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中国天然药物 2013年第4期11卷 362-370页

作者： A.Linza p.J.Wills p.n.ansil S.p.prabha A.nitha B.Latha K.O.Sheeba M.S.Latha Biochemistry and pharmacognosy Research Laboratory School of BiosciencesMahatma Gandhi UniversityP.D.Hills.P.O.Kottayam-686560KeralaIndia MIMS Research Foundation Malabar Institute of Medical SciencesCalicut-673007KeralaIndia

AIM:A decoction of Elephantopus scaber(Asteraceae) root is used to treat liver disorders in Indian and Chinese traditional *** study was designed to examine the dose response effects of *** methanolic extract on rats exposed to n-nitrosodiethylamine(nDEA) induced hepatotoxicity(0.02% nDEA in water five days per week,per oral) in preventive and curative ***:In preventive groups,nDEA was administered for six *** doses of *** methanolic extract(200 and 100 mg kg 1) started one week before the onset of nDEA intoxication and continued for six *** curative animals,nDEA was administered for six weeks followed by treatment with the methanolic n-hexane extract of ***(200 and 100 mg kg 1) for ten ***:*** extract treatment significantly(p ≤ 0.05) reduced the levels of AST,ALT,and MDA in both experimental *** extract also enhanced the antioxidant enzyme and protein levels in rats intoxicated with *** with the extract dose dependently protected the liver from nDEA-induced hepatotoxicity with normal hepatocytes and uniform sinusoids,but in some areas showed degenerating hepatic cells in both treatment ***:*** methanolic extract dose dependently prevented and reversed the hepatotoxicity induced by nDEA in both experimental models.

关键词：实验药理学药理病理作用天然药物

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protective effect of Amorphophallus campanulatus(Roxb.) *** against thioacetamide induced oxidative stress in rats

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Asian pacific Journal of Tropical Medicine 2011年第11期4卷 870-877页

作者： puthuparampil nazarudeen ansil Anand nitha Santhibhavan prabhakaran prabha pallara Janardhanan Wills Vahab Jazaira Mukalel Sankunni Latha Biochemistry and pharmacognosy Research Laboratory School of BiosciencesM.G.UniversityP.O.Hills.P.O.KottayamKerala-686560India

Objective:To identify the phytochemical constituents of Amorphopkallus campanulatus(A. campanulatus) tuber and to evaluate its antioxidant potential through in vitro and in vivo models. Methods:phytochemical screening and in vitro antioxidant activities of *** tuber n-hexane extract(ACHE) and methanolic extract(ACME) were evaluated using DppH,hydroxyl radical,reducing power and total antioxidant capacity *** total phenolic and flavonoid contents were also *** protective potential of two different doses of ACME(125 and 250 mg/kg) was also evaluated against thioaeetamide(TAA) induced oxidative stress in rats. Silymarin used as a standard drug *** was assessed by quantifying the serum levels of aspartate aminotransferase(AST),alanine aminotransferase(AIT),alkaline phosphatase (ALp) and lactate dehydrogenase(LDH).The antioxidant potential of ACME were also evaluated by the estimation of catalase(CAT),glutathione peroxidase(Gpx),glutathione reductase (OR),glutathione-S-transferase(GST),reduced glutathione(GSH) and lipid peroxidation (Thiobarbituric acid reactive substances) in hepatic and renal *** changes of liver were also ***:In vitro studies revealed that ACME has higher antioxidant and radical scavenging activity than ACHE,which may be attributed to its higher phenolic and flavonoid *** significandy prevented the elevation of serum AST,***,LDH,and tissue malondialdehyde levels(p patic and renal ***,Gpx,and catalase levels were remarkably increased by the treatment with the *** of histopathological changes also supported the dose dependent protective effects of ***:The results do suggest that *** tuber could be considered as a potential source of natural antioxidant.

关键词： Amorphophallus campanulatus Thioacetamide DppH Hepatotoxicity Hepatoprotective Antioxidant aclivily Silymarin

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