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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven p.Hooker Humberto parada jr. John Bellettiere Arun Kumar Herbert Wertheim School of public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness prediction algorithms Epidemiology Mortality

Legume Green Manure and Intercropping for High Biomass Sorghum production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely Francis M. Rouquette jr. Cristine L. S. Morgan Frank M. Hons William L. Rooney Gerald R. Smith Department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Department of Soil and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor L.) production systems on a Lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [Cynodon dactylon (L.) pers.] pasture. In this split-split plot design, ‘Dixie’ crimson clover (Trifolium incarnatum L.) and ‘Iron and Clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, C concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOC). Main plots were split into crimson clover green manure (CLGM) and winter fallow (FALL) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (CpGM), cowpea-sorghum intercrop (CpSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The CLGM increased (p sorghum biomass yield (16.5 t DM∙ha−1) 28% in year three but had no effect in the first two years. The CpSR treatment reduced sorghum yield up to 62% compared to SORG;whereas CpGM increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. Decrease in SOC and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. Cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-Biomass Sorghum Legumes Green Manure Intercrop Cowpea Crimson Clover Soil Organic Carbon Soil Nitrogen

Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

A pseudo-Stokes Mesh Motion Algorithm

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Advances in Applied Mathematics and Mechanics 2013年第2期5卷 194-211页

作者： Luciano Goncalves Noleto Manuel N.D.Barcelos jr. Antonio C.p.Brasil jr. Universidade de Brasılia Faculdade de TecnologiaDepartamento de Engenharia MecanicaLaboratorio de Energia e Ambiente.Asa Norte.Brasılia-DFBrasil70.910-900 Universidade de Brasılia no Gama.Complexo de Educa¸c˜ao CulturaEsporte e Lazer.A rea Especial de Industria 1Setor LesteFaculdade Lote 1.Gama-DFBrasil72.444-210

This work presents a moving mesh methodology based on the solution of a pseudo flow *** mesh motion is modeled as a pseudo Stokes problem solved by an explicit finite element projection *** mesh quality requirements are satisfied by employing a null divergent velocity *** methodology is applied to triangular unstructured meshes and compared to well known approaches such as the ones based on diffusion and pseudo structural *** of the test cases is an airfoil with a fully meshed domain.A specific rotation velocity is imposed as the airfoil boundary *** other test is a set of two cylinders that move toward each other.A mesh quality criteria is employed to identify critically distorted elements and to evaluate the performance of each mesh motion *** results obtained for each test case show that the pseudo-flow methodology produces satisfactory meshes during the moving process.

关键词： Moving boundaries mesh motion strategy finite element projection methods

Crustal thickening in an active margin setting （philippines）： The whys and the hows

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Episodes 2004年第4期27卷 260-264页

作者： C.B.Dimalanta G.p.Yumul,jr. NationalInstituteofGeologicalSciences CollegeofScienceUniversityofthePhilippinesDilimanQuezonCityPhilippines1101.

A synthesis of crustal thickness estimates was made recently utilizing available field, geochemical, seismicity, shear wave velocity and gravity data in the philippines. The results show that a significant portion of the philippine archipelago is generally characterized by crust with a thickness of around 25 to 30 kilometers. However, two zones, which are made up of a thicker crust (from 30 to 65 km) have also been delineated. The Luzon Central Cordillera region is characterized by thick crust. Another belt of thickened crust is observed in the Bicol-Negros-panay-Central Mindanao region. This paper examines the interplay of tectonic and magmatic processes and their role in modifying philippine arc crust. The processes, which could account for the observed crustal thicknesses, are presented. The contributions of magmatic arcs as compared to the contribution of the emplacement and accretion of ophiolite complexes to crustal thickness are also discussed.

关键词：地壳增厚活跃边缘环境剪力波速度菲律宾群岛地质构造

Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra pereira Leonardo Cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro jr.Marcus Fernando Kodama pertille Ramos Department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil Department of pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(pD-1/pD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,pD-L1 can express differently between metastatic sites and primary tumors(pT).AIM To compare pD-L1 status in pT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the pD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone Sp142)using the com-bined positive *** pD-L1+pT staged as pN+were also tested for pD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had pD-L1+pT and 24 of them had pN+.For comparison,44 pD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the pD-L1+pT,54.2%(13/24 cases)were also pD-L1+in the *** pD-L1(-)pT,9.1%(4/44)had pD-L1+in the *** agreement between pT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with pD-L1 positivity in both *** was no statistical difference in overall survival for pT and LNM according to the pD-L1 status(p=0.166 and p=0.837,respectively).CONCLUSION Intra-patient heterogeneity in pD-L1 expression was observed between the pT and matched *** disagreement in pD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

Thermodynamic Feedback between Clouds and the Ocean Surface Mixed Layer

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Advances in Atmospheric Sciences 1990年第1期7卷 1-10页

作者： p.C.Chu Roland W.Garwood jr. Department of Oceanography. Naval postgraduate School Monterey CA 93943 U.S.A.Department of Oceanography. Naval Postgraduate School Monterey CA 93943 U.S.A.

A cloud-ocean planetary boundary layer (OpBL) feedback mechanism is presented and tested in this paper. Water vapor, evaporated from the ocean surface or transported by the large-scale air flow, often forms convective clouds under a conditionally unstable lapse rate. The variable cloud cover and rainfall may have positive and negative feedback with the ocean mixed layer temperature and salinity structure. The coupling of the simplified Kuo's (1965) cumulus cloud model to the Kraus-Turner's (1967) ocean mixed layer model shows the existence of this feedback mechanism. The theory also predicts the generation of low frequency oscillation in the atmosphere and oceans.

关键词： Cl Feedback Thermodynamic Feedback between Clouds and the Ocean Surface Mixed Layer

photoluminescent Tb^(3+)-based metal-organic framework as a sensor for detection of methanol in ethanol fuel

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Journal of Rare Earths 2019年第3期37卷 225-231页

作者： Ramon R.F.Fonseca Rafael D.L.Gaspar Ivo M.Raimundo jr. priscilla p.Luz Department of Chemistry Federal University of Espírito Santo Institute of Chemistry University of Campinas

The sensing capability of a Tb^(3+)-metal-organic framework, based on its photoluminescence, was used for detection of methanol in ethanol fuel. It was synthesized using terbium and trimesic acid as a metal ion center and ligand, respectively. powder X-ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy were employed to characterize the synthesized MOF-76 structural features. According to the results, MOF-76 was successfully obtained with minor synthetic modification and its activated form(named TbTMA) was tested as a sensor for methanol. Tb^(3+) luminescence intensity increases as the methanol concentration in ethanol fuel also increases and the water content does not affect this response. Our findings indicate TbTMA as an appropriate sensor for evaluating ethanol fuel adulteration by methanol addition above the allowed limit.

关键词： Lanthanide Metal-organic frameworks Luminescence Ethanol fuel Sensor Adulteration

Choosing between a rock and a hard place： Camouflage in the round-tailed horned lizard phrynosoma modestum

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Current Zoology 2012年第4期58卷 541-548页

作者： William E. COOpER, jr. Wade C. SHERBROOKE Department of Biology Indiana University Purdue University Fort Wayne Fort Wayne IN 46805 USA Southwestern Research Station American Museum of Natural History PO Box 16553 Portal AZ 85632 USA

The round-tailed homed lizard phrynosoma modestum is cryptically colored and resembles a small stone when it draws legs close to its body and elevates its back. We investigated effectiveness of camouflage in p. modestum and its dependence on stones by placing a lizard in one of two microhabitats （uniform sand or sand with surface rocks approximately the same size as lizards）. An observer who knew which microhabitat contained the lizard was asked to locate the lizard visually. Latency to detec- tion was longer and probability of no detection within 60 s was higher for lizards on rock background than on bare sand. In arenas where lizards could choose to occupy rock or bare sand, much higher proportions selected rocky backgrounds throughout the day; at night all lizards slept among stones. A unique posture gives p modestum a rounded appearance similar to many natural stones. Lizards occasionally adopted the posture, but none did so in response to a nearby experimenter. Stimuli that elicit the posture are unknown. That p. modestum is better camouflaged among rocks than on bare sand and prefers to occupy rocky areas suggests that special resemblance to rocks （masquerade） enhances camouflage attributable to coloration and immobility.

关键词： Animal defense Background matching Camouflage Crypsis Masquerade Squamata