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Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial

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Stroke & Vascular Neurology 2021年第2期6卷 180-186页

作者： Lucy Beishon Lisa j Woodhouse Daniel Bereczki Hanne K Christensen Ronan Collins john Gommans Christina Kruuse George Ntaios Serefnur Ozturk Stephen phillips Stuart pocock Szabolcs Szatmari joanna Wardlaw Nikola Sprigg philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Bispebjerg Hospital and University of Copenhagen University of CopenhagenCopenhagenDenmark Department of Geriatric and Stroke Medicine Adelaide and Meath HospitalDublinIreland Department of Medicine Hawke's Bay HospitalCamberleyNew Zealand Department of Neurology Herlev Gentofte HospitalUniversity of CopenhagenCopenhagenDenmark Department of Medicine Larissa University HospitalUniversity of ThessalyVolosGreece Department of Neurology Selcuk University Medical FacultyKonyaTurkey Department of Neurology Queen Elizabeth II Health Sciences CentreHalifaxNova ScotiaCanada Medical Statistics Unit London School of Hygiene&Tropical MedicineLondonUK Department of Neurology George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTargu MuresRomania Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK

Introduction Nitrate-induced headache is common and may signify responsive cerebral *** assessed the relationship between nitrate headache and outcome in patients with acute *** and methods patients were those randomised to glyceryl trinitrate(GTN)versus no GTN in the efficacy of nitric oxide in stroke *** of headache by end of treatment(day 7),and functional outcome(modified Rankin Scale,primary outcome)at day 90,were *** are adjusted for baseline prognostic factors and give OR and mean difference(MD)with 95%*** In 4011 patients,headache was more common in GTN than control(360,18.0% vs 170,8.5%;ppressure,non-total anterior circulation syndrome,milder stroke and absence of dysphasia(pproved functional outcome(OR 0.90,95% CI 0.73 to 1.10,p=0.30)or death(day 90)(HR 0.64,95% CI 0.40 to 1.02,p=0.062),but reduced death or deterioration(day 7)(OR 0.45,95% CI 0.25 to 0.82),death in hospital(OR 0.44,95% CI 0.22 to 0.88)and improved activities of daily living(Barthel index,MD 3.7,95% CI 0.3 to 7.1)and cognition(telephone interview cognitive screen,MD 2.0,95% CI 0.7 to 3.3)(day 90).Non-nitrate headache was not associated with death,disability or *** and conclusion Development of a nitrate headache by day 7 after stroke may be associated with improved activities of daily living and cognitive impairment at day 90,which was not seen with non-nitrate headache.

关键词： headache patients nitrate

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Microfungi on Tamarix

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Fungal Diversity 2017年第1期82卷 239-306页

作者： Kasun M.Thambugala Dinushani A.Daranagama Alan j.L.phillips Timur S.Bulgakov Darbhe j.Bhat Erio Camporesi Ali H.Bahkali prapassorn D.Eungwanichayapant Zuo-Yi Liu Kevin D.Hyde Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesNo 31st West Beichen RoadChaoyang DistrictBeijing 100101People’s Republic of China Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Academy of Biology and Biotechnology Southern Federal UniversityRostov-on-Don344090 Rostov RegionRussia Formerly Department of Botany Goa UniversityGoaIndia Curca No.128/1–JAzad Housing SocietyGoa VelhaIndia A.M.B.Gruppo Micologico ForliveseBAntonio Cicognani^ Via Roma 18ForlìItaly A.M.B.Circolo Micologico BGiovanni Carini^ C.P.314BresciaItaly Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia

Tamarix species are small trees that grow in various natural habitats and have a wide geographic *** species previously found on Tamarix and recently collected in Italy and Russia were identified based on morphological characters and analyses of gene sequence *** sexual morph of the coelomycetous genus Homortomyces was collected for the first time and is described and illustrated.A new family,Homortomycetaceae(Dothideomycetes,families incertae sedis)is introduced to accommodate *** new genera Neomicrosphaeropsis(Didymellaceae)and Tamaricicola(pleosporaceae)are introduced in this *** tamaricicola was recollected and is placed in Neomicrosphaeropsis based on morphology and molecular *** new species,Cytospora italica,***,Diaporthe ravennica,Eutypella tamaricis,Neomicrosphaeropsis italica,***,***,Keissleriella tamaricicola,paracamarosporium tamaricis and Tamaricicola muriformis are introduced,while Alternaria tenuissima,Dothiorella sarmentorum,Neofusicoccum luteum,paraepicoccum amazonense,pleospora herbarum and pseudocamarosporium propinquum are reported for the first time on Tamarix *** descriptions and ***-gene analyses show that paraepicoccum amazonense should be placed in pleosporineae,pleosporales,where it is closely related to Camarosporium sensu *** herbarium specimens were studied to illustrate other fungal species recorded on Tamarix species.A comprehensive account of microfungi on Tamarix is provided,which includes a list with data from the literature,as well as those identified in the present *** taxonomic placement of most taxa discussed in this study is based on a modern taxonomic framework based on analysis of multi-gene sequence data.

关键词： Dothideomycetes Homortomycetaceae Incertae sedis New species phylogeny pleosporales Sordariomycetes Tamaricaceae Taxonomy

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数值分析的理论及其应用

数值分析的理论及其应用

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丛书名：书名原文:Theory and applications of numerical analysis

1980年

作者：（英）菲利普斯（G.M. phillips）（美）泰勒（p.j. Taylor）熊西文等译

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Diversity of Botryosphaeriaceae species associated with grapevine and other woody hosts in Italy,Algeria and Tunisia,with descriptions of Lasiodiplodia exigua and Lasiodiplodia mediterranea ***

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Fungal Diversity 2015年第2期71卷 201-214页

作者： B.T.Linaldeddu A.Deidda B.Scanu A.Franceschini S.Serra A.Berraf-Tebbal M.Zouaoui Boutiti M.L.Ben jamâa A.j.L.phillips Dipartimento di Agraria Sezione di Patologia vegetale ed EntomologiaUniversitàdegli Studi di Sassarivia E.De Nicola 107100 SassariItaly Département des Biotechnologies Facultédes Sciences de la Vie et de la TerreUniversitéSaad Dahleb09000 BlidaAlgeria INRGREF Laboratoire de Gestion et de Valorisation des Ressources ForestièresB.P.N 22080 ArianaTunisia Centro de Recursos Microbiológicos Departamento de Ciências da VidaFaculdade de Ciências e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal

The diversity of Botryosphaeriaceae species associated with“Botryosphaeria dieback”of grapevine was investigated in 18 vineyards in Sardinia,*** isolates obtained from different woody hosts including holm oak,sweet orange and broom bush in Italy,Algeria and Tunisia were also *** and cultural characteristics as well as ITS and EF1-αsequence data were used to identify the fungal ***-eight botryosphaeriaceous isolates were obtained from 113 symptomatic grapevine samples,from which ten species were *** seriata was the dominant species(25%of isolates),followed by Neofusicoccum parvum(21.7%).Two species,Diplodia olivarum and *** are reported for the first time on *** addition,two new species namely Lasiodiplodia mediterranea *** grapevine,holm oak and sweet orange and Lasiodiplodia exigua *** broom bush are *** artificial inoculation experiments conducted on excised green grapevine shoots and lignified canes as well as holm oak seedlings,*** was shown to be an aggressive pathogen.

关键词： Citrus×sinensis Diplodia Lasiodiplodia Neofusicoccum Quercus ilex Retama raetam

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DISCOMYCETES: the apothecial representatives of the phylum Ascomycota

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Fungal Diversity 2017年第6期87卷 237-298页

作者： A.H.Ekanayaka H.A.Ariyawansa K.D.Hyde E.B.G.jones D.A.Daranagama A.j.L.phillips S.Hongsanan S.C.jayasiri Qi Zhao Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Department of plant pathology and Microbiology College of Bio-resources and AgricultureNational Taiwan UniversityNo.1Sec.4Roosevelt RoadTaipei 106TaiwanROC Department of Entomology and plant pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Biotechnology and Germplasm Resources Institute Yunnan Academy of Agricultural ScienceKunming 650221YunnanPeople’s Republic of China

Discomycetes are an artificial grouping of apothecia-producing fungi in the phylum ***-based studies have revealed that the discomycetes can be found among ten classes of *** classification of discomycetes has been a major challenge due to the lack of a clear understanding of the important morphological characters,as well as a lack of reference *** this review,we provide a historical perspective of discomycetes,notes on their morphology(including both asexual and sexual morphs),ecology and importance,an outline of discomycete families and a synoptical cladogram of currently accepted families in Ascomycota showing their systematic *** also calculated evolutionary divergence times for major discomycetous taxa based on phylogenetic relationships using a combined LSU,SSU and RpB2 data set from 175 strains and fossil *** results confirm that discomycetes are found in two major subphyla of the Ascomycota:Taphrinomycotina and *** taxonomic placement of major discomycete taxa is briefly *** most basal group of discomycetes is the class Neolectomycetes,which diverged from other Taphrinomycotina around 417 MYA(216–572),and the most derived group of discomycetes,the class Lecanoromycetes,diverged from Eurotiomycetes around 340 MYA(282–414).Further clarifications based on type specimens,designation of epitypes or reference specimens from fresh collections,and multi-gene analyses are needed to determine the taxonomic arrangement of many discomycetes.

关键词： Asci amyloidity Lichenized discomycetes Non-operculate discomycetes Operculate discomycetes

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用脉冲辐解研究9,10-菲醌的单电子还原性质(英文)

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辐射研究与辐射工艺学报 1997年第1期15卷 10-14页

作者：包华影 S.Navaratnam B.j.parsons G.O.phillips 北京师范大学化学系北京100875 FacultyofScienceandTechnology TheNorthEastWalesInstitutePlasCochWrexhamClwydLL112AWUK

用脉冲辐解技术研究了水溶液中的9，10－菲醌（phQ）单电子还原性质，给出了phQ半醌阴离子和中性自由基的吸收光谱，中性自由基的酸解离常数，以及phQ的单电子还原电位。还研究了phQ半醌自由基的生成动力学，获得了水化电子和异丙醇自... 详细信息

用脉冲辐解技术研究了水溶液中的9，10－菲醌（phQ）单电子还原性质，给出了phQ半醌阴离子和中性自由基的吸收光谱，中性自由基的酸解离常数，以及phQ的单电子还原电位。还研究了phQ半醌自由基的生成动力学，获得了水化电子和异丙醇自由基与phQ反的二级速率常数。同时还获得了phQ半醌自由基的衰变速率常数。

关键词：脉冲辐解,9.10-菲醌单电子还原

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Identification of a Native Novel Oncolytic Immunoglobulin on Exfoliated Colon Epithelial Cells: A Bispecific Heterodimeric Chimera of IgA/IgG*

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Open journal of preventive Medicine 2020年第6期10卷 126-150页

作者： George p. Albaugh Sudhir K. Dutta Vasantha Iyengar Samina Shami Althaf Lohani Eduardo Sainz George Kessie prasanna Nair Sara Lagerholm Alka Kamra j.-H. joshua Chen Shilpa Kalavapudi Rakesh Vinayek Robert Shores Laila E. phillips Ram Nair padmanabhan p. Nair Beltsville Human Nutrition Research Centre Agricultural Research Service Beltsville MD USA Division of Gastroenterology Sinai Hospital of Baltimore Baltimore MD USA Department of International Health Johns Hopkins University Bloomberg School of Public Health Baltimore MD USA NonInvasive Technologies LLC Elkridge MD USA Department of pediatrics University of Maryland School of Medicine Baltimore MD USA

Understanding the nature of cell surface markers on exfoliated colonic cells is a crucial step in establishing criteria for a normally functioning mucosa. We have found that colonic cells isolated from stool samples (SCSR-010 Fecal Cell Isolation Kit, NonInvasive Technologies, Elkridge, MD), preserved at room temperature for up to one week, with viability of >85% and low levels of apoptosis (8% - 10%) exhibit two distinct cell size subpopulations, in the 2.5 μM - 5.0 μM and 5.0 μM - 8.0 μM range. In addition to IgA, about 60% of the cells expressed a novel heterodimeric IgA/IgG immunoglobulin that conferred a broad-spectrum cell mediated cytotoxicity against tumor cells. In a cohort of 58 subjects the exclusive absence of this immunoglobulin in two African-Americans was suggestive of a germline deletion. Serial cultures in stem cell medium retained the expression of this heterodimer. Since a majority of the cystic cells expressed the stem cell markers Lgr5 and Musashi-1 we termed these cells as gastrointestinal progenitor stem cells (GIp-C**). CXCR-4, the cytokine co-receptor for HIV was markedly expressed. These cells also expressed CD20, IgA, IgG, CD45, and COX-2. We assume that they originated from mature columnar epithelium by dedifferentiation. Our observations indicate that we have a robust noninvasive method to study mucosal pathophysiology and a direct method to create a database for applications in regenerative medicine.

关键词： Colon Epithelial Cells CXCR-4 IgA/IgG Chimeric Immunoglobulin Heterodimer COX-2 LGR-5 Musashi-1 Dedifferentiation Cellular Engraftment Oncoly-sis Gastrointestinal progenitor Stem Cells (GIp-C)

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Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum

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Translational Neurodegeneration 2023年第1期12卷 50-69页

作者： Ting Shen jacob W.Vogel jeffrey Duda jeffrey S.phillips philip ACook james Gee Lauren Elman Colin Quinn Defne A.Amado Michael Baer Lauren Massimo Murray Grossman David j.Irwin Corey T.McMillan penn Frontotemporal Degeneration Center Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Clinical Sciences SciLifeLabLund University22242 LundSweden penn Image Computing and Science Lab(pICSL) Department of RadiologyPerelman School of MedicineUniversity of Penn-sylvaniaPhiladelphiaPA 19104USA Department of Neurology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Digital Neuropathology Laboratory Department of NeurologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA.

Background TDp-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibits a diverse range of clinical presentations with overlapping phenotypes,highlighting its *** study was aimed to use disease progression modeling to identify novel data-driven spatial and temporal subtypes of brain atrophy and its progression in the ALS-FTD *** We used a data-driven procedure to identify 13 anatomic clusters of brain volume for 57 behavioral variant FTD(bvFTD;with either autopsy-confirmed TDp-43 or TDp-43 proteinopathy-associated genetic variants),103 ALS,and 47 ALS-FTD patients with likely TDp-43.A Subtype and Stage Inference(SuStaIn)model was trained to identify subtypes of individuals along the ALS-FTD spectrum with distinct brain atrophy patterns,and we related subtypes and stages to clinical,genetic,and neuropathological features of *** SuStaIn identified three novel subtypes:two disease subtypes with predominant brain atrophy in either prefrontal/somatomotor regions or limbic-related regions,and a normal-appearing group without obvious brain *** limbic-predominant subtype tended to present with more impaired cognition,higher frequencies of pathogenic variants in TBK1 and TARDBp genes,and a higher proportion of TDp-43 types B,E and *** contrast,the prefrontal/somatomotor-predominant subtype had higher frequencies of pathogenic variants in C9orf72 and GRN genes and higher proportion of TDp-43 type *** normal-appearing brain group showed higher frequency of ALS relative to ALS-FTD and bvFTD patients,higher cognitive capacity,higher proportion of lower motor neuron onset,milder motor symptoms,and lower frequencies of genetic pathogenic *** overall SuStaIn stages also correlated with evidence for clinical progression including longer disease duration,higher King’s stage,and cog

关键词： Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model

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Dictyosporiaceae ***.

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Fungal Diversity 2016年第5期80卷 457-482页

作者： Saranyaphat Boonmee Melvina j.D’souza Zonglong Luo Umpava pinruan Kazuaki Tanaka Hongyan Su Darbhe j.Bhat Eric H.C.McKenzie E.B.Gareth jones joanne E.Taylor Alan j.L.phillips Kazuyuki Hirayama prapassorn D.Eungwanichayapant Kevin D.Hyde Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand College of Agriculture and Biology Sciences Dali UniversityDaliYunnan 671003China National Center for Genetic Engineering and Biotechnology National Science and Technology Development AgencyThailand Science Park113 Phahonyothin RoadKlong 1Klong Luang Pathumthani 12120Thailand Formerly Department of BotanyGoa UniversityNo.128/1-JAzad Housing SocietyCurca Goa VelhaIndia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Faculty of Sciences Biosystems and Integrative Sciences Institute(BioISI)University of LisbonCampo Grande1749-016 LisbonPortugal Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Faculty of Agriculture and Life Science Hirosaki University3 Bunkyo-choHirosakiAomori 036-8561Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan

Dictyosporiaceae *** introduced to accommodate a holomorphic group of Dothideomycetes that are saprobes on decaying wood and plant debris in terrestrial and freshwater *** sexual morph comprises Dictyosporium meiosporum,***,Gregarithecium curvisporum,pseudocoleophoma calamagrostidis and *** sexual morphs are characterized by immersed to erumpent,superficial,globose to subglobose,dark brown to black ascomata,bitunicate asci,and septate,hyaline,sheathed *** asexual morphs are hyphomycetous with brown,multi-septate,cheirosporous conidia,produced from holoblastic conidiogenous cells,on micronematous *** analyses of LSU,SSU and TEF1 sequence data place the genera with cheirospores in a monophyletic clade in the order *** analyses based on ITS sequence data show the family to comprise 44 distinct lineages that correspond to ten genera and an undetermined *** new genera Dictyocheirospora,Dictyopalmispora,jalapriya and Vikalpa,and eight new species Dictyocheirospora bannica,***,***,Dictyopalmispora palmae,Dictyosporium olivaceosporum,***,jalapriya pulchra,and Vikalpa lignicola,are introduced in the family.

关键词： Cheirosporous conidia Keylphylogeny Sexual states Sporodochial fungi

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菲利浦型Cr_2O_3/SiO_2催化剂二级颗粒分裂模式的研究

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Chinese journal of Catalysis 1990年第6期11卷 514-519页

作者：王社民 Tait p.j.T Marsden C.E. 化工部北京化工研究院北京100013 CHEMISTRY DEpARTMENT UMIST CROSFIELD CHEMICALS LTD.

在烯烃非均相配位聚合研究领域中,对于催化剂颗粒在聚合过程中产生分裂的观察和研究可以追溯到很久以前。人们的兴趣主要集中在这种分裂对于催化活性中心数目、性质以及对于聚合反应动力学和有关工程问题的影响。这些研究无疑将会对新... 详细信息

在烯烃非均相配位聚合研究领域中,对于催化剂颗粒在聚合过程中产生分裂的观察和研究可以追溯到很久以前。人们的兴趣主要集中在这种分裂对于催化活性中心数目、性质以及对于聚合反应动力学和有关工程问题的影响。这些研究无疑将会对新催化剂的研制、现有催化剂的改进以及解决有关聚合工程问题等提供有益的启示。

关键词： Cr2O3/SiO2 二级颗粒分裂

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