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国际医学放射学杂志 2024年第4期 502-502页

作者： J.G.Harper E.N.York R.Meijboom A.kampaite M.J.Thrippleton p.k.a.kearns 杨程

摘要目的通过纵向T1值的测量来量化近期诊断的复发缓解型多发性硬化症（RRMS）病人大脑微观结构的变化，及其与临床残疾之间的关系。方法从一项单中心队列子研

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Clinical validity and utility of genetic risk scores in prostate cancer

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Asian Journal of Andrology 2016年第4期18卷 509-514页

作者： Brian T Helfand James kearns Carly Conran Jianfeng Xu Department of Surgery NorthShore University HealthSystem Program for Personalized Cancer Care Evanston IL 60201 USA.

Current issues related to prostate cancer （pCa） clinical care （e.g., over-screening, over-diagnosis, and over-treatment of nonaggressive pCa） call for risk assessment tools that can be combined with family history （FH） to stratify disease risk among men in the general population. Since 2007, genome-wide association studies （GWASs） have identified more than 100 SNps associated with pCa susceptibility. In this review, we discuss （1） the validity of these pCa risk-associated SNps, individually and collectively; （2） the various methods used for measuring the cumulative effect of multiple SNps, including genetic risk score （GRS）; （3） the adequate number of SNps needed for risk assessment; （4） reclassification of risk based on evolving numbers of SNps used to calculate genetic risk, （5） risk assessment for men from various racial groups, and （6） the clinical utility of genetic risk assessment. In conclusion, data available to date support the clinical validity of pCa risk-associated SNps and GRS in risk assessment among men with or without FH. pCa risk-associated SNps are not intended for diagnostic use; rather, they should be used the same way as FH. Combining GRS and FH can significantly improve the performance of risk assessment. Improved risk assessment may have important clinical utility in targeted pCa testing. However, clinical trials are urgently needed to evaluate this clinical utility as well as the acceptance of GRS by patients and physicians.

关键词： genetic risk score prostate cancer pyramid model single nucleotide polymorphisms

Fractal-based autonomous partial discharge pattern recognition method for MV motors

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High Voltage 2018年第2期3卷 103-114页

作者： Zhuo Ma Yang Yang Martin kearns kevin Cowan Huajie Yi Donald M.Hepburn Chengke Zhou School of Engineering and Built Environment Glasgow Caledonian UniversityGlasgowG40BAUK Electrical System Group Engineering DivisionNuclear GenerationEDF EnergyGlasgowG745PGUK

On-line partial discharge(pD)monitoring is being increasingly adopted to improve the asset management and maintenance of medium-voltage(MV)*** study presents a novel method for autonomous analysis and classification of motor pD patterns in situations where a phase-reference voltage waveform is not *** main contributions include a polar pD(ppD)pattern and a fractal theory-based autonomous pD recognition *** pattern that is applied to convert the traditional phase-resolved pD pattern into a circular form addresses the lack of phase information in on-line pD monitoring *** fractal theory is then presented in detail to address the task of discrimination of 6 kinds of single source and 15 kinds of multi-source pD patterns related to motors,as outlined in IEC *** classification of known and unknown defects is calculated by a method known as centre *** of the proposed method is demonstrated using data from laboratory experiments on three typical pD *** study also discusses the application of the proposed techniques with 24 sets of on-site pD measurement data from 4 motors in 2 nuclear power *** results show that the proposed method performs effectively in recognising not only the single-source pD but also multi-source pDs.

关键词： method autonomous fractal

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BLUE MOON

英语学习 1994年第11期 42-49页

作者： Lionel kearns 立青

Whenever Harvey hears the song he thinks of SybilChalmers, who in 1949 came into the grade seven class, and sangit,astonishing them all."We have a new face with us this morning,"the teacher had

关键词： BLUE MOON

Houston16:A stable geodetic reference frame for subsidence and faulting study in the Houston metropolitan area,Texas,U.S.

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Geodesy and Geodynamics 2019年第5期10卷 382-393页

作者： Timothy J.kearns Guoquan Wang Michael Turco Jennifer Welch Vasilios Tsibanos Hanlin Liu Dept.of Earth and Atmospheric Sciences National Center for Airborne Laser MappingUniversity of HoustonHoustonTX77204USA Harris-Galveston Subsidence District FriendswoodTX77546USA

Houston,Texas,is one of the earliest regions to employ continuous GpS technology for land subsidence ***,there are over 200 permanent GpS stations located in the greater Houston *** need for a consistent and stable reference frame to precisely interpret local ground deformation has become critically important since the 1990s,because of the significant spreading of *** have established a stable Houston reference frame,designated Houston16,using publicly available GpS observations(>5 years)from 15 Continuously Operating Reference Stations(CORS)located outside of the greater Houston *** of the reference frame in subsidence and faulting studies are demonstrated in this ***16 is aligned in origin and scale with the International GNSS Reference Frame of 2008(IGS08).A 7-parameter method was employed to transform the GpS-derived positional time series from IGS08 to *** primary product of this study is the seven parameters for transforming Earth-Centered-Earth-Fixed XYZ coordinates from IGS08 to *** frame stability of Houston16 is approximately 1 mm/***16 will be updated every few years to mitigate degradation of the frame’s stability with time and to synchronize with future updates of the IGS reference frame.

关键词： Faulting GpS Houston IGS08 Reference frame Subsidence

practices of caring for nursing students: A clinical learning environment

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International Journal of Nursing Sciences 2020年第2期7卷 214-219页

作者： Jennifer Subke Charlene Downing Irene kearns Department of Nursing University of JohannesburgJohannesburgSouth Africa

Objective:The purpose of this study was to explore,describe and illuminate nursing students'best encounters of caring in the clinical learning *** for nursing students was emphasized and recommendations provided to enhance caring for nursing students within their clinical learning ***:Qualitative data was collected by the researcher using semi-structured individual interviews and an Appreciative Inquiry(AI)*** second year nursing students undertaking the bridging course leading to registration as general nurses in terms of Regulation 683 of the South African Nursing Council(SANC)were purposively sampled from 3 private hospitals within the Western *** was analysed using Giorgi's ***:The main theme included the best and'least best'caring practices embedded in the centrality of the *** subthemes comprised of the nursing students'experiences of caring literacy and caring *** second theme included the creation of best caring practices within a conducive clinical learning *** this theme,the subthemes comprised of the caring attributes required in reflecting best caring practices,as well the creation of a clinical learning environment to optimise ***:The significance and necessity of caring for the nursing student were clearly illustrated and confirmed by *** was equated to the heart as the core to the nursing students'*** for nursing education,management,practice and research were therefore specifically formulated to enhance caring towards nursing students.

关键词： Clinical learning environment Empathy Nursing students Nursing education

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如何在护理领域实现性别平等

英国医学杂志中文版 2022年第3期25卷 138-141页

作者： Thomas kearns paul Mahon 梁爽(译) 李真(校) Faculty of Nursing and Midwifery Royal College of Surgeons in IrelandDublinIreland Centre for Nursing and Midwifery Advancement.Faculty of Nursing and Midwifery Royal College of Surgeons in IrelandDublinIreland 中国医学科学院北京协和医院

Thomas kearns和paul Mahon认为,消除阻碍男性从事护理工作的刻板印象和预设,对解决日益严峻的护士短缺问题和提升护理多元化至关重要。

关键词：护理领域刻板印象护士短缺护理工作性别平等多元化

Genetic Normalization of Differentiating Aneuploid Human Embryos microarray pGS

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Genetic Normalization of Differentiating Aneuploid Human Emb...

对就地养老的反思——“人”与“地方”关系视角

中华医学会第六次全国生殖医学学术会议

作者： William Gerard kearns The Johns Hopkins University School of Medicine

kearns Abstract part 1 of talk Evaluation of 4,873 embryos using 23-chromosome single nucleotide polymorphism(SNp)microarray preimplantation genetic screening(pGS) Spontaneous miscarriages in human pregnancies have been well documented to be associated with chromosomal *** technology to evaluate this aneuploidy in early human embryos has been avail-

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地理科学进展 2015年第12期34卷 1495-1511页

作者： Alexandra BOYLE Janine L.WILES Robin A.kearns 伦敦玛丽女王大学地理学院奥克兰大学人口健康学院奥克兰大学环境学院

在有关养老的老年学和地理学研究中,"就地养老"是一个广泛使用的概念,并一直被认为是解决老龄人口养老需求的有效政策手段。迄今为止,关于就地养老的研究主要关注了很多能够让老年人健康就地(或在家)养老的物质方面的因素,比如住房条件... 详细信息

在有关养老的老年学和地理学研究中,"就地养老"是一个广泛使用的概念,并一直被认为是解决老龄人口养老需求的有效政策手段。迄今为止,关于就地养老的研究主要关注了很多能够让老年人健康就地(或在家)养老的物质方面的因素,比如住房条件或家庭照护。有些老年学研究者们认识到,就地养老受到居住环境中实体环境和社会、情感因素的共同影响。但我们认为,在养老体验研究中,要更加深入地审视"人"和"地方"之间的复杂关系。特别是,我们主张就地养老成功的因素是地方具有维持良好关系的潜力。提到"地方(place)"一词的时候,人们过分局限于关注老年人身体上接近的地理空间,或是具有实体边界的地方,例如房子或社区。而我们通过回顾现有文献发现,对许多选择就地养老的人来说,更具有意义的是随着时间的推移,他们在不同空间尺度上所建立起来的多元的、网络化的社会和非社会关系。基于这个新的视角,可以更好地理解老年人与地方的多层次的联系,以及从不同尺度和不同类型的人与地方的关系来考察就地养老的意义。

关键词：就地养老人际关系社区老年人老龄化地方人

k12学校的新蓝图(上)——支持混合学习的创新学校设计:Intrinsic学校

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中国信息技术教育 2018年第6期 87-90页

作者：张渝江 Larry kearns 重庆市聚奎中学校芝加哥惠勒·卡恩斯建筑师事务所

混合学习以一种独特的方式利用学校时间,将在线教学与传统教学相结合,让学生在学习方式、时间和地点上都有更多的自主权.而其中的第三个变量“地点”要求我们认真反思学校空间的组织和部署方式.实践中,我们发现建筑设计要么支持,要么挫... 详细信息

混合学习以一种独特的方式利用学校时间,将在线教学与传统教学相结合,让学生在学习方式、时间和地点上都有更多的自主权.而其中的第三个变量“地点”要求我们认真反思学校空间的组织和部署方式.实践中,我们发现建筑设计要么支持,要么挫败学校的使命一它从来不是一个“无辜的旁观者”.

关键词：混合学习建筑设计学校 k12 创新传统教学在线教学学习方式