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玻璃化克隆牛胚胎解冻后的体外存活

国外畜牧科技 1998年第4期25卷 32-32页

作者： p.j.booth 覃能斌

玻璃化克隆牛胚胎解冻后的体外存活Ｐ．Ｊ．Ｂｏｏｔｈ等著覃能斌摘译曾申明校最近创新的玻璃化体外生产牛胚胎（Ｖａｊｔａ等，１９９５）的细管内重水合（ｒｅｈｙｄｒａ－ｔｉｏｎ）方法使得胚胎可以直接移植，因而这是一种实用、可... 详细信息

玻璃化克隆牛胚胎解冻后的体外存活Ｐ．Ｊ．Ｂｏｏｔｈ等著覃能斌摘译曾申明校最近创新的玻璃化体外生产牛胚胎（Ｖａｊｔａ等，１９９５）的细管内重水合（ｒｅｈｙｄｒａ－ｔｉｏｎ）方法使得胚胎可以直接移植，因而这是一种实用、可现场操作的技术。该方法囊胚存活率和...

关键词：玻璃化牛胚胎解冻体外存活

Adaptive optical microscopy: the ongoing quest for a perfect image

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Light(Science & Applications) 2014年第1期3卷 243-249页

作者： Martin j booth Department of Engineering Science University of OxfordOxford OX13PJUK Centre for Neural Circuits and Behaviour University of OxfordOxford OX13SRUnited Kingdom School in Advanced Optical Technologies Friedrich-Alexander Universita¨t Erlangen-Nu¨rnberg91052 ErlangenGermany

Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of *** is proving particularly promising for applications that require images from deep within biological tissue *** review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.

关键词： aberrations adaptive optics microscopy

Evaluating rock mass disturbance within open-pit excavations using seismic methods:A case study from the Hinkley point C nuclear power station

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journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 500-512页

作者： Antony Butcher Anna L.Stork james p.Verdon j-Michael Kendall Katrin plenkers Finlay booth Marcus Boneham Adrian Koe School of Earth Sciences University of BristolWills Memorial BuildingQueen’s RoadBristolBS81RJUK Department of Earth Sciences University of OxfordSouth Parks RoadOxfordOX13ANUK Gesellschaft für Materialprüfung und Geophysik(GMuG) Bad Nauheim61231Germany Mott MacDonald 10 Temple BackBristolBS16FLUK Atkins The Hub500 Park AvenueAztec WestBristolBS324RZUK Atkins The Axis10 Holliday StreetBirminghamB11TFUK

Understanding rock strength is essential when undertaking major excavation projects,as accurate assessments ensure both safe and cost-effective engineered *** the cost-safety trade-off becomes more imperative during the construction of critical infrastructure such as nuclear power stations,where key components are built within relatively deep *** these engineered slopes is reliant on rock strength models,which are generally parameterised using estimates of rock properties(*** compressive strength,rock disturbance)measured prior to the commencement of ***,the physical process of excavation weakens the remaining rock ***,the model also requires an adjustment for the anticipated rock *** practice,this parameter is difficult to quantify and as a result it is often poorly *** can have a significant impact on the final design and cost of *** present results from passive and active seismic surveys,which image the extent and degree of disturbance within recently excavated slopes at the construction site of Hinkley point C nuclear power *** from active seismic surveys indicate that the disturbance is primarily confined to 0.5 m from the excavated *** conjunction,passive monitoring is used to detected seismic events corresponding to fracturing on the cm-scale and event locations are in agreement with 0.5 m of disturbance into the rock *** suggests rock disturbance at this site is relatively low and occurred during and immediately after the excavation.A ratio of seismic velocities recorded before and after excavations are used to determine the disturbance parameter required for the Hoek eBrown rock failure criterion,and we assess that rock disturbance is low with the magnitude of the disturbance diminishing more quickly than expected into the excavated *** methods provide a low-cost and quick method to assess excavation related rock mass disturbance,

关键词： Rock mass strength Rock disturbance Seismic tomography piezoelectric surveys picoseismicity Acoustic emissions

polarisation optics for biomedical and clinical applications:a review

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Light(Science & Applications) 2021年第11期10卷 2028-2047页

作者： Chao He Honghui He jintao Chang Binguo Chen Hui Ma Martin j.booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK Guangdong Engineering Center of polarisation Imaging and Sensing Technology Tsinghua Shenzhen International Graduate SchoolTsinghua University518055 ShenzhenChina Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua University518055 ShenzhenChina Department of physics Tsinghua University100084 BeijingChina Department of Biomedical Engineering Tsinghua University100084 BeijingChina

Many polarisation techniques have been harnessed for decades in biological and clinical research,each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by *** advanced vector measurement/sensing techniques,physical interpretation methods,and approaches to analyse biomedically relevant information have been developed and *** this review,we focus mainly on summarising methodologies and applications related to tissue polarimetry,with an emphasis on the adoption of the Stokes-Mueller *** recent breakthroughs,development trends,and potential multimodal uses in conjunction with other techniques are also *** primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research.

关键词： clinical optics breakthrough

Vectorial adaptive optics

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eLight 2023年第1期3卷 35-44页

作者： Chao He jacopo Antonello Martin j.booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUnited Kingdom

Adaptive optics normally concerns the feedback correction of phase *** correction has been of benefit in various optical systems,with applications ranging in scale from astronomical telescopes to super-resolution *** we extend this powerful tool into the vectorial domain,encompassing higher-dimensional feedback correction of both polarisation and *** technique is termed vectorial adaptive optics(V-AO).We show that V-AO can be implemented using sensor feedback,indirectly using sensorless AO,or in hybrid form combining aspects of *** validate improvements in both vector field state and the focal quality of an optical system,through correction for commonplace vectorial aberration sources,ranging from objective lenses to biological *** technique pushes the boundaries of traditional scalar beam shaping by providing feedback control of extra vectorial degrees of *** paves the way for next generation AO functionality by manipulating the complex vectorial field.

关键词： field optics correction

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有无透明带牛卵母细胞孤雌发育研究

黑龙江畜牧兽医 2004年第2期 8-11页

作者：谭世俭 p.j.booth H Callesen 广西大学动物繁殖研究所广西南宁530005 丹麦农业科学院繁殖生物学研究室

研究探讨了不同浓度的钙离子载体 (A2 3187)结合 6 二甲氨基嘌呤 (DMAp)或丁内酯I (BL -I)激活处理对有或无透明带牛卵母细胞孤雌发育的影响。结果表明 :使用A2 3187浓度从 0 .6 2 5～ 10 .0 0 0 μmol/L配合 2 .0mmol/LDMAp孤雌激活... 详细信息

研究探讨了不同浓度的钙离子载体 (A2 3187)结合 6 二甲氨基嘌呤 (DMAp)或丁内酯I (BL -I)激活处理对有或无透明带牛卵母细胞孤雌发育的影响。结果表明 :使用A2 3187浓度从 0 .6 2 5～ 10 .0 0 0 μmol/L配合 2 .0mmol/LDMAp孤雌激活牛具透明带卵均能获得良好的卵裂及早期胚胎发育效果 ;对于去透明带卵来说 ,使用 0 .6 2 5 μmol/L浓度的A2 3187激活效果最佳。BL I的激活效果则明显差于DMAp ;当采用 0 .3%pVA取代激活液中的 5 %血清时 ,BL I的激活效率显著提高。

关键词：牛卵母细胞孤雌发育浓度钙离子载体 6-二甲氨基嘌呤 DMAp 丁内酯I BL-I 早期胚胎透明带

Interaction of IFNL3 with insulin resistance,steatosis and lipid metabolism in chronic hepatitis C virus infection

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World journal of Gastroenterology 2013年第41期19卷 7055-7061页

作者： Mohammed Eslam David R booth jacob George Golo Ahlenstiel Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia

Metabolic changes are inextricably linked to chronic hepatitis C(CHC).Recently polymorphisms in the IFNL3(IL28B)region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus(HCV)***,circumstantial evidence suggests a link between IFNL3single nucleotide polymorphisms and lipid metabolism,steatosis and insulin resistance in *** emerging picture suggests that the responder genotypes of IFNL3polymorphisms are associated with a higher serum lipid profile,and less frequent steatosis and insulin *** review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.

关键词： IFNL3 Chronic hepatitis C Insulin resistance Lipids

Dendritic cells in hepatitis C virus infection:Key players in the IFNL3-genotype response

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World journal of Gastroenterology 2014年第47期20卷 17830-17838页

作者： Kate S O'Connor jacob George David booth Golo Ahlenstiel Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia

Recently,single nucleotide polymorphisms,in the vicinity of the interferon lambda 3(IFNL3)gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus(HCV)*** then,increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype *** cells(DCs)are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is *** have identified subclasses of DCs,particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV *** the complexities of dendritic cell biology and the conflicting current available data,this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to placeit into context of what is know about lambda interferons and dendritic cells in general.

关键词： Hepatitis C virus Interferon lambda 3 Dendritic cells plasmacytoid dendritic cells Myeloid dendritic cells Innate immunity

Adaptive optics in laser processing

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Light(Science & Applications) 2019年第1期8卷 140-155页

作者： patrick S.Salter Martin j.booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK

Adaptive optics are becoming a valuable tool for laser processing,providing enhanced functionality and flexibility for a range of *** a single adaptive element,it is possible to correct for aberrations introduced when focusing inside the workpiece,tailor the focal intensity distribution for the particular fabrication task and/or provide parallelisation to reduce processing *** is particularly promising for applications using ultrafast lasers for threedimensional *** review recent developments in adaptive laser processing,including methods and applications,before discussing prospects for the future.

关键词： laser optics workpiece