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Modeling lateral placement and movement of vehicles on urban undivided roads in mixed traf?c:A case study of India

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 860-873页

作者： punith BKotagi pooja Raj Gowri asaithambi Department of Civil Engineering The National Institute of Engineering MysuruMysuru 570008India Department of Civil Engineering National Institute of Technology KarnatakaMangalore 575025India Department of Civil and Environmental Engineering Indian Institute of Technology TirupatiTirupati 517506India

In India,the majority of urban roads are undivided where the behavior of flows in a particular direction is predominantly influenced by the opposing *** to lack of lane segregation,the vehicles in ongoing direction occupy the opposing lane,which increases the lateral interactions between *** lateral interactions are influenced by various parameters such as vehicle types,driver behavior and vehicular *** of such complex interactions plays an important role in evaluating various management measures using microscopic simulation *** lateral characteristics of vehicles,such as placement,separation and movement,act as necessary input for simulation *** present study aims to analyze and model the lateral characteristics of vehicles on two-lane urban undivided *** achieve this,traffic flow data were collected from an urban undivided mid-block section in Bangalore City,India,using video graphic *** linear regression model was developed for predicting the lateral placement of subject vehicle and it was found that lateral placement of subject vehicle is influenced by types and speeds of subject and opposing *** separation for different types of ongoing(subject)and opposing pairs was also *** results show that both the ongoing and opposing vehicles have less freedom to move laterally when their sizes increase and hence,lateral separation *** choice of path of vehicles’lateral shifts(left,current and right)on urban undivided roads was modeled using multinomial logistic *** shift of a vehicle is influenced by speeds of subject vehicle and leader vehicle in current path,speed of leader vehicle in target path,and lateral gap between leader vehicles in current path and target path.

关键词： Transportation Urban undivided road Mixed traffic Lateral placement Lateral separation Lateral movement

Overtaking behaviour of vehicles on undivided roads in non-lane based mixed traffic conditions

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第3期4卷 252-261页

作者： Gowri asaithambi Gugulothu Shravani Department of Civil Engineering National Institute of Technology Karnataka Mangalore 575025 India

Traffic on Indian roads is highly mixed in nature with wide variations in the static and dynamic characteristics of vehicles. These vehicles do not follow strict lane discipline and occupy any available lateral position on the road space. Overtaking is one of the most complex and important manoeuvre on undivided roads where the vehicles use the opposing lane to overtake the slower vehicles with the presence of oncoming vehicles from opposite direction. They are unavoidable especially in the case of mixed traffic conditions where there is always a speed difference between the fast and slow moving vehicles. Overtaking process involves lane-changing manoeuvres, acceleration and deceleration actions and estimation of relative speed of overtaking and overtaken vehicles, and also, estimation of speed and distance of the oncoming vehicle. The main objective of the present study is to study the overtaking characteristics of vehicles on undivided roads under mixed traffic conditions. For this purpose, details of overtaking data were collected on a two-lane two-way undivided road using moving car observer method and registration plate method. The overtaking characteristics of all types of vehicles under mixed traffic conditions were observed and mathematically modelled. The data extracted and analysed were the acceleration characteristics, speeds of the overtaking vehicles, overtaking time, overtaking distances, safe opposing gap required for overtaking, flow rates, overtaking frequencies, types of overtaking strategy, and types of overtaking and overtaken vehicles. Two types of overtaking strategies were observed in the field such as flying overtaking and accelerative overtaking. Graphs were plotted between the relative speed of the overtaking and overtaken vehicles against the overtaking time and negative correlation was found between the speed differential and total overtaking time for all categories of vehicles. It was observed that the number of overtaking increases wit

关键词： Overtaking behaviour Mixed traffic Non-lane discipline Undivided roads

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Analysis of occupation time of vehicles at urban unsignalized intersections in non-lane-based mixed traffic conditions

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Journal of Modern Transportation 2016年第4期24卷 304-313页

作者： Gowri asaithambi Chepuru Anuroop Department of Civil Engineering National Institute of Technology Karnataka

In India, traffic flow on roads is highly mixed in nature with wide variations in the static and dynamic characteristics of vehicles. At unsignalized intersections, vehicles generally do not follow lane discipline and ignore the rules of priority. Drivers generally become more aggressive and tend to cross the uncontrolled intersections without considering the conflicting traffic. All these conditions cause a very complex traffic situation at unsignal- ized intersections which have a great impact on the capacity and performance of traffic intersections. A new method called additive conflict flow （ACF） method is suitable to determine the capacity of unsignalized inter- sections in non-lane-based mixed traffic conditions as prevailing in India. Occupation time is the key parameter for ACF method, which is defined as the time spent by a vehicle in the conflict area at the intersection. Data for this study were collected at two three-legged unsignalized intersections （one is uncontrolled and other one is semi- controlled） in Mangalore city, India using video-graphic technique during peak periods on three consecutive week days. The occupation time of vehicles at these intersections were studied and compared. The data on conflicting traffic volume and occupation time by each subject vehicle at the conflict area were extracted from the videos using image processing software. The subject vehicles were divided into three categories： two wheelers,cars, and auto-rickshaws. Mathematical relationships were developed to relate the occupation time of different cate- gories of vehicles with the conflicting flow of vehicles for various movements at both the intersections. It was found that occupation time increases with the increasing con- flicting traffic and observed to be higher at the uncontrolled intersection compared to the semicontrolled intersec- tion. The segregated turning movements and the presence of mini roundabout at the semicontrolled intersection reduces the confli

关键词： Occupation time Conflicting flow Unsignalized intersection Conflict area Mixed traffic Uncontrolled intersection Semicontrolled intersection

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Venous thromboembolism among Medicare acute ischaemic stroke patients with and without COVID-19

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Stroke & Vascular Neurology 2023年第3期8卷 259-262,I0111页

作者： Xin Tong Quanhe Yang Ganesh asaithambi Robert K Merritt Division for Heart Disease and Stroke prevention National Center for Chronic Disease Prevention and Health PromotionCenters for Disease Control and PreventionAtlantaGeorgiaUSA Department of Neurosciences United HospitalSaint PaulMinnesotaUSA

background COVID-19 is associated with an increased risk of venous thromboembolism(VTE).This study examined the prevalence of VTE among acute ischaemic stroke(AIS)patients with and without a history of *** We identified AIS hospitalisations of Medicare fee-for-service(FFS)beneficiaries aged≥65 years from 1 April 2020 to 31 March *** compared the prevalence and adjusted prevalence ratio of VTE among AIS patients with and without a history of *** Among 283034 Medicare FFS beneficiaries with AIS hospitalisations,the prevalence of VTE was 4.51%,2.96%and 2.61%among those with a history of hospitalised COVID-19,non-hospitalised COVID-19 and without COVID-19,*** compared with patients without a history of COVID-19,the prevalence of VTE among patients with a history of hospitalised or non-hospitalised COVID-19 were 1.62(95%CI 1.54 to 1.70)and 1.13(95%CI 1.03 to 1.23)times greater,*** There appeared to be a notably higher prevalence of VTE among Medicare beneficiaries with AIS accompanied by a current or prior *** recognition of coagulation abnormalities and appropriate interventions may help improve patients’clinical outcomes.

关键词： patients Medicare prevalence

Adding new dimension to non-directed C（sp3）–H functionalizations

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Science China Chemistry 2025年

作者： Konstantin p.Bryliakov Laboratory of Selective Oxidation Catalysis N.D.Zelinsky Institute of Organic Chemistry RAS

Aliphatic C–H groups are among the most abundant yet least reactive functional groups in organic molecules. Nature has evolved metalloenzymes such as those of the cytochrome p450 superfamily that efficiently activate individual tertiary（3） and secondary （2） C（sp3）–H bonds in complex molecules with the highest level of regio-and stereoselectivity [1], thus encouraging studies aimed at engineering artificial metalloenzymes for synthetic applications [2].

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SpAST spastin