检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

考虑软件不同失效过程偏差的软件可靠性模型

计算机学报 2010年第7期33卷 1263-1271页

作者：楼俊钢江建慧靳昂同济大学计算机科学与技术系上海201804

软件可靠性分析是根据软件失效数据等信息,通过合理建模来对软件可靠性进行预计和评价.现有的基于随机过程的可靠性模型一般采用均值过程来描述软件失效数据,然而,软件失效数据的模型化实质上应该是使其成为某个随机过程的一个样本轨迹... 详细信息

软件可靠性分析是根据软件失效数据等信息,通过合理建模来对软件可靠性进行预计和评价.现有的基于随机过程的可靠性模型一般采用均值过程来描述软件失效数据,然而,软件失效数据的模型化实质上应该是使其成为某个随机过程的一个样本轨迹.文中建立了考虑软件不同失效过程偏差的软件可靠性模型,用NHpp过程表示失效过程均值函数的变化趋势,ARMA过程表示实际失效过程对均值过程的偏差序列.在两组公开发表的真实数据集上对模型的实验表明,新模型较之一些广泛使用的NHpp软件可靠性模型在拟合能力及适用性上有明显的提高,并且保持了较好的预测能力.

关键词：软件可靠性模型样本轨迹非齐次泊松过程模型随机过程自回归滑动平均过程

磺酰腙的高效快速合成及其抗菌性能初探——推荐一个医学本科院校化学创新实验

在线全文

学校读者我要写书评

暂无评论

大学化学 2024年第3期39卷 316-326页

作者：唐敬杰谢露影刘嘉昱石尚玉孙欣雨林家阳杨琦堃于传昂王泽诚王盈盈解增洋济宁医学院基础医学院新型抗肿瘤药物分子设计与合成实验室山东济宁272067 济宁医学院临床医学院山东济宁272067 济宁医学院第二临床医学院山东济宁272067

在有机化学实验教学过程中,实验内容通常是完成某一化合物的合成或提取,缺少对目标化合物的结构鉴定和性质检验。为了提高有机化学实验教学质量,培养学生的科研素养和创新能力。以商业易得的醛、酮和对甲苯磺酰肼为反应原料,于室温无溶... 详细信息

在有机化学实验教学过程中,实验内容通常是完成某一化合物的合成或提取,缺少对目标化合物的结构鉴定和性质检验。为了提高有机化学实验教学质量,培养学生的科研素养和创新能力。以商业易得的醛、酮和对甲苯磺酰肼为反应原料,于室温无溶剂条件下,利用研磨方法在1 min内高效快速合成磺酰腙,并对产物进行结构表征和性质研究。产物应用于抗菌实验研究时,化合物3i和3h对大肠杆菌有最好的抑制效果。实验涉及合成、TLC检测和柱色谱层析等操作,可以锻炼学生在有机化合物合成、纯化及结构鉴定等方面的操作技能。要求学生独立查阅文献,熟练掌握Origin、ChemDraw和MestRec等软件的使用,可以提升学生分析问题并解决问题的能力。改进的实验以提高学生综合素质为宗旨,适用于有机化学基础实验教学。

关键词：无溶剂条件磺酰腙研磨方式抗菌性能

维普期刊数据库博看期刊

Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第8期26卷 116-127页

作者： Ming Li Yuan Gao Miaowen Jiang Hongkang zhang Yang zhang Yan Wu Wenhao zhou Di Wu Chuanjie Wu Longfei Wu Luzi Bao Xiaoxiao Ge zhengfei Qi Ming Wei ang Li Yuchuan Ding Jicheng zhang Guangzhen pan Yu Wu Yan Cheng Yufeng zheng Xunming Ji China-America Institute of Neuroscience and Beijing Institute of Geriatrics Xuanwu HospitalCapital Medical UniversityBeijing100053China School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing100191China Beijing Institute for Brain Disorders Capital Medical UniversityBeijing100069China School of Materials Science and Engineering Peking UniversityBeijing100871China Shaanxi Key Laboratory of Biomedical Metallic Materials Northwest Institute for Nonferrous Metal ResearchXi’an710016China Department of Biomedical Engineering Columbia UniversityNew York CityNY10027USA Department of Neurosurgery Wayne State University School of MedicineDetroitMI48201USA Gong Yi Van-research Innovation Composite Material Co.Ltd Zheng Zhou451299China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing100053China

Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection,but current catheters do not support thermally-insulated transfer of cold infusate,which results in an increased exit temperature,causes hemodilution,and limits its cooling ***,air-sprayed fibroin/silica-based coatings combined with chemical vapor deposited parylene-C capping film was prepared on *** coating features in dual-sized-hollow-microparticle incorporated structures with low thermal *** infusate exit temperature is tunable by adjusting the coating thickness and infusion *** peeling or cracking was observed on the coatings under bending and rotational scenarios in the vascular *** efficiency was verified in a swine model,and the outlet temperature of coated catheter(75μm thickness)was 1.8-2.0◦C lower than that of the uncoated *** pioneering work on catheter thermal insulation coatings may facilitate the clinical translation of selective endovascular hypothermia for neuroprotection in patients with acute ischemic stroke.

关键词： Silk fibroin Thermal insulation coating Catheter Stroke Hypothermia

Density Depletion and Hall Effect in Magnetic Reconnection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Density Depletion and Hall Effect in Magnetic Reconnection

改进CAR-T细胞有效性和安全性的设计策略

第十一届全国日地空间物理学术讨论会

作者： Hong-ang Yang and Shu-ping Jin ( School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026 )

＜正＞We investigate the layers of density depletion in magnetic reconnection using a 2.5 dimensional Hall MHD code developed from a multi-step implicit scheme. The numerical results at the quasi-steady state of Hall MHD reconnection with di/L0 ＞0.1 （di is the ion inertial length and L0 is the length of simulation domain in z direction） show not only the density depletions along the magnetic separatrices but also a dip in the density in the vicinity of the X neutral line. To understand the physics underlying the density depletions in the reconnection processes we examine a series of cases with di/L0 ranging from 0.25 to 0.01 and find the depleting layers of density along the separatrices become more and more slight as the Hall effect weakens with decreasing di/L0, and they are hardly distinguishable for the cases with di/L0≤1/20. What’ s more, the profile of the density ρ* at the central point of the diffusion region as the function of di/L0 illustrates that ρ* decreases as Hall effect strengthens with increasing di/L0. As seen in the profile of ρ* versus di/L0,ρ* is approximate to 2.0 in the cases with di/L0＜1/50 where the Hall effect is very weak and the reconnection dynamics are controlled by the resistivity. However, ρ* is less then 1.0 in the cases with di/L0 ＞ 0.1 where the reconnection dynamics are dominated by Hall effect. It demonstrates that the density depletion in the magnetic reconnection is a peculiar feature to the case with a strong Hall term.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中国肿瘤生物治疗杂志 2017年第5期24卷 461-466页

作者：张昂张斌陈虎解放军第307医院造血干细胞移植科全军造血干细胞研究所北京100071

嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其... 详细信息

嵌合抗原受体T(chimeric antigen receptor T cells,CAR-T)细胞已从实验室走向了临床试验,在治疗B细胞恶性肿瘤中取得了显著疗效,但在探索CAR-T细胞治疗恶性肿瘤的临床研究中,仍面临不少困难与挑战:难以找到肿瘤特异性的靶点,以克服其脱靶效应(on-target off tumor effect);在治疗实体瘤中CAR-T细胞很难达到肿瘤部位,以改善免疫抑制微环境发挥作用;CAR-T细胞在清除肿瘤细胞的同时也会杀伤表达相同靶点的正常细胞;针对除B细胞肿瘤之外的血液肿瘤以及实体瘤而言,CAR-T细胞的有效性还有待提高。本文重点介绍如何通过CAR-T细胞结构的优化使得CAR-T细胞能够精准地识别肿瘤细胞,克服肿瘤的免疫抑制微环境来提高CAR-T细胞治疗恶性肿瘤的有效性;同时使得CAR-T细胞可以被更好地控制,使得CAR-T细胞的安全性更高。

关键词： CAR—T细胞设计策略结构改造有效性安全性

Microstructure and mechanical behavior of laser aided additive manufactured low carbon interstitial Fe_(49.5)Mn_(30)Co_(10)Cr_(10)C_(0.5)multicomponent alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第18期77卷 38-46页

作者： Y.Chew z.G.zhu F.Weng S.B.Gao F.L.Ng B.Y Lee G.J.Bi Singapore Institute of Manufacturing Technology 73 Nanyang Drive637662Singapore School of Mechanical Aerospace Engineering Nanyang Technological University50 N any ang Avenue639798Singapore

Laser aided additive manufacturing(LAAM)was used to fabricate bulk Fe_(49.5)Mn_(30)Co_(10)Cr_(10)C_(0.5)interstitial multicomponent alloy using pre-alloyed *** room temperature yield strength(σ_y),ultimate tensile strength(σ_(UTS))and elongation(ε_(UTS))were 645 Mpa,917 Mpa and 27.0%*** asbuilt sample consisted of equiaxed and dendritic cellular structures formed by elemental *** cellular structures together with oxide particle inclusions were deemed to strengthen the *** other contributing components include dislocation strengthening,friction stress and grain boundary *** highε_(UTS)was attributed to dislocation motion and activation of both twinning and transformation-induced plasticity(TWIp and TRIp).Tensile tests performed at-40℃and-130℃demonstrated superior tensile strength of 1041 Mpa and 1267 Mpa ***,almost no twinning was observed in the fractured sample tested at-40℃and-130℃.Instead,higher fraction of strain-induced hexagonal close-packed(HCp)εphase transformation of 21.2%were observed for fractured sample tested at-40℃,compared with 6.3%in fractured room temperature sample.

关键词： Multicomponent alloys Laser aided additive manufacturing Additive manufacturing Microstructure Mechanical property

在线全文

学校读者我要写书评

暂无评论

药物性肝损伤慢性化的研究近况

临床肝胆病杂志 2020年第3期36卷 501-504页

作者：黄昂孙颖邹正升解放军总医院第五医学中心非感染性肝病诊疗与研究中心北京100039

尽管药物性肝损伤(DILI)通常表现为急性过程,但仍有约20%患者会发生慢性化。慢性DILI病程反复且无有效﹑公认的治疗方法。随着新药的不断研发及其临床应用,以及中药和食物补充剂的应用,DILI慢性化的发生率不断增高。通过DILI流行病学﹑... 详细信息

尽管药物性肝损伤(DILI)通常表现为急性过程,但仍有约20%患者会发生慢性化。慢性DILI病程反复且无有效﹑公认的治疗方法。随着新药的不断研发及其临床应用,以及中药和食物补充剂的应用,DILI慢性化的发生率不断增高。通过DILI流行病学﹑危险因素﹑临床表现﹑诊断及治疗等角度对DILI慢性化的最新研究近况进行概述,以期更加全面地了解认识慢性DILI。

关键词：药物性肝损伤慢性病诊断治疗学

网络演化博弈视角下的跨国公司逆向知识转移动态过程研究

在线全文

学校读者我要写书评

暂无评论

管理评论 2017年第11期29卷 159-170页

作者：肖振红刘昂周文哈尔滨工程大学经济管理学院哈尔滨150001 国防科学技术大学信息系统与管理学院长沙410003

逆向知识转移是跨国公司获取海外东道国知识资源、维持竞争优势的重要途径。为了探索逆向知识转移的运行机制和过程规律,针对跨国公司中母子公司之间逆向知识转移的动态过程,构建跨国公司逆向知识转移动态过程的网络演化博弈模型,并对... 详细信息

逆向知识转移是跨国公司获取海外东道国知识资源、维持竞争优势的重要途径。为了探索逆向知识转移的运行机制和过程规律,针对跨国公司中母子公司之间逆向知识转移的动态过程,构建跨国公司逆向知识转移动态过程的网络演化博弈模型,并对跨国公司逆向知识转移的动态过程进行仿真分析。研究结果表明,博弈策略的信号传递噪音对母子公司博弈策略的采纳和更新均具有重要影响;母子公司单位成本以及子公司努力成本对母子公司积极策略稳态实现速度的影响均具有可分离特征,而母公司努力成本的影响存在最优区间;子公司之间博弈策略的信号传递和策略的模仿强烈依赖于作为载体的网络结构,无标度网络结构更有利于促成积极策略的传递扩散。

关键词：逆向知识转移跨国公司演化博弈复杂网络

Antithrombin gene Arg197Stop mutation-associated venous sinus thrombosis in a Chinese family

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2011年第20期6卷 1575-1579页

作者： ang Li Tianhui Liu zhandong Liu Jimei Li Chunling zhang Jun Chen Jinmei Sun Yanfei Han Lili Wang Dexin Wang Qiming Xue Baoen Wang Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Liver Research Center Beijing Friendship Hspital Capital Medical University Beijing 100050 China Department of Neurology Health Care Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

This study sought to elucidate the genetic correlation of cerebral venous sinus thrombosis caused by a hereditary antithrombin deficiency in a Chinese family, at the genetic and protein levels. A nonsense mutation from C to T on locus 6431 in exon 3B of the antithrombin gene was observed, leading to an arginine （CGA） to stop codon （TGA） change in the protein. This is the first report of this mutation in China. Ineffective heparin therapy in the propositus patient is associated with a lack of heparin binding sites after antithrombin gene mutation. Characteristic low intracranial pressure in the acute phase might be specific to this patient with cerebral venous sinus thrombosis.

关键词： antithrombin cerebral venous sinus thrombosis intracranial hypotension nonsense mutation brain edema