检索结果-南通市图书馆

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

含有纳米结构涂层的电弧喷涂技术

国外机车车辆工艺 2008年第4期 34-35页

作者： p.georgieva 汤明春

纳米结构的涂层具有硬度高、抗腐蚀和耐磨性好等特点。文章介绍了含有纳米结构材料电弧喷涂丝的化学成分及在工业中的应用。通过对涂层性能的比较,表明这种新开发的TAFA 100MXC、110MXC纳米结构涂层具有良好的应用前景。

关键词：焊丝纳米结构涂层电弧喷涂研究应用

Controversies regarding transplantation of mesenchymal stem cells

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第2期14卷 48-61页

作者： Tsvetelina Velikova Tereza Dekova Dimitrina georgieva Miteva Department of Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria

Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation.

关键词： Mesenchymal stem cells Transplantation controversies Regenerative medicine Autoimmune diseases Chronic inflammatory illnesses Tumor growth Metastasis Therapeutic potential Clinical use of mesenchymal stem cell

Genetic screening of liver cancer:State of the art

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第5期16卷 716-730页

作者： Milena peruhova Sonya Banova-Chakarova Dimitrina georgieva Miteva Tsvetelina Velikova Department of Gastroenterology University Hospital"Heart and Brain"Burgas 8000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment OhridskiSofia 1164Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

Liver cancer,primarily hepatocellular carcinoma,remains a global health challenge with rising incidence and limited therapeutic options.Genetic factors play a pivotal role in the development and progression of liver cancer.This state-of-the-art paper provides a comprehensive review of the current landscape of genetic screening strategies for liver cancer.We discuss the genetic underpinnings of liver cancer,emphasizing the critical role of risk-associated genetic variants,somatic mutations,and epigenetic alterations.We also explore the intricate interplay between environmental factors and genetics,highlighting how genetic screening can aid in risk stratification and early detection via using liquid biopsy,and advancements in high-throughput sequencing technologies.By synthesizing the latest research findings,we aim to provide a comprehensive overview of the state-of-the-art genetic screening methods for liver cancer,shedding light on their potential to revolutionize early detection,risk assessment,and targeted therapies in the fight against this devastating disease.

关键词： Hepatocellular carcinoma Liver cancer Genetic screening Risk-associated genetic variants Epigenetic alterations Genetic biomarkers Circulating tumor DNA Next-generation sequencing

Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第12期12卷 2031-2039页

作者： Tsvetelina Velikova Georgi Vasilev Russka Shumnalieva Lyubomir Chervenkov Dimitrina georgieva Miteva Milena Gulinac Stamatios priftis Snezhina Lazova Medical Faculty Sofia University"St.Kliment Ohridski"Sofia 1407Bulgaria Clinic of Neurology and Department of Emergency Medicine UMHAT"Sv.Georgi"Plovdiv 4000Bulgaria Department of Rheumatology Clinic of RheumatologyUniversity Hospital"St.Ivan Rilski"Medical University-SofiaSofia 1612Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of General and Clinical pathology Medical University of PlovdivPlovdiv 4002Bulgaria Department of Healthcare Faculty of Public Health“Prof.Tsekomir VodenicharovMDDSc”Medical University of SofiaSofia 1407Bulgaria Department of pediatric University Hospital"N.I.Pirogov"Sofia 1606Bulgaria

Gluten ataxia and other central nervous system disorders could be linked to gluten enteropathy and related autoantibodies.In this narrative review,we focus on the various neuro-logical manifestations in patients with gluten sensitivity/celiac disease,immunological and autoimmune mechanisms of ataxia in connection to gluten sensitivity and the autoantibodies that could be used as a biomarker for diagnosing and following.We focused on the anti-gliadin antibodies,antibodies to different isoforms of tissue transglutaminase(TG)(anti-TG2,3,and 6 antibodies),anti-glycine receptor antibodies,anti-glutamine acid decarboxylase antibodies,anti-deamidated gliadin peptides antibodies,etc.Most studies found a higher prevalence of these antibodies in patients with gluten sensitivity and neurological dysfunction,presented as different neurological disorders.We also discuss the role of a gluten-free diet on the clinical improvement of patients and also on imaging of these disorders.

关键词： Gluten ataxia Celiac disease Gluten enteropathy Autoantibodies Anti-gliadin antibodies Anti-bodies to tissue transglutaminase Anti-tissue transglutaminase antibodies Anti-transglutaminase 6 antibodies Anti-glycine receptor antibodies Anti-glutamine acid decarboxylase antibodies

Dual-polarization multiplexing amorphous Si:H grating couplers for silicon photonic transmitters in the photonic BiCMOS backend of line

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2022年第1期15卷 143-155页

作者： Galina georgieva Christian Mai pascal M.Seiler Anna peczek Lars Zimmermann Hochfrequenztechnik-photonik/Siliziumphotonik Technische Universität BerlinStraße des 17.Juni 13510623 BerlinGermany IHp-Leibnitz Institut für innovative Mikroelektronik Im Technologiepark 2515236 Frankfurt(Oder)Germany IHp Solutions GmbH Im Technologiepark 715236 Frankfurt(Oder)Germany

In this paper,we report on polarization combining two-dimensional grating couplers(2D GCs)on amorphous Si:H,fabricated in the backend of line of a photonic BiCMOS platform.The 2D GCs can be used as an interface of a hybrid silicon photonic coherent transmitter,which can be implemented on bulk Si wafers.The fabricated 2D GCs operate in the telecom C-band and show an experimental coupling efficiency of−5 dB with a wafer variation of±1.2 dB.possibilities for efficiency enhancement and improved performance stability in future design generations are outlined and extension toward O-band devices is also investigated.

关键词： Hybrid integration photonic BiCMOS Amorphous silicon Two-dimensional grating coupler(2D GC) Dual-polarization coherent communication Silicon photonics

Applications of time series analysis in epidemiology: Literature review and our experience during COVID-19 pandemic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第29期11卷 6974-6983页

作者： Latchezar Tomov Lyubomir Chervenkov Dimitrina georgieva Miteva Hristiana Batselova TsvetelinaVelikova Department of Informatics New Bulgarian UniversitySofia 1618Bulgaria Department of Diagnostic Imaging Medical University PlovdivPlovdiv 4000Bulgaria Department of Genetics Faculty of BiologySofia University"St.Kliment Ohridski"Sofia 1164Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityUniversity Hospital"St George"Plovdiv 4000Bulgaria Department of Medical Faculty Sofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria

Time series analysis is a valuable tool in epidemiology that complements the classical epidemiological models in two different ways:prediction and forecast.prediction is related to explaining past and current data based on various internal and external influences that may or may not have a causative role.Forecasting is an exploration of the possible future values based on the predictive ability of the model and hypothesized future values of the external and/or internal influences.The time series analysis approach has the advantage of being easier to use(in the cases of more straightforward and linear models such as Auto-Regressive Integrated Moving Average).Still,it is limited in forecasting time,unlike the classical models such as Susceptible-Exposed-Infectious-Removed.Its applicability in forecasting comes from its better accuracy for short-term prediction.In its basic form,it does not assume much theoretical knowledge of the mechanisms of spreading and mutating pathogens or the reaction of people and regulatory structures(governments,companies,etc.).Instead,it estimates from the data directly.Its predictive ability allows testing hypotheses for different factors that positively or negatively contribute to the pandemic spread;be it school closures,emerging variants,etc.It can be used in mortality or hospital risk estimation from new cases,seroprevalence studies,assessing properties of emerging variants,and estimating excess mortality and its relationship with a pandemic.

关键词： Time series analysis Epidemiology COVID-19 pandemic Auto-regressive integrated moving average Excess mortality Seroprevalence

MNN-XSS:Modular Neural Network Based Approach for XSS Attack Detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第2期70卷 4075-4085页

作者： Ahmed Abdullah Alqarni Nizar Alsharif Nayeem Ahmad Khan Lilia georgieva Eric pardade Mohammed Y.Alzahrani Department of Computer Sciences and Information Technology AlBaha UniversityAlBahaSaudi Arabia Department of Computer Science Heriot-Watt UniversityEdinburghUK Department of Computer Science and Information Technology La Trobe UniversityMelbourneVIC 3086Australia

The rapid growth and uptake of network-based communication technologies have made cybersecurity a significant challenge as the number of cyber-attacks is also increasing.A number of detection systems are used in an attempt to detect known attacks using signatures in network traffic.In recent years,researchers have used different machine learning methods to detect network attacks without relying on those signatures.The methods generally have a high false-positive rate which is not adequate for an industry-ready intrusion detection product.In this study,we propose and implement a new method that relies on a modular deep neural network for reducing the false positive rate in the XSS attack detection system.Experiments were performed using a dataset consists of 1000 malicious and 10000 benign sample.The model uses 50 features selected by using pearson correlation method and will be used in the detection and preventions of XSS attacks.The results obtained from the experiments depict improvement in the detection accuracy as high as 99.96%compared to other approaches.

关键词： Cybersecurity XSS deep learning modular neural network

Long-term effectiveness,outcomes and complications of bariatric surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第19期11卷 4504-4512页

作者： Milena Gulinac Dimitrina georgieva Miteva Monika peshevska-Sekulovska Ivan p Novakov Svetozar Antovic Milena peruhova Violeta Snegarova plamena Kabakchieva Yavor Assyov Georgi Vasilev Metodija Sekulovski Snezhina Lazova Latchezar Tomov Tsvetelina Velikova Department of General and Clinical pathology Medical University of PlovdivPlovdiv 4000Bulgaria Department of Genetics Sofia University"St.Kliment Ohridski"Faculty of BiologySofia 1164Bulgaria Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Department of Thoraco-abdominal Surgery Medical University PlovdivPlovdiv 6000Bulgaria University Clinic for Digestive Surgery Medical FacultySkopjeSkopje 1000North Macedonia Department of Gastroenterology Heart and Brain HospitalBurgasBurgas 1000Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyMedical FacultyMedical UniversityVarna 9000Bulgaria Clinic of Internal Diseases Naval Hospital-VarnaMilitary Medical AcademyVarna 9010Bulgaria Clinic of Endocrinology University Hospital AlexandrovskaSofia 1431Bulgaria Department of Internal Diseases Medical University–SofiaSofia 1431Bulgaria Clinic of Endocrinology and Metabolic Disorders UMHAT"Sv.Georgi"Plovdiv 4000Bulgaria Department of Anesthesiology and Intensive Care University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia UniversitySt.Kliment OhridskiSofia 1407Bulgaria Department of pediatric University Hospital"N.I.Pirogov"Sofia 1606Bulgaria Department of Healthcare Faculty of Public Health"Prof.Tsekomir VodenicharovMDDSc"Sofia 1527Bulgaria Department of Informatics New Bulgarian UniversitySofia 1618Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

Dietary imbalance and overeating can lead to an increasingly widespread disease-obesity.Aesthetic considerations aside,obesity is defined as an excess of adipose tissue that can lead to serious health problems and can predispose to a number of pathological changes and clinical diseases,including diabetes;hypertension;atherosclerosis;coronary artery disease and stroke;obstructive sleep apnea;depression;weight-related arthropathies and endometrial and breast cancer.A body weight 20%above ideal for age,gender and height is a severe health risk.Bariatric surgery is a set of surgical methods to treat morbid obesity when other treatments such as diet,increased physical activity,behavioral changes and drugs have failed.The two most common procedures currently used are sleeve gastrectomy and gastric bypass.This procedure has gained popularity recently and is generally considered safe and effective.Although current data show that perioperative mortality is low and better control of comorbidities and short-term complications is achieved,more randomized trials are needed to evaluate the long-term outcomes of bariatric procedures.This review aims to synthesize and summarize the growing evidence on the long-term effectiveness,outcomes and complications of bariatric surgery.

关键词： Bariatric surgery Long-term outcomes Obesity Roux-en-Y gastric bypass sleeve gastrectomy Effectiveness Safety Quality of life

physical-Chemical Characterization of Nanodispersed powders produced by a plasma-Chemical Technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

plasma Science and Technology 2007年第3期9卷 273-279页

作者： M.georgieva G.VISSOKOV Iv.GRANCHAROV Department of Technology of Inorganic Substances University of Chemical Technology and Metallurgy8St.Kliment Ohridski Blvd.1756 SofiaBulgaria

This article presents a review on the physical-chemical properties and characteristics of plasma-chemically produced nanodispersed powders （NDp）, such as metals, oxides, nitrides, carbides, and catalysts. The plasma-chemical preparatior~ of the powders was carried out in thermal plasma （Tp） created by means of high-current electric arcs, plasma jets, high-frequency （HF） discharges, etc. We also discuss certain properties and characteristics of the NDps, which are determined largely by the conditions of preparation.

关键词： plasma-chemical treatment nitrides thermodynamic analysis