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中华医学会第六次全国生殖医学学术会议

作者： p.c.ho Department of Obstetrics and Gynaecology The University of Hong KongPokfulam RoadHong Kong Special Administrative RegionChina

Letrozole is an aromatase inhibitor which inhibits the aromatization of androgens to *** is a drug marketed for the treatment of breast *** has been shown that after administration of letrozole, the serum oestrogen le...

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多囊卵巢综合征

生殖医学杂志 2004年第6期13卷 334-337页

作者：何柏松 p.c.ho 田秦杰香港大学妇产科

在鹿特丹ESHRE/ASRM主办的多囊卵巢综合征 (pcOS)协调会上 ,专家们同意 ,如果妇女有下列三项中的两项即可诊断pcOS :(1)排卵少或不排卵 ;(2 )有高雄激素血症的临床和生化特征 ;(3)超声检查有多囊性卵巢。pcOS确切的病理生理尚不清楚。... 详细信息

在鹿特丹ESHRE/ASRM主办的多囊卵巢综合征 (pcOS)协调会上 ,专家们同意 ,如果妇女有下列三项中的两项即可诊断pcOS :(1)排卵少或不排卵 ;(2 )有高雄激素血症的临床和生化特征 ;(3)超声检查有多囊性卵巢。pcOS确切的病理生理尚不清楚。常见有促性腺激素紊乱导致不排卵和高雄激素血症。近年来 ,有越来越多的证据显示胰岛素抵抗可能在其中起重要的作用。pcOS可能表现有不同的症状 ,包括月经不规律、闭经、多毛或其他高雄激素血症的多种症状和不育。对pcOS患者的处理取决于存在的症状和对生育的要求。有月经不规律的妇女应采用复合口服避孕药或孕激素治疗。合并不育 ,应考虑诱导排卵。如果肥胖 ,应建议减肥。部分妇女在成功减肥后会有排卵 ,减肥也将使诱导排卵药物更为有效。pcOS中诱导排卵的一线药物为克罗米酚 ;如果克罗米酚不能诱导排卵 ,可试用胰岛素增敏剂如二甲双胍加克罗米酚 ;再不排卵 ,应当使用人促性腺激素。pcOS患者通常对促性腺激素非常敏感 ,卵巢过度刺激综合征和多胎妊娠的危险性高。在对克罗米酚无反应的妇女中 ,腹腔镜下卵巢打孔也是有效的。对主要表现多毛 ,有多种药物可以应用如环丙孕酮和安体舒通。有关pcOS长期患者可能合并内膜癌、糖尿病、高血压和心血管疾病的危险。

关键词：多囊卵巢综合征

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超声在辅助生育的应用

生殖医学杂志 2001年第3期10卷 131-134页

作者：何柏松 Department of Obstetrics and Gynaecology University of Hong Kong

超声是现代辅助生育技术中不可缺少的设备。它不仅可以用于治疗前的筛查，还可用于监测卵巢和子宫内膜的反应性，指导取卵及胚胎移植。一、治疗前筛查在治疗前，即卵巢刺激之前超声检查可以评估卵巢及子宫(包括内膜)的情况。它还可发... 详细信息

超声是现代辅助生育技术中不可缺少的设备。它不仅可以用于治疗前的筛查，还可用于监测卵巢和子宫内膜的反应性，指导取卵及胚胎移植。一、治疗前筛查在治疗前，即卵巢刺激之前超声检查可以评估卵巢及子宫(包括内膜)的情况。它还可发现盆腔的疾病。在大多数辅助生育周期中，病人常用促性腺激素释放激素激动剂来降调节。在卵巢刺激前通常进行超声检查，以证实有足够的降调节：即卵泡直径<10 mm，子宫内膜≤4 mm。超声检查还可以发现卵巢的其它病变如子宫内膜息肉、子宫肌瘤、卵巢囊肿和输卵管积水。

关键词：辅助生育技术超声波卵巢子宫内膜取卵胚胎移植

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computational fluid dynamics simulation of the wind flow over an airport terminal building

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Journal of Zhejiang University-Science A(Applied physics & Engineering) 2010年第6期11卷 389-401页

作者： chun-ho LIU Dennis Y.c.LEUNG Alex c.S.MAN p.W.cHAN Department of Mechanical Engineering The University of Hong Kong hong Kong Observatory

Turbulence in the wake generated by wind flow over buildings or obstacles may produce complex flow patterns in downstream *** include the recirculating flow and wind deficit areas behind an airport terminal building and their potential impacts on the aircraft landing on nearby runways.A computational fluid dynamics(cFD) simulation of the wind flow over an airport terminal building was performed in this study of the effect of the building wake on landing *** normal meteorological conditions,the studied airport terminal building causes limited effects on landing aircraft because most of the aircraft have already landed before entering the turbulent wake *** simulating the approach of a tropical cyclone,additional cFD sensitivity tests were performed to study the impacts of building wake under extreme meteorological *** was found that,in a narrow range of prevalent wind directions with wind speeds larger than a certain threshold value,a substantial drop in wind speed(>3.6 m/s) along the glide path of aircraft was observed in the building *** cFD results also showed that under the most critical situation,a drop in wind speed as large as 6.4 m/s occurred right at the touchdown point of landing aircraft on the runway,an effect which may have a significant impact on aircraft *** study indicated that a comprehensive analysis of the potential impacts of building wake on aircraft operations should be carried out for airport terminals and associated buildings in airfields to ensure safe aviation operation under all meteorological conditions and to facilitate implementation of precautionary measures.

关键词： Aviation safety Building aerodynamics computational fluid dynamics (cFD) k-e turbulence model Tropicalcyclone

Luminescent concentrators enable highly efficient and broadband photodetection

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Light(Science & Applications) 2022年第6期11卷 1013-1015页

作者： Wei Wang Johnny c.ho Department of Materials Science and Engineering City University of Hong KongHong Kong SARPR China State Key Laboratory of Terahertz and Millimeter Waves City University of Hong KongHong Kong SARPR China

With luminescent concentrators,the high quantum yield luminescence emitted by embedded chromophores,featuring a broad absorption spectrum,can be well-tuned to match the peak response of integrated *** integration can ... 详细信息

关键词： enable luminescence quantum

Romance of the three domains:how cladistics transformed the classifi cation of cellular organisms

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protein & cell 2013年第9期4卷 664-676页

作者： chi-chun ho Susanna K.p.Lau patrick c.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Research centre of Infection and Immunology The University of Hong KongHong KongChina carol Yu centre of Infection The University of Hong KongHong KongChina

cladistics is a biological philosophy that uses genealogi-cal relationship among species and an inferred sequence of divergence as the basis of classifi *** review critically surveys the chronological development of bio-logical classification from Aristotle through our post-genomic era with a central focus on *** 1957,Julian Huxley coined cladogenesis to denote splitting from *** 1960,the English translation of Willi Hennig’s 1950 work,Systematic phylogenetics,was published,which received strong opposition from phenet-icists,such as numerical taxonomists peter Sneath and Robert Sokal,and evolutionary taxonomist,Ernst Mayr,and sparked acrimonious debates in *** 1977-1990,carl Woese pioneered in using small subunit rRNA gene sequences to delimitate the three domains of cellu-lar life and established major prokaryotic *** has since dominated *** being compatible with modern microbiological observations,*** with unusual phenotypes,restricted expression of charac-teristics and occasionally being uncultivable,increasing recognition of pervasiveness and abundance of horizon-tal gene transfer has challenged relevance and validity of *** mosaic nature of eukaryotic and prokary-otic genomes was also gradually *** the mid-2000s,high-throughput and whole-genome sequencing became routine and complex geneologies of organisms have led to the proposal of a reticulated web of *** genomics only indirectly leads to understanding of func-tional adaptations to ecological niches,computational modeling of entire organisms is underway and the gap between genomics and phenetics may soon be *** are not expected to settle as taxonomic classifi cations shall remain subjective to serve the human scientist,not the classifi ed.

关键词： cladistics phenetics phylogeny classifi ca-tion evolution

Numerical study on the ozone formation inside street canyons using a chemistry box model

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Journal of Environmental Sciences 2008年第7期20卷 832-837页

作者： chun-ho Liu Dennis Y.c.Leung Department of Mechanical Engineering The University of Hong KongHong Kong.

Tropospheric ozone is a secondary air pollutant produced in the presence of nitrogen oxides (NO_x),volatile organic compounds (VOcs),and solar *** an urban environment,ground-level vehicular exhaust is the major anthropogenic source of ozone *** the cases of street canyons,pollutant dilution is weakened by the surrounding buildings that creates localized high concentration of NO_x and VOcs,and thus leads to high potential of ozone *** considering the major physical and chemical p...

关键词： volatile organic compounds VOcs-to-NO_x ratio air quality vehicular emission chemistry box model

Formulation optimization of scutellarin-loaded Hp-β-cD/chitosan nanoparticles using response surface methodology with Box–Behnken design

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Asian Journal of pharmaceutical Sciences 2017年第4期12卷 378-385页

作者： Shanshan Liu paul c.ho National University of Singapore

The aim of this paper is to investigate and optimize the preparation of scutellarin(ScU)-loaded Hp-β-cD/chitosan(cS) nanoparticles(cD/cS-ScU-Nps). cD/cS-ScU-Nps were prepared by ionic cross-linking method and the process and formulation variables were optimized using response surface methodology(RSM) with a three-level, three factor Box–Behnken design(BBD).The independent variables were the added amounts of cS, sodium tripolyphosphate(Tpp)and pluronic F-68 during the preparation. Dependent variables(responses) were particle size and entrapment efficiency. Mathematical equations and respond surface plots were used to correlate independent and dependent *** preparation process and formulation variables were optimized to achieve minimum particle size and maximum entrapment efficiency by calculating the overall desirability value(OD). The optimized Np formulation was characterized for particle size, pDI, zeta potential, entrapment efficiency and in vitro drug *** to the results, an optimized cD/cS-ScU-Np formulation was prepared. Results for particle size, pDI, zeta potential and entrapment efficiency were found to be around 200 nm,0.5, 25 mV, and 70% respectively. For in vitro study, the release of ScU from the Nps exhibited a biphasic release and was in accordance with Higuchi equation. The optimized preparation was simple with the probability for industrialization. The combination use of RSM, BBD and overall desirability values could provide a promising application for incorporating cD into cS nanoparticles as drug delivery carrier and help develop lab-scale procedures.

关键词： Scutellarin Response surface methodology Box–Behnken design chitosan Hp-β-cD Nanoparticles

Minimal observability of Boolean networks

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Science china(Information Sciences) 2022年第5期65卷 157-168页

作者： Yang LIU Jie ZhoNG Daniel W.c.ho Weihua GUI college of Mathematics and computer Science Zhejiang Normal University Department of Mathematics City University of Hong Kong School of Information Science and Engineering Central South University

In this study, the minimum observability of Boolean networks(BNs) is investigated by using the semi-tensor product(STp) of matrices. First, a new system based on the considered BN is obtained to analyze states pair dynamic trajectories, from which a necessary and sufficient condition for the observability of BNs is determined. Second, adding a new observer improves the observability without affecting the observable states. Thus, an algorithm is presented to design an observer for an unobservable BN. In addition, a necessary condition is obtained to determine the minimum number of nodes required to be directly measurable. Further,an algorithm to address the minimal observability is presented. Finally, examples are provided to demonstrate the effectiveness of the obtained results.

关键词： Boolean networks minimal observability semi-tensor product

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