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physics, chemistry, and hirshfeld surface analyses of gamma-irradiated thalidomide to evaluate behavior under sterilization doses

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Journal of pharmaceutical Analysis 2018年第3期8卷 194-201页

作者： Valner A.F.S.n.Mussel Max R Ferreira Maria B.E Marques Maria I.Yoshida Mariana R.Almeida Bernardo l.Rodrigues Wagner n.Mussel Departamento de Quimica ICExUniversidade Federal de Minas Gerais-UFMGAv.Antonio Carlos 662731270-901 Belo HorizonteMGBrazil CnEn-CDTn Comissao Nacional de Energia Nuclear-Centro de Desenvolvimento da Tecnologia NuclearAv.Antonio Carlos6627 Belo HorizonteMGBrazil

Thalidomide was indicated as a sedative and antiemetic and prescribed for pregnant women. Its tragic teratogenic effects culminated in withdrawal from the market. Since the discovery of its anti-angiogenic and anti-inflammatory actions, thalidomide has been used in the treatment of leprosy and multiple myeloma, which justify studies of its stability. We investigated the effects of irradiation of thalidomide up to 100 kGy （fourfold the usual sterilizing dose for pharmaceutics）. The polymorph of thalidomide was obtained in an isothermal experiment at 270℃. All samples underwent gamma irradiation for specific times. At different doses, decomposition of the pharmaceutical was not observed up to 100 kGy. The observed effect was angle turning between the phthalimide and glutarimide rings modulated by repulsion towards the carbonyl group, leading to a stable energetic configuration, as measured by the equilibrium in the torsion angle after irradiation. The thalidomide molecule has a center of symmetry, so a full turn starting from 57.3° will lead to an identical molecule. Further irradiation will start the process again. Samples irradiated at 30 and 100 kGy have more compact unit cells and a lower volume, which leads to an increase in the intermolecular hydrogen interaction within the unit cell, resulting in higher thermal stability for polymorph α.

关键词： Thalidomide Thermal stability polymorphs Gamma irradiation hirshfeld

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MicroRnA: a new and promising potential biomarker for diagnosis and prognosis of ovarian cancer

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Cancer Biology & Medicine 2015年第4期12卷 328-341页

作者： Manish K.pal Shyam p.Jaiswar Vinaya n.Dwivedi Amit K.Tripathi Ashish Dwivedi pushplata Sankhwar Department of Obstetrics and Gynecology King George Medical University Biochemistry and Molecular Biology laboratory Center for Advanced Study in Zoology Department of Zoology Banaras Hindu University Endocrinology Division Central Drug Research Institute photobiology Division Indian Institute of Toxicology Research

Epithelial ovarian cancer(EOC) is the leading cause of death among all gynecological malignancies. Despite the technological and medical advances over the past four decades, such as the development of several biological markers(mRnA and proteins biomarkers), the mortality rate of ovarian cancer remains a challenge because of its late diagnosis, which is specifically attributed to low specificities and sensitivities. Under this compulsive scenario, recent advances in expression biology have shifted in identifying and developing specific and sensitive biomarkers, such as micro RnAs(miRnAs) for cancer diagnosis and prognosis. MiRnAs are a novel class of small non-coding RnAs that deregulate gene expression at the posttranscriptional level, either by translational repression or by mRnA degradation. These mechanisms may be involved in a complex cascade of cellular events associated with the pathophysiology of many types of cancer. MiRnAs are easily detectable in tissue and blood samples of cancer patients. Therefore, miRnAs hold good promise as potential biomarkers in ovarian cancer. In this review, we attempted to provide a comprehensive profile of key miRnAs involved in ovarian carcinoma to establish mi RnAs as more reliable non-invasive clinical biomarkers for early detection of ovarian cancer compared with protein and DnA biomarkers.

关键词： Micro RnAs(miRnA) biomarker chemoresistance detection RT-pCR

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1,2,3-Triazole incorporated coumarin derivatives as potential antifungal and antioxidant agents

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Chinese Chemical letters 2016年第2期27卷 295-301页

作者： Mubarak h.Shaikh Dnyaneshwar D.Subhedar Firoz A.Kalam Khan Jaiprakash n.Sangshetti Bapurao B.Shingate Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Department of pharmaceutical Chemistry Y. B. Chavan College of Pharmacy Dr. Rafiq Zakaria Campus

A series of novel ethyl-7-（（1-（benzyl）-1h-1,2,3-triazol-4-yl）methoxy）-2-oxo-2h-chromene-3-carboxylates 8a-h as potential antifungal agents were synthesized via click chemistry. The antifungal activity was evaluated against five human pathogenic fungal strains, such as Candida albicans, Fusarium oxysporum, Aspergillus flavus, Aspergillus niger and Cryptococcus neoformans. Compound 8c, 8d, 8e and 8h were found to be equipotent against C. albicans when compared with miconazole and compound 8f was found to be two-fold more active compared with miconazole and equipotent to fluconazole against ***. The coumarin-based triazole derivatives were also evaluated for antioxidant activity and compound 8a was found to be potent antioxidant when compared with standard drug. Furthermore,molecular docking study of the newly synthesized compounds was performed and results showed good binding mode in the active site of fungal C. albicans enzyme p450 cytochrome lanosterol 14 ademethylase. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential to build up as good oral drug candidates.

关键词： ADME prediction Antifungal Antioxidant Docking study 1,2,3-Triazole

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Quality problems in Waters Used for Drinking purposes in Italy

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Biomedical and Environmental Sciences 1991年第4期4卷 339-347页

作者： E.FUnARI.A.BASTOnE p.BOTTOnI D.DEDOnnO l.DOnATI Department of Environmental hygiene National Institute of HealthDepartment of Environmental Hygiene National Institute of HealthDepartment of Environmental Hygiene National Institute of HealthDepartment of Environmental Hygiene National Institute of Health

With a grant from the Italian Ministry of the Environment, the national Institute of health (Istituto Superiore di Sanita) promoted and coordinated some activities aimed at determining the extent and the intensity of contamination of waters used for human consumption by some chemical agents, and describing causes and modalities of contamination and human health implications. The chemical agents examined were herbicides, nitrates, trihalomethanes, asbestos, manganese and fluoride. In this paper a first nationwide picture of these problems is reported.

关键词： Quality problems in Waters Used for Drinking purposes in Italy

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nanomechanical hydrodynamic force sensing using suspended microfluidic channels

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微系统与纳米工程(英文) 2023年第3期9卷 95-102页

作者： Alberto Martín-pérez Daniel Ramos Optomechanics lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow

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Studies on composite solid propellant with tri-modal ammonium perchlorate containing an ultrafine fraction

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Defence Technology（防务技术） 2017年第4期13卷 239-245页

作者： K.V. Suresh Babu p. Kanaka Raju C.R. Thomas A. Syed hamed K.n. ninan Solid propellant Space Booster plant Satish Dhawan Space Centre Sriharikota 524124 India Rocket propellant plant Vikram Sarabhai Space Centre Thiruvananthapuram 695 022 India Department of Chemistry Indian Institute of Space Science and Technology Thiruvananthapuram 695 547 India

Composite solid propellant is prepared using tri-modal Ammonium perchlorate(Ap)containing coarse,fine and ultrafine fractions of Ap with average particle size(ApS)340,40 and 5 mm respectively,in various compositions and their rheological,mechanical and burn rate characteristics are *** optimum combination of Ap coarse to fine to ultrafine weight fraction was obtained by testing of series of propellant samples by varying the Ap fractions at fixed solid *** concentration of aluminium was maintained constant throughout the experiments for ballistics *** propellant formulation prepared using Ap with coarse to fine to ultrafine ratio of 67:24:9 has lowest viscosity for the propellant paste and highest tensile strength due to dense packing as supported by the literature.A minimum modulus value was also observed at 9 wt.%of ultrafine Ap concentration indicates the maximum solids packing density at this ratio of Ap *** burn rate is evaluated at different pressures to obtain pressure *** of ultrafine fraction of Ap in propellant increased burn rate without adversely affecting the pressure *** solid loading propellants are prepared by increased Ap concentration from 67 to 71 wt.%using Ap with coarse to fine to ultrafine ratio of67:24:*** solid content up to 89 wt.%was achieved and hence increased solid motor *** unloading viscosity showed a trend with increased Ap content and the propellant couldn't able to cast beyond 71 wt.%of *** properties were also studied and from the experiments noticed that%elongation decreased with increased Ap content from 67 to 71 wt.%,whereas tensile strength and modulus *** rate increased with increased Ap content and observed that pressure exponent also increased and it is high for the propellant containing with 71 wt.%of Ap due to increased oxidiser to fuel *** composite solid propellant is prepared by using burn rate modifie

关键词： Ammonium perchlorate Composite propellant Burn rate Copper chromite Iron oxide

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Electrochemical synthesis of boron-containing coatings on Mg alloy for thermal neutron shielding

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Journal of Magnesium and Alloys 2023年第10期11卷 3779-3789页

作者： K.V.nadaraia S.n.Suchkov n.S.Markin I.M.Imshinetskiy S.I.Ivannikov D.V.Mashtalyar A.Yu.Ustinov S.l.Sinebryukhov S.V.Gnedenkov Institute of Chemistry FEB RAS 159 Pr.100-Letiya VladivostokaVladivostok 690022Russia

The work provides the results of the one-step formation of boron-containing coatings on an Mg–Mn–Ce alloy by plasma electrolytic oxidation. The results of studies of the composition, structure and morphology of heteroxide coatings are presented. It was established that the boron is contained in the coating mainly in the form of B or B_(2)O_(3). The introduction of B changes the color of coatings, and also helps to increase their porosity. The method of determining the full cross section of the interaction of thermal neutron absorption efficiency by samples material using the installation of neutron-activation analysis based on ^(252)Cf was developed. It was shown that the introduction of boron into the formed coatings allows to increase the macroscopic cross-section of the interaction of samples with thermal neutrons by 3.8 times. This effect opens the potential for the use of synthesized material in the field of nuclear technologies and aerospace industry.

关键词： plasma electrolytic oxidation Boron neutron capture neutron shielding protective coatings

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Influence of cerium content on the corrosion behavior of Al-Co-Ce amorphous alloys in 0.6 M naCl solution

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Journal of Materials Science & Technology 2019年第7期35卷 1378-1387页

作者： l.M.Zhang S.D.Zhang A.l.Ma A.J.Umoh h.X.hu Y.G.Zheng B.J.Yang J.Q.Wang CAS Key laboratory of nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of Sciences62 Wencui RoadShenyang 110016PR China School of Materials Science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang 110016PR China Shenyang national laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016PR China

The effect of cerium content on the corrosion behavior of Al-Co-Ce amorphous alloys in 0.6 M naCl solution was investigated by cyclic polarization, Mott-Schottky and X-ray photoelectron spectroscopy techniques. Results indicated that the open circuit potential of Al-Co-Ce amorphous alloys displayed a decreased tendency with the increase in Ce content, and the amorphous alloy with 4 at.% Ce presented both the lowest passive current density and donor density indicating the best corrosion resistance, while adding excess Ce led to the reduced corrosion resistance of Al-Co-Ce alloys, Furthermore, it was found that a low Ce content is beneficial to the formation of a more protective passive film on Al-Co-Ce amorphous alloys, and the corrosion inhibition reactions of Al-Co-Ce alloys in 0.6 M naCl solution were changed with the increase in Ce content and the detailed reasons were discussed.

关键词： Amorphous materials polarization Corrosion photoelectron spectroscopies

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Improving the hard magnetic properties by intragrain pinning for Ta doped nanocrystalline Ce-Fe-B alloys

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Journal of Materials Science & Technology 2019年第9期35卷 1877-1885页

作者： J.S.Zhang W. li X.F. liao h.Y. Yu l.Z. Zhao h.X. Zeng D.R. peng Z.W. liu School of Materials Science and Engineering South China University of TechnologyGuangzhou510640China Innovative Center for Advanced Materials (ICAM) Hangzhou Dianzi UniversityHangzhou310012China

To develop Ce based permanent magnets with high performance/cost ratio, Ta doping is was employed to enhance the magnetic performance of Ce-Fe-B alloys. For melt spun Cei7Fe78-xTaxB6 (x = 0-1) alloys, the coercivity hc increases from 439 to 553 kA/m with increasing x value from 0 to 0.75. Microstructure characterizations indicate that Ta doping is helpful for grain refinement. A second phase of TaB2 is observed in Ce17Fe77.25Tao.75B6 alloy, which acts as the pinning center of the magnetic domains, resulting in the change of coercivity mechanism from nucleation type to nucleation +pinning type. The micromagnetic simulation confirms that non-magnetic particles within hard magnetic phase can increase the demagnetization field around them and it is crucial for preventing the further magnetization reverse by pinning effect. Take the advantage of Ta doping for enhancing the coercivity, Ce content of Ce-Fe-B alloy can be further cut down to increase the remanence Jr due to the reduced volume fraction of CeFe2 phase and increased Fe/Ce ratio. As a result, a good combination of magnetic properties with hc = 514 kA/m, Jr = 0.49 T, and the maximum energy product (Bh)max = 36 kJ/m^3 have been obtained in Ce15Fe79.25Tao.75B6 alloy. It is expected that the present work can serve as a useful reference for designing new permanent magnetic materials with low-cost.

关键词： Melt-spinning permanent magnets Second phase Coercivity mechanism Thermal stability

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Wafer-level SlID bonding for MEMS encapsulation

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Advances in Manufacturing 2013年第3期1卷 226-235页

作者： h.Xu T.Suni V.Vuorinen J.li h.heikkinen p.Monnoyer M.paulasto-Krckel Department of Electronics School of Electrical EngineeringAalto University VTT Technical Research Centre of Finland

hermetic packaging is often an essential requirement to enable proper functionality throughout the device＇s lifetime and ensure the optimal performance of a micro electronic mechanical system （MEMS） device. Solid-liquid interdiffusion （SlID） bonding is a novel and attractive way to encapsulate MEMS devices at a wafer level. SlID bonding utilizes a low-melting-point metal to reduce the bonding process temperature; and metallic seal rings take out less of the valuable surface area and have a lower gas permeability compared to polymer or glass- based sealing materials. In addition, ductile metals can adopt mechanical and thermo-mechanical stresses during their service lifetime, which improves their reliability. In this study, the principles of Au-Sn and Cu-Sn SlID bonding are presented, which are meant to be used for wafer-level hermetic sealing of MEMS resonators. Seal rings in 15.24 cm silicon wafers were bonded at a width of 60 gin, electroplated, and used with Au-Sn and Cu-Sn layer structures. The wafer bonding temperature varied between 300 ℃ and 350 ℃, and the bonding force was 3.5 kn under the ambient pressure, that is, it was less than 0.1 pa. A shear test was used to compare the mechanical properties of the interconnections between both material systems, in addition, important factors pertaining to bond ring design are discussed according to their effects on the failure mechanisms. The results show that the design ofmetal structures can significantly affect the reliability of bond rings.

关键词： (MEMS)bondingDefects Micro electronic mechanical systemSolid-liquid interdiffusion (SlID)Transient liquid-phase (Tlp) bondingShear test Reliability

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