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Dynamic evolution of terpenoid biosynthesis in the Lamiaceae

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Molecular plant 2023年第6期16卷 963-965页

作者： Zhibiao Wang Reuben j.peters School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China Roy j.Carver Department of Biochemistry Biophysics&Molecular Biologylowa State UniversityAmesIA 50011USA

With the increasing accessibility of whole-genome sequencing it has become standard practice to apply such an approach to investigation of plants with important and/or interesting natural *** part,this reflects recognition that plants have occasionally rearranged or shuffled their genes to generate biosynthetic gene clusters(BGCs)for certain natural products(Smit and Lichman,2022;Zhan et al.,2022).

关键词： products evolution

Breaking the biotrophic interfacial complex:How genome editing can lead to rice blast resistance

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Molecular plant 2023年第8期16卷 1243-1245页

作者： Vincent Were Nicholas j.Talbot The Sainsbury Laboratory University of East AngliaNorwich Research ParkNorwich NR47UHUK

Genome editing is a transformational technology—by precisely altering the coding or regulatory sequence of a specific gene,it is now possible to change specific traits within a wide variety of *** a consequence,plant breeding can be taken to a new level of precision,and many countries are moving rapidly to adopt new legislation to permit genome editing(Greenwood et al.,2023).However,genome editing has so far seldom been used to develop disease-resistant *** is because plant immunity often depends on single dominant resistance genes,which encode immune receptors that recognize secreted effectors deployed by plant pathogens(jones and Dangl,2006).In this context,genetic modification has proven to be a much more powerful technology so far to introduce these genes from distinct varieties,or even different species,to develop disease resistant crop species(Greenwood et al.,2023),especially when multiple disease-resistance loci can be introduced together to provide more durable resistance(Luo et al.,2021).Genome editing can be used in an innovative way to resurrect previously effective resistance genes(Contreras et al.,2023),but it has been less effective at introducing new forms of disease resistance to crops.

关键词： breeding resistance editing

Subtypes of functional dyspepsia

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World journal of Gastroenterology 2006年第17期12卷 2667-2671页

作者： Georgina Baker Robert j Fraser Graeme Young Department of Gastroenterology Repatriation General Hospital and Flinders Medical Centre Australia

Functional dyspepsia is a common clinical condition characterised by chronic or recurrent upper abdominal pain or discomfort commonly associated with a variety of associated gastrointestinal symptoms and a normal endoscopy. To standardise research-based approaches, an initial categorisation of into sub groups was agreed to, based on clusters of symptoms. However the early expectation that these subgroups would be associated with distinct pathophysiologies amenable to specific therapy has not been realised. A classification based on the most troublesome symptom has been suggested but the utility of this is also unclear. More recent data suggest that some of the pathophysiologic dysfunctions may be associated with specific symptoms and so provide a better tool for grouping patients. But this approach remains incomplete as current insights into the pathogenesis are still too limited for this to be satisfactory. In conclusion, no classification provides for an adequate treatment-based approach to the syndrome of functional dyspepsia. As a consequence treatment remains largely empiric.

关键词： Functional dyspepsia Classification Subtypes Symptoms pathophysiology Management

Early cisternal fibrinolysis is more effective than rescue spasmolysis for the prevention of delayed infarction after subarachnoid haemorrhage

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Stroke & Vascular Neurology 2022年第2期7卷 108-113页

作者： Roland Roelz Christian Scheiwe jürgen Grauvogel Istvan Csok Volker Arnd Coenen jürgen Beck peter C Reinacher Department of Neurosurgery Medical Center-University of FreiburgFreiburgGermany Department of Stereotactic and Functional Neurosurgery Medical Center-University of FreiburgFaculty of MedicineFreiburgGermany Fraunhofer Institute for Laser Technology(ILT) AachenGermany

Background To compare the efficacy of two different concepts of cisternal therapy—pREVENTIVE fibrinolysis plus on-demand spasmolysis versus RESCUE spasmolysis—for the prevention of cerebral vasospasm(CVS)and delayed cerebral infarction(DCI)in patients with aneurysmal subarachnoid haemorrhage(aSAH).Methods Retrospective analysis of 84 aSAH patients selected for cisternal therapy for DCI prevention.66 high-risk patients received pREVENTIVE cisternal therapy to enhance blood *** stereotactic catheter ventriculocisternostomy(STX-VCS)or intraoperative placement of a cisterno-ventriculostomy catheter(CVC),followed by fibrinolytic cisternal lavage using urokinase was *** case of vasospasm,nimodipine was applied intrathecally.22 low-risk patients who developed CVS against expectations were selected for STX-VCS as RESCUE intervention for cisternal spasmolysis with *** of DCI and mean flow velocities of daily transcranial Doppler(TCD)ultrasonographies were *** Despite a higher prespecified DCI risk,patients selected for pREVENTIVE intervention primarily aiming at blood clearance had a lower DCI rate compared with patients selected for intrathecal spasmolysis as a RESCUE therapy(11.3%vs 18.2%).After intrathecal treatment onset,CVS(TCD>160 cm/s)occurred in 45%of patients with pREVENTIVE and 77%of patients with RESCUE therapy(p=0.013).A stronger response of CVS to intrathecal nimodipine was observed in patients with pREVENTIVE intervention as the mean CVS duration after start of intrathecal nimodipine was 3.2 days compared with 5.8 days in patients with RESCUE therapy(p=0.026).Conclusions pREVENTIVE cisternal therapy directed at blood clearance is more effective for the prevention of CVS and delayed infarction compared with cisternal RESCUE spasmolysis.

关键词： prevention spasmolysis infarction

Swiss pumped hydro storage potential for Germany’s electricity system under high penetration of intermittent renewable energy

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journal of Modern power Systems and Clean Energy 2016年第4期4卷 542-553页

作者： Aagje j.H.van MEERWIjK RenéM.j.BENDERS Alejandro DAVILA-MARTINEZ Gideon A.H.LAUGS IVEM(ESRIG) University of GroningenGroningenThe Netherlands

In order to cut greenhouse-gas emissions and increase energy security,the European Commission stimulates the deployment of intermittent renewable energy sources(IRES) towards *** an electricity system with high shares of IRES implemented in the network,energy balancing like storage is needed to secure grid stability and smooth demand *** hydro storage(pHS) is at this moment the best option for large scale *** has strong ambitions to further develop their pHS sector and become the battery of *** this research,the potential of the Swiss pSH plants is explored,whilst taking inflow into the upper reservoirs of the pHS plants into *** simulate electricity imbalance,Germany is used as a case *** already has a high penetration of IRES and has plans to increase installed IRES *** using an energy planning model(power plan),three future scenarios of the German electricity system were designed,each with a different set of IRES installed(solar,mixed and wind).Results show that the Swiss battery ambition offers most benefits to a wind-oriented scenario,reducing both shortages as well as *** inflow in Swiss pHS-reservoirs is of minor importance when looking at security of supply,although it was shown that the solarscenario profits more from inflow in terms of system ***,a potential conflict was observed in the solar-scenario between the need for electricity storage and the storage of natural inflow,resulting in more surpluses in the system when inflow was taken into account.

关键词： pumped hydro storage(pHS) Local hydrology Germany Switzerland Intermittent renewable energy sources(IRES) Scenarios

In vivo exploration of the functional activity of the non-coding 8q24 prostate cancer risk locus

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Asian journal of Andrology 2010年第6期12卷 787-789页

作者： Dolores j. Lamb Mounia Tannour-Louet Scott Department of Urology Baylor College of Medicine Houston TX 77030 USA Department of Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA

Genome-wide association studies （GWAS） have successfully identified a substantial number of risk variants for prostate cancer [1-10]. In total, more than 20 single nucleotide polymorphisms （SNps） that predispose to prostate malignancy have been found scattered throughout the genome in coding and non-coding regions. The 8q24 chromosomal region is an intriguing locus as it harbors five independent susceptibility variants （rs10086908; rs16901979; rs620861; rs6983267; rs1447295） that span a 440-kb genomic interval devoid of genes or protein-coding transcripts.

关键词： Genomes Cancer (genus) Neoplasms Variants prostate Genes Andean region

Unsteady flow and heat transfer of porous media sandwiched between viscous fluids

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Applied Mathematics and Mechanics(English Edition) 2010年第12期31卷 1497-1516页

作者： j. C. UMAVATHI I. C. LIU j. pRATHAp-KUMAR D. SHAIK-MEERA Department of Mathematics Gulbarga University Gulbarga 585106 Karnaktaka India Department of Civil Engineering National Chi Nan University University Road Puli Nantou Hsien 54561 Taiwan China

The problem of unsteady oscillatory flow and heat transfer of porous medin sandwiched between viscous fluids has been considered through a horizontal channel with isothermal wall temperatures. The flow in the porous medium is modeled using the Brinkman equation. The governing partial differential equations are transformed to ordinary differential equations by collecting the non-periodic and periodic terms. Closed-form solutions for each region are found after applying the boundary and interface conditions. The influence of physical parameters, such as the porous parameter, the frequency parameter, the periodic frequency parameter, the viscosity ratios, the conductivity ratios, and the prandtl number, on the velocity and temperature fields is computed numerically and presented graphically. In addition, the numerical values of the Nusselt number at the top and bottom walls are derived and tabulated.

关键词： unsteady porous medium immiscible fluid horizontal channel analyticalsolution

Fisher Information and Complexity Measure of Generalized Morse potential Model

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Communications in Theoretical physics 2016年第9期65卷 275-279页

作者： C.A. Onate j.O.A. Idiodi physics Department University of Benin Nigeria

The spreading of the quantum-mechanical probability distribution density of the three-dimensional system is quantitatively determined by means of the local information-theoretic quantity of the Shannon information and information energy in both position and momentum spaces. The complexity measure which is equivalent to Cramer–Rao uncertainty product is determined. We have obtained the information content stored, the concentration of quantum system and complexity measure numerically for n = 0, 1, 2 and 3 respectively.

关键词： fisher information Shannon entropy complexity measures

Landslides at Qingjiang River in the Downstream Area of Shuibuya Dam Site, China

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journal of China University of Geosciences 2006年第2期17卷 158-162页

作者： Kallen D 项伟 Ehret D Rohn j University of Karlsruhe Department of Applied Geology Faculty of Engineering China University of Geosciences

To enhance the general knowledge of landslides in China, the DAAD （German Academic Exchange Service） is financing an investigative project. As part of this project, at the Qingjiang （清江） River, a 10 km^2 area downstream of the Shuibuya （水布垭） dam site was geologically and geotechnicaUy mapped to gather information concerning landslides and their correlation to lithology, slope angles and texture. The geological mapping contained the characterization of the lithological units. The characterization of the shape of landslides and the classification of rocks into units with similar geotechnical behavior is contained in the geotechnical map. Samples were taken and investigated using X-ray diffraction to identify the clay minerals and geotechnical tests to determine the effective shear angle and cohesion of rocks and soils. Geotechnical mapping showed a close connection between lithology, slope angle and texture concerning the occurrence of landslides. Most landslides occur on the northern bank of the Qingjiang River where the dip angle of the bedding is nearly parallel to the slope, resulting in potential and effective slide planes. On the southern bank only sporadic and small landslides occur because the bedding is antipodal to the slope angle. This pilot work is a base for further and more detailed investigations in this area.

关键词： landslide geotechnical mapping geological mapping shear test and X-ray diffraction Shuibuya dam site.