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Impacts of pI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(pI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the pI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/pI3K/AKT/connexin 43,and Notch/pI3K/AKT *** targeting the inactivation of the pI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the pI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

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Application of Kaiser Sepsis Calculator in culture-positive infants with early onset sepsis

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World Journal of pediatrics 2021年第4期17卷 429-433页

作者： Gretchen Kopec Marc collin Anirudha Das Department of Neonatology University of Illinois College of MedicinePeoria campusPeoriaUSA Department of Neonatology MetroHealth Medical CenterClevelandUSA Department of Neonatology Cleveland Clinic Children’s Hospital9500 Euclid AvenueClevelandOH44195USA

Background Kaiser Sepsis Calculator(KSC)reduces antibiotic use,testing and intravenous infiltrates but there are concerns about the missed early onset sepsis(eOS)*** sought to apply the KSC score for culture-positive infants retrospectively in infants born in the last 10 years in our *** In a retrospective cohort study,the comparison groups were divided into Group A(no antibiotics recommended by KSC)and Group B(antibiotics recommended).Results Overall,17/24(71%)infants would have been started on antibiotics per KSC but 7/24(29%)would *** initial eOS risk was not significantly different between the groups(Group A *** B:0.44 vs.0.76,p=0.41),but the final risk score was(0.33 vs.9.41,pp A(no antibiotics),3/7 infants became symptomatic between 9 and 42 *** There may be a potential delay in starting antibiotics in infants that are asymptomatic at birth while using KSC.

关键词： early onset sepsis eOS Kaiser Sepsis Calculator Neonatal sepsis Neonate Newborn Blood culture

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Anisotropic modelling of Opalinus Clay behaviour: From triaxial tests to gallery excavation application

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Journal of Rock Mechanics and Geotechnical engineering 2017年第3期9卷 53-66页

作者： Francois Bertrand Frédéric collin Université de Liège Département ArGEnCo/Géomécanique Allée de la découverte 9 4000 Liège Belgium F.R.I.A Fonds de la Recherche Scientifique e FNRS Brussels Belgium

Deep repository in geological formations is the preferential solution considered in many countries to manage high-level nuclear wastes. In Switzerland, the Opalinus Clay is a candidate host rock. In this context, in situ and laboratory tests are conducted on Opalinus Clay to demonstrate the feasibility of deep disposal in this argillaceous formation. This paper presents a constitutive model able to fit the experimental data obtained from some triaxial tests conducted by Jahns(2013) on cores from borehole Schlattingen SLA-1. The elasto-plastic behaviour of Opalinus Clay is reproduced thanks to a Druckerprager model, taking into account the anisotropy behaviour of this sedimentary rock. The objective is to employ a single set of parameters representative of the material. In a second version of the model, the stress-dependence of the elastic properties and damage are taken into account. Finally, the parameters calibrated with experimental tests are used to simulate the excavation of a gallery with a second gradient approach.

关键词： Opalinus Clay Schlattingen Constitutive modelling Anisotropy Dilatancy Localisation Tunnel excavation

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Improving health care usage in a very low birth weight population

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World Journal of pediatrics 2015年第3期11卷 239-244页

作者： Wambui Waruingi Sai Iyer Marc collin Department of pediatrics Division of NeonatologyCase Western ReserveMetrohealth Medical Center2500 Metrohealth DriveClevelandOH 44109USA Department of pediatrics Cincinnati Children's Hospital Medical Center3333 Burnett avenueCincinnatiOH 45229USA

Background:prematurity is the biggest contributor to admissions in the neonatal intensive care unit(NICU).The period following hospital discharge is a vital continuum for the very low birth weight(VLBW)infant The objective of this study was to assess the impact of a unique discharge and follow-up process on the outcomes of VLBW infants leaving the ***:All outpatient health care usage by VLBW infants born in the study year(cases)was retrospectively tracked through 12 months of age.A cohort of healthy newborn infants were matched by birthdate to each VLBW infant(controls)and similarly ***:In this study,there were 85 cases and 85 *** mean gestational age at birth for the cases was 29.1±2.7 weeks with a mean birth weight of 1079±263 *** of the controls was 38.9±13 weeks and 3202±447 *** 90%of both populations had Medicaid *** VLBW infants received care at the Special Care Developmental Follow-Up *** compared with the controls,VLBW infants discharged from the NICU made fewer acute,unscheduled visits to the emergency Department or Urgent Care Clinic(2.3±2.5 vs.3.7±3.5;p=0.007)despite their high-risk medical and social *** growth pattern showed significant"catch-up"and was similar to the matched controls at the last scheduled visit for each ***:Outcomes including health care utilization in high-risk infants can be improved through meticulous discharge planning and follow-up measures that utilize existing hospital infrastructure to provide affordable comprehensive care.

关键词： health care usage special care clinic very low birth weight

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina p.Bracho-Rincon Luis H.pagan Rivera Jorge D.Miranda Department of physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

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Three-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography:A review

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Journal of Innovative Optical Health Sciences 2020年第1期3卷 97-112页

作者： Fangjian Xing Jang-Hoon Lee collin polucha Jonghwan Lee Jiangsu Key Laboratory for Opto-electronic Technology School of physics and Technology Nanjing Normal University Nanjing 210023P.R.China Center for Biomedical engineering School of engineering Brown University ProvidenceRhode IslandUSA Carney Institute for Brain Science Brown University ProvidenceRI 02906USA

Optical coherence tomography angiography(OCTA)has emerged as an advanced in vivo im-aging modality,which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among *** on the high numerical aperture(NA)probing lens and the motion-corrected algorithms,a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5μm to 10μm in *** OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries,here we present a review on the latest techniques for the dynamic flow *** on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.

关键词： Capillary vessel dynamics blood flow OCT angiography brain cortex micro-angiogram

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Testicular vasomotion in different mammals

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Asian Journal of Andrology 2000年第4期2卷 297-300页

作者： Ola collin JimL.Zupp Brianp.Setchell Department of Integrative Medical Biology Section for Anatomy Umed University SwedenDepartment of Animal Science University of Adelaide AustraliaDepartment of Animal Science University of Adelaide Australia

Vasomotion is a rhythmical variation in arterial blood flow present in many different organs among them the mttestis. Vasomofion is suggested to play an important role for the transvascular fluid exchange and the exchange of nutri-ents over the capillary wall as well as the formation of interstitial fluid. The present study was undertaken to elucidatewhether vasomotion is present in the testes of different species independent of their anatomical vascular *** flow in the testes of mouse, brush-tailed possum, tammar wallaby, ram and human was investigated by using alaser Doppler fiowmeter. Vasomotion was found in all the species investigated. (Asian J Androl 2000 Dec; 2: 297-30O)

关键词： testis vasomotion human rats possum rams mice tammar-wallaby

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Three-dimensional models:from cell culture to patient-Derived Organoid and its application to future liposarcoma research

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Oncology Research 2025年第1期33卷 1-13页

作者： SAYUMI TAHARA SYDNeY ReNTSCH FeRNANDA COSTAS CASAL De FARIA pATRICIA SARCHeT ROMA KARNA FeDeRICA CALORe RApHAeL e.pOLLOCK Department of Surgery Division of Surgical OncologyThe James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA Department of Cancer Biology and Genetics The James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other *** to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma *** cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under *** vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell ***,they do not fully recapitulate human dedifferentiated liposarcoma(DDLpS)***,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between *** the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and patient-Derived tumor Organoids(pDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy *** this review,we first provide a general overview of 3D cell cultures compared to 2D cell *** then focus on one of the recent 3D cell culture applications,patient-Derived Organoids(pDOs),summarizing and discussing several pDO ***,we discuss the current and future applications of pDOs to sarcoma,particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma patient-Derived Organoid(pDO) Spheroid Three-dimensional(3D)cell culture

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