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荧光增白棉织物的耐光色牢度

国际纺织导报 2018年第3期46卷 34-34,36,37,38页

作者： B.Müller B.Holz E.Redling W.Herter U.Mücke J.Schad W.Bomon A.Mehlhorn p.hardt 刘蒙稣 Archroma公司(瑞士) CHT R.Beitlich公司(德国) Huntsman纺织染化公司(瑞士) Kapp化工公司(德国) pulcra化工公司(德国) Tanatex化工公司(荷兰) Zschimmer & Schwarz公司(德国) 表面活性剂制造商协会(德国) 不详

耐光色牢度作为评价染色织物在特定应用领域适用性的重要标准之一,被深入研究和应用。相比之下,对白色这种属性,尤其是荧光增白,则鲜有重视。展示了不同实验室采用的测试程序的差异,为确定合适的耐光色牢度测试程序提供指导。

关键词：荧光增白棉织物耐光色牢度循环测试等级

Diagnosis and treatment of diabetes mellitus in chronic pancreatitis

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World Journal of Gastroenterology 2013年第42期19卷 7276-7281页

作者： Nils Ewald philip D hardt Justus-Liebig-University Giessen 35392 GiessenGermany Department of Internal Medicine General Hospital Luebbecke-Rahden32312 LuebbeckeGermany

Diabetes secondary to pancreatic diseases is commonly referred to as pancreatogenic diabetes or type 3c diabetes *** is a clinically relevant condition with a prevalence of 5%-10%among all diabetic subjects in Western *** nearly 80%of all type 3c diabetes mellitus cases,chronic pancreatitis seems to be the underlying *** prevalence and clinical importance of diabetes secondary to chronic pancreatitis has certainly been underestimated and underappreciated so *** contrast to the management of type 1 or type2 diabetes mellitus,the endocrinopathy in type 3c is very *** course of the disease is complicated by additional present comorbidities such as maldigestion and concomitant qualitative *** awareness that patients with known and/or clinically overt chronic pancreatitis will develop type 3c diabetes mellitus(up to 90%of all cases)is rather ***,in a patient first presenting with diabetes mellitus,chronic pancreatitis as a potential causative condition is seldom *** many patients are *** failure to correctly diagnose type 3 diabetes mellitus leads to a failure to implement an appropriate medical *** patients with type 3c diabetes mellitus treating exocrine pancreatic insufficiency,preventing or treating a lack of fat-soluble vitamins(especially vitamin D)and restoring impaired fat hydrolysis and incretin secretion are key-features of medical therapy.

关键词： Diabetes mellitus Chronic pancreatitis Type 3c diabetes pancreatogenic diabetes pancreatitis

pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases

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World Journal of Gastroenterology 2010年第46期16卷 5830-5837页

作者： Johannes W Rey Andrea Noetel Aline hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans peter Dienes Uta Drebber Margarete Odenthal Institute for pathology University Hospital of Freiburg Department of Gastroenterology and Hepatology University Hospital of Essen Department of General Visceral and Cancer SurgeryUniversity Hospital of Cologne

AIM:To test the occurrence of the pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (ppARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific ***:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 ppARγ2-allele,differing from only 1.5% cases in the healthy *** NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver ***,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,p=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory *** linkage of the malfunctioning Ala12-positive ppARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of ppARγ2 in progression of AFLD than of ***:In AFLD patients,the pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis.

关键词： Single nucleotide polymorphism peroxisome proliferator-activated receptor γ Non-alcoholic steatohepatitis Alcoholic steatohepatitis Inflammation Fibrosis Hepatitis Steatosis Steatohepatitis

Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea: Importance of co-morbidity and serum C-reactive protein

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World Journal of Gastroenterology 2008年第27期14卷 4338-4341页

作者： Christian hardt Thomas Berns Wolfgang Treder Franz Ludwig Dumoulin Department of Medicine Gemeinschaftskrankenhaus Bonn Department of Surgery St.-Agnes-Hospital Bocholt Münster Center for Laboratory Diagnostics

AIM: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients. METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review. RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, p proportion of longer hospital stay exceeding 14 d (74% vs 52%, p = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, p protein at diagnosis (OR 1.15 for 10 mg/L increment, p pendent predictors of severe CDAD. CONCLUSION: patients with a severe level of co- morbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.

关键词： Clostridium difficile Nosocomial diarrhoea Co-morbidity C-reactive protein 30-day mortality

Dual and opposing roles of EIN3 reveal a generation conflict during seed growth

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Molecular plant 2022年第2期15卷 363-371页

作者： Juliane Heydlauff Isil Erbasol Serbes Dieu Vo Yanbo Mao Sonja Gieseking Thomas Nakel Theresa Harten Ronny Völz Anja Hoffmann Rita GroΒ-hardt University of Bremen Centre for Biomolecular Interactions Bremen(CBIB)Leobenerstrasse 528359 BremenGermany ZMBp University of TübingenAuf der Morgenstelle 3272076 TübingenGermany

Seed size critically affects grain yield of crops and hence represents a key breeding *** develop-ment of embryo-nourishing endosperm is a key driver of seed *** here report unexpected dual roles of the transcription factor EIN3 in regulating seed *** EIN3 functions have remained largely undiscovered because they oppose each *** on the analysis of multiple ethylene biosynthesis mutants,we demonstrate that EIN3 represses endosperm and seed development in a pathway regulated by ***,in addition,provide evidence that EIN3-mediated synergid nucleus disintegration promotes endosperm ***,synergid nucleus disintegration is not affected in various ethylene biosynthesis mutants,suggesting that this promoting function of EIN3 is inde-pendent of *** the growth-inhibitory ethylene-dependent EIN3 action appears to be encoded by sporophytic tissue,the growth-promoting role of EIN3 is induced by fertilization,revealing a generation conflict that converges toward the key signaling component EIN3.

关键词： seed size EIN3 ethylene biosynthesis fertilization generation conflict synergid disintegration

Mechanisms of toxic effects and tumor induction by DDT

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中国药理学与毒理学杂志 2002年第6期16卷 410-410页

作者： hardt YamaS InstituteofEnvironmentalToxicology Mitsukaido－shiIbarakiJapan

In order to clarify to medchanisms of toxiceffects and tumor induction by DDT,we conducted a 2-year feeding study of p,p'-DDT in F344 rats at doses of 5,50,and 500 ppm,Investigations on toxicokinetics,hematology,biochemistry and histopathology were performed after 26,52,78,and 104 *** addition,potential factors involved in hepatocarcinogenesis were *** sexes at 500ppm showed tremor,body weight depression,anemia,microsomal enzyme induction,and increases in hepatic *** concentrations of DDT and its metabolites in the liver tended to be higher in males,while those in the brain and plasma were higher in females,which might contribute to sex differences in toxic effects and tumor *** was found to inhibit intercellular communication and to produce oxidative stress secondary to metabolic activation in the *** oxidative stress may be a key factor in hepatocarcinogenesis by *** analysis of hepatic lesions is now underway.

关键词： DDT 毒性反应肿瘤生成机制

Multiple Imputation of Missing Data:A Simulation Study on a Binary Response

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Open Journal of Statistics 2013年第5期3卷 370-378页

作者： Jochen hardt Max Herke Tamara Brian Wilfried Laubach Medizinische psychologie und Medizinische Soziologie Klinik fur Psychosomatische Medizin und PsychotherapieUniversitatsmedizin MainzMainzGermany

Currently, a growing number of programs become available in statistical software for multiple imputation of missing values. Among others, two algorithms are mainly implemented: Expectation Maximization (EM) and Multiple Imputation by Chained Equations (MICE). They have been shown to work well in large samples or when only small proportions of missing data are to be imputed. However, some researchers have begun to impute large proportions of missing data or to apply the method to small samples. A simulation was performed using MICE on datasets with 50, 100 or 200 cases and four or eleven variables. A varying proportion of data (3% - 63%) was set as missing completely at random and subsequently substituted using multiple imputation by chained equations. In a logistic regression model, four coefficients, i.e. non-zero and zero main effects as well as non-zero and zero interaction effects were examined. Estimations of all main and interaction effects were unbiased. There was a considerable variance in the estimates, increasing with the proportion of missing data and decreasing with sample size. The imputation of missing data by chained equations is a useful tool for imputing small to moderate proportions of missing data. The method has its limits, however. In small samples, there are considerable random errors for all effects.

关键词： Multiple Imputation Chained Equation Large proportion Missing Main Effect Interaction Effect

Distributed High-Level Scheduling Concept for Synchronised, Wireless Sensor and Actuator Networks

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通讯和计算机（中英文版） 2010年第11期7卷 27-35页

作者： Matthias Vodel Mirko Caspar Mirko Lippmann Wolfram hardt Dept. of Computer Science Chemnitz University of Technology Chemnitz 09107 Germany

Endoscopic sphincterotomy in patients with stenosis of ampulla of Vater:Three-year follow-up of exocrine pancreatic function and clinical symptoms

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World Journal of Gastroenterology 2007年第6期13卷 901-905页

作者： Nils Ewald Axel Michael Marzeion Reinhard Georg Bretzel Hans Ulrich Kloer philip Daniel hardt Third Medical Depart-ment and policlinic University Hospital Giessen and Marburg Giessen Site D-35392 Giessen Germany

AIM: To investigate retrospectively the long-term effect of endoscopic sphincterotomy (ES) including exocrine pancreatic function in patients with stenosis of ampulla of Vater. METHODS: After diagnostic endoscopic retrograde cholangiopancreatography (ERCp) and ES because of stenosis of the ampulla of Vater (SOD Type Ⅰ), follow-up examinations were performed in 60 patients (mean follow-up time 37.7 mo). patients were asked about clini-cal signs and symptoms at present and before interven-tion using a standard questionnaire. Before and after ES exocrine pancreatic function was assessed by determina-tion of immunoreactive fecal elastase 1. Serum enzymes indicating cholestasis as well as serum lipase and amy-lase were measured. RESULTS: Eighty percent of patients reported an im-provement in their general condition after ES. The fecal elastase 1 concentrations (FEC) in all patients increased significantly after ES. This effect was even more marked in patients with pathologically low concentrations (prior to ES. The levels of serum lipase and amylase as well as serum alcaline phosphatase (Ap) and gamma-glutamyltranspeptidase (GGT) decreased signifi-cantly after ES. CONCLUSION: The results of this study demonstrate that patients with stenosis of the ampulla of Vater can be successfully treated with endoscopic sphincterotomy. The positive effect is not only indicated by sustained improvement of clinical symptoms and cholestasis but also by improvement of exocrine pancreatic function.

关键词： Endoscopic sphincterotomy Fecal elastase Chronic pancreatitis papillary stenosis Oddi dysfunction