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long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 335-342页

作者： Kenneth W Chow Matthew T Bell nicholas Cumpian Maryanne Amour Ryan h hsu Viktor E Eysselein neetika Srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUnD Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in november *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(p=0.77),40.0%established post-AI(p=0.44),and 39.5%late post-AI(p=0.77).There were no significant differences in polyp detection rate(pDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic pDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

performance analysis of solar still with cow dung cakes and blue metal stones

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Frontiers in Energy 2015年第2期9卷 180-186页

作者： hitesh n. pAnChAl Mechanical Engineering Department Gujarat Power Engineering andResearch Institute Mevad 382710 India

The aims of this paper is to investigate the effects of various materials inside the solar still on the increase of the productivity of potable water. here, blue metal stones and cow dung cakes were used as materials. To investigate their effect, three identical solar stills with an effective area of 1 m square made from locally available materials were tested in climate conditions of Mehsana （23°50＇ n 72° 23＇）. The first and second solar stills were filled with blue metal, stones and cow dung cakes, while the third one was taken as a reference which consisted of only blue paint at the basin. The experiments show that blue metal stones have the highest distillate output at daytime, followed by cow dung cakes solar still and reference solar still. On the other hand, the overall distillate output of blue metal stones and cow dung cakes at daytime as well as at night were 35% and 20% compared with that of reference solar still.

关键词： blue metal stones cow dung cakes distillateoutput solar still solar intensity

Taking care of volunteers in a stroke trial: a new assisted-management strategy

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Stroke & Vascular neurology 2016年第3期1卷 108-114页

作者： Amber C Stuart Jason J Sico Catherine M Viscoli Ashis h Tayal Silvio E Inzucchi Gary A Ford Karen l Furie Robert Cote J David Spence David Tanne Walter n Kernan on behalf of the IRIS Trial Investigators Department of Internal Medicine Yale University School of MedicineNew HavenConnecticutUSA Department of neurology Yale University School of MedicineNew HavenConnecticutUSA Department of neurology Service Veterans Affairs Connecticut Healthcare SystemWest HavenConnecticutUSA neuroscience Institute Allegheny Health NetworkPittsburghPennsylvaniaUSA lewis Katz School of Medicine at Temple University PhiladelphiaPennsylvaniaUSA Division of Medical Sciences Oxford UniversityOxfordUK The Warren Alpert Medical School of Brown University ProvidenceRhode IslandUSA Department of neurology Neurosurgery and MedicineMcGill UniversityMontrealQuebecCanada University of Western Ontario LondonOntarioCanada 10Sheba Medical CenterTel Aviv UniversityTel AvivIsrael 不详

Background and purpose:providing participants with evidence-based care for secondary prevention is an ethical and scientific priority for trials in stroke *** optimal strategy,however,is *** report the performance of a new approach for delivering preventive care to trial ***:participants were enrolled in the Insulin Resistance Intervention after Stroke trial,which examined the insulin sensitiser,pioglitazone versus placebo for prevention of stroke and myocardial infarction after ischaemic stroke or transient ischaemic *** care was the responsibility of the participants’personal healthcare providers,but investigators monitored care and provided feedback *** studied achievement of 8 prevention goals at baseline and 3 annual visits,with a focus on 3 priority goals:blood pressurehg,lowdensity lipoprotein(lDl)cholesteroll/l and antithrombotic ***:The proportion of participants achieving the priority goals was highest for antithrombotic use(96–99%in each year)and similar for blood pressure(66–72%in each year)and lDl(68–70%in each year).All 3 priority goals were achieved by 47–52%of participants in any given ***,only 22%of participants achieved all 3 goals in each ***:A strategy of monitoring care and providing feedback was associated with high average yearly achievement of 3 priority secondary prevention goals,but the majority of trial participants did not persist in being at goal over *** registration number:nCT00091949.

关键词： prevention annually goals

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智能化煤矿数据治理能力评估与提升策略研究

矿业科学学报 2024年第1期9卷 106-115页

作者：王美君谭章禄李慧园吕晗冰中国矿业大学(北京)管理学院北京100083

数据治理能力是实现煤矿智能化建设整体目标的重要基础,对于加快煤矿智能化建设、促进煤炭工业数字化转型、构建现代化能源体系、建设数字中国具有重要意义。本文针对智能化煤矿数据治理能力提升的理论和方法进行探讨。首先剖析了煤矿... 详细信息

数据治理能力是实现煤矿智能化建设整体目标的重要基础,对于加快煤矿智能化建设、促进煤炭工业数字化转型、构建现代化能源体系、建设数字中国具有重要意义。本文针对智能化煤矿数据治理能力提升的理论和方法进行探讨。首先剖析了煤矿智能化建设对数据治理的战略诉求,界定智能化煤矿数据治理能力的概念、内涵;然后构建智能化煤矿数据治理能力体系,为数据治理能力的科学评估提供依据;进而基于能力成熟度理论,构建智能化煤矿数据治理能力成熟度模型,指明智能化煤矿数据治理能力提升路径;最后基于pDCA循环理论,提出智能化煤矿数据治理能力提升策略,以期补充完善数据治理能力提升的理论基础,为数据治理最佳实践提供参考。

关键词：智能化煤矿数据治理能力成熟度数据管理数据标准

Role of capsule endoscopy in inflammatory bowel disease:Anything new?

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Artificial Intelligence in Gastrointestinal Endoscopy 2021年第4期2卷 136-148页

作者： Edith pérez de Arce Rodrigo Quera paulina núñez F Raúl Araya Department of Gastroenterology Hospital Clínico Universidad de ChileSantiago 8380456Chile Digestive Disease Center Inflammatory Bowel Disease ProgramClínica Universidad de los AndesSantiago 7620157Chile Department of Gastroenterology Hospital San Juan De DiosSantiago 8350488Chile

Capsule endoscopy(CE)is a recently developed diagnostic method for diseases of the small bowel that is non-invasive,safe,and highly *** role in patients with inflammatory bowel disease has been widely validated in suspected and established Crohn’s disease(CD)due to its ability to assess superficial lesions not detected by cross-sectional imaging and proximal lesions of the small bowel not evaluable by *** CE is a highly sensitive but less specific technique,differential diagnoses that can simulate CD must be considered,and its interpretation should be supported by other clinical and laboratory *** use of validated scoring systems to characterize and estimate lesion severity(lewis score,Capsule Endoscopy Crohn’s Disease Activity Index),as well as the standardization of the language used to define the lesions(Delphi Consensus),have reduced the interobserver variability in CE reading observed in clinical practice,allowing for the optimization of diagnoses and clinical management *** appearance of the panenteric CE,the incorporation of artificial intelligence,magnetically-guided capsules,and tissue biopsies are elements that contribute to CE being a promising,unique diagnostic tool in digestive tract diseases.

关键词： Capsule endoscopy Inflammatory bowel disease Crohn’s disease Artificial intelligence Capsule Endoscopy Crohn’s Disease Activity Index lewis score

热应激和低营养摄入对猪肠道完整性和功能的影响

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中国饲料 2016年第3期 36-43页

作者： pearce S C Mani V Weber T E Rhoads R p patience J F Baumgard l h Gabler n K 爱荷华州立大学动物科技学院美国埃姆斯50011 弗吉尼亚理工大学动物和家禽科学系美国布莱克斯堡24061

热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激（通过减少采食量）对生长猪肠道通透性的影响。选用体重（43±4）kg的杂交后备母猪（n=48）,分别安置在以下控制环境中：热中性（Tn）环境（20℃,湿度35%~50%... 详细信息

热应激会损害肠道完整性,并诱发肠渗漏。因此,本试验研究了直接或间接热应激（通过减少采食量）对生长猪肠道通透性的影响。选用体重（43±4）kg的杂交后备母猪（n=48）,分别安置在以下控制环境中：热中性（Tn）环境（20℃,湿度35%~50%,自由采食）、热应激（hS）环境（35℃,湿度20%~35%,自由采食）、热中性环境配对饲喂（pFTn,以消除不同采食量的交互影响）。第1、3、7天使猪只安乐死,采集的空肠样品被安装到尤式灌流室,测定跨膜电阻抗值（TER）和异硫氰基荧光标记的脂多糖（lpS）渗透性（App,表示为表观渗透系数）。此外,评估肠道完整性以及应激基因和蛋白标志物。结果表明,不考虑热应激天数,hS组与Tn组猪相比,血浆内毒素水平增加45%（p〈0.05）,空肠TER降低30%（p〈0.05）,lpS渗透率增加2倍（p〈0.01）。此外,与pFTn组相比,hS组第7天的猪lpS渗透性有增加的趋势（p=0.06）。整个试验阶段hS组溶菌酶和碱性磷酸酶活性下降,分别下降46%和59%（p〈0.05）;然而,3 d和7 d空肠免疫细胞标记物——髓过氧化物酶活性增加（p〈0.05）。由此可见,热应激和减少采食量都会降低肠道完整性,并增加内毒素渗透性。推测这可能会导致炎症加重,在炎热的夏季可能是导致猪生长性能降低的原因。

关键词：内毒素热应激肠道完整性猪

A Study on Refractive Index Sensors Based on Optical Micro-Ring Resonators

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photonic Sensors 2017年第3期7卷 217-225页

作者： Georgios n. TSIGARIDAS Department of physics School of Applied Mathematical and Physical Sciences National Technical University of Athens Zografou Campus GR-15780 Zografou Athens Greece

In this work, the behavior of refractive index sensors based on optical micro-ring resonators is studied in detail. Using a result of waveguide perturbation theory in combination with numerical simulations, the optimum design parameters of the system, maximizing the sensitivity of the sensor, are determined. It is found that, when optimally designed, the sensor can detect relative refractive index changes of the order of △n/n≈3×10^-4, assuming that the experimental setup can detect relative wavelength shifts of the order of △λ/λ≈3×10^-5. The behavior of the system as bio-sensor has also been examined. It is found that, when optimally designed, the system can detect refractive index changes of the order of △n≈ 10^-3 for a layer thickness of t=- 10 nm, and changes in the layer thickness of the order of △t≈0.24 nm, for a refractive index change of △n=0.05.

关键词： Optical micro-ring resonators refractive index sensors bio-sensors nano-photonic sensors

MUSCl TYpE SChEMES AnD DISCRETE EnTROpY COnDITIOnS

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Journal of Computational Mathematics 1997年第1期15卷 72-80页

作者： Zhao, n Wu, hM nAnJInG UnIV DEPT AERODYNAMNANJING 210008PEOPLES R CHINA ChInESE ACAD SCI STATE KEY LAB SCI & ENGN COMPICMSECBEIJINGPEOPLES R CHINA

In this paper, the semi-discrete entropy conditions with so called the proper discrete entropy flux of a class of high resolution MUSCl type schemes are discussed for genuinely nonlinear scalar conservation laws. It is shown that the high resolution schemes satisfying such;semi-discrete entropy conditions cannot preserve second order accuracy in the rarefaction region.

关键词： Computational fluid dynamics Convergence of numerical methods nonlinear equations numerical methods

A DnA-Binding Bromodomain-Containing protein Interacts with and Reduces Rx1-Mediated Immune Response to potato Virus X

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plant Communications 2020年第4期1卷 101-114页

作者： Octavina C.A.Sukarta philip D.Townsend Alexander llewelyn Christopher h.Dixon Erik J.Slootweg lars-Olof pålsson Frank l.W.Takken Aska Goverse Martin J.Cann laboratory of nematology Department of Plant SciencesWageningen University6708 PB WageningenThe Netherlands Department of Biosciences Durham UniversitySouth RoadDurham DH13LEUK Biophysical Sciences Institute Durham UniversitySouth RoadDurham DH13LEUK Department of Chemistry Durham UniversitySouth RoadDurham DH13LEUK Molecular plant pathology Swammerdam Institute for Life SciencesUniversity of AmsterdamScience Park 9041098 XH AmsterdamThe Netherlands

plant nlR proteins enable the immune systemto recognize and respond to pathogen *** early consequence of immune activation is transcriptional *** have been shownto act in the nucleus and interact with transcription *** Rx1 nlR protein of potato binds and distorts doublestranded ***,the components of the chromatin-localized Rx1 complex are largely ***,we report a physical and functional interaction between Rx1 and nbDBCp,a bromodomaincontaining chromatin-interacting *** accumulates in the nucleoplasmand nucleolus,interacts with chromatin,and redistributes Rx1 tothe nucleolus in a subpopulation of imaged ***1 overexpression reduces the interaction between nbDBCp and *** is a negative regulator of Rx1-mediated immune responses to potato virus X(pVX),and this activity requires an intact ***,Rx1 has been shown to regulate the DnA-binding activity of a Golden2-like transcription factor,***1 and nbDBCp act synergistically to reduce nbGlk1 DnA binding,suggesting a mode of action for nbDBCp’s inhibitory effect on *** study provides new mechanistic insight into the mechanism by which a chromatin-localized nlR complex co-ordinates immune signaling after pathogen perception.

关键词： cellular immune response DnA-binding protein host-pathogen interaction plant biochemistry plant defense plant virus