张东宾秦亚飞朱亚东张军辉翟水亭河南大学人民医院河南省人民医院血管外科河南郑州450003

目的探讨下肢深静脉血栓患者采用准分子激光辅助回收嵌入型下腔静脉滤器(IVCF)的效果及安全性。方法2020年10月—2023年3月河南省人民医院诊治下肢深静脉血栓且置入IVCF患者29例,均为嵌入型IVCF,其中行准分子激光辅助回收IVCF者13例为... 详细信息

目的探讨下肢深静脉血栓患者采用准分子激光辅助回收嵌入型下腔静脉滤器(IVCF)的效果及安全性。方法2020年10月—2023年3月河南省人民医院诊治下肢深静脉血栓且置入IVCF患者29例,均为嵌入型IVCF,其中行准分子激光辅助回收IVCF者13例为激光组,行球囊扩张辅助回收IVCF者16例为球囊组,记录2组IVCF置入至回收时间、IVCF型号、D-二聚体水平,手术成功率、术中X线透视时间、手术时间、术中疼痛程度、住院时间、术后并发症发生率;随访至2023年6月,记录不良事件发生情况。结果激光组IVCF置入至回收时间[2065(254,3508)d]长于球囊组[61(25,118)d](z=-4.079,p=0.001),IVCF型号、D-二聚体水平与球囊组比较差异均无统计学意义(p>0.05)。激光组手术成功率(100.0%)高于球囊组(62.5%)(χ^(2)=4.909,p=0.027),术中X线透视时间[13.6(8.4,21.0)min]短于球囊组[32.1(19.6,51.2)min](z=-2.939,p=0.003),术中重度疼痛比率(0)、术后并发症发生率(0)均低于球囊组(18.8%、31.3%)(χ^(2)=7.431,p=0.038;χ^(2)=4.909,p=0.027),手术时间、住院时间与球囊组比较差异均无统计学意义(p>0.05)。结论准分子激光辅助回收嵌入型IVCF较球囊扩张辅助回收成功率高,术中X线透视时间短、疼痛程度轻,术后并发症发生率低。

关键词：下肢深静脉血栓下腔静脉滤器嵌入型准分子激光球囊

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p2p流媒体分发模型及在视频会议系统中的应用

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西南交通大学学报 2013年第1期48卷 88-93页

作者：高昂许爽李增智李默西安交通大学电子与信息工程学院陕西西安710049 中州大学信息工程学院河南郑州450044

针对传统视频会议系统服务质量较差的问题,提出了一种混合式流媒体分发模型VCStream(videoconference stream).模型中,由数据源节点构成一个树状系统,一旦树满,新加入的节点将进入一个备选池,从而备选池中的节点与树的所有叶子节点又构... 详细信息

针对传统视频会议系统服务质量较差的问题,提出了一种混合式流媒体分发模型VCStream(videoconference stream).模型中,由数据源节点构成一个树状系统,一旦树满,新加入的节点将进入一个备选池,从而备选池中的节点与树的所有叶子节点又构成了一个网状系统.基于该模型,设计了循环缓冲和两阶段调度算法,以优化流媒体数据的传输,达到提高可扩展性和容错性的目的.实验结果表明:与树状分发模型和随机拓扑结构模型相比,所提出的模型减少了10%～20%的传输延时以及新节点的加入时间;鲁棒性也比随机拓扑模型高5%,从而能更好地满足视频会议系统的需要.

关键词：对等网络流媒体分发模型视频会议

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钠米材料Fe＿2O＿3微结构的正电子寿命谱学研究

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物理学报 1994年第7期43卷 1208-1216页

作者：彭郁卿王涛周诗瑶卜为张立德中国科学院上海原子核研究所中国科学院核分析技术开放研究实验室中国科学院固体物理研究所上海师范大学

用Ｘ射线衍射确定了纳米材料Ｆｅ＿２Ｏ＿３的平均粒径。测量了正电子的寿命。给出了平均粒径随退火温度的变化和短寿命成分τ＿１、中等寿命成分τ＿２以及它们的强度比Ｉ＿２／Ｉ＿１随平均粒径的变化。讨论了纳米材料Ｆｅ＿２Ｏ＿３... 详细信息

用Ｘ射线衍射确定了纳米材料Ｆｅ＿２Ｏ＿３的平均粒径。测量了正电子的寿命。给出了平均粒径随退火温度的变化和短寿命成分τ＿１、中等寿命成分τ＿２以及它们的强度比Ｉ＿２／Ｉ＿１随平均粒径的变化。讨论了纳米材料Ｆｅ＿２Ｏ＿３的界面结构、平均正电子寿命τ与多普勒展宽谱Ｓ参效间的对应关系。

关键词：纳米材料氧化铁正电子湮灭缺陷

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