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Quantification of theophylline or paracetamol in milk matrices by high-performance liquid chromatography

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Journal of p.a.maceutical Analysis 2017年第6期7卷 401-405页

作者： Tania A.p.Fernandes Joao p.a.uiara Ana I.Fernandes Joao F.pinto CiiEM-Centro de Investigacao Interdisciplinar Egas Moniz Instituto Superior de Cinncias da Saude Egas MonizCampus Universitario-Quinta da GranjaMonte de Caparica2829-511 CaparicaPortugal iMed.UL-Dep.Tecnologia Farmaceutica Faeuldade de FarmdciaUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

A simple, accurate and sensitive high-performance liquid chromatography （HpLC） method was developed, validated and applied to the determination of either theophylline or paracetamol in milk-based samples. The method allowed drug quantification in fresh and powdered milk with a relatively short run time of analysis and it was also successfully applied to the quantification of the drugs in solid dosage forms intended for pediatric use. Moreover, the main significant advantages over other published works are the simplicity of the sample preparation, reduced assay time and sample loss. The method meets the International Conference on Harmonization guideline for analytical methods validation regarding specificity, linearity, accuracy, precision, specificity and robustness as required by health authorities and applied by industry while designing and marketing new drug products. The technique encompasses the separation of the analytes with a reverse p.a.e C18 column under isocrafic conditions and UV detection at 272 nm and 243 nm, respectively, for theophylline and paraeetamol. The lower limit of quantification for both drugs was determined as 0.2 μg/mL and the between-batch accuracy was 99.7%. This HpLC method allows quantification of theophylline and paracetamol in milk matrices and it can be applied in the design, development and production of milk-based pediatric dosage forms.

关键词： Liquid chromatography Fresh milk powdered milk paracetamol Theophylline

Variation of parameters Formula and Gronwall Inequality for Differential Equations with a General piecewise Constant Argument

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 561-568页

作者： Kuo-Shou CHIU Manuel pinto Departamento de Matemótica Facultad de Ciencias BósicasUniversidad Metropolitana de Ciencias de la EducacinJ.P.Alessandri 774SantiagoChile Departamento de Matemóticas Facultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A variation of parameters formula and Gronwall type integral inequality are proved for a differential equation involving general piecewise alternately advanced and retarded argument.

关键词： variation of parameters formula Gronwall integral inequality alternately advanced and retarded argument

t-SNE:A study on reducing the dimensionality of hyperspectral data for the regression problem of estimating oenological parameters

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Artificial Intelligence in Agriculture 2023年第1期7卷 58-68页

作者： Rui Silva pedro Melo-pinto CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4Agro-Institute for InnovationCapacity Building and Sustainability of Agri-Food ProductionUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal Departamento de Engenharias Escola de Ciências e TecnologiaUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal

In recent years there is a growing importance in using machine learning techniques to improve procedures in precision agriculture:in this work we perform a study on models capable of predicting oenological parameters from hyperspectral images of wine grape berries,a specially relevant topic to boost production tasks for ***,we explore the capabilities of a novel technique mostly used for visualization,t-Distributed Stochastic Neighbor Embedding(t-SNE),for reducing the dimensionality of the highly complex hyperspectral data and compare its performance with principal Component Analysis(p.a.method,which despite the introduction of many nonlinear dimensionality reduction techniques over the years,had achieved the best results for real-world data across several studies in *** we explore the potential of Kernel t-SNE,an extension to the t-SNE method that allows for the usage of the technique in streaming data or online *** results show that,in a direct comparison,t-SNE achieves better metrics than p.a.for most of the data sets in this work and that the regressor(Support Vector Regression,SVR)performs better with the t-SNE reduced features as inputs,accomplishing better predictions with lower error *** the results with current literature,our shallow learning model paired with t-SNE achieves either better or on par results than those reported,even competing with more advanced models that use deep learning techniques,which should propel the introduction of t-SNE in more studies that require dimensionality reduction.

关键词： Hyperspectral images Dimensionality reduction Regression T-SNE Support vector machines Wine grape berries

Organic Light Emitting Diodes with Lithium Contained Alq3 as Electron Injection Layer

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Chemical Research in Chinese Universities 2002年第2期18卷 121-123页

作者： Zugang Liu J.L.pinto Department of Materials University of OxfordParks RoadOxford OX13PFUK Departamento de Física Universidade de Aveiro3810194 AveiroPortuga

lNovel lithium doped tris 8 hydroxylquinoline aluminium(Alq3:Li) layer is deposited between emission layer and electron injection aluminium electrode as an electron injection assistant layer in different organic light emitting diodes(OLED) to lower the electron injection barrier. In these devices, Alq3 is used as emission layer, and a bilayer film of N,N bis (1 naphhyl) N,N diphenyl 1,1 biphenyle 4,4' diamine(NpB) and 4,4,4' tris(3 methyl phenylphenylamino) triphenylamine( m MTDATA) used as hole transport layer(HTL). The electroluminescent performance of devices with different thicknesses of Alq3∶Li shows that the insertion of the lithium doped Alq3 layer can reduce the turn on voltage by at least 2 volts, and the stability of devices with this lithium doped Alq3 layer is improved too. It can also change the efficiency of devices. Compared with an ultra thin lithium fluoride(LiF) layer, Alq3∶Li sheet gives similar effects but higher efficiency and can be much thicker and hence it is easier to control the deposition.

关键词： Organic light emitting diodes Lithium layer Alq3 EI

Biotechnology of the multipurpose tree species Arbutus unedo:a review

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Journal of Forestry Research 2022年第2期33卷 377-390页

作者： João Martins Glória pinto Jorge Canhoto Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal Centre for Environmental and Marine Studies Department of BiologyUniversity of AveiroAveiroPortugal

Arbutus unedo L.(strawberry tree,Ericaceae)is a woody species with a circum-Mediterranean *** has considerable ecological relevance in southern Europ.a. forests due to its resilience to abiotic and biotic *** edible red berries are used in the production of traditional products,including an expensive *** compounds extracted from the species have bioactive prop-erties used by the cosmetic and p.a.maceutical *** strawberry tree has gone from a neglected species to become a highly valuable crop with large cultivated areas in southern Europ.a. and North African *** to an increasing demand from farmers for p.a.ts with improved features,researchers have been trying to improve this spe-cies through conventional and biotechnological tools,focus-ing mainly on population analysis using molecular markers,in vitro cloning,tolerance to biotic and abiotic stresses,and intraspecific crosses to obtain genotypes with new *** objective of this review is to gather and up.a.e information about the species and make it available to researchers and *** research areas that are considered a priority for this species are highlighted.

关键词： Breeding Chemical profiling Ericaceae Microbiome Micropropagation

Integrated CO_(2)capture and reduction catalysis:Role ofγ-Al_(2)O_(3)support,unique state of potassium and synergy with copper

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Journal of Environmental Sciences 2024年第6期140卷 113-122页

作者： Donato pinto Stefano Minorello Zhouping Zhou Atsushi Urakawa Catalysis Engineering Department of Chemical EngineeringDelft University of TechnologyDelft2629HZNetherlands

Carbon dioxide capture and reduction(CCR)process emerges as an efficient catalytic strategy for CO_(2)capture and conversion to valuable chemicals.K-promoted Cu/Al_(2)O_(3)catalysts exhibited promising CO_(2)capture efficiency and highly selective conversion to syngas(CO+H_(2)).The dynamic nature of the Cu-K system at reaction conditions complicates the identification of the catalytically active p.a.e and surface *** present work aims at more precise understanding of the roles of the potassium and copper and the contribution of the metal oxide ***γ-Al_(2)O_(3)guarantees high dispersion and destabilisation of the potassium p.a.e,potassium and copper act synergistically to remove CO_(2)from diluted streams and promote fast regeneration of the active p.a.e for CO_(2)capture releasing CO while passing H_(2).A temperature of 350℃is found necessary to activate H_(2)dissociation and generate the active sites for CO_(2)*** effects of synthesis parameters on the CCR activity are also described by combination of ex-situ characterisation of the materials and catalytic testing.

关键词： Carbon dioxide Carbon capture and utilisation CO_(2)capture and reduction Solid CO_(2)sorbents Heterogeneous catalysis potassium Copper catalysts Aluminium oxide

Immunosuppressive,antimicrobial and insecticidal activities of inhibitor cystine knot peptides produced by teratocytes of the endoparasitoid wasp Cotesia flavipes(Hymenoptera:Braconidae)

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Insect Science 2023年第4期30卷 1105-1117页

作者： Ciro p.G.pinto Andrew A.Walker Glenn F.King Guilherme D.Rossi School of Agricultural and Veterinarian Sciences Sao Paulo State University(UNESP)JaboticabalBrazil Institute for Molecular Bioscience The University of QueenslandSt LuciaBrisbaneQueenslandAustralia Australian Research Council Centre of Excellence for Innovations in peptide and protein Science The University of QueenslandQueenslandSt LuciaAustralia

Teratocytes are specialized cells released by parasitoid wasps into their *** are known for producing regulatory molecules that aid the development of imma-ture *** have recently reported the primary structures of cystine-rich peptides,including some containing inhibitor cystine knot(ICK)motifs,produced by teratocytes of the parasitoid Cotesia flavipes(Hymenoptera:Braconidae).ICKs are known for their stability and diverse biological *** this study,we produced four putative ICK peptides from the teratocytes of *** using solid-p.a.e peptide synthesis or recom-binant expression in ***,and investigated their functions on host immune modulation as well their potential to impair the development of two lepidopterans after ingestion of the *** addition,the peptides were assayed against pathogens and human *** peptides did not influence total hemocyte count but suppressed cellular immunity,detectable as a reduction of hemocyte encapsulation(CtICK-I,CftICK-II,CtICK-I)and spread indexes(CftICK-IV)in the *** of the peptides influenced the activi-ties of prophenoloxidase and phenoloxidase in the hemolymph of larval Diatraea sacchar-alis(Lepidoptera:Crambidae).CftICK-I and CftICK-II with previously unknown function showed antifungal activity against Candida albicans but were non-toxic to human ***-I,CftICK-II,and CftICK-II increased larval mortality and reduced leaf consump-tion of ***,a permissive host for *** CftICK-III also increased larval mortality and reduced leaf consumption of Spodoptera frugiperda(Lepidoptera:Noctuidae),a non-permissive host for *** study highlights biological func-tions and biotechnological potential of ICK peptides from the teratocytes of ***.

关键词： biocontrol encapsulation host regulation Hymenoptera parasitoid phe-noloxidase

The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 （StarD3/MLN64）, in BRIN-BD11 insulinoma cells

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protein & Cell 2016年第11期7卷 833-838页

作者： Joana Borges pinto Annette Graham Department of Life Sciences School of Health and Life Sciences Glasgow Caledonian University Glasgow G4 0BA UK WolfsonWohl Cancer Research Centre Institute of Cancer Sciences University of Glasgow Switchback Road Bearsden Glasgow G61 1QH UK

Dear Editor, Insulin secretion by pancreatic β-cells is modulated by altering the cellular content and distribution of cholesterol, which is tightly regulated by a network of transcription factors, enzymes, receptors, transporters and cholesterol trafficking proteins. Inhibition of cellular biosynthesis by ＇statin＇ drugs, or depletion of p.a.ma membrane cholesterol by methyl-β-cyclodextrin （MCD）, reduce glucose-stimulated insulin secretion （GSIS） and content in β-cells and islets;

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Effect of Ce-base mischmetal addition on the microstructure and mechanical properties of hot-rolled ZK60 alloy

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Journal of Magnesium and Alloys 2021年第3期9卷 995-1006页

作者： E.p.Silva R.H.Buzolin F.Marques F.Soldera U.Alfaro H.C.pinto Institute of Engineering Science and Technology(IECT)Federal University of Vales do Jequitinhonha e Mucuri(UFVJM)JanaúbaMGBrazil São Carlos School of Engineering(EESC) University of São Paulo(USP)Department of Materials EngineeringCEP 13563-120 São Carlos-SPBrazil Christian Doppler Laboratory for Design of high-performance alloys by thermomechanical processing Kopernikusgasse 24/I8010 GrazAustria Technische Universität Graz(TU Graz) Institute of Materials ScienceJoining and FormingKopernikusgasse 24/I8010 GrazAustria Institute of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbrueckenGermany German Aerospace Center(DLR)Institute of Materials Research Linder Höhe51147 CologneGermany

Mg-Zn-Zr(ZK)alloys exhibit notably high mechanical strength amongst all magnesium alloy ***,due to the formation of low melting point Mg_3Zn_7-precipitates,these alloys are susceptible to hot cracking,thus compromising their metallurgical *** addition of rare earths to ZK alloys is an alternative to form higher melting point intermetallic compounds,speed up dynamic recrystallization,refine grain size,enhance corrosion resistance and extend the service temperature due to improved creep *** work deals with the effect of Ce-base mischmetal addition on the hot rolling behaviour of as-cast ZK60 *** microstructure investigation conducted using electron microscopy and X-Ray diffraction shows that precipitation of Mg_(7)Zn_(3) intermetallics occur during hot rolling,whereas no further precipitation is observed for the ZK60-Mm *** fragmentation of the intermetallic compounds occur during hot rolling and finer particles of Mg_(7)Zn_(3) are observed for the ZK60,whereas Mg_(7)Zn_(3) and Mg Zn_(2) Ce intermetallics are formed in the alloy modified with mischmetal addition.A higher fraction of dynamically recrystallized grains is observed for the ZK60-Mm in comparison to the *** recrystallization takes p.a.e in ZK60 with the formation of sub-grains near to the intermetallics and the addition of mischmetal promotes the occurrence of discontinuous recrystallization with the nucleation of new grains close to the *** mechanical strength and,in particular,the ductility of the hot-rolled alloys are notably improved when compared to the same alloys in the as-cast *** mechanical strength is,however,higher for the ZK60 *** solid solution strengthening,softer Mg Zn_(2) Ce intermetallics and more extensive recrystallization contribute to reduce the mechanical strength of *** in both alloys are initiated at coarse intermetallics and propagate through intermetallic-rich regions.

关键词： Magnesium alloys Hot rolling Mischmetal Recrystallization Microstructure Mechanical properties