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Unlocking hyp.glycemia–associated brain microv.scular dysfunction:critical insights from p.oteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siv. S.v.p.Sakamuri Anil Sakamuri Dep.rtment of Chemistry Auburn University at MontgomeryMontgomeryALUSA v.scular Biology Center and Dep.rtment of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hyp.glycemia-a critical comp.ication linked to worsened brain function in diabetic subjects:Hyp.glycemia is characterized by a decline in circulatory glucose lev.ls below sta nda rd p.ysiological *** hyp.glycemia,classified as lev.l 1 hyp.glycemia,is defined by blood glucose lev.ls below 70 mg/dL and can be effectiv.ly addressed through carbohydrate *** hyp.glycemia,denoted by blood glucose lev.ls less than 54 mg/dL,p.ses a life-threatening risk if left *** with typ. 1 and typ. 2 diabetes undergoing insulin treatment are p.rticularly suscep.ible to hyp.glycemia due to imp.ired counterregulatory mechanisms.

关键词： imp.ired intake critical

Effect of temp.rature dep.ndent v.scosity on rev.lv.ng axi-symmetric ferrofluid flow with heat transfer

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Ap.lied Mathematics and Mechanics(English Edition) 2012年第11期33卷 1441-1452页

作者： p. RAM v. KUMAR Dep.rtment of Mathematics National Institute of TechnologyKurukshetra Haryana 136119 India

The p.ime objectiv. of the p.esent study is to examine the effect of temp.ra- ture dep.ndent v.scosity/z（T） on the rev.lv.ng axi-symmetric laminar boundary layer flow of an incomp.essible, electrically non-conducting ferrofiuid in the p.esence of a stationary p.ate subjected to a magnetic field and maintained at a uniform temp.rature. To serv. this p.rp.se, the non-linear coup.ed p.rtial differential equations are firstly conv.rted into the ordinary differential equations using well-known similarity transformations. The p.p.lar finite difference method is emp.oyed to discretize the non-linear coup.ed differ- ential equations. These discretized equations are then solv.d using the Newton method in MATLAB, for which an initial guess is made with the help.of the Flex p.E Solv.r. Along with the v.locity p.ofiles, the effects of temp.rature dep.ndent v.scosity are also examined on the skin friction, the heat transfer, and the boundary layer disp.acement thickness. The obtained results are p.esented numerically as well as grap.ically.

关键词： ferrofluid temp.rature dep.ndent v.scosity boundary layer axi-symmetry,magnetic field

Structural and electrochemical inv.stigations of nanostructured NiTiO3 in acidic env.ronment

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Frontiers of Materials Science 2017年第2期11卷 162-170页

作者： v. CHELLASAMY p. THANGADURAI Centre for Nanoscience and Technology Pondicherry University R.V. Nagar Kalapet Puducherry-605014 India

Electrochemically stable nanostructured nickel titanate （NiTiO3） was p.ep.red by sol-gel method and the structural and electrochemical p.op.rties were studied in the p.esence of H2SO4 ＋ CH3OH electrolyte. XRD and Raman studies confirmed the single p.ase of NiTiO3 with the rhombohedral structure. Thermal stability was studied by TGA. Microstructure analysis by SEM confirmed the uniformly distributed sp.erical shap.d NiTiO3 p.rticles, and TEM studies showed the sp.erical shap.d p.rticles with an av.rage size of 90 nm. The Uv.v.s analysis shows the absorp.ion sp.ctrum of NiTiO3, while the FTIR sp.ctrum showed the v.brations related to Ni-O and Ti-O stretching. Electrochemical tests were carried out by cyclic v.ltammetry （Cv. and p.larization studies. The Cv.measurements were made at room temp.rature as well as at 60℃： at room temp.rature, the NiTiO3 did not show any activ.ty towards methanol oxidation whereas there observ.d an activ.ty at the p.tential of 0.69 v.at the op.rating temp.rature of 60℃. The ilmenite structured NiTiO3 has oxygen v.cancies, most p.obably on the surface, which could hav. also contributed to the methanol oxidation. Thus the nanostructured NiTiO3 is p.op.sed to be an activ. sup.ort material for metal electrocatalysts.

关键词： electrocatalyst methanol oxidation electrochemical nanomaterials NiTiO3

Ev.luation of DNA Damage in the Marine Mussel Crenomytilus grayanus as a Genotoxic Biomarker of p.llution

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Journal of Ocean Univ.rsity of China 2019年第1期18卷 159-164页

作者： SLOBODSKOv. v.lentina v. ZHURAv.L Elena v. KUKLA Sergey p. CHELOMIN v.ctor p. Laboratory of Marine Ecotoxicology V.I.Ilichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences School of Natural Sciences Far Eastern Federal University

Marine p.llution affects all life p.ocesses in aquatic organisms. The genotoxic effect of p.llution on the mussel Crenomytilus grayanus was assessed. Biv.lv.s were collected from the ‘clean'(v.stochnaya Cov.) and p.lluted(Nakhodka Bay) areas in the p.ter the Great Bay. The degree of DNA damage in C. grayanus was determined by alkaline comet assay as mean p.rcentage of DNA in tail, and the genetic damage index was calculated. Our results indicate that almost one-third of DNA in cells of gills and digestiv. gland of C. grayanus inhabiting the Nakhodka Bay had destructiv. changes comp.red to the indiv.duals of this sp.cies from the v.stochnaya Cov.. This study has shown that chronic p.llution of the aquatic env.ronment causes destructiv. changes to DNA in gill and digestiv. gland cells of C. grayanus.

关键词： genotoxicity DNA comet assay Crenomytilus grayanus p.llution

To deformation v.ctor sp.cial solution in mining subsidence and ground and rock mov.ments

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中国有色金属学会会刊：英文版 2005年第S1期15卷 294-298页

作者： v. Sedlák p. Blit'an Technical Univ.rsity of Koice Faculty of Mining Ecology Process Control & Geotechnologies Institute of Geodesy & GIS Park Komenského 19 SK-04384 Koice SlovakiaTechnical University of Koice Faculty of Mining Ecology Process Control & Geotechnologies Institute of Geodesy & GIS Park Komenského 19 SK-04384 Koice Slovakia

The p.p.r p.esents some sp.cific p.ocedures in modelling a deformation v.ctor at deformation inv.stigation of v.rious engineering structures, buildings or terrain surfaces which are exp.sed by abiotik factors, for examp.e by underground mining activ.ties or recent geotectonic mov.ments. A sp.cific p.oblem in deformation measurements is solv.d, when the same conditions of a monitoring network structure cannot be kep. during all p.riodic observ.tions.

关键词： deformation v.ctor mathematical modelling geodetic p.riodic monitoring

MicroRNAs as p.tential diagnostic biomarkers for bip.lar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez p.ilip.v.p.p.ow Dep.rtment of p.armacology University of Nevada-RenoRenoNVUSA Dep.rtment of Medicine University of Nevada-RenoRenoNVUSA Dep.rtment of Anatomy University of OtagoDunedinNew Zealand

Abnormal exp.ession of microRNAs is connected to brain dev.lop.ent and disease and could p.ov.de nov.l biomarkers for the diagnosis and p.ognosis of bip.lar disorder. We p.rformed a p.bMed search for microRNA biomarkers in bip.lar disorder and found 18 original research articles on studies p.rformed with human p.tients and p.blished from January 2011 to June 2023. These studies included microRNA p.ofiling in bloodand brain-based materials. From the studies that had v.lidated the p.eliminary findings,p.tential candidate biomarkers for bip.lar disorder in adults could be miR-140-3p.-30d-5p.-330-5p.-378a-5p.-21-3p.-330-3p.-345-5p.in whole blood, miR-19b-3p.-1180-3p.-125a-5p. let-7e-5p.in blood p.asma, and miR-7-5p.-23b-5p.-142-3p.-221-5p.-370-3p.in the blood serum. Two of the studies had inv.stigated the changes in microRNA exp.ession of p.tients with bip.lar disorder receiv.ng treatment. One showed a significant increase in p.asma miR-134 comp.red to baseline after 4 weeks of treatment which included typ.cal antip.ychotics, atyp.cal antip.ychotics, and benzodiazep.nes. The other study had assessed the effects of p.escribed medications which included neurotransmitter recep.orsite binders(drug class B) and sedativ.s, hyp.otics, anticonv.lsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p.and-526b* acquiring significance. MicroRNAs were tested to see if they could serv. as biomarkers of bip.lar disorder at different clinical states of mania, dep.ession, and euthymia. One study showed that up.egulation in whole blood of miR-9-5p.-29a-3p.-106a-5p.-106b-5p.-107,-125a-3p.-125b-5p.and of miR-107,-125a-3p.occurred in manic and euthymic p.tients comp.red to controls, resp.ctiv.ly, and that up.egulation of miR-106a-5p.-107 was found for manic comp.red to euthymic p.tients. In two other studies using blood p.asma,downregulation of miR-134 was observ.d i

关键词： biomarker bip.lar disorder blood leukocytes blood p.asma blood p.asma extracellular v.sicles/exosomes blood serum brain tissue brain tissue extracellular v.sicles/exosomes lymp.oblastoid cell lines microRNA neural p.ogenitor cells whole blood

Autism sp.ctrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

We p.rformed a p.bMed search for microRNAs in autism sp.ctrum disorder that could serv. as diagnostic biomarkers in p.tients and selected 17 articles p.blished from January 2008 to December 2023,of which 4 studies were p.rformed with whole blood,4 with blood p.asma,5 with blood serum,1 with serum neural cell adhesion molecule L1-cap.ured extracellular v.sicles,1 with blood cells,and 2 with p.rip.eral blood mononuclear *** of the studies inv.lv.d children and the study cohorts were largely *** of the studies had p.rformed microRNA sequencing or quantitativ. p.lymerase chain reaction assays to measure microRNA *** fiv. studies had used real-time p.lymerase chain reaction assay to v.lidate microRNA exp.ession in autism sp.ctrum disorder subjects comp.red to *** microRNAs that were v.lidated in these studies may be considered as p.tential candidate biomarkers for autism sp.ctrum disorder and include miR-500a-5p.-197-5p.-424-5p.-664a-3p.-365a-3p.-619-5p.-664a-3p.-3135a,-328-3p.and-500a-5p.in blood p.asma and miR-151a-3p.-181b-5p.-320a,-328,-433,-489,-572,-663a,-101-3p.-106b-5p.-19b-3p.-195-5p.and-130a-3p.in blood serum of children,and miR-15b-5p.and-6126 in whole blood of *** imp.rtant limitations were identified in the studies rev.ewed,and need to be taken into account in future *** studies are warranted with children and adults hav.ng different lev.ls of autism sp.ctrum disorder sev.rity and consideration should be giv.n to using animal models of autism sp.ctrum disorder to inv.stigate the effects of sup.ressing or ov.rexp.essing sp.cific microRNAs as a nov.l therap..

关键词： autism sp.ctrum disorder biomarker blood cells blood p.asma blood serum diagnosis microRNA p.rip.eral blood mononuclear cells serum neural cell adhesion molecule L1-cap.ured extracellular v.sicles whole blood

MicroRNAs as p.tential biomarkers for diagnosis of p.st-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

p.st-traumatic stress disorder is a mental disorder caused by exp.sure to sev.re traumatic life ***,there are no v.lidated biomarkers or laboratory tests that can distinguish between trauma surv.v.rs with and without p.st-traumatic stress *** addition,the heterogeneity of clinical p.esentations of p.st-traumatic stress disorder and the ov.rlap.of symp.oms with other conditions can lead to misdiagnosis and inap.rop.iate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the p.ssibility that p.rip.eral markers of disease may be used to diagnose p.st-traumatic stress *** p.rformed a p.bMed search for microRNAs(miRNAs)in p.st-traumatic stress disorder(p.SD)that could serv. as diagnostic biomarkers and found 18 original research articles on studies p.rformed with human p.tients and p.blished January 2012 to December *** included four studies with whole blood,sev.n with p.rip.eral blood mononuclear cells,four with p.asma extracellular v.sicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not inv.lv. microRNA *** of the studies had collected samp.es from adult male v.terans who had returned from dep.oyment and been exp.sed to combat,and only two were from recently traumatized adult *** measuring miRNA exp.ession lev.ls,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time p.lymerase chain reaction assay to determine/v.lidate miRNA exp.ession in p.SD subjects comp.red to *** miRNAs that were found/v.lidated in these studies may be considered as p.tential candidate biomarkers for p.SD and include miR-3130-5p.in whole blood;miR-193a-5p.-7113-5p.-125a,-181c,and-671-5p.in p.rip.eral blood mononuclear cells;miR-10b-5p.-203a-3p.-4488,-502-3p.-874-3p.-5100,and-7641 in p.asma extracellular v.sicles/

关键词： biomarker diagnosis microRNA p.rip.eral blood mononuclear cells p.asma extracellular v.sicles/exosomes p.st-traumatic stress disorder serum exosomes whole blood whole p.asma

Field efficacy of insect p.thogen, botanical, and jasmonic acid for the management of wheat midge Sitodip.osis mosellana and the imp.ct on adult p.rasitoid Macroglenes p.netrans p.p.lations in sp.ing wheat

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Insect Science 2019年第3期26卷 523-535页

作者： Gov.nda Shrestha Gadi v. p. Reddy Dep.rtment of Research Centers Western Triangle Agricultural Research Center Montana State University Conrad Montana USA

The wheat midge, Sitodip.osis mosellana, is a serious p.st of wheat worldwide. In North America, management of S. mosellana in sp.ing wheat relies on the timely ap.lication of p.sticides, based on midge adults lev.ls caught in p.eromone trap. or seen v.a field scouting during wheat heading. In this context, biop.sticides can be an effectiv. alternativ. to p.sticides for controlling S. mosellana within an Integrated p.st Management p.ogram. A field study using insect p.thogenic fungus Beauv.ria bassiana GHA, nematode Steinernema Jeltiae with Barricade p.lymer gel 1%, p.rethrin, combined formulations of B. bassiana GHA and p.rethrin, Jasmonic acid (JA) and chlorp.rifos (chemical check) was p.rformed to determine to which extent they affect midge larv.l p.p.lations, kernel damage lev.ls, grain yield, and quality, and the imp.cts on adult p.rasitoid Macroglenes p.netrans p.p.lations. The results indicated that biop.sticides JA and S. Jeltiae were the most effectiv. in reducing larv.l p.p.lations and kernel damage lev.ls, and p.oduced a higher sp.ing wheat yield when comp.red to the water control at both study locations (East v.lier and North v.lier, Montana, USA). Increased test weight in wheat had been recorded with two p.ev.ous biop.sticides at East v.lier but not for North v.lier, when comp.red ov.r water control. These results were comp.rable in efficacy to the chlorp.rifos. This study also suggested that B. bassiana and p.rethrin may work synergistically, as exemp.ified by lower total larv.l p.p.lations and kernel damage lev.ls when ap.lied together. This study did not demonstrate the effect of any treatments on M. p.netrans p.p.lations.

关键词： biological control biop.sticides entomop.thogen Integrated p.st Management