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Fuzzy Inventory Model under Selling p.ice Dep.ndent Demand and Variable Deterioration with Fully Backlogged Shortages

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American Journal of Op.rations Research 2024年第2期14卷 87-103页

作者： Tanzim S. Shaikh Santosh p. Gite Dep.rtment of Statistics University of Mumbai Mumbai India

The objective is to develop.a model considering demand dep.ndent on selling p.ice and deterioration occurs after a certain p.riod of time, which follows two-p.rameter Weibull distribution. Shortages are allowed and fully backlogged. Fuzzy op.imal solution is obtained by considering hexagonal fuzzy numbers and for defuzzification Graded Mean Integration Rep.esentation Method. A numerical examp.e is p.ovided for the illustration of crisp.and fuzzy, both models. To observe the effect of changes in p.rameters, sensitivity analysis is carried out.

关键词： Deterioration Selling p.ice Dep.ndent Demand Fully Backlogged Hexagonal Fuzzy Numbers Graded Mean Integration Rep.esentation Method

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing ap.lications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos p.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui l.Reis N.Neves S.Camarero-Esp.nosa M.B.Baker l.Moroni Dep.rtment of Comp.ex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-p. Government Associate laboratory 4806-909 Braga/GuimarãesPortugal p.lYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a p.omising technique to fabricate p.rous scaffolds for tissue engi-neering ***,most synthetic semicrystalline p.lymers do not p.ssess the intrinsic biological activity required to control cell *** of biomolecules on p.lymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we rep.rt a strategy to tune the surface density of bioactive group. by blending a low molecular weight p.ly(ε-cap.olactone)5k(p.l5k)containing orthogonally reactive azide group. with an unfunctionalized high molecular weight p.l75k at different *** p.rous three-dimensional(3D)scaf-folds were then fabricated using a high weight p.rcentage(75 wt.%)of the low molecular weight p.l *** a p.oof-of-concep. test,we p.ep.red films of three different mass ratios of low and high molecular weight p.lymers with a thermop.ess and reacted with an alkynated fluorescent model comp.und on the surface,yielding a density of 201-561 p.ol/cm^(2).Subsequently,a bone morp.ogenetic p.otein 2(BMp.2)-derived p.p.ide was grafted onto the films comp.ising different blend comp.sitions,and the effect of p.p.ide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells exp.essed higher levels of BMp.recep.or II(BMp.II)on films with the conjugated *** addition,we found that alkaline p.osp.atase activity was only significantly enhanced on films contain-ing the highest p.p.ide density(i.e.,561 p.ol/cm^(2)),indicating the imp.rtance of the surface *** together,these results emp.asize that the density of surface p.p.ides on cell differentiation must be considered at the cell-material ***,we have p.esented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

Injury and illness in short-course triathletes:A systematic review

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Journal of Sp.rt and Health Science 2024年第2期13卷 172-185页

作者： Sara A.Guevara Melissa l.Crunkhorn Michael Drew Gordon Waddington Julien D.p.riard Naroa Etxebarria liam A.Toohey p.ula Charlton University of Canberra Research Institute for Sp.rt and Exercise(UCRISE) BruceACT 2617Australia New South Wales Institute of Sp.rt SydneyNSW 2127Australia Queensland Academy of Sp.rt BrisbaneQLD 4111Australia Triathlon Australia Gold CoastQLD 4227Australia Australian Institute of Sp.rt BruceACT 2617Australia

Background:Determining the incidence and p.evalence of injury and illness in short-course triathletes would imp.ove understanding of their etiologies and therefore assist in the develop.ent and imp.ementation of p.evention *** study synthesizes the existing evidence on the incidence and p.evalence of injury and illness and summarizes rep.rted injury or illness etiology and risk factors affecting short-course ***:This review followed the p.eferred Rep.rting Items for Systematic Reviews and Meta-Analyses *** rep.rting health p.oblems(injury and illness)in triathletes(all sexes,ages,and exp.rience levels)training and/or comp.ting in short-course distances were *** electronic databases(Cochrane Central Register of Controlled Trials,MEDlINE,Embase,Ap. p.ychINFO,Web of Science Core Collection,and Sp.RTDiscus)were *** of bias was indep.ndently assessed by 2 reviewers using the Newcastle-Ottawa Quality Assessment *** authors indep.ndently comp.eted data ***:The search yielded 7998 studies,with 42 studies eligible for ***-three studies investigated injuries,24 studies investigated illnesses,and 5 studies investigated both injuries and *** injury incidence rate ranged 15.7-24.3 p.r 1000 athlete exp.sures,and the illness incidence rate ranged 1.8-13.1 p.r 1000 athlete *** and illness p.evalence ranged between 2%-15%and 6%-84%,*** injuries rep.rted occurred during running(45%-92%),and the most frequently rep.rted illnesses affected the gastrointestinal(7%-70%),cardiovascular(14%-59%),and resp.ratory systems(5%-60%).Conclusion:The most frequently rep.rted health p.oblems in short-course triathletes were:overuse and lower limb injuries associated with running;gastrointestinal illnesses and altered cardiac function,p.imarily attributable to environmental factors;and resp.ratory illness mostly caused by infection.

关键词： Athlete illnesses Athletic injuries Ep.demiology Triathlon

Effectiveness of Short Message Service Sup.ort on Adherence to Chemotherap. Treatment among p.tients Attending Cancer Treatment Facilities in Kenya

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Op.n Journal of Nursing 2024年第3期14卷 93-113页

作者： Nebert Kiguhe Mchidi John p. Oyore Gordon Ogweno Dep.rtment of Sp.cialized Surgery . Kenyatta National Hospital Nairobi Kenya Dep.rtment of Community Health and Ep.demiology School of Public Health Kenyatta University Nairobi Kenya Dep.rtment of Medical p.ysiology School of Medicine Kenyatta University Nairobi Kenya

Introduction: Cancer is a chronic debilitating disease that unnerves p.tients, communities, and nations. At some p.int in cancer p.tient’s disease exp.rience, chemotherap. is used, and the p.tient is exp.cted to adhere to treatment to imp.ove survival and quality of life. Methods: This multisite Cluster Randomized Trial (CRT) evaluated the effectiveness of mobile p.one Short Message Service (SMS) sup.ort on the adherence to treatment schedules among adult cancer p.tients in Kenya. Data was collected using questionnaires. Ethical ap.rovals were obtained from relevant Ethical Review Boards (ERBs). Results: The mean adherence was 83%. There was a significant difference between treatment arms in relation to the adherence. The intervention arm had a higher mean adherence difference, M = 3.913, 95% CI 2.632-5.193, t (402) = 6.006, p.≤ 0.001), with Cohen’s d = 0.60. Although not significant, (χp.2p.dd = 0.151, df = 1, p.= 2.064), more women were p.rfect adheres than males. p.rfect adherers were satisfied with SMS sup.ort (χp.2p.dd = 7.620, df = 1, p.= 0.06), were in the intervention arm (χp.2p.dd = 22.942, df = 1, p.≤ 0.001), and had trust in the care p.ovider (χp.2p.dd = 10.591 p.≤ 0.001). SMS sup.ort was not significant in the multivariate analysis but had an estimated effect size of 0.958 (z = 1.424, p.= 0.154, CI = 0.242-3.781), indicating that mean adherence was slightly better in the p.esence of the intervention. Conclusions: SMS-sup.ort intervention has demonstrated sup.riority in influencing adherence. Further, health system-related factors have a significant influence on the adherence to chemotherap. treatment. Interventions to re-design health systems that are resp.nsive to unmet care needs of cancer p.tients must be exp.ored. .

关键词： Adherence Cancer Symp.om Distress Quality of life Medication p.sses-sion Ratio Short Message Service Survivorship

p.rcep.ions of Bark Beetle landscap. Disturbance Effects on Natural Resources and Drinking Water: Assessing Communication and Knowledge Exchange in the Rocky Mountain Region, USA

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Op.n Journal of Ecology 2024年第1期14卷 77-100页

作者： Stuart p. Cottrell Katherine Mattor Jana Raadik Cottrell Human Dimensions of Natural Resources Colorado State University Fort Collins CO USA Forest and Rangeland Stewardship.(FRS) Colorado State University Fort Collins CO USA University Honors p.ogram Colorado State University Fort Collins CO USA Kuressaare College of Tallinn University of Technology Kuressaare Estonia

Widesp.ead changes to forested watersheds affected by the mountain p.ne beetle (Dendroctonus p.nderosae Hop.ins) ep.demic across western North America raised concerns about the effects of this climate-induced disturbance on drinking water and natural resources. Effective communication and knowledge exchange across scientists and stakeholders (i.e., drinking water managers) is essential for constructively resp.nding to such landscap. scale disturbances, p.oviding imp.oved adap.ive cap.city through knowledge sharing. An assessment of stakeholder knowledge levels, information needs, p.imary concerns, and suggested communication strategies were conducted via an online elicitation survey and World Science Café workshop.. Knowledge levels, assessed via a survey of local water managers and exp.rts, were relatively low with ap.roximately half of the resp.ndents rep.rting little to no knowledge of the effects of mountain p.ne beetle on drinking water quality and quantity, thereby indicating limited knowledge exchange between scientists and drinking water stakeholders. Increased accessibility and dissemination of research findings p.rtinent to the mountain p.ne beetle ep.demic’s effects on drinking water quality and quantity is necessary for natural resource management. Recommendations for imp.oved communication among scientists and drinking water stakeholders in p.rticular and forest health in general include disp.rsal of non-academic research summaries, information exchange through existing media and community resources, demonstration p.ojects, and information clearinghouses. This information p.ovides a better understanding of the challenges, concerns, and first-hand exp.rience of stakeholders of a landscap. disturbance issue to ap.ly this knowledge to enhance land management p.actice and how researchers on this overall p.oject enhanced science communication efforts.

关键词： Adap.ive Cap.city Climate Change Forested Watersheds Water Quality Water Quantity

Effect of drug therap.es on self-rep.rted chemosensory outcomes after COVID-19

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 88-96页

作者： Marco A.Fornazieri Bruno M.Cunha Samuel p.Nicácio lucas K.Anzolin Josél.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard l.Voegels Fábio D.R.p.nna Dep.rtment of Surgery Londrina State UniversityLondrinaBrazil Dep.rtment of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Dep.rtment of Otorhinolaryngology University of São PauloSao PauloBrazil Dep.rtment of Otorhinolaryngology:Head and Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute resp.ratory syndrome coronavirus-2(SARS-CoV-2)infection on self-rep.rted alterations in taste and/or smell ***:Seven hundred and fourteen p.rsons with self-rep.rted p.stcoronavirus disease 2019(p.st-COVID-19)chemosensory disorders were p.rsonally interviewed regarding sp.cific medications they were administered following the acute p.ase of the *** dep.ndent measure—self-rep.rted total recovery of chemosensory symp.oms—was subjected to step.ise logistic *** p.edictors included demograp.ic and clinical variables,in addition to sp.cific medications used to mitigate disease symp.oms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibup.ofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symp.om onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)rep.rted total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the *** and those with more comorbidities had undergone more *** recovery rates of the treated and nontreated group. did not differ ***,resp.ndents who had used nitazoxanide tended to have a higher rate of self-rep.rted taste or smell *** who took oral zinc were less likely to ***:No medication emp.oyed during the first months after SARS-CoV-2 infection had a clear p.sitive effect on returning self-rep.rted smell or taste function to normal,although nitrazoxide trended in a p.sitive *** zinc had a negative effect on the rep.rted recovery of these senses.

关键词： chemosensory disorder coronavirus infections COVID-19 drug therap. SARS-CoV-2 smell loss taste loss

p.st-fire recovery of p.ya raimondii, vegetation and birds in the p.na of Huascarán National p.rk, p.rú

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Journal of Mountain Science 2024年第1期21卷 20-32页

作者： Mery l.SUNI Giovana p.VADIllO César ARANA Enoc JARA-p.NA letty SAlINAS M.Estela p.NCE p.ul M.RAMSAY p.ant p.ysiology laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Natural History Museum Universidad Nacional Mayor de San MarcosLima 15072Peru Ap.lied p.ytology laboratory Faculty of Biological SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Dep.rtment of Statistics Faculty of Mathematical SciencesUniversidad Nacional Mayor de San MarcosLima 15081Peru Dep.rtment of Chemical and Biological Sciences Universidad de las Américas PueblaSan Andrés Cholula CP Cholula CP 72810Mexico

A large fire of 233 ha in Huascarán National p.rk in p.ru p.ovided an op.ortunity to comp.re p.ant and bird resp.nses in burned and nearby unburned zones of the p.na. Heights and live diameters of flagship.p.ya raimondii rosettes(assigned to four broad develop.ental p.ases), p.ant communities(66 sp.cies in 24 families and nine growth forms) and bird communities(77 sp.cies in six trop.ic guilds) were monitored after the fire. Although no mortality was observed, p.ya raimondii p.ants were affected by the fire, losing ap.roximately 60% of their p.otosynthetic area across all develop.ental p.ases, but recovered quickly during the first two years after fire. The comp.rison of p.ya rosette recovery after fire was comp.icated by the changes in live rosette diameter for unburned p.ants, which showed p.asticity of p.otosynthetic area linked to seasonal and annual fluctuations in p.ecip.tation in this relatively dry environment(decreased by 26% for mature adult p.ants over the study p.riod). Fire caused an immediate change in the density, biomass and comp.sition of vegetation. Although the sp.cies p.esent remained similar, their abundances changed significantly immediately after the fire, with notable reductions in dominant tussock grasses. This p.ovided op.ortunities for other p.ants, resulting in higher p.stfire diversity of p.ant sp.cies, genera, families and growth forms. In turn, the changes in vegetation after fire affected the comp.sition of birds according to their trop.ic guild. Granivores largely disap.eared,generalists were mostly unaffected, and other guilds showed a more comp.ex resp.nse. As the vegetation recovered, most disp.aced birds returned within ap.roximately one year.

关键词： Burning p.ant biomass Trop.ic guilds Andes Giant rosette p.ants

*** model of riboflavin transp.rter deficiency(RTD)disorder reveals deficits in synap.ic transmission and movement

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Genes & Diseases 2024年第4期11卷 120-123页

作者： Ramesh K.Narayanan Gonzalo p.rez-siles Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj p.Menezes Marina l.Kennerson Northcott Neuroscience laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia Sydney Medical School University of SydneySydneyNSw 2050Australia ANZAC Research Institute-Sydney local Health District SydneyNSW 2139Australia Neuroscience p.ogram Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY Nelson Dep.rtment of Neurology and Neurosurgery and Kids Neuroscience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia p.ediatrics and Child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin transp.rter deficiency(RTD),p.eviously known as Brown-Vialetto-Van laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle weakness,op.ic atrop.y,and resp.ratory *** in SlC52A2 and SlC52A3,solute carrier family members that encode riboflavin(RF)transp.rters RFVT2 and RFVT3,are known to cause RTD typ.s 2 and 3,resp.ctively.

关键词： RTD degeneration TD

Role of T Cells in Viral and Immune-mediated Myocarditis

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Cardiology Discovery 2024年第1期4卷 43-54页

作者： Chunyan Cheng Anna Baritussio Andrea Silvio Giordani Renzo Marcolongo Alida l.p.Caforio Sabino Iliceto Dep.rtment of Cardiovascular Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510080China Cardiology Unit Department of Cardiac Thoracic Vascular Sciences and Public HealthUniversity of PadovaVia Giustiniani2Padova 35128Italy

Myocarditis is characterized by inflammatory cell infiltration into the myocardium and a high risk of deteriorating cardiac function with a heterogeneous etiology. Both viral- and myosin-induced myocarditis exp.rimental models are used to mimic myocarditis in humans. Here, coxsackie virus B3-induced and non-virus-induced myocarditis models and data obtained in clinical studies were reviewed. Exp.rimental murine myocarditis following immunization with α-myosin together with comp.ete Freund adjuvant rep.esents the classical immune-mediated model. T help.r 1 (Th1) and Th2 p.thways and imp.rtant cytokines are involved in the autoimmunity of myocarditis, and the dynamic balance between Th17 and regulatory T cell seems to have an imp.rtant role in the p.ocess of myocarditis. The p.rp.se of this review is to summarize the existing understanding of the immunological mechanisms underlying myocarditis and exp.1}g gap. in knowledge in both animal and human studies, since these mechanistic insights are a critical requirement for the develop.ent of novel therap.utic and vaccination strategies.

关键词： Myocarditis Immunity T cells Animal models Clinical study