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四维CT评价心动周期中右室流出道和肺动脉畸形

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国际医学放射学杂志 2011年第2期 189-189页

作者： S.Schievano C.Capelli C.Young P.Lurz J.Nordmeyer C.Owens 秦乃姗 Cardiovascular Unit UCL Institute of Child Health & Great Ormond Street Hospital for Children

目的描述心动周期过程中右室流出道(RVOT)/肺动脉(pA)畸形的三维特征,评价传统二维方法的误差。方法回顾性分析了12例病人对比增强、心电门控心血管CT成像

关键词：肺心病 CT 血流动力学畸形四维

percutaneous pulmonary and tricuspid valve implantations: An update

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World Journal of Cardiology 2015年第4期7卷 167-177页

作者： Robert Wagner Ingo Daehnert philipP.Lurz Department of paediatric Cardiology University of Leipzig-Heart Center Department of Internal Medicine/Cardiology University of Leipzig-Heart Center

The field of percutaneous valvular interventions is one of the most exciting and rapidly developing within interventional cardiology.percutaneous procedures focusing on aortic and mitral valve replacement or interventional treatment as well as techniques of percutaneous pulmonary valve implantation have already reached worldwide clinical acceptance and routine interventional procedure status.Although techniquesof percutaneous pulmonary valve implantation have been described just a decade ago,two stent-mounted complementary devices were successfully introduced and more than 3000 of these procedures have been performed worldwide.In contrast,percutaneous treatment of tricuspid valve dysfunction is still evolving on a much earlier level and has so far not reached routine interventional procedure status.Taking into account that an "interdisciplinary challenging",heterogeneous population of patients previously treated by corrective,semi-corrective or palliative surgical procedures is growing inexorably,there is a rapidly increasing need of treatment options besides redo-surgery.Therefore,the review intends to reflect on clinical expansion of percutaneous pulmonary and tricuspid valve procedures,to update on current devices,to discuss indications and patient selection criteria,to report on clinical results and finally to consider future directions.

关键词： Congenital heart disease Right ventricular outflow tract dysfunction pulmonary regurgitation percutaneous pulmonary valve implantation percutaneous tricuspid valve implantation

窄波UVB311nm与宽波UVB疗法联合局部外用钙泊三醇与安慰剂治疗白癜风的比较研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 3-4页

作者： Hartmann A lurz C Hamm H 焦婷 Department of Dermatology and Venereology University of Würzburg Josef-Schneider-Str. 2 97080 Würzburg Germany.Dr

Background: Recently, it has been shown that UVB phototherapymay bemore effect ive than UVA in the treatment of vitiligo. Currently, however, no studies have c ompared the efficacy of UVB 311 nm and broad-band UVB therapy. Calcipotriol has recently been reported to be effective adjunctive treatment for vitiligo, enhan cing the efficacy of 8-methoxypsoralen plus UVA (pUVA) therapy. Methods: Ten pa tients were enrolled in the study; nine completed the 12 months of therapy. The upper part of the body was treated twice weekly with UVB 311 nm and the lower pa rt with broad-band UVB. Calcipotriolwas applied onto the vitiligo lesions of th e right side of the body and placebo on the left side. Repigmentation was docume nted by photography, planimetry, and Vitiligo Disease Activity (VIDA) score. The quality of life was measured by the Dermatology Life Quality Index (DLQI). Resu lts: After 7-16 weeks, six of the nine patients showed initial repigmentation o n the side treated with UVB311 nm. After 6 months of treatment, none of the patients showed repigmentation on the areas treated wit h broad-band UVB, which prompted us to apply UVB 311 nm all over the body. At t he end of 12 months, two patients showed > 75%repigmentation, two showed 51-75 %, two showed 26-50%, and three showed 0-25%. In all patients with progress ive vitiligo (seven of the nine patients), disease activity was stopped. Remarka bly, vitiligo lesions treated with calcipotriol initially showed delayed repigme ntation compared with control areas; however, there was no therapeutic differenc e between calcipotriol and placebo, both in combination with UVB 311 nm, by the end of the study.The DLQI score improved significantly by an average of 28%. Co nclusion: UVB 311 nm therapy was effective in the treatment of vitiligo, whereas broad-band UVB had no effect. Combination with calcipotriol ointment was not s uperior to UVB 311 nm monotherapy.The quality of life significantly improved wit h narrow-band UVB 311 nm phototherapy.

关键词：钙泊三醇 UVB311nm 安慰剂甲氧补骨脂素复色光疗法生存质量疾病活动度照相术

Renal sympathetic denervation in therapy resistant hypertension-pathophysiological aspects and predictors for treatment success

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World Journal of Cardiology 2016年第8期8卷 436-446页

作者： Karl Fengler Karl philipp Rommel Thomas Okon Gerhard Schuler philipP.Lurz Department of Internal Medicine/Cardiology University of Leipzig-Heart Center

Many forms of human hypertension are associated with an increased systemic sympathetic activity. Especially the renal sympathetic nervous system has been found to play a prominent role in this context. Therefore, catheterinterventional renal sympathetic denervation(RDN) has been established as a treatment for patients suffering from therapy resistant hypertension in the past decade. The initial enthusiasm for this treatment was markedly dampened by the results of the Symplicity-HTN-3 trial, although the transferability of the results into clinical practice to date appears to be questionable. In contrast to the extensive use of RDN in treating hypertensive patients within or without clinical trial settings over the past years, its effects on the complex pathophysiological mechanisms underlying therapy resistant hypertension are only partly understood and are part of ongoing research. Effects of RDN have been described on many levels in human trials: From altered systemic sympathetic activity across cardiac and metabolic alterations down to changes in renal function. Most of these changes could sustainably change long-term morbidity and mortality of the treated patients, even if blood pressure remains unchanged. Furthermore, a number of promising predictors for a successful treatment with RDN have been identified recently and further trials are ongoing. This will certainly help to improve the preselection of potential candidates for RDN and thereby optimize treatment outcomes. This review summarizes important pathophysiologic effects of renal denervation and illustrates the currently known predictors for therapy success.

关键词： Renal sympathetic denervation Sympathetic nervous system predictors Hypertension Renal Hypertension

采用不同导管和技术的去肾交感神经术治疗单纯收缩期高血压:一项随机试验结果

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中华高血压杂志 2019年第7期27卷 699-699页

作者： Fengler K Rommel Kp Lapusca R Blazek S Besler C Hartung p von Roeder M Kresoja Kp Desch S Thiele H lurz p 赵狄练桂丽不详

目前认为单纯收缩期高血压(isolated systolic hypertension,ISH)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RD... 详细信息

目前认为单纯收缩期高血压(isolated systolic hypertension,ISH)患者经去肾交感神经术(renal sympathetic denervation,RDN)后血压降低。此结论绝大多数来自单极射频导管消融的研究。但采用新的RDN的数据有限。研究者采用比较3种不同RDN方法的RADIOSOUND-HTN(采用不同RDN导管与技术治疗顽固性高血压患者的三臂随机试验)数据,探讨ISH与RDN反应的可能交互作用。

关键词：单纯收缩期高血压射频导管消融随机试验 hypertension 治疗经术交感高血压患者

伴有急慢性心衰症状心肌炎的心脏MRI及心肌T1、T2图纹理分析

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国际医学放射学杂志 2019年第6期 727-727页

作者： B.Baessler C.Luecke J.lurz K.Klingel A.Das M.V.Roeder 蒋梦迪 Institute of Diagnostic and Interventional Radiology University of Cologne Medical Faculty and University Hospital Cologne

摘要及时、准确诊断心力衰竭样心肌炎(以心力衰竭为表现的心肌炎)一直是临床心脏病学研究的难点之一。目的以心内膜活检为参考标准,评价纹理分析对心力衰竭样心肌

关键词：心肌炎慢性心衰 T1 T2 纹理分析心衰症状急慢性 MRI

心肌梗死样急性心肌炎病人心脏MRI T1和T2 maps的纹理分析

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国际医学放射学杂志 2019年第1期 104-104页

作者： B.Baessler C.Luecke J.lurz K.Klingel M.V.Roeder S.D.Waha 王佳佳 Department of Radiology University Hospital of Cologne

摘要目的探讨心脏MRI T和Tmaps的纹理分析对梗死样急性心肌炎的潜在诊断价值。材料与方法这项前瞻性研究纳入了2012年8月—2015年5月从Magnetic Reso-

关键词：急性心肌炎 MRI T1 T2 maps 心肌梗死纹理分析

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窄谱UVB 311或宽谱UVB联合外用卡泊三醇治疗白癜风

作者： (德)卢茨·赛勒(lurz Seiler)

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国际皮肤性病学杂志 2006年第3期32卷 161-161页

作者： Hartmann A[英] lurz C[英] Hamm H[英] 尚淑贤（摘）

近来，研究认为UVB比UVA治疗白癜风更为有效，然而。还没有试验对UVB311和宽谱UVB的疗效进行比较。卡泊三醇近来被认为是治疗白癜风有效的辅助制剂，可以增强UVA和8-甲氧补骨脂素的疗效。德国Wurzburg大学的Hartmann等对窄谱UVB311和宽... 详细信息

近来，研究认为UVB比UVA治疗白癜风更为有效，然而。还没有试验对UVB311和宽谱UVB的疗效进行比较。卡泊三醇近来被认为是治疗白癜风有效的辅助制剂，可以增强UVA和8-甲氧补骨脂素的疗效。德国Wurzburg大学的Hartmann等对窄谱UVB311和宽谱UVB治疗白癜风的疗效进行了比较，同时对卡泊三醇的作用进行了观察。总共10例患者，9例完成了12个月的治疗观察。患者身体上半部分每周2次用UVB311照射，下部用宽谱UVB照射，右侧皮损外涂卡泊三醇，左侧皮损用安慰剂。通过照相，求积法和白癜风疾病活动评分来评价色素恢复程度。患者生活质量用皮肤病生活质量指数（DLQI）来评价。

关键词：窄谱UVB 治疗观察卡泊三醇白癜风联合外用皮肤病生活质量指数患者生活质量 8-甲氧补骨脂素 UVB照射 UVA