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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(pET)biomarkers that enable the detection of the hallmark p.o.eins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our app.o.ch to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)p.o.ides an app.o.riate framework to reduce levels of clinico-pathologic mismatch and imp.o.e in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to p.o.ide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for molecular and Cell Biology(IBmC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exp.o.ation is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these p.o.esses,potentially stalling scientific p.o.ress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exp.o.ation of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics app.o.ch to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic p.o.erties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane p.o.rusion growth or retraction(Yamada and Sixt,2019).Cell p.o.rusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a p.o.ess called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(minegishi et al.,2023;pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate p.o.ram College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health p.o.lem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

A Class of parallel Implicit Runge-Kutta Formulas

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Journal of Systems Engineering and Electronics 1993年第4期4卷 53-63页

作者： Fei JinggaoBeijing Institute of Computer Application and Simulation Technology p.o. Box 3929, Beijing 100854, China Beijing Institute of Computer Application and Simulation Technology p.o. Box 3929 Beijing 100854 China

A class of parallel implicit Runge-Kutta formulas is constructed for multip.o.essor system. A family of parallel implicit two-stage fourth order Runge-Kutta formulas is given. For these formulas, the convergence is p.o.ed and the stability analysis is given. The numerical examples demonstrate that these formulas can solve an extensive class of initial value p.o.lems for the ordinary differential equations.

关键词： multip.o.essor system parallel algorithm ordinary differential equation Implicit Runge-Kutta formula.

Study on the Effects of End-bend Cantilevered Stator in a 2-stage Axial Compressor

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Journal of Thermal Science 2009年第2期18卷 119-125页

作者： Songtao WANG Xin DU Zhongqi WANG Harbin Institute of Technology, p.o. BoX 458, Harbin 150001, China Harbin Institute of Technology Harbin China

Leading edge recambering is applied to the cantilevered stator vanes in a 2-stage compressor in this paper. Differentcurving effects are p.o.uced when the end-bend stator vanes are stacked in different ways. Stacking on theleading edge induces a positive curving effect near the *** it is stacked on the centre of gravity, a negativecurving effect takes place. The numerical investigation shows that the flow field is redistributed when theend-bend stators with leading edge stacking are applied. The variations in the stage matching for the mainstreamand near the hub have an impact on the performance of the 2-stage compressor. The isentropic efficiency and thetotal pressure ratio of the compressor are increased near the design condition. The compressor total pressure ratiois decreased near choke and near stall. The maximum flow rate is reduced and the stall margin is decreased.

关键词： axial compressor end-bend blade stacking stage matching

Numerical Simulation of Shock (Blast) Wave Interaction with Bodies

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Communications in Nonlinear Science and Numerical Simulation 1999年第1期4卷 1-7页

作者： Jialing LE (China Aerodynamics Research and Development Center p.o. Box 211 mianyang Sichuan China) China Aerodynamics Research and Development Center p.o. Box 211 mianyang Sichuan China China

Some typical results of computation on the shock (blast) wave interaction (2-D and 3-D) with bodies and its experimental validation in shock tube are summarized, suggestions for imp.o.ing the numerical method (difference scheme and grid systems),developing 3-D optical quantitative visualization technology and further studying the unsteady turbulent flow are put forward.

关键词： shock wave blast wave numerical simulation

Coarse to Fine: The Role of Severe plastic Deformation in Advancing Titanium-Based medical Implants - A Comprehensive Review

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Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 295-306页

作者： Dragana R mihajlović Bojan I međo Ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the Republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SpD)p.o.edures,which are utilized to form an ultrafine-grained structure in metallic *** the SpD p.o.ess,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HpT)p.o.ess,as one of the SpD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the p.o.erties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HpT p.o.ess parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile p.o.erties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SpD p.o.ess show imp.o.ed mechanical and physical p.o.erties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion p.o.ess ultrafine-grained titanium-based materials electrochemical anodization physical p.o.erties mechanical p.o.erties

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is emp.o.ed for the analysis. Utilizing a p.o.er translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the p.o.osed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration