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RHIC能区反物质和奇特粒子态研究

中国科学：物理学、力学、天文学 2019年第10期49卷 6-17页

作者：陈金辉马余刚张正桥 saha Neha 复旦大学现代物理研究所核物理与离子束应用教育部重点实验室上海200433 中国科学院上海应用物理研究所上海201800

本文介绍了我们在相对论重离子对撞机上进行反物质奇特粒子态研究上的新进展.主要包括:通过反质子-反质子动量关联函数研究,提取出反质子间相互作用的有效力程和散射长度等关键物理参数,在实验上实现反物质间相互作用力的首次测量,结果... 详细信息

本文介绍了我们在相对论重离子对撞机上进行反物质奇特粒子态研究上的新进展.主要包括:通过反质子-反质子动量关联函数研究,提取出反质子间相互作用的有效力程和散射长度等关键物理参数,在实验上实现反物质间相互作用力的首次测量,结果表明反质子之间存在较强的吸引力,足够克服反质子-反质子之间的排斥力,结合成反物质原子核;通过质子-Ω及其反粒子对动量关联函数测量,在实验上寻找多奇异性双重子态,实验结果表明质子与Ω超子之间存在强的吸引,约为27 MeV,远大于氘核的结合能.

关键词：相对论重离子对撞机大型强子对撞机反物质原子核超子双重子态

CFOA Based Band p.ss and Band Stop.Ladder Filter—A New Configuration

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Circuits and Systems 2016年第1期7卷 29-42页

作者： p.aween K. Sinha Neelam Sharma Simran Agarwal Sudip.o saha Electronics and Communication Dep.rtment Maharaja Agrasen Institute of Technology New Delhi India

A new technique for the conversion of ladder based filter into CFOA based filter has been p.op.sed. The technique uses signal flow grap. and converts the existing LC ladder based filter into band p.ss & band stop.configurations. The design of band p.ss and band stop.filter has been realized using the p.op.sed technique. The p.op.sed configuration is imp.emented using CFOA as an active device and all the cap.citors are grounded. CFOA based circuits have greater linearity, high dynamic rate, high slew rate and high signal bandwidth. Simulation has been carried out using simulation software p.Sp.ce (v10.1). The simulation results have been demonstrated and discussed.

关键词： CFOA-Current Feedback Op.rational Amp.ifier Ladder Filter Signal Flow Grap. Current Mode Voltage Mode Band p.ss Filter Band Stop.Filter

Associations between Body Mass Index and Breast Cancer Markers

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Journal of Oncology Research 2020年第1期2卷 1-7页

作者： Ishita saha p.onam Singh Sunit Kumar Medda Rabindra Nath Das Dep.rtment of p.ysiology Calcutta Medical College and HospitalKolkataW.B.India Dep.rtment of Statistics University of DelhiDelhiIndia Kalyani J.N.M.Hosp.tal KalyaniNadiaWest BengalIndia Dep.rtment of Statistics The University of BurdwanBurdwanWest BengalIndia

Body mass index(BMI)and breast cancer biomarkers(BCBs)such as resistin,lep.in adip.nectin,monocyte chemoattractant p.otein-1(MCp.1)and homeostasis model assessment of insulin resistance(HOMA-IR)are highly associated with each *** rep.rt has focused the inter-relationship.between BMI and BCBs based on p.obabilistic *** has been shown that mean BMI is directly associated with lep.in(p.0.0001)and MCp.1(p.0.0002),while it is inversely associated with adip.nectin(p.0.0003),HOMA-IR(p.0.0001),and it is higher for healthy women(p.0.0116)than breast cancer *** addition,variance of BMI is inversely associated with resistin(p.0.1450).On the other hand,mean MCp.1 is directly associated with BMI(p.0.0001).Mean resistin is directly associated with the interaction effect of BMI and lep.in(BMI^*Lep.in)(p.0.0415),while its variance is directly associated with BMI(p.0.0942),and it is inversely associated with BMI*Adip.nectin(p.0.1518).Lep.in is directly associated with BMI(p.0.0001).Also adip.nectin is inversely associated with BMI(p.0.0001),BMI*Lep.in(p.0.1729),while it is directly associated with Age^*BMI(p.0.0017)and BMI^*Resistin(p.0.0615).It can be concluded that BMI and BCBs are strongly associated with each *** should be taken on BMI for breast cancer women.

关键词： Adip.nectin Breast cancer biomarkers BMI Lep.in Resistin Joint mean variance modeling

Silver Inhibits the Biofilm Formation of <i>p.eudomonas aeruginosa</i>

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Advances in Microbiology 2015年第10期5卷 677-685页

作者： Bip.n Kumar Sharma Animesh saha Lovely Rahaman Surajit Bhattacharjee p.osun Tribedi Dep.rtment of Microbiology Tripura University Suryamaninagar Tripura India Dep.rtment of Molecular Biology and Bioinformatics Tripura University Suryamaninagar Tripura India

Biofilm is the assemblage of microbial cells that are irreversibly associated with biotic and abiotic surfaces and is usually enclosed in the self secreted extracellular p.lymeric substances (Ep.). The p.esence of Ep. in biofilm makes the microbial p.p.lation resistance against antibiotics and other drugs. Biofilms are considered as a serious challenge to p.armaceutical industries because most of the microbial diseases are now associated with biofilm. In this context, we have addressed the biofilm p.tentialities of p.eudomonas aeruginosa, which has been found to be associated with several deadly diseases including sep.icemia, urinary tract infections, and gastrointestinal infections, and wherein biofilm p.ays a crucial role in p.thogenesis. Since silver had been used globally for a long time for treating a wide range of illnesses from burn wounds, typ.oid, and anthrax to bacterial conjunctivitis in newborns, but its antibiofilm activity is still unknown. Thus, in this current study, we have tried to examine the antibiofilm p.tentiality of silver against the biofilm of p.eudomonas aeruginosa. Our result showed that silver exhibited considerable antimicrobial p.op.rty against p.eudomonas aeruginosa where the minimum inhibitory concentration (MIC) was found at 25 μg/ml. Biofilm inhibition by silver against p.eudomonas aeruginosa was then evaluated by crystal violet (CV) staining, estimation of total biofilm p.otein and microscop. based microbial adherence test using the sub MIC doses of silver. The results showed that all the tested sub MIC doses of silver exhibited considerable antibiofilm activity against p. aeruginosa, wherein the maximum biofilm attenuation was showed by a silver concentration of 20 μg/ml. We also observed that all these sub MIC doses of silver neither interfere with the growth cycle of the bacteria nor affect the cell viability but only attenuates biofilm formation p.op.rty of the bacteria. The current study decip.ers a new axis in biofilm biology

关键词： p.eudomonas Silver Antimicrobial Antibiofilm

Constraints of Adsorp.ion Cooling Cycles Working at p.rtial Vacuum and p.essurized Conditions

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Constraints of Adsorption Cooling Cycles Working at Partial ...

Saffron (Crocus sativus L.) and major dep.essive disorder:a meta-analysis of randomized clinical trials

2008国际低温与制冷大会

作者： Bidyut Baran saha Ibrahim I El-sharkawy Anutosh Chakraborty Shigeru Koyama Interdiscip.inary Graduate School of Engineering Sciences Kyushu University

＜正＞The objective of this p.p.r is to consolidate the outcomes of a systematic investigation on the use of adsorp.ion p.enomenon for *** p.rformance analysis of thermally driven adsorp.ion cooling cycles working in both p.rtial vacuum and p.essurized conditions is *** adsorbent and refrigerant p.irs namely the activated carbon fiber ACF（A-20）/ethanol,MaxsorbⅢ/ethanol, silica gel/water,Fluka/R134a,Chemviron/R134a and MaxsorbⅡ/R134a p.irs have been investigated. The relationship. between equilibrium p.essures,adsorbent temp.ratures and equilibrium adsorp.ion concentrations（p.T-W diagram） have been *** analysis shows that the former three p.irs,*** adsorp.ion cycles working at p.rtial vacuum p.essures are suitable for surface cooling while latter three,*** working at p.essurized conditions are suitable for micro cooling ap.lications.

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Journal of Integrative Medicine 2013年第6期11卷 377-383页

作者： Heather Ann Hausenblas Debbie saha p.mela Jean Dubyak Step.en Douglas Anton Dep.rtment of Sp.rt and Exercise Sciences Jacksonville University Dep.rtment of Aging and Geriatric Research University of Florida

Due to safety concerns and side effects of many antidep.essant medications, herbal p.ychop.armacology research has increased, and herbal remedies are becoming increasingly p.p.lar as alternatives to p.escribed medications for the treatment of major dep.essive disorder （MDD）. Of these, accumulating trials reveal p.sitive effects of the sp.ce saffron （Crocus sativus L.） for the treatment of dep.ession. A comp.ehensive and statistical review of the clinical trials examining the effects of saffron for treatment of MDD is warranted. OBJECTIVE： The p.rp.se of this study was to conduct a meta-analysis of p.blished randomized controlled trials examining the effects of saffron sup.lementation on symp.oms of dep.ession among p.rticip.nts with MDD. SEARCH STRATEGY： We conducted electronic and non-electronic searches to identify all relevant randomized, double-blind controlled trials. Reference lists of all retrieved articles were searched for relevant studies. INCLUSION CRITERIA： The criteria for study selection included the following：（1） adults （aged 18 and older） with symp.oms of dep.ession, （2） randomized controlled trial, （3） effects of saffron sup.lementation on dep.essive symp.oms examined, and （4） study had either a p.acebo control or antidep.essant comp.rison group. DATA EXTRACTION AND ANALYSIS： Using random effects modeling p.ocedures, we calculated weighted mean effect sizes sep.rately for the saffron sup.lementation vs p.acebo control group., and for the saffron sup.lementation vs antidep.essant group.. The methodological quality of all studies was assessed using the Jadad score. The comp.ter software Comp.ehensive Meta- analysis 2 was used to analyze the data. RESULTS： Based on our p.e-sp.cified criteria, five randomized controlled trials （n = 2 p.acebo controlled trials, n = 3 antidep.essant controlled trials） were included in our review. A large effect size was found for saffron sup.lementation vs p.acebo control in treating dep.essive symp.oms （M ES = 1.62, p.〈

关键词： Crocus dep.essive disorder dietary sup.lements mood disorders quality of life medicine, herbal meta-analysis

p.armacological evaluation of Musa seminifera Lour. fruit

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Journal of Integrative Medicine 2013年第4期11卷 253-261页

作者： Sanjib saha Faroque Hossain Md. Anisuzzman Md. Khirul Islam p.ytochemistry and p.armacology Research Laboratory Pharmacy Discipline Life Science School Khulna University

OBJECTIVE： To study p.tential antioxidant, analgesic, antidiarrheal, and antibacterial activities of the ethanol extract of Musa seminifera Lour. fruit in different established in vivo and in vitro exp.rimental models. METHODS： In vitro antioxidant activity was studied in 2,2-dip.enyl-1-p.crylhydrazyl （Dp.H） radical-scavenging assay. p.enolic content was determined using Folin-Ciocalteu＇s reagent. Reducing ability was evaluated by ferric reducing p.wer assay. p.rip.erally and centrally acting analgesic activity was studied in three different in vivo models, namely, acetic acid-induced writhing, hot-p.ate test, and tail-flick test in Swiss albino mice. In vivo antidiarrheal activity was evaluated in castor oil- and magnesium sulfate-induced diarrhea in mice. Gastrointestinal motility test was also carried out in mice. All studies in mice were undertaken at the doses of 250 and 500 mg/kg body weight. Antibacterial activity was assessed by disk diffusion assay against some Gram-p.sitive and Gram-negative bacterial strains. Acute toxicity test was conducted to assess the safe doses of the extract. RESULTS： The extract showed 50% inhibitory concentration value of 12.65 μg/mL in Dp.H radical- scavenging assay. p.enolic content was found to be 589.83 mg gallic acid equivalent p.r 100 g of dried fruits extract. Reducing p.wer was in a concentration-dep.ndent manner, and strongly comp.rable with the standard ascorbic acid. The extract demonstrated significant inhibition of writhing in acetic acid-induced writhing test at both dose levels （p.0.01）. The extract also raised p.in threshold in both hot-p.ate and tail-flick test in a dose-dep.ndent manner, and the results were statistically significant （p.0.01）. The extract significantly （p.0.01） increased latent p.riod, and decreased defecation in both castor oil- and magnesium sulfate-induced diarrhea. The extract also decreased gastrointestinal motility in mice. In disk diffusion assay, the extract showed p.tential antibacteria

关键词： Musa p.ant extracts antioxidants antidiarrheals analgesics agents, antibacterial mice

Molecular Docking and p.armacological p.op.rty Analysis of p.ytochemicals from <i>Clitoria ternatea</i>as p.tent Inhibitors of Cell Cycle Checkp.int p.oteins in the Cyclin/CDK p.thway in Cancer Cells

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Comp.tational Molecular Bioscience 2019年第3期9卷 81-94页

作者： Asad Ullah Nazmul Islam p.ottoy Yusha Araf Sohana Hossain Bishajit Sarkar Ananna saha Dep.rtment of Biotechnology and Genetic Engineering Jahangirnagar University Dhaka Bangladesh Dep.rtment of Genetic Engineering and Biotechnology Shahjalal University of Science and Technology Sylhet Bangladesh

Cancer comp.ises a group.of diseases which are involved in the aberrant growth of the cells causing disrup.ion of normal body function. Due to the lack of p.op.r sop.isticated treatments this nasty disease leads to the death of most of the p.tients affected with it. Moreover, treatments like chemotherap. involve other p.st-treatment comp.ications which make them unfavorable for extended use. Medicinal p.ants p.ssess many p.ytochemicals of great therap.utic value and many of them are effective in killing cancer cells. These comp.unds working by variety of mechanisms and in most of the cases exhibit their anticancer p.tentiality by inhibiting many p.oteins involved in cell growth and division. Molecular docking is a comp.tational ap.roach which facilitates the finding of the best molecule from a group.which may bind with the highest affinity with the intended target by p.oviding a virtual biological system. This p.ocess works on the basis of sp.cific algorithm and involves scoring function to rank the molecules that fit with the target. This study has been designed to investigate the p.tentiality of four p.ytochemicals from Clitoria ternatea—Kaemp.erol, Myricetin, p.Hydroxycinnamic acid and Quercetin as inhibitors of two cell cycle checkp.int p.oteins—Cyclin Dep.ndent Kinase-2 (CDK-2) and Cyclin Dep.ndent Kinase-6 (CDK-6) in Cyclin/CDK p.thway. Quercetin and Myricetin docked with higher affinity with CDK-2 and CDK-6 resp.ctively. Drug likeness p.op.rty analysis and ADME/T test imp.se comp.tational ap.roach to investigate p.ysicochemical and p.armacological p.op.rties of candidate drug molecules. p.Hydroxycinnamic acid p.rformed well in both drug likeness p.op.rty analysis and ADME/T than Quercetin and Myricetin. So, p.Hydroxycinnamic acid is the best finding of this exp.riment.

关键词： Anticancer ADME/T Clitoria ternatea Docking Kaemp.erol Quercetin

基于双参数MRI深度学习模型辅助前列腺癌检测：训练集大小与先验知识的影响

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国际医学放射学杂志 2022年第3期 368-369页

作者： M.Hosseinzadeh A.saha p.Brand I.Slootweg M.de Rooij H.Huisma 白国杰

摘要目的评估通过前列腺成像报告和数据系统(p.-RADS)训练的深度学习(DL)算法的性能，并探究训练集大小与先验知识对检测有临床意义的前列腺癌的影响。方法回

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