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surgery for Crohn’s disease:upfront or last resort?

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Gastroenterology Report 2022年第1期10卷 188-194页

作者： U.Ahmed Ali Ravi p.kiran Division of Colorectal surgery New York–Presbyterian/Columbia University Medical CenterNew YorkUSA

Crohn’s disease(CD)can involve the entire gastrointestinal tract from the mouth to the anus and can lead to a constellation of symptoms.With the advancement of effective medical treatments for CD,a tendency has emerged to consider surgical treatment as a last resort.This potentially has the disadvantage of delaying surgery and if it fails might leave patients sicker,less well nourished,and with more severe complications.As with most non-malignant diseases,the choice of surgery vs medical treatment is a patient’s personal preference under the guidance of the treating physician,except in extreme situations where surgery might be the only option.In this article,we will discuss the available evidence regarding the optimal timing of surgery in CD,focusing on whether early surgery can bring benefits in terms of disease control,symptom relief,and quality of life.

关键词： surgery timing Crohn’s disease outcome

Throughflow and g-jitter effects on binary fluid saturated porous medium

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Applied Mathematics and Mechanics(English Edition) 2015年第10期36卷 1285-1304页

作者： p.kiran Department of Applied Mathematics School for Physical Sciences Babasaheb Bhimrao Ambedkar University

A non-autonomous complex Ginzburg-Landau equation （CGLE） for the finite amplitude of convection is derived, and a method is presented here to determine the amplitude of this convection with a weakly nonlinear thermal instability for an oscillatory mode under throughflow and gravity modulation. Only infinitesimal disturbances are considered. The disturbances in velocity, temperature, and solutal fields are treated by a perturbation expansion in powers of the amplitude of the applied gravity field. Throughfiow can stabilize or destabilize the system for stress free and isothermal boundary conditions. The Nusselt and sherwood numbers are obtained numerically to present the results of heat and mass transfer. It is found that throughfiow and gravity modulation can be used alternately to heat and mass transfer. Further, oscillatory flow, rather than stationary flow, enhances heat and mass transfer.

关键词： weakly nonlinear theory throughflow complex Ginzburg-Landau equation（CGLE） gravity modulation

performance analysis of multiple gain boost converter with hybrid maximum power point tracker for solar pV connected to grid

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Clean Energy 2021年第4期5卷 655-672页

作者： b.M.kiran Kumar M.s.Indira s.Nagaraja Rao M s Ramaiah University of Applied sciences Department of Electrical EngineeringBangaloreIndia-560058

This paper analyses the performance of a multiple gain boost converter(MGbC)connected to a solar photovoltaic(spV)system with a grid-tied inverter.The capacitor inductor capacitor(CLC)-based MGbC is integrated to lift the output voltage of the spV to the required level.The voltage lifts/levels in a boost converter(bC)are based on the number of CLC cells.The suggested MGbC is compared with various conventional bCs in terms of boost factor and component count.A hybrid fuzzy logic-perturb&observe maximum power point tracker(HFL-p&O MppT)developed is used to monitor p_(max)(maximum power)generated by the spV.Also,a comparative analysis of the suggested MppT with a conventional p&O and fuzzy logic-based(FLb)MppT for a CLC-based MGbC is presented.The comparison is made in terms of rise time,voltage ripples(%),steady-state time and boost factor.The output characteristics of the developed model for different irradiation conditions are analysed using the MATLAb/simulink tool.The MppT simulation result exhibits minimum oscillations at Mpp and a significantly better rise time of 0.015 s when compared with a conventional MppT and FLb MppT.The proposed CLC-MGbC gives an appreciable boost factor of 4.The generated spV power is supplied to the grid through a conventional inverter and synchronized using a phase-locked loop system.The total harmonic distortion of 1.66%obtained in the output current of the inverter is within the permissible range of the IEEE standards.

关键词： CLC-MGbC FLb MppT Grid-tie inverter spV THD

A Two-stage Kalman Filter for Cyber-attack Detection in Automatic Generation Control system

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Journal of Modern power systems and Clean Energy 2022年第1期10卷 50-59页

作者： Ayyarao s.L.V.Tummala Ravi kiran Inapakurthi GMR Institute of Technology RajamSrikakulamAndhra PradeshIndia Raghu Engineering College DakamarriVisakhapatnamAndhra PradeshIndia

Communication plays a vital role in incorporating smartness into the interconnected power system.However,historical records prove that the data transfer has always been vulnerable to cyber-attacks.Unless these cyber-attacks are identified and cordoned off,they may lead to black-out and result in national security issues.This paper proposes an optimal two-stage Kalman filter(OTs-KF)for simultaneous state and cyber-attack estimation in automatic generation control(AGC)system.biases/cyber-attacks are modeled as unknown inputs in the AGC dynamics.Five types of cyber-attacks,i.e.,false data injection(FDI),data replay attack,denial of service(Dos),scaling,and ramp attacks,are injected into the measurements and estimated using OTs-KF.As the load variations of each area are seldom available,OTs-KF is reformulated to estimate the states and outliers along with the load variations of the system.The proposed technique is validated on the benchmark two-area,three-area,and five-area power system models.The simulation results under various test conditions demonstrate the efficacy of the proposed filter.

关键词： Cyber-security automatic generation control(AGC) load frequency control false data injection cyber-attack detection

Development of artificial neural network to predict the performance of spark ignition engine fuelled with waste pomegranate ethanol blends

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Information processing in Agriculture 2023年第4期10卷 459-474页

作者： D.Y.Dhande C.s.Choudhari D.p.Gaikwad kiran b.Dahe Department of Mechanical Engineering AISSMS College of EngineeringPuneMaharashtra State 411001India Department of Computer Engineering AISSMS College of EngineeringPuneMaharashtra State 411001India

In this study,an artificial neural network(ANN)is developed to predict the performance of a spark-ignition engine using waste pomegranate ethanol blends.A series of experiments on a single-cylinder,four-stroke spark-ignition engine yielded the data needed for neural network training and validation.70 percent of the experimental data was used to train the network using the feed-forward back propagation(FFbp)algorithm.The developed network model’s performance was evaluated by contrasting its output with experimental results.Input parameters included engine speed,ethanol blends,and output parameters included indicated and brake power,thermal,volumetric,and mechanical efficiencies.Training and testing data had regression coefficients that were almost identical to one.The research revealed that the ANN model can be a better option for predicting engine performance with a higher level of accuracy.

关键词： ANN biofuel pomegranate ethanol solid waste management spark ignition engine performance

Interleaved high-gain boost converter powered by solar energy using hybrid-based Mpp tracking technique

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Clean Energy 2022年第3期6卷 460-475页

作者： s.Nagaraja Rao suresh Kumar Anisetty b.M.Manjunatha b.M.kiran Kumar V.praveen Kumar s.pranupa Ms Ramaiah University of Applied sciences Department of Electrical EngineeringBangaloreIndia RGM College of Engineering and Technology(Autonomous) NandyalIndia

This paper presents a solar-powered interleaved high-gain boost converter(IHGbC)that increases voltage gain with fewer ripples in the output voltage in comparison to existing DC-DC converters.The goal of this research is to develop a hybrid-based maximum power point tracking(MppT)approach with the combination of a flower pollination(Fp)algorithm assisted with a perturb&observe(p&O)MppT approach for solar photovoltaic(spV)systems integrated with IHGbC.To ensure effective usage of both Fp and p&O algorithms,this study incorporates and validates the hybrid-based MppT approach.The proposed solar-powered IHGbC with a hybrid-based MppT algorithm has been computationally modelled and simulated using MATLAb®and simulink®for both uniform and non-uniform irradiation and analysed for voltage gain,ripples in the output waveforms and convergence time.The proposed hybrid-based MppT is based on a number of flowers that forecast the initial global peak,assisted by p&O in the last stage for faster convergence to attain the maximum power point(Mpp).As a result,the hybrid-based MppT approach alleviates the computational issues encountered in p&O and Fp-based Mpp approaches.The proposed hybrid MppT is compared with conventional MppT for spV and the results show that the solar-powered IHGbC using a hybrid-based MppT technique has negligible oscillations of 0.14%with a high-voltage gain of 7.992 and a fast convergence rate of 0.05 seconds compared to individual p&O-based MppT and Fp-based MppT techniques.The simulation results of the proposed MppT with IHGbC outperform the conventional MppT with high-gain converters.

关键词： flower pollination interleaved high-gain boost converter maximum power point tracking technique perturb&observe solar photovoltaic

Investigation of antioxidant and anti-inflammatory activity of leaves of Dalbergia paniculata(Roxb)

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Asian pacific Journal of Tropical Medicine 2012年第6期5卷 455-458页

作者： Ganga Rao b Madhu kiran p Vijaya Raju AD pharmacognosy and phytochemistry A.U College of Pharmaceutical SciencesAndhra UniversityVisakhapatnamA.P.India-530 003 A.U College of pharmaceutical sciences Andhra UniversityVisakhapatnamA.PIndia-530 003

Objective:To investigate the antioxidant and anti-inflammatory activity of orally administered methanolic leaf extract of Dalbergia paniculala(D.paniculata) in Carrageenan induced inflammation in rats.Methods:In vitro antioxidant activity was evaluated for superoxide radical, Hydroxyl radical and DppH radical scavenging activity.Three doses 200 mg/kg,400 mg/kg and 800 mg/kg of D.paniculala were tested for anti-inflammatory activity in Carrageenan induced rat paw edema model and paw thickness was measured every one hour up to 6 h. Results:The melhanolic leaf extract of D.paniculala produced dose dependent inhibition of superoxide radical,Hydroxyl radical and OppH radicals.In Carrageenan induced inflammation model,all three doses produced significant percentage inhibition of rat paw edema and 800 mg/kg dose produced maximum percent inhibition of rat paw edema(47.83%) at 3h compared to control group.Conclusions:In the present study we found that methanolic leaf extract of D.paniculata showed good in vitro antioxidant activity and in vivo anti-inflammatory activity in rats.

关键词： Anti-inflammatory activity Antioxidant activity Dalbergia paniculata Free radicals Carragenan Inflammation Edema

Investigation of hepatoprotective activity of Cyathea gigantea(Wall.ex.Hook.)leaves against paracetamol-induced hepatotoxicity in rats

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Asian pacific Journal of Tropical biomedicine 2012年第5期2卷 352-356页

作者： p Madhu kiran A Vijaya Raju b Ganga Rao A.U College of pharmaceutical sciences Andhra University

Objective:To investigate the hepatoprotective activity of methanolic leaf extract of Cyathea gigantea(C.gigantea)against paracetamol induced liver damage in rats.Methods:The hepatoprotective activity for plant extract was investigated for paracetamol induced hepatoxicity in rats.Wislar albino rats of either sex were divided into five groups of 6 animals each and are given orally the following treatment for seven days.The normal control group was given 1%Na.CMC 1mL/kg bw,p.o.paracetamol at dose of 1g/kg bw,p.***.was given as toxic dose for inducing hepatoloxicity.silymarin(50mg/kg.p.o.) was given as reference standard.Two doses of C. gigantea extract i.e.,100 mg/kg.***.o.and 200 mg/kg,p.***.were tested for hepatoprotective activity. The treatment was given for seven days and after 24 h of last treatment blood was collected from retro-orbital plexus and analysed for various serum parameters like serum glutamic-oxaloacetic transaminase(sGOT),serum glutamic pyruvic transaminase(sGpT),alkaline phosphatase(ALp),total bilirubin(Tb)and total protein(Tp)in different groups.Results:The paracetamol intoxication lead to histological and biochemical deteriorations.The treatment with methanolic leaf extract of C.gigantea reduced the elevated levels of sCOT,sGpT,ALp,Tb and also reversed the hepatic damage towards normal which further supports the hepatoprotective activity of leaf extract of C.gigantea.Conclusions:The methanolic extract of leaves of C.gigantea at doses of 100 mg/kg bw and 200 mg/kg bw have significant effect on liver of paracetamol induced hepatotoxicity model in rats.

关键词： Hepatoprotective Cyathea gigantea paracetamol silymarin Hepatotoxicity

Lactobionic Acid as a New synergist in Combination with phosphonate-Zn(Ⅱ)system for Corrosion Inhibition of Carbon steel

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Journal of Materials science & Technology 2014年第1期30卷 77-89页

作者： s.srinivasa Rao b.V.Appa Rao s.Roopas kiran b.sreedhar Department of Chemistry V.R.Siddhartha Engineering College(Autonomous) Department of Chemistry National Institute of Technology Warangal(NITW) INFN Sezione di Padova Inorganic & physical Chemistry Division Indian Institute of Chemical Technology(IICT)

studies on lactobionic acid introduced as a synergist in the presence of phosphonobutane-1,2,4-tricarboxylic acid （pbTC） and zinc ions for corrosion control of carbon steel in aqueous environment are presented. The investigations revealed that lactobionic acid （LbA） acts as an excellent synergist in corrosion inhibition. Optimum concentrations of all the three components of the ternary formulation are established by gravimetric studies. potentiodynamic polarization studies indicate that the new ternary system is a mixed inhibitor. Impedance studies show that a protective film is formed on the metal surface in the presence of the inhibitor formulation. The film is found to exhibit its protective nature even at higher temperatures up to 60 ~C. Analysis of the protective film by X-ray photoelectron spectroscopy （Xps） and reflection absorption Fourier transform infrared （FTIR） spectroscopy infers the presence of Zn（OH）2, oxides and hydroxides of iron and the inhibitor molecules in the surface film probably in the form of a complex, [Zn（II）-pbTC-LbA]. The morphological studies by scanning electron microscopy （sEM） and the topographical studies by atomic force microscopy （AFM） also indicate the presence of protective film on the metal surface. A plausible mechanism of corrosion inhibition is proposed.

关键词： Corrosion inhibitor Carbon steel synergism X-ray photoelectron spectroscopy Electrochemical impedance spectroscopy