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Ecometrics:The traits that bind the past and present together

Integrative Zoology 2010年第2期5卷 88-101页

作者： Jussi T.ERONEN p.david polly Marianne FRED John DAMUTH david C.FRANK Volker MOSBRUGGER Christoph SCHEIDEGGER Nils Chr.STENSETH Mikael FORTELIUS Department of Geosciences and Geography Helsinki UniversityFinland Department of Geological Sciences Indiana UniversityUSA ARONIA Research Institute atÅbo Akademi University and Novia University of Applied SciencesCoastal Zone Research TeamEkenäFinland Department of Ecology Evolution and Marine BiologyUniversity of CaliforniaSanta BarbaraCaliforniaUSA Swiss Federal Research Institute WSL BirmensdorfSwitzerland Senckenberg Natural History Museum and Research Institute FrankfurtGermany Centre for Ecological and Evolutionary Synthesis(CEES) Department of BiologyUniversity of OsloOsloNorway

We outline here an approach for understanding the biology of climate change,one that integrates data at multiple spatial and temporal ***-free trait analysis,or“ecometrics,”is based on the idea that the distribution in a community of ecomorphological traits such as tooth structure,limb proportions,body mass,leaf shape,incubation temperature,claw shape,any aspect of anatomy or physiology can be measured across some subset of the organisms in a *** of temporal or spatial scale,traits are the means by which organisms interact with their environment,biotic and *** measures these interactions by focusing on traits which are easily measurable,whose structure is closely related to their function,and whose function interacts directly with local *** trait distributions are thus a comparatively universal metric for exploring systems dynamics at all *** main challenge now is to move beyond investigating how future climate change will affect the distribution of organisms and how it will impact ecosystem services and to shift the perspective to ask how biotic systems interact with changing climate in general,and how climate change affects the interactions within and between the components of the whole biotic-physical *** believe that it is possible to provide believable,quantitative answers to these *** of this we have initiated an IUBS program iCCB(integrative Climate Change Biology).

关键词： community structure ecometrics integrative Climate Change Biology Taxon-free trait distribution

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Homogentisic acid γ-lactone suppresses the virulence factors of pseudomonas aeruginosa by quenching its quorum sensing signal molecules

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Chinese Chemical Letters 2018年第2期29卷 313-316页

作者： Shuihong Li polly H.M. Leung Xinya Xu Chunhui Wu Department of Health Technology and Informatics The Hong Kong Polytechnic University Hong Kong China Hunan province Cooperative Innovation Center for Molecular Target New Drug Study University of South China Hengyang 421001 China Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510201 Chino Center for Informational Biology University of Electronic Science and Technology of China Chengdu 610054 China

Bacterial quorum sensing（QS） molecules are involved in the coordination of certain behaviors such as biofilm formation, virulence and antibiotic resistance. QS molecules（autoinducers） and their corresponding receptors have been recognized as important therapeutic targets for drug-resistant infections and biofilm-associated infections（BAI）. This study assessed the multiple biological effects of homogentisic acid y-lactone（HgAL）, a furanone derivative. The anti-QS and anti-biofilm effects of HgAL against pAO1 strain were evaluated using CLSM, SEM, HpLC and other biochemical methods The results showed that HgAL could effectively inhibit the production of pyocyanin and extracellular matrix, as well as reduce the adherence ability and biofilm formation of pseudomonas aeruginosa. Inhibition of virulence is attributed to the suppressive effect of HgAL on biosynthesis of 3-oxo-C12-HSLand C4-HSL（two kinds of QS signaling molecules in p. aeruginosa）. Our results support HgAL as a potential agent for prevention of BAI in the healthcare settings.

关键词： Homogentisicacid γ-lactone Quorum sensing Biofilm pseudomonas aeruginosa pyocyanin

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A randomized controlled trial of topical tea tree preparation for MRSA colonized wounds

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International Journal of Nursing Sciences 2014年第1期1卷 7-14页

作者： Rainbow L.p.Lee polly H.M.Leung Thomas K.S.Wong School of Nursing The Hong Kong Polytechnic UniversityHong Kong Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong Kong Faculty of Health and Social Sciences The Hong Kong Polytechnic UniversityHong Kong

Background:The prevalence of MRSA(Methicillin-resistant Staphylococcus aureus)colonized wounds in home care residents is expected to grow continuously as a result of the substantial proportion of older people requiring institutionalized care due to chronic disease and declining functional status,which contribute to more frequent skin breakdown and wound *** tree oil has been claimed to have anti-bacterial,analgesic and anti-inflammatory effects that have been suggested in many in-vitro studies to have good efficacy against *** aims of this study were to evaluate the effectiveness of 10%topical tea tree preparation to eradicateMRSA and to ascertain its influence on wound healing forMRSA-colonized ***:It was a randomized controlled trial,single-blind *** with stage II or above MRSA-colonized wounds and who had given their informed consent formed the *** determined sample sizewasbasedonthe effect size of our previouspilot study,whichwas *** outcome measurements were taken for the MRSA bacterial count and wound healing condition at baseline and at 1-week intervals during the 4-week dressing intervention ***:Thirty-two participants were recruited from two non-government nursing homes,16 in the control group and 16 in the tea tree oil *** control group residents received routine saline gauze dressing,while the tea tree oil group residents received the 10%topical tea tree preparation *** the tea tree oil group,all chronic wounds that had previously been delayed in healing were healed within 28 days without adverse *** was also completely eradicated in 14(87.5%)out of 16 wounds in the group receiving the 10%topical tea tree preparation.

关键词： MRSA Topical tea tree preparation Wounds

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On the Bifurcations and Multiple Endemic States of a Single Strain HIV Model Dedicated to professor Toshikazu Sunada on the Occasion of his 60th Birthday

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 913-930页

作者： Lindley Kent M.FAINA Lorna S.ALMOCERA polly W.SY College of Arts and Sciences University of the Philippines Visayas Natural Sciences and Mathematics Division University of the Philippines VisayasCebu College Institute of Mathematics University of the Philippines

The dynamics of a single strain HIV model is studied. The basic reproduction number R0 used as a bifurcation parameter shows that the system undergoes transcritical and saddle-node bifurcations. The usual threshold unit value of R0 does not completely determine the eradication of the disease in an HIV infected person. In particular, a sub-threshold value Rc is established which determines the system＇s number of endemic states： multiple if Rc 〈 Ro 〈 1, only one if Rc=Ro = 1, and none if R0 〈 Rc 〈 1.

关键词： single strain HIV model multiple endemic states transcritical bifurcation s^idle-node bifurcation hysteresis

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Review of evolution of clinical, training and educational services and research program for autism spectrum disorders in Hong Kong

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Science China(Life Sciences) 2015年第10期58卷 991-1009页

作者： Virginia Chun-Nei WONG Cheuk-Wing FUNG So-Lun LEE polly Tsz Yan WONG Department of paediatrics and Adolescent Medicine the University of Hong Kong Queen Mary Hospital

The evolution of a local fragmented model of services for children with autism in Hong Kong emerged gradually over the past three decades with lack of government funding or support. This had been due to increasing number of children with autism being detected and referred for earlier assessment. With increasing pressure from parents due to long waiting time for assessment and training services and the increasing polarization by mass media there had been a gradual increasing public awareness over the past five years. Though still highly fragmented in the availability of services, there is a growing "business model" available in the community due to increasing need and lack of public funding for support. There is a lack of strategic planning for medical diagnostic and management issues in Hong Kong. Our University of Hong Kong based Autism Research program was pioneered in 1985 based on the increasing load of autism cases referred for assessment for other developmental problems and diagnosed as Autism in the Duchess of Kent Children's Hospital. As the first author has been the staff of the University of Hong Kong, this program flourished as a research based program. The benefits of early identification and intervention of autism spectrum disorder(ASD) had been increasingly recognized, and with the increased public awareness and increasing trend of earlier diagnosis, there has been a continuously high demand from parents for earlier assessment and training for children suspected to have ASD. This model had not received extra funding for this integrated program for research, teaching and training in autism. We had to apply for various donations and grants to support the development of this pioneer program. The research output and organization of forums for public education and awareness are reviewed. The latter part of the paper reports the summary of clinical profile of autism cases(N=1441) assessed from 1985 to 2010 June under the University of Hong Kong. As the waiti

关键词： autism spectrum disorder (ASD) autism Asperger syndrome children

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HOpF BIFURCATION AND ANALYSIS OF EQUILIBRIUM FOR A THIRD-ORDER DIFFERENTIAL EQUATION IN A MODEL OF COMpETITION

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Acta Mathematicae Applicatae Sinica 2001年第1期17卷 68-80页

作者： LORNA S. ALMOCERA polly W. SY 井竹君 Department of Mathematics University of the Philippines Quezon City Philippines Department of Mathematics Hunan Normal University Changsha China

In this paper, a mathematical model of competition between plasmid-bearing and plasmidfree organisms in a chemostat with an inhibitor is investigated. The model is in the form of a system of nonlinear differential equations. By using qualitative methods, the conditions for the existence and local stability of the equilibria are obtained. The existence and stability of periodic solutions of the Hopf type are studied. Numerical simulations about the Hop f bifurcation value and Hopf limit cycle are also given.

关键词： Chemostat competition local stability periodic solutions of the Hopf type

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Distance caregiving a family member with cancer:A review of the literature on distance caregiving and recommendations for future research

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World Journal of Clinical Oncology 2016年第2期7卷 214-219页

作者： Sara L Douglas polly Mazanec Amy Lipson Mary Leuchtag Frances payne Bolton School of Nursing Case Western Reserve University

Distance caregivers(DCGs) are a growing phenomenon in the United States Family members are struggling to provide care to loved ones with chronic illnesses such as cancer,from a *** local caregiving research,distance caregiving research is limited and inconsistent definitions of distance make it difficult to compare *** date,DCGs have not been afforded the opportunities for educational and emotional support that local caregivers have received from the health care *** they are not usually present at medical appointments,DCGs do not receive first-hand information from the health care team about the patient's condition,disease progression,and/or treatment *** caregivers report feeling left out of important family *** experience anxiety related to the uncertainty of the family members' well-being and guilt related to not being available to help local caregivers *** challenges of distance caregiving are especially evident when the distance caregiver has a parent with advanced ***-centered care,attending to the needs of the whole family regardless of their geographic location is critical for quality cancer *** this manuscript,the sparse literature on distance caregiving is *** for future research and for the development of creative technologically advanced interventions for this underserved caregiving population are suggested.

关键词： Distance caregivers Caregiving Cancer caregivers Long distance caregivers Caregivers

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MRBLES 2.0: High-throughput generation of chemically functionalized spectrally and magnetically encoded hydrogel beads using a simple single-layer microfluidic device

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Microsystems & Nanoengineering 2020年第1期6卷 145-157页

作者： Yinnian Feng Adam K.White Jamin B.Hein Eric A.Appel polly M.Fordyce Department of Genetics Stanford UniversityStanfordCA 94305USA Department of Bioengineering Stanford UniversityStanfordCA 94305USA Department of Biology Stanford UniversityStanfordCA 94305USA The Novo Nordisk Foundation Center for protein Research Faculty of Health and Medical SciencesUniversity of CopenhagenBlegdamsvej 3b2200 CopenhagenDenmark Department of Materials Science&Engineering Stanford UniversityStanfordCA 94305USA Stanford ChEM-H Stanford UniversityStanfordCA 94305USA Chan Zuckerberg Biohub San FranciscoCA 94110USA

The widespread adoption of bead-based multiplexed bioassays requires the ability to easily synthesize encoded microspheres and conjugate analytes of interest to their ***,we present a simple method(MRBLEs 2.0)for the efficient high-throughput generation of microspheres with ratiometric barcode lanthanide encoding(MRBLEs)that bear functional groups for downstream surface *** production in MRBLEs 2.0 relies on the manual mixing of lanthanide/polymer mixtures(each of which comprises a unique spectral code)followed by droplet generation using single-layer,parallel flow-focusing devices and the off-chip batch polymerization of droplets into *** streamline downstream analyte coupling,MRBLEs 2.0 crosslinks copolymers bearing functional groups on the bead surface during bead *** the MRBLEs 2.0 pipeline,we generate monodisperse MRBLEs containing 48 distinct well-resolved spectral codes with high throughput(>150,000/min and can be boosted to 450,000/min).We further demonstrate the efficient conjugation of oligonucleotides and entire proteins to carboxyl MRBLEs and of biotin to amino ***,we show that MRBLEs can also be magnetized via the simultaneous incorporation of magnetic nanoparticles with only a minor decrease in the potential code *** the advantages of dramatically simplified device fabrication,elimination of the need for custom-made equipment,and the ability to produce spectrally and magnetically encoded beads with direct surface functionalization with high throughput,MRBLEs 2.0 can be directly applied by many labs towards a wide variety of downstream assays,from basic biology to diagnostics and other translational research.

关键词： beads spectral functional

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"Frequent Flyers" Costing NHS ￡2.3bn A Year

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当代外语研究 2006年第5期 35-37页

作者： polly Curtis 何琼

英国国民健康保险制度每年要为"经常就医者"花费23亿英镑的医疗费用,是其赤字的四倍。随着老龄化问题的加重,这一严峻形势也将加剧。一项调查表明,通过病发前的及时预防可以大大避免紧急抢救的发生,专家还指出信息对于医疗服务的改进至... 详细信息

英国国民健康保险制度每年要为"经常就医者"花费23亿英镑的医疗费用,是其赤字的四倍。随着老龄化问题的加重,这一严峻形势也将加剧。一项调查表明,通过病发前的及时预防可以大大避免紧急抢救的发生,专家还指出信息对于医疗服务的改进至关重要。

关键词：英国国民健康保险严峻形势医疗费用老龄化问题医疗服务抢救制度赤字预防

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Current understanding and management of aggressive posterior retinopathy of prematurity

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World Journal of Ophthalmology 2015年第2期5卷 73-79页

作者： Christine M pulido polly A Quiram Vitreo Retinal Surgery P.A.

Aggressive posterior retinopathy of prematurity(ROp), previously referred to as "Rush disease", is a rapidly progressive form of ROp. This form of ROp typically presents in very low birth weight babies of early gestational age. Historically, anatomical and functional outcomes have been poor with standard treatment. This review is designed to discuss current knowledge and treatment regarding this aggressive form of ROp. Recommendations regarding management of these difficult cases are detailed.

关键词： Bevacizumab Eliminates the Angiogenic Threat of Retinopathy of prematurity photographic Screening for Retinopathy of prematurity Aggressive posterior retinopathy of prematurity Retinopathy of prematurity Intravitreal bevacizumab Early Treatment of Retinopathy of prematurity Study Stanford University Network for Diagnosis of Retinopathy of prematurity

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