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Loco-regional hepatocellular carcinoma treatment services as a bridge to liver transplantation

Hepatobiliary & pancreatic Diseases International 2019年第3期18卷 228-236页

作者： Sophia Schmitz Georg Lurje Florian Ulmer Anne Andert philipp Bruners Maximilian Schulze-Hagen Ulf neumann Wenzel Schoening Department of General- Visceral- and Transplantation Surgery University Hospital of RWTH Aachen Aachen Germany Department of Diagnostic and Interventional Radiology University Hospital of RWTH Aachen Aachen Germany Department of Surgery Maastricht University Medical Center (MUMC) Maastricht Netherlands Department of Surgery Charité– University Medicine at Berlin Germany

Background: Liver transplantation remains the main curative treatment option for hepatocellular carcinoma(HCC) patients. In the Eurotransplant area Milan criteria are used to assign priority extra points(exceptional MELD, ex MELD) for patients on the waiting list. To prevent patients from tumor progression, loco-regional(neoadjuvant) treatment(LRT) is used. For patients unlikely to timely receive an organ via primary allocation,“extended critera donor(ECD) organs” are used. The present study aimed to investigate the survival after LT with a strategy of minimizing waiting list dropouts by using LRT for bridging and transplanting ECD organs if possible and necessary. Methods: Between October 2010 and May 2015, 50 liver transplants for HCC were included in this retrospective study. Of those, 42(84%) met the Milan criteria according to the preoperative radiological examination. Forty-one patients(82%) received LRT. The waiting time was analyzed according to LRT. Kaplan-Meier curves with log-rank statistics were used for survival analyses. Results: One-and five-year overall survival within Milan criteria was 94.3% and 83.7% compared with 91.7% and 67.9% beyond Milan criteria, though statistical significance was not reached( p = 0.487). LRT had no impact on overall survival( p = 0.629). Median waiting time was shorter if no LRT was performed(4.6 months vs. 1.5 months, p = 0.006) and there were no cases of waiting list dropouts. Using ECD organs had no impact on overall survival( p = 0.663). Conclusions: patients with an expected waiting time to transplantation of > 6 months could be successfully treated with LRT as a bridge to transplant. Overall and disease-free survival for patients within and beyond Milan criteria was comparable and the use of ECD organs in this cohort of HCC patients proved to be a safe option.

关键词： Hepatocellular carcinoma Liver transplantation Therapeutic embolization Liver neoplasms Organ transplantation

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Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss

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Bone Research 2021年第4期9卷 549-556页

作者： Martina Rauner Marta Murray Sylvia Thiele Deepika Watts Drorit neumann Yankel Gabet Lorenz C.Hofbauer Ben Wielockx Department of Medicine III&Center for Healthy Aging Technische Universitat DresdenDresdenGermany lnstitute for Clinical Chemistry and Laboratory Medicine Technische Universitat DresdenDresdenGermany Department of Cell and Developmental Biology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Anatomy&Anthropology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

High erythropoietin(Epo)levels are detrimental to bone health in adult *** mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone *** humans,high serum Epo levels are linked to fractures in elderly *** earlier studies indicated that Epo modulates osteoblast activity;however,direct evidence that Epo acts via its receptor(EpoR)on osteoblasts in vivo is still ***,we created mice lacking EpoR in osteoprogenitor cells to specifically address this *** of EpoR in osteoprogenitors(EpoR:Osx-cre,cKO)starting at 5 weeks of age did not alter red blood cell parameters but increased vertebral bone volume by 25%in 12-week-old female *** was associated with low bone ***(osteoblast number,bone formation rate)and serum(p1Np,osteocalcin)bone formation parameters were all reduced,as were the number of osteoclasts and TRAp serum *** of osteoblast precursors isolated from cKO versus control mice resulted in lower expression of osteoblast marker genes including Runx2,Alp,and Col1a1 on day 21,whereas the mineralization capacity was ***,the RANKL70pG ratio,which determines the osteoclast-supporting potential of osteoblasts,was substantially decreased by 50%.Similarly,coculturing cKO osteoblasts with control or cKO osteoclast precursors produced significantly fewer osteoclasts than coculture with control ***,exposing female mice to Epo pumps(10 U-d_1)for 4 weeks resulted in trabecular bone loss(-25%)and increased osteoclast numbers(1.7-fold)in control mice only,not in cKO *** data show that EpoR in osteoprogenitors is essential in regulating osteoblast function and osteoblast-mediated osteoclastogenesis via the RANKI70pG ***,osteogenic Epo/EpoR signaling controls bone mass maintenance and contributes to Epo-induced bone loss.

关键词： progenitor homeostasis doses

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First detection of viruses in Africanized honey bees from peru

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Virologica Sinica 2014年第5期29卷 321-323页

作者： Orlando Yaez Graciano Tejada peter neumann Institute of Bee Health University of Bern Schwarzenburgstrasse 161Bern CH-3003Switzerland Swiss Bee Research Centre Federal Department of Economic Affairs EVD.Research Station Agroscope-Haras Liebefeld-Posieux ALP Schwarzenburgstrasse 161Bern CH-3003Switzerland Servicio Nacional de Sanidad Agraria del peru(Senasa) Av.La Molina 1915 La MolinaLimaPeru Social Insect Research Group Zoology and Entomology DepartmentUniversity of Pretoria Private Bag X20 HatfieldPretoria 0028South Africa

Dear Editor,The ability of the Western honey bee,Apis mellifera,to adapt to most climates of the world and the ongoing standardization of colony management has made this species of honey bees the most important species for crop *** recent years,peru emerged as a main exporter of industrial *** industry is mainly concentrated in the peruvian coastal region,because the local climate permits off-season production

关键词： honey mellifera Apis season colony adapt coastal crops emerged concentrated

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performance of silver nanoparticles in the catalysis of the oxygen reduction reaction in neutral media： Efficiency limitation due to hydrogen peroxide escape

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Nano Research 2013年第7期6卷 511-524页

作者： Christopher C. M. neumann Eduardo Laborda Kristina Tschulik Kristopher R. Ward Richard G. Compton Department of Chemistry Physical and Theoretical Chemistry Laboratory Oxford University South Parks Road Oxford OXl 3QZUnited Kingdom

The electrocatalytic activity for oxygen reduction reaction （ORR） at neutral pH of citrate-capped silver nanoparticles （diameter = 18 nm） supported on glassy carbon （GC） is investigated voltammetrically. Novelly, the modification of the substrate by nanoparticles sticking to form a random nanoparticle array and the voltammetric experiments are carried out simultaneously by immersion of the GC electrode in an air-saturated 0.1 M NaC104 solution （pH = 5.8） containing chemically-synthesized nanoparticles. The experimental voltammograms of the resulting nanoparticle array are simulated with homemade programs according to the two-proton, two-electron reduction of oxygen to hydrogen peroxide where the first electron transfer is rate determining. In the case of silver electrodes, the hydrogen peroxide generated is partially further reduced to water via heterogeneous decomposition. Comparison of the results obtained on a silver macroelectrode and silver nanoparticles indicates that, for the silver nanoparticles and particle coverages （0.035%-0.457%） employed in this study, the ORR electrode kinetics is slower and the production of hydrogen peroxide larger on the glassy carbon-supported nanoparticles than on bulk silver.

关键词： oxygen reduction reaction silver nanoparticles nanoelectrocatalysis hydrogen peroxide escape fuel cells

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Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer

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World journal of Gastrointestinal Oncology 2021年第11期13卷 1632-1647页

作者： Katharina joechle jessica Guenzle Claus Hellerbrand pavel Strnad Thorsten Cramer Ulf peter neumann Sven Arke Lang Visceral and Transplantation Surgery University Hospital Rheinisch-Westfalisch Technische Hochschule AachenAachen 52074Germany Department of General and Visceral Surgery Medical Center-University of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79106Germany Institute of Biochemistry Friedrich-Alexander University Erlangen-NurnbergErlangen 91054Germany Department of Internal Medicine Ⅲ University Hospital Rheinisch-Westfalisch Technische Hochschule AachenAachen 52074Germany

The mammalian target of rapamycin(mTOR)acts in two structurally and functionally distinct protein complexes,mTOR complex 1(mTORC1)and mTOR complex 2(mTORC2).Upon deregulation,activated mTOR signaling is associated with multiple processes involved in tumor growth and *** with mTORC1,much less is known about mTORC2 in cancer,mainly because of the unavailability of a selective ***,existing data suggest that mTORC2 with its two distinct subunits Rictor and mSin1 might play a more important role than assumed so *** is one of the key effectors of the pI3K/AKT/mTOR pathway and stimulates cell growth,cell survival,metabolism,and cytoskeletal *** is not only implicated in tumor progression,metastasis,and the tumor microenvironment but also in resistance to ***,the central subunit of mTORC2,was found to be upregulated in different kinds of cancers and is associated with advanced tumor stages and a bad ***,AKT,the main downstream regulator of mTORC2/Rictor,is one of the most highly activated proteins in *** and secondary liver cancer are major problems for current cancer therapy due to the lack of specific medical treatment,emphasizing the need for further therapeutic *** review,therefore,summarizes the role of mTORC2/Rictor in cancer,with special focus on primary liver cancer but also on liver metastases.

关键词： Mammalian target of rapamycin Mammalian target of rapamycin complex 2 Rictor Liver cancer Liver metastases Hepatocellular carcinoma Cholangiocellular carcinoma

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Diagnosis of Laron syndrome using monoplex-polymerase chain reaction technology with a whole-genome amplification template: A case report

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World journal of Clinical Cases 2019年第23期7卷 4029-4035页

作者： Adina neumann Miguel Angel Alcantara-Ortigoza Ariadna Gonzalez-del Angel Felipe Camargo-Diaz Esther Lopez-Bayghen Laboratorio de Investigacion y Diagnostico Molecular Instituto de Infertilidad y Genetica Mexico SCINGENESMexico City 05320Mexico Instituto Nacional de pediatria Torre de InvestigacionMexico City 04530Mexico Laboratorio de Biologia Molecular Departamento de Genetica HumanaInstituto Nacional de PediatriaMexico City 04530Mexico Departamento de Toxicologia Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional(CINVESTAV-IPN)Mexico City 07360Mexico

BACKGROUND Laron syndrome(LS)is an autosomal recessive hereditary condition affecting only 1/1000000 *** cause is associated with mutations in the growth hormone(GH)receptor(GHR),leading to GH *** patients typically present with severe growth retardation,obesity,and abnormal sexual ***,LS diagnosis is performed ***,we assessed the efficiency of pre-implantation Genetic Testing(pGT)coupled with monoplex-polymerase chain reaction(pCR)technology for detecting this monogenic disease in embryos from a couple confirmed as LS heterozygous carriers CASE SUMMARY The couple LS-carriers were confirmed by the presence of a first child born with *** couple underwent a standard in vitro fertilization(IVF)*** was collected from trophectoderm cells from day 5 *** genome amplification(WGA)was performed using a Sureplex DNA Amplification System and analyzed by pCR,targeting the deletion of the exons 5 and 6 in the GHR gene as well as pGT by Next-generation Sequencing(Illumina).Eleven embryos were collected and analyzed.27.3%were the wild type for GHR,45.5%were heterozygotes,and 18.2%homozygous *** embryo yielded no *** 2-embryos transfers were performed;2 normal homozygous and four heterozygous carriers were selected for *** first two transfers were unsuccessful,whereas the final transfer with two heterozygous embryos resulted in clinical *** genomic composition of the fetus was verified,applying the same techniques using amniocytes,extracted after 21 wk of the ongoing *** fetus was confirmed as GHR deletion in exon 5-6,carrier.A non-affected baby was *** Here,we present a case demonstrating that using WGA as a template in addition to pCR targeting specific gene regions,exons 5 and 6 on the GHR gene,could identify LS carrier *** provides evidence that WGA and pCR serve as an excellent tool to detect this specific monogenic disease in IVF e

关键词： Growth hormone insensitivity Growth hormone receptor mutations Intragenic deletions Molecular diagnosis Embryo diagnosis Laron syndrome Case report

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AI powered, automated discovery of polymer membranes for carbon capture

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npj Computational Materials 2023年第1期9卷 966-976页

作者： Ronaldo Giro Hsianghan Hsu Akihiro Kishimoto Toshiyuki Hama Rodrigo F.neumann Binquan Luan Seiji Takeda Lisa Hamada Mathias B.Steiner IBM Research Av.República do Chile330CEP 20031-170 Rio de JaneiroRJBrazil IBM Research 7-7Shin-KawasakiSaiwai-KuKawasakiKanagawa 212-0032Japan IBM Research 1101 Kitchawan Road PO Box 218Yorktown HeightsNY 10598-0218USA

The generation of molecules with artificial intelligence(AI)or,more specifically,machine learning(ML),is poised to revolutionize materials *** applications range from development of potent drugs to efficient carbon capture and separation ***,existing computational discovery frameworks for polymer membranes lack automated training data creation,generative design,and physical performance validation at meso-scale where complex properties of amorphous materials *** methodological gaps are less relevant to the ML design of individual molecules such as the monomers which constitute the building blocks of ***,we report automated discovery of complex materials through inverse molecular design which is informed by meso-scale target features and process *** have explored the multi-scale discovery regime by computationally generating and validating hundreds of polymer candidates designed for application in post-combustion carbon dioxide ***,we have validated each discovery step,from training dataset creation,via graph-based generative design of optimized monomer units,to molecular dynamics simulation of gas permeation through the polymer *** the latter,we have devised a representative elementary volume(REV)enabling permeability simulations at about 1000×the volume of an individual,ML-generated monomer,obtaining quantitative *** discovery-to-validation time per polymer candidate is on the order of 100 h using one CpU and one GpU,offering a computational screening alternative prior to lab validation.

关键词： monomer latter elementary

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基于MR类CT影像与传统CT评估关节盂骨缺损和其他肩关节骨性病变的比较研究

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国际医学放射学杂志 2024年第1期 130-130页

作者： G.Feuerriegel S.Kronthaler K.Weiss B.Haller Y.Leonhardt j.neumann 刘爽

摘要目的评价和比较基于3D T1加权扰相梯度回波(T1GRE)序列、超短回波时间(UTE)序列、3D T1加权扰相多回波梯度回波(FRACTURE)序列这3种类CT影像与传统

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DAMS:A Distributed Analytics Metadata Schema

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Data Intelligence 2021年第4期3卷 528-547页

作者： Sascha Welten Laurenz neumann Yeliz Ucer Yediel Luiz Olavo Bonino da Silva Santos Stefan Decker Oya Beyan Chair Informatik 5 RWTH Aachen University52056 AachenGermany Fraunhofer Institute for Applied Information Techniques(FIT) 53757 Sankt AugustinGermany Faculty of Electrical Engineering Mathematics and Computer ScienceUniversity of Twente7500AE EnschedeThe Netherlands Department of Human Genetics Leiden University Medical CentreLeiden 2333 ZAThe Netherlands Institute of Medical Information Faculty of Medicine&University Hospital CologneUniversity of Cologne50674 CologneGermany

In recent years,implementations enabling Distributed Analytics(DA)have gained considerable attention due to their ability to perform complex analysis tasks on decentralised data by bringing the analysis to the *** concepts propose privacy-enhancing alternatives to data centralisation approaches,which have restricted applicability in case of sensitive data due to ethical,legal or social ***,the immanent problem of DA-enabling architectures is the black-box-alike behaviour of the highly distributed components originating from the lack of semantically enriched descriptions,particularly the absence of basic metadata for data sets or analysis *** approach the mentioned problems,we propose a metadata schema for DA infrastructures,which provides a vocabulary to enrich the involved entities with descriptive *** initially perform a requirement analysis with domain experts to reveal necessary metadata items,which represents the foundation of our ***,we transform the obtained domain expert knowledge into user stories and derive the most significant semantic *** the final step,we enable machine-readability via RDF(S)and SHACL *** deploy our schema in a proof-of-concept monitoring dashboard to validate its contribution to the transparency of DA ***,we evaluate the schema’s compliance with the FAIR *** evaluation shows that the schema succeeds in increasing transparency while being compliant with most of the FAIR *** a common metadata model is critical for enhancing the compatibility between multiple DA infrastructures,our work lowers data access and analysis *** represents an initial and infrastructure-independent foundation for the FAIRification of DA and the underlying scientific data management.

关键词： Distributed analytics Federated analytics personal Health Train Metadata schema RDF(S) SHACL FAIR

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Grade of donor liver microvesicular steatosis does not affect the postoperative outcome after liver transplantation

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Hepatobiliary & pancreatic Diseases International 2017年第6期16卷 617-623页

作者： Anne Andert Tom Florian Ulmer Wenzel Schoning Daniela Kroy Marc Hein patrick Hamid Alizai Christoph Heidenhain Ulf neumann Maximilian Schmeding Department of General Visceral and Transplant SurgeryUniklinik RWTH Aachen AachenGermany Department of Internal Medicine Uniklinik RWTH Aachen AachenGermany Department of Anaesthesiology Uniklinik RWTH Aachen AachenGermany Department of General and Visceral Surgery Sana Hospital Düsseldorf-Gerresheim Germany

BACKGROUND:The potential effect of graft steatosis on the postoperative liver function is discussed controversially. The present study aimed to evaluate the effect of the donor liver microvesicular steatosis on the postoperative outcome after liver ***:Ninety-four patients undergoing liver transplantation at the University Hospital Aachen were included in this study. The patient cohort was divided into three groups according to the grade of microvesicular steatosis(MiS):MiS 60%(n=26).The outcomes after liver transplantation were evaluated, including the 30-day and 1-year patient and graft survival rates and the incidences of early allograft dysfunction(EAD) and primary nonfunction(pNF). RESULTS:The incidences of EAD and pNF did not differ significantly between the groups. We observed 5 cases of pNF,one occurred in the MiS p and 4 in the MiS 30%-60% group. The 30-day and 1-year graft survivals did not differ significantly between groups. The 30-day patient survival rates were 100% in all groups. The 1-year patient survival rates were 94.4% in the MiS p, 87.9% in the MiS 30%-60% group and 90.9% in the MiS >60% ***:Microvesicular steatosis of donor livers has no negative effect on the postoperative outcome after liver transplantation.

关键词： liver transplantation liver steatosis microvesicular steatosis early allograft dysfunction

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