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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.o.Beeren G.Dos Santos p.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-pT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal poLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(pCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight pCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight pCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMp-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMp receptor II(BMpRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

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Traveling wave solutions of the nonlinear Gilson-pickering equation in crystal lattice theory

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Journal of ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.T.Nguyen o.Nikan Z.Avazzadeh Division of Applied Mathematics Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Faculty of Technology Van Lang UniversityHo Chi Minh CityVietnam School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Applied Mathematics Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

This paper focuses on obtaining the traveling wave solutions of the nonlinear Gilson-pickering equa-tion(GpE),which describes the prorogation of waves in crystal lattice theory and plasma *** solution of the GpE is approximated via the finite difference technique and the localized meshless radial basis function generated finite *** association of the technique results in a meshless approach that does not require linearizing the nonlinear *** the first step,the pDE is converted to a system of nonlinear oDEs with the help of the radial *** the second step,a high-order oDE solver is adopted to discretize the nonlinear oDE *** global collocation techniques pose a considerable computationl burden due to the calculation of the dense algebraic *** proposed method approx-imates differential operators over the local support domain,leading to sparse differentiation matrices and decreasing the computational *** results and comparisons are provided to confirm the efficiency and accuracy of the method.

关键词： Nonlinear Gilson–pickering equation Soliton wave solutions Meshless technique RBF LRBF-FD optimal shape parameter

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optimizing artificial intelligence in sepsis management: opportunities in the present and looking closely to the future

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Journal of Intensive Medicine 2024年第1期4卷 34-45页

作者： Darragh o’Reilly Jennifer McGrath Ignacio Martin-Loeches Department of Intensive Care Medicine Multidisciplinary Intensive Care Research Organization(MICRO)St James’HospitalDublinIreland Department of Respiratory Intensive care Hospital ClinicUniversitat de BarcelonaIDIBAPSCIBERESBarcelonaSpain

Sepsis remains a major challenge internationally for healthcare *** incidence is rising due to poor public awareness and delays in its recognition and subsequent *** sepsis,mortality increases with every hour left *** intelligence(AI)is transforming worldwide healthcare delivery at *** review has outlined how AI can augment strategies to address this global disease *** and machine learning(ML)algorithms can analyze vast quantities of increasingly complex clinical datasets from electronic medical records to assist clinicians in diagnosing and treating sepsis earlier than traditional *** review highlights how these models can predict the risk of sepsis and organ failure even before it *** gives providers additional time to plan and execute treatment plans,thereby avoiding increasing complications associated with delayed diagnosis of *** potential for cost savings with AI implementation is also discussed,including improving workflow efficiencies,reducing administrative costs,and improving healthcare *** these advantages,clinicians have been slow to adopt AI into clinical *** of the limitations posed by AI solutions include the lack of diverse data sets for model building so that they are widely applicable for routine clinical ***,the subsequent algorithms are often based on complex mathematics leading to clinician hesitancy to embrace such ***,we highlight the need for robust political and regulatory frameworks in this area to achieve the trust and approval of clinicians and patients to implement this transformational technology。

关键词： Artificial intelligence Data science Machine learning Intensive care unit(ICU) Critical care Sepsis

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photonics Research 2024年第4期12卷 804-812页

作者： XIAoYU NIE HAoTIAN SoNG WENHAN REN ZHEDoNG ZHANG TAo pENG MARLAN o.SCULLY Institute for Quantum Science and Engineering Texas A&M UniversityCollege StationTexas 77843USA School of physics Xi’an Jiaotong UniversityXi’an 710049China Department of physics City University of Hong KongHong KongChina Baylor University WacoTexas 76706USA

The generation of speckle patterns via random matrices, statistical definitions, or apertures may not always result in optimal outcomes. Issues such as correlation fluctuations in low ensemble numbers and diffraction in long-distance propagation can arise. Instead of improving results of specific applications, our solution is catching deep correlations of patterns with the framework, Speckle-Net, which is fundamental and universally applicable to various systems. We demonstrate this in computational ghost imaging(CGI) and structured illumination microscopy(SIM). In CGI with extremely low ensemble number, it customizes correlation width and minimizes correlation fluctuations in illuminating patterns to achieve higher-quality images. It also creates non-Rayleigh nondiffracting speckle patterns only through a phase mask modulation, which overcomes the power loss in the traditional ring-aperture method. our approach provides new insights into the nontrivial speckle patterns and has great potential for a variety of applications including dynamic SIM, X-ray and photo-acoustic imaging, and disorder physics.

关键词： CGI Deep ghost

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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(pET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of optoelectronics 2024年第2期17卷 87-97页

作者： o.Castelló Sofía M.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-pérez Y.M.Meziani J.M.Caridad J.A.Delgado-Notario Department of Applied physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz photodetector Field-effect transistor plasmonic

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public perspectives on AI diagnosis of mental illness

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General psychiatry 2024年第3期37卷 348-351页

作者： Cliodhna o'Connor University College Dublin DublinIreland

To the editor:psychiatric theory,policy and practice are currently grappling with the risks and opportunities presented by artificial intelligence(AI)applications in mental *** data to generate diagnosis is an aspect of mental healthcare where AI is anticipated to have the greatest and soonest impact.1-4 While such technologies remain some distance from clinical application,preliminary evidence suggests AI-derived classifications may predict certain treatment outcomes and clinical trajectories,and could soon become available to supplement or replace traditional manual-based diagnostic assessment.

关键词： diagnosis replace editor

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Null surfaces of pseudo-spherical spacelike framed curves in the anti-de Sitter 3-space

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Acta Mathematica Sinica,English Series 2024年

作者： o.ogulcan TUNCER Department of Mathematics Hacettepe University

We introduce null surfaces (or nullcone fronts) of pseudo-spherical spacelike framed curves in the three-dimensional anti-de Sitter space. These surfaces are formed by the light rays emitted from points on anti-de Sitter spacelike framed curves. We then classify singularities of the nullcone front of a pseudo-spherical spacelike framed curve and show how these singularities are related to the singularities of the associated framed curve. We also define a family of functions called the Anti-de Sitter distance-squared functions to explain the nullcone front of a pseudo-spherical spacelike framed curve as a wavefront from the viewpoint of the Legendrian singularity theory. We finally provide some examples to illustrate the results of this paper.

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Energy and blast performance of beryllium in a model thermobaric composition in comparison with aluminum and magnesium

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Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： Thomas M.Klapotke Stanisław Cudziło Waldemar A.Trzcinski Jozef paszula Energetic Materials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany Military University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct comparison is made between the effectiveness of Al,Mg,and Be powders as additional fuels in model thermobaric compositions containing 20%fuel,20%ammonium perchlorate,and 60%RDX(1,3,5-Trinitro-1,3,5-triazacyclohexane)passivated with *** determined calorimetric measurements of the heat of detonation,along with the overpressure histories in an explosion chamber filled with nitrogen,were used to determine the quasi-static pressure(QSp)under anaerobic *** measurements were also performed in a semi-closed bunker,and all blast wave parameters generated after the detonation of 500 g charges of the tested explosives were *** calorimetry results,QSp values,and blast wave parameters(pressure amplitude,specific and total impulses)clearly indicate that Be is much more effective as an additional fuel than either Al or Mg in both anaerobic post-detonation reactions as well as the subsequent aerobic *** heat of detonation of the RDXwax/Ap/Be explosive mixture is over 40%and 50%higher than that of the mixture containing aluminum and magnesium instead of beryllium,***,the TNT equivalent of the Be-containing composition due to the overpressure in the nitrogen-filled explosion chamber is 1.66,while the equivalent calculated using an air shock wave-specific impulse at a distance of 2.5 m is equal to *** high values of these parameters confirm the high reactivity of beryllium in both the anaerobic and aerobic stages of the thermobaric explosion.

关键词： Thermobaric explosives Beryllium Heat of detonation Quasi-static overpressure Blast wave parameters

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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

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