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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven p.Hooker Humberto parada jr. John Bellettiere Arun Kumar Herbert Wertheim School of public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness prediction algorithms Epidemiology Mortality

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EFFECT OF IMpURITIES ON THE DIELECTRIC pROpERTIES OF OLEIC ACID

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Journal of Advanced Dielectrics 2012年第3期2卷 47-54页

作者： F.F.DE SOUSA p.T.C.FREIRE J.MENDES FILHO A.C.OLIVEIRA E.LONGHINOTTI p.H.M.DE VASCONCELOS G.D.SARAIVA S.G.C.MOREIRA p.alcantara jr. Faculdade de Cincias Exatas e Naturais Universidade Federal do para CEP 68.507-970 Maraba-PABrazil Departamento de Fisica Universidade Federal do Ceara CEP 60.455-760Fortaleza-CEBrazil Universidade Federal do Ceara Campus do pici-Bloco 940 Langmuir Lab.de Adsorcao e Catalise CEp 60.000-000 Fortaleza-CEBrazil Faculdade de Educacao Ciencias e Letras do Sertao Central Universidade Estadual do Ceara CEP 63.900-000 Quixada-CEBrazil Faculdade de Fisica Universidade Federal do Para CEP 66.075-110Belem-PABrazil

Temperature dependence of the dielectric constant of oleic acid with different degrees of puritywas measured in the 233-313 K *** was observed that the presence of impurities(palmiticand linolenic acids)strongly influences the dielectric constant,melting point and dipole moment of the oleic *** values of apparent dipole moment and the Kirkwood correlation parameterswere evaluated using the Kirkwood's model and were estimated to be about 1.20,1.61 and 2.27 D,respectively for 60,90 and 97 wt%oleic acid.

关键词： Oleic acid dielectric properties fatty acids Kirkwood's theory.

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Legume Green Manure and Intercropping for High Biomass Sorghum production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely Francis M. Rouquette jr. Cristine L. S. Morgan Frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor L.) production systems on a Lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [Cynodon dactylon (L.) pers.] pasture. In this split-split plot design, ‘Dixie’ crimson clover (Trifolium incarnatum L.) and ‘Iron and Clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, C concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOC). Main plots were split into crimson clover green manure (CLGM) and winter fallow (FALL) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (CpGM), cowpea-sorghum intercrop (CpSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The CLGM increased (p sorghum biomass yield (16.5 t DM∙ha−1) 28% in year three but had no effect in the first two years. The CpSR treatment reduced sorghum yield up to 62% compared to SORG;whereas CpGM increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. Decrease in SOC and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. Cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-Biomass Sorghum Legumes Green Manure Intercrop Cowpea Crimson Clover Soil Organic Carbon Soil Nitrogen

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Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra pereira Leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro jr.Marcus Fernando Kodama pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(pD-1/pD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,pD-L1 can express differently between metastatic sites and primary tumors(pT).AIM To compare pD-L1 status in pT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the pD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone Sp142)using the com-bined positive *** pD-L1+pT staged as pN+were also tested for pD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had pD-L1+pT and 24 of them had pN+.For comparison,44 pD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the pD-L1+pT,54.2%(13/24 cases)were also pD-L1+in the *** pD-L1(-)pT,9.1%(4/44)had pD-L1+in the *** agreement between pT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with pD-L1 positivity in both *** was no statistical difference in overall survival for pT and LNM according to the pD-L1 status(p=0.166 and p=0.837,respectively).CONCLUSION Intra-patient heterogeneity in pD-L1 expression was observed between the pT and matched *** disagreement in pD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

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The paleoarchean Northern Mundo Novo Greenstone Belt,São Francisco Craton:Geochemistry,U-pb-Hf-O in zircon and pyriteδ^(34)S-Δ^(33)S-Δ^(36)S signatures

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Geoscience Frontiers 2022年第5期13卷 190-206页

作者： Guilherme S.Teles Farid Chemale jr. Janaína N.Ávila Trevor R.Ireland Unidade Acadêmica de Mineração e Geologia Universidade Federal de Campina GrandeCampina GrandeBrazil programa de pós-Graduação em Geologia Universidade de BrasíliaBrasíliaBrazil programa de pós-Graduação em Geologia Universidade do Vale do Rio dos SinosSão LeopoldoBrazil Research School of Earth Sciences The Australian National UniversityCanberraACT 2601Australia Griffith Centre for Social and Cultural Research Griffith UniversityNathanQueensland 4111Australia

Greenstone belts contain several clues about the evolutionary history of primitive ***,we describe the volcano-sedimentary rock association exposed along the eastern margin of the Gavião Block,named the Northern Mundo Novo Greenstone Belt(N-MNGB),and present data collected with different techniques,including U–pb–Hf–O isotopes of zircon and multiple sulfur isotopes(^(32)S,^(33)S,^(34)S,and ^(36)S)of pyrite from this supracrustal sequence.A pillowed metabasalt situated in the upper section of the N-MNGB is 3337±25 Ma old and has zircon with ε_(Hf)(t)=2.47 to1.40,Hf model ages between 3.75 Ga and 3.82 Ga,and δ^(18)O=+3.6‰to+7.3‰.These isotopic data,together with compiled whole-rock trace element data,suggest that the mafic metavolcanic rocks formed in a subduction-related setting,likely a back-arc basin juxtaposed to a continental *** this context,the magma interacted with older Eoarchean crustal components from the Gavião *** zircons from the overlying quartzites of the Jacobina Group are sourced from paleoarchean rocks,in accordance with previous studies,yielding a maximum depositional age of 3353±22 *** detrital zircons have ε_(Hf)(t)=5.40 to0.84,Hf model ages between 3.66 Ga and 4.30 Ga,and δ^(18)O=+4.8‰to+6.4‰.The pyrite multiple sulfur isotope investigation of the 3.3 Ga supracrustal rocks from the N-MNGB enabled a further understanding of paleoarchean sulfur *** samples have diverse isotopic compositions that indicate sulfur sourced from distinct ***,they preserve the signal of the anoxic Archean atmosphere,expressed by MIF-S signatures(Δ^(33)S between1.3‰to+1.4‰)and a Δ^(36)S/Δ^(33)S slope of0.81 that is indistinguishable from the so-called Archean array.A BIF sample has a magmatic origin of sulfur,as indicated by the limited Δ^(34)S range(0 to+2‰),Δ^(33)S~0‰,and Δ^(36)S~0‰.A carbonaceous schist shows positive Δ^(34)S(2.1‰–3.5‰)and elevated Δ^(33)S(1.2‰–1.4‰)values,with corresponding negative Δ^(36)S

关键词： Northern Mundo Novo Greenstone Belt Multiple sulfur isotopes Geochronology paleoarchean Gavião Block São Francisco Craton

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脑瘫髋关节的定期监控和及时手术预防疼痛性髋脱位

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中华骨科杂志 2023年第9期43卷 605-612页

作者：刘海清 David p.Roye jr. 李旭汕头大学广州华新骨科医院广州510630

脑瘫是最常见的发病于儿童期而机体功能受损影响终身的神经肌肉系统疾患,新生儿发病率约为1/500,目前全世界约有1700万脑瘫患者。脑瘫并不特指某个具体疾病,而是指发育中的胎儿或婴幼儿遭受非进展性脑损伤引发运动发育和姿势控制的永久... 详细信息

脑瘫是最常见的发病于儿童期而机体功能受损影响终身的神经肌肉系统疾患,新生儿发病率约为1/500,目前全世界约有1700万脑瘫患者。脑瘫并不特指某个具体疾病,而是指发育中的胎儿或婴幼儿遭受非进展性脑损伤引发运动发育和姿势控制的永久性异常而导致机体活动受限的一组临床症候群。脑瘫可引发诸多肢体畸形,其中髋关节移位是常见的畸形之一,发生比例仅次于马蹄足。本文回顾文献并总结归纳脑瘫髋关节移位的病理生理机制、临床症状、与大运动功能分级的关系及骨科相关治疗。脑瘫髋关节移位主要是由于早期缺乏正常应力刺激及髋关节周围持续的不对称性肌力牵拉所致。髋关节移位早期常无症状,但若不及时治疗会逐渐出现髋关节半脱位或脱位,导致髋关节疼痛和活动受限,从而影响患者活动能力和增加日常护理难度。脑瘫髋移位与大运动功能分级密切相关,大运动分级越高髋移位风险越大,而通过髋关节监控可明显减少髋关节脱位的发生率。因此,建立规范的脑瘫髋关节监控流程、及时干预、防止髋脱位和疼痛的出现是国内外学者的共识。目前脑瘫髋关节移位的手术治疗主要分为三类:预防性手术、重建性手术和姑息性手术。

关键词：脑性瘫痪髋关节关节脱位早期医疗干预

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Near-infrared electroluminescence of AlGaN capped InGaN quantum dots formed by controlled growth on photoelectrochemical etched quantum dot templates

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photonics Research 2022年第1期10卷 33-40页

作者： XIONGLIANG WEI SYED AHMED AL MUYEED HAOTIAN XUE ELIA pALMESE RENBO SONG NELSON TANSU JONATHAN J.WIERER,jr. Center for photonics and Nanoelectronics Department of Electrical and Computer EngineeringLehigh UniversityBethlehemPennsylvania 18015USA School of Electrical and Electronic Engineering The University of AdelaideAdelaideSA 5005Australia Institute for photonics and Advanced Sensing The University of AdelaideAdelaideSA 5005Australia

Near-infrared electroluminescence of InGaN quantum dots(QDs)formed by controlled growth on photoelectrochemical(pEC)etched QD templates is *** QD template consists of pEC InGaN QDs with high density and controlled sizes,an AlGaN capping layer to protect the QDs,and a GaN barrier layer to planarize the *** transmission electron microscopy(STEM)of Stranski-Krastanov(SK)growth on the QD template shows high-In-content InGaN QDs that align vertically to the pEC QDs due to localized strain.A highAl-content A1_(0.9)Ga_(0.1)N capping layer prevents the collapse of the SK QDs due to intermixing or decomposition during higher temperature GaN growth as verified by *** of low-temperature(830℃)p-type layers is used to complete the p-n junction and further ensure QD ***,electroluminescence shows a significant wavelength shift(800 nm to 500 nm),caused by the SK QDs’tall height,high In content,and strong polarization-induced electric fields.

关键词： AlGaN polarization template

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New Approach to the Strain Analysis of Bragg Grating Sensors

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photonic Sensors 2013年第1期3卷 74-80页

作者： José R. Alves da CUNHA petrus alcantara jr. Angela Santa BRJGIDA Gilvan BORGES Joāo Weyl COSTA programa de pós-Graduacāo em Fisica Universidade Federal do Pará Belém 66075-11 O Brazil programa de pós Graduacāo em Engenharia Elétrica Universidade Federal do Pará Belém 66075-11 O Brazil

The response of an optical strain sensor based on the fiber Bragg grating is theoretically analyzed with a different approach of that found usually in the literature. In this model, geometrical changes suffered by the grating itself are taken into account. The results are compared with those from experiments, showing very good agreement.

关键词：布拉格光栅传感器应变分析光纤布拉格光栅应变传感器比较实验显示效果

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CBASp Adapted to Child play Therapy Structure to prevent Early-Onset persistent Depressive Disorder

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Open Journal of psychiatry 2022年第1期12卷 53-72页

作者： James p. McCullough jr. Kara Elizabeth Burr Department of psychology Virginia Commonwealth University Henrico VA USA Restoration Clinic Fort Worth TX USA

The current paper is a theoretical proposal that interfaces the Cognitive Behavioral Analysis System of psychotherapy (CBASp) and its emphasis on interpersonal consequences with the structured order of a play Therapy Model for troubled 3 - 8-year-old children. This proposal is not a research paper or a review of literature;instead, it is a treatment proposal that is novel and untested. CBASp psychotherapy, an empirically validated treatment, was developed originally to treat the persistently depressed adult. CBASp’s major focus of interpersonal consequation will be interfaced with a play Therapy structured model to rectify the maladaptive preoperational functioning of five interpersonal types of problem-children. The types are classified interpersonally using D.J. Kiesler’s Interpersonal Message Inventory (IMI). Kiesler’s IMI is employed in this proposal as an ongoing assessment modality, a source of information to make treatment strategy consequation decisions, and thirdly as an evaluative outcome variable. The troubled child types described herein frequently become candidates for early-onset persistent Depressive Disorder (pDD) unless rescued by successful treatment. The origins of early-onset pDD arise in dysfunctional households where toxic interpersonal relationships predominate: where “survival from abuse,” not growth, describes the child’s modal developmental experiences. These children are often exposed to either serious traumas (e.g., sexual abuse, loss of a parent, physical abuse, physical or emotional neglect) or psychological insults (e.g., continuous, and chronic verbal and nonverbal abuse). The result, in the most serious cases, is a maturational stunting at the preoperational stage of development which, as noted above, if not successfully resolved, thrusts the child into early-onset pDD.

关键词： play Therapy Early-Onset persistent Depressive Disorder CBASp psychotherapy preoperational Functioning Impact Message Inventory Interpersonal Circle

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