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中华耳鼻咽喉头颈外科杂志 1954年第2期02卷 159-160页

作者： A.Aubin G.Loiseau p.clerc J.B.VanNieuwenhuyse 胡同增

自可卡因应用于临床以来,严重之意外时有发生。著者等最近曾遇三例患者,于施行可卡因表面麻醉时发生严重意外,其中最后一例,在可卡因急

关键词：麻醉并发症

Unveiling the Threat: Case Reports of Extra-pulmonary Tuberculosis among Sanctuary Chimpanzees

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Advances in Infectious Diseases 2024年第1期14卷 105-132页

作者： Emeline Chanove Yedra Feltrer Antoine Collomb-clerc Angela Ceballos-Caro Marina Spinu Department of Infectious Diseases University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Romania International primate Health and Welfare Group (IpHWG) Madrid Spain NeuroX Institute and Brain Mind Institute School of Life Sciences Swiss Federal Institute of Technology (EPFL) Lausanne Switzerland Malaria and Emerging parasitic Diseases Laboratory National Centre for Microbiology Instituto de Salud Carlos III Madrid Spain

primate sanctuaries across Africa play a pivotal role in the rescue and rehabilitation of confiscated and rescued wild primates, many of whom have had extensive contact with humans prior to their arrival and throughout the rehabilitation process, heightening the risk of disease transmission. While tuberculosis is not naturally occurring in free-living chimpanzees, it has been extensively observed in captive primates that have been in close proximity to humans or other captive primates infected with Mycobacterium tuberculosis. This case report delves into an outbreak of extra-pulmonary tuberculosis among juvenile chimpanzees within a sanctuary, detailing the associated diagnostic challenges and treatment approaches. The five cases had close contact with a caregiver infected with tuberculosis, subsequently transmitting the infection to other in-contact chimpanzees. prolonged treatment, employing the human protocol of quadri-therapy (rifampicin, isoniazid, pyrazinamide, and ethambutol), followed by bi-therapy (rifampicin and isoniazid), resulted in complete resolution for all five cases. These cases underscore the critical importance of maintaining high levels of biosecurity, implementing effective quarantine measures, and adhering to strict hygiene practices when working with non-human primates.

关键词： Extrapulmonary Tuberculosis Tuberculosis Chimpanzees Zoonotic Risk Biosecurity Diagnosis Challenges

Structure-based design of novel heterocyclesubstituted ATDp analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

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Acta pharmaceutica Sinica B 2023年第12期13卷 4906-4917页

作者： Li-Min Zhao Christophe pannecouque Erik De clerc Shuai Wang Fen-Er Chen Key Laboratory of Natural Resources of Changbai Mountain&Functional Molecules Ministry of EducationYanbian University College of PharmacyYanbian UniversityYanji 133002China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China Rega Institute for Medical Research KU LeuvenLeuven B-3000Belgium

Following on our recently developed biphenyl-ATDp non-nucleoside reverse transcriptase inhibitor ZLM-66(SI=2019.80,S=1.9μg/mL),a series of novel heterocycle-substituted ATDp derivatives with significantly improved selectivity and solubility were identified by replacement of the biphenyl moiety of ZLM-66 with heterocyclic group with lower ***,the representative analog 7w in this series exhibited dramatically enhanced selectivity and solubility(SI=12,497.73,S=4472μg/mL)in comparison with ZLM-66(SI=2019.80,S=1.9μg/mL).This new NNRTI conferred low nanomolar inhibition of wild-type HIV-1 strain and tested mutant strains(K103N,L1001,Y181C,E138K,and K103N+Y181C).The analog also demonstrated favorable safety and pharmacokinetic profiles,as evidenced by its insensitivity to CYp and hERG,lack of mortality and pathological damage,and good oral bioavailability in rats(F=27.1%).Further development of 7w for HIV therapy will be facilitated by this valuable information.

关键词： HIV-1 RT NNRTIS ATDp pyridone

prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

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World Journal of Gastroenterology 2021年第31期27卷 5272-5287页

作者： Christian Balamou Akoi Koivogui Christelle M Rodrigue Aurelie clerc Claire piccotti Anne Deloraine Catherine Exbrayat Site de l'Ain Centre Régional de Coordination des Dépistages des Cancers en Auvergne-Rhône-AlpesBourg-en-Bresse 01000France Site de Seine-Saint-Denis Centre Régional de Coordination des Dépistages des Cancers en Ile-de-FranceBondy 93146France Sites Savoie&Haute Savoie Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesChambery 73000France Site de Drome Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesValence 26000France Site Isere&Drome-Ardeche Centre Regional de Coordination des Depistages des Cancers en Auvergne-Rhone-AlpesMeylan 38240France

BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been *** To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening *** This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and December *** between test_((-1))and test_((0))was>1year and test_((-1))result was negative(p between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression *** The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;p=0.001].people with a Fhb_((-1))within(100-150 ngHb/mL)(p=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of *** risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to

关键词： Colorectal cancer screening Fecal immunochemical test Fecal hemoglobin concentration Colorectal lesion severity

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石墨烯柔性纸及其复合材料的制备与性能

石墨烯柔性纸及其复合材料的制备与性能

作者： Germain clerc（热曼）哈尔滨工业大学

学位级别：硕士

本文以平板玻璃为衬底,采用不同浓度的氧化石墨烯(Graphite Oxide,GO)溶液制备了柔性的氧化石墨烯纸,并对其采用热还原的方式得到了不同还原程度的柔性石墨烯纸。采用XRD、SEM、XpS等方式对其进行了结构表征,并对其导电及力学性能分别... 详细信息

本文以平板玻璃为衬底,采用不同浓度的氧化石墨烯(Graphite Oxide,GO)溶液制备了柔性的氧化石墨烯纸,并对其采用热还原的方式得到了不同还原程度的柔性石墨烯纸。采用XRD、SEM、XpS等方式对其进行了结构表征,并对其导电及力学性能分别进行了测试。研究表明,溶液浓度对柔性氧化石墨烯纸的制备具有重要的影响,选择浓度为4.33 mg/ml的GO溶液2.5ml,可以得到质量为9.5mg、厚度为4?m的完整柔性氧化石墨烯纸。SEM观察表明,该氧化石墨烯纸由排列规则的氧化石墨烯片层叠而成,与空气接触的一面具有褶皱起伏的特性,而与玻璃接触的另一面则光滑平整。该氧化石墨烯纸的C/O值为1.43,具有较高的氧化程度。氩气气氛下高温还原实验结果表明,随着还原温度升高,氧化石墨烯纸的XRD衍射峰逐渐消失,当还原温度为1100℃,保温时间1h时,其衍射特征峰已消失,体现了良好的还原特性。力学测试结果表明,柔性石墨烯纸的拉伸强度随还原程度的增加而增加。相比于氧化石墨烯纸的力学性能,杨氏模量16Gpa,拉伸强度26Mpa,石墨烯纸的的性能改善为杨氏模量76Gpa,拉伸强度89Mpa。高温还原的石墨烯纸的电阻率为59.7Ω。采用层叠法制备了石墨纸/pDMS复合材料,其杨氏模量从基体的3.4 Gpa提高到101 Gpa,但拉伸应力有所降低。复合材料的界面润湿及界面结合仍待探讨。

关键词：氧化石墨烯纸热还原石墨烯纸机械性能电学性能

Influence of teeth on the smile and physical attractiveness.A new internet based assessing method

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Open Journal of Stomatology 2013年第1期3卷 52-57页

作者： Yoann Lopez Jérémie Le Rouzic Valérie Bertaud Matthieu pérard Justine Le clerc Jean-Marie Vulcain Faculte d’Odontologie Universite de Rennes 1RennesFrance CHU Rennes Pole d’Odontologie et Chirurgie BuccaleRennesFrance EA 3888 IFR 140Faculte de MédecineUniversite de Rennes 1RennesFrance U6226 CNRSSciences Chimiques de RennesEquipe de Biomatériaux en Site OsseuxRennesFrance

Objectives: Traditional methods for evaluating aesthetic perceptions of the teeth have involved panels of people observing photographs, and the person commenting on the appearance of the teeth generally is aware that his opinion of the dental appearance is being sought. The situation is artificial and may involve bias. We propose a novel method for evaluating the effect of dental imperfections on perceptions in which the participant is unaware of participating in a survey and in which his or her opinion is not sought. Rather, involvement in the study betrays the importance of dental aesthetics for the observer. Methods: Starting with a digitally manipulated photograph of a smiling young woman, two portrait photographs A and B were produced in which the only differences were in the dentition revealed by the smile. The two photographs were anonymously posted on an online dating service site covering two large cities in southwestern France. During a period of one month, all “hits” on each of the photographs and all attempts to make contact were counted. Results: There was no significant difference between the number of hits on each of the portraits A and B. On the other hand, the ratio of attempts to contact to hits showed a clear difference: the ratio was 4.8 times greater for portrait A than for portrait B

关键词： Dental Aesthetics Smile Appearance Communication Internet

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感官隧道

汽车生活 2011年第9期 90-95页

作者： NICOLAS clerc

~~（共6页)

关键词：男士

Identifying High-Risk Medication prescriptions to prevent potentially Severe Adverse Drug Events in primary-Care patients with Chronic Multimorbidities:The polychrome Study

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Journal of pharmacy and pharmacology 2020年第2期8卷 35-43页

作者： pascal clerc Virginie Boyer FranÇoise Haramburu Annie Fourrier-Reglat Julien Le Breton Inserm U955 Universite Paris Est Creteil(UPEC)Institut Mondor de Recherche Biomedicale(IMRB)equipe CEpiA(Clinical Epidemiology and Ageing)CreteilFrance Societe FranÇaise de Medecine Generale SFMG141 avenue de VerdunIssy-Les-Moulineaux92130France Mutualite Sociale Agricole 13 Rue FerrereBordeaux cedex33052France Inserm U 657 Universite Bordeaux Segalen146 rue Leo SaignatBordeaux cedex33076France CIC-p 0005 CHU de BordeauxPlace Amelie Raba LeonBordeaux33000France Departement universitaire de medecine generale Universite Paris Est Creteil8 avenue du General SarrailCreteil 94090France Centre de sante universitaire 2 mail de l'egaliteLa Courneuve 93120France

Background:The association between multimorbidities and polypharmacy among elderly individuals is well documented,and polypharmacy has been shown to increase the risk of adverse drug events(ADEs).However,little information is available about the risks associated with the lifelong use of medications to treat chronic ***:To determine the prevalence and nature of high-risk prescriptions among primary-care patients with chronic ***:We studied a weighted stratified random sample of 105 prescriptions for different patients with chronic multimorbidities taken from the polychrome database established using information from the French primary-care record database(Observatoire de la Médecine Générale).A medication review was conducted to identify contra-indications and potential drug-drug interactions for each ***:Contra-indications were identified for 60(57.1%)prescriptions,potential drug-drug interactions for 70(66.7%),absolute contra-indications for 9(8.6%),and inadvisable drug combinations for 11(10.5%).In all,19(18.1%)different patients were at risk for major *** and nervous-system drugs contributed 66.2% of contra-indications and 69.3% of potential drug-drug ***:This exploratory study confirms the high prevalence and potential seriousness of prescriptions at risk for ADEs in a population of primary-care patients with chronic *** high prevalence of interactions involving the cardiovascular and nervous systems indicates that efforts to improve prescription practices should target these two categories of conditions and drugs in patients with chronic multimorbidities.

关键词： primary care General practice Chronic disease pharmacotherapy management Drug-drug interactions Medication review