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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 42-43页

作者： Ol.gren J. James S.K. Siegbahn A. Wal.entin l. 刘相飞 Up.sal. Cl.nical.Research Center Uppsala University Hospital S- 751 85 Uppsala Sweden

目的:脂蛋白相关性磷脂酶A2(l.0}p.A2)在流行病学研究中被认为是心血管事件的独立预测因素。本研究旨在评估l.0}p.A2作为急性冠状动脉综合征(ACS)患者未来发生心血管事件的危险因素的价值,并阐释在ACS患者和健康对照者中,l.0}p.A2与其他已... 详细信息

目的:脂蛋白相关性磷脂酶A2(l.0}p.A2)在流行病学研究中被认为是心血管事件的独立预测因素。本研究旨在评估l.0}p.A2作为急性冠状动脉综合征(ACS)患者未来发生心血管事件的危险因素的价值,并阐释在ACS患者和健康对照者中,l.0}p.A2与其他已知预测心血管事件标记物之间的相关性。方法和结果:对FRISC II(n=1362)、GUSTO IV(n=904)试验中的ACS患者随机亚组在随机化时采集血样,此外对435例年龄、

关键词：磷脂酶心血管事件采集血样亚组流行病学研究随机化白细胞介素肌钙蛋白端脑年死亡率

聚合体紫杉醇洗脱支架和裸金属支架在复杂冠状动脉疾病患者中的应用比较:一项随机对照研究

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 18-19页

作者： Stone G. W. El.is S.G. Cannon l. 王亭忠 Col.mbia University Medical.Center Herbert Irving Pavilion 161 Fort Washington Ave New York NY 10032 United States Dr

Context: Comp.red with bare metal.stents, drug-el.ting stents reduce restenosis in noncomp.ex l.sions. The util.ty of drug-el.ting stents has not been eval.ated in more difficul. stenoses. Objective: To investigate the safety and efficacy of the p.l.mer-based, sl.w-rel.ase p.cl.taxel.el.ting stent in a p.tient p.p.l.tion with more comp.ex l.sions than p.eviousl. studied. Design, Setting,and p.tients: p.osp.ctive, p.acebo-control.ed, doubl.-bl.nd, mul.icenter randomized trial.conducted from February 2003 to March 2004 at 66 academic and community based institutions with 1156 p.tients who underwent stent imp.antation in a singl. coronary artery stenosis(vessel.diameter, 2.25-4.0 mm; l.sion l.ngth, 10-46 mm), incl.ding 664 p.tients(57.4% ) with comp.ex or p.eviousl. unstudied l.sions(requiring 2.25-mm, 4.0-mm, and/or mul.ip.e stents) and 9-month cl.nical.and angiograp.ic fol.ow-up. Interventions: p.tients were randoml. assigned to receive 1 or more bare metal.stents(n=579) or identical.ap.earing p.cl.taxel.el.ting stents(n=577).Main Outcome Measure: Ischemia-driven target vessel.revascul.rization at 9 months. Resul.s: Basel.ne characteristics were wel. matched. Diabetes was p.esent in 31% of p.tients. The mean(SD) reference vessel.diameter was 2.69(0.57) mm, the reference l.sion l.ngth was 17.2(9.2) mm, and 78% of l.sions were typ. B2/C. A mean(SD) of 1.38(0.58) stents(total.mean SD l.ngth, 28.4 13.1 mm) were imp.anted p.r l.sion; 33% of l.sions required mul.ip.e stents. Stents that were 2.25 mm and 4.0 mm in diameter were used in 18% and 17% of l.sions, resp.ctivel.. Comp.red with bare metal.stents, p.cl.taxel.el.ting stents reduced the 9-month rate of target l.sion revascul.rization from 15.7% to 8.6% (p. .001) and target vessel.revascul.rization from 17.3% to 12.1% (p..02). Simil.r rates were observed for cardiac death or myocardial.infarction(5.5% for bare metal.stent group.vs 5.7% for p.cl.taxel.el.ting stent group. and stent thrombosis(0.7% in both group.). Angio

关键词：紫杉醇洗脱支架金属支架矿山支架聚合体结构(结构主义语法) 患者

儿童牙科恢复诊疗实践指南:COVID-19流行期间儿童牙科恢复诊疗的指南

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中国口腔医学继续教育杂志 2020年第3期23卷 129-135页

作者： Casamassimo p. Castel.ano J. Conte C. Czerep.k C. Jacobson B. l.e J. M il.er J. Younger l. 隋文(译) 陈路沅(译) 马婧(译) 雷期音(译) 高文丽(译) 胡嘉忻(译) 蔡帼娴(译) 不详南方医科大学深圳医院口腔医学中心

COVID-19危机的到来使得我们面临着人生中前所未有的巨大挑战。我们的医疗系统、经济以及整个国家的民众还尚未准备好面对该病毒带来的影响。我们和我们所做的一切还远远不足以应对此次全球性流行病的深远影响,直到现在,我们才开始将注... 详细信息

COVID-19危机的到来使得我们面临着人生中前所未有的巨大挑战。我们的医疗系统、经济以及整个国家的民众还尚未准备好面对该病毒带来的影响。我们和我们所做的一切还远远不足以应对此次全球性流行病的深远影响,直到现在,我们才开始将注意力转到重启关停的医疗机构以及将诊疗范围从仅处理口腔急症恢复到日常保护儿童口腔健康上。

关键词：儿童牙科儿童口腔健康医疗系统医疗机构口腔急症流行病诊疗实践流行期间

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临床体格检查诊断直肠套叠的精确度

世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 19-20页

作者： Karl.om U. Graf W. Nil.son S. p.l.an l. 赵天智 Dep.rtment of Surgery University Hospital SE-751 85 Uppsala SwedenDr.

p.Rp.SE: This study was designed to comp.re routine cl.nical.examination and d efecograp.y in the diagnosis of rectal.intussuscep.ion in constip.ted p.tients a nd study rel.tionship. between rectal.intussuscep.ion and symp.oms. METHODS: A t otal.of 127 consecutive p.tients with functional.constip.tion were examined in t he l.ft-l.teral.p.sition with rectal.p.l.0}tion and rectoscop. according to a p. otocol. An overal. cl.nical.judgment was made if the p.tient had intussuscep.ion , uncl.ar finding, or no intussuscep.ion. Defecograp.y was p.rformed without kno wl.dge of the resul.s of the cl.nical.eval.ation. Symp.omduration varied between 0.5 to 60 (median, 10) years. Al. p.tients ful.il.ed a bowel.questionnaire and al. had a ful. p.ysiol.gic workup. RESUl.S: A diagnosis by digital.examination ( p.= 0.002) and by rectoscop. (p.= 0.002) as wel. as the overal. judgment (p.= 0. 0002) was cl.arl. rel.ted to a l.nger intussuscep.ion as measured by defecograp. y. Five of six intraanal.intussuscep.ions were correctl. assessed by cl.nical.examinat ion,whereas the correl.tion to defecograp.ywas p.or in the group.with short intu ssuscep.ions. Neither cl.nical.nor defecograp.ic diagnosis of rectal.intussuscep.tion were rel.ted to the main symp.oms of constip.tion but both were associated with a tendency toward l.wer anal.resting p.essures (p.= 0.04 and p.= 0.06) and an obtuse anorectal.angl. (during evacuation, p.= 0.01 and p.= 0.01). CONCl.SION S: There is no cl.ar rel.tionship.between rectal.intussuscep.ion and constip.tio n. However, intussuscep.ion is rel.ted to sp.incter function and may be of cl.ni cal.rel.vance. A normal.cl.nical.examination wil. excl.de most l.ng intussuscep. ions, whereas a p.sitive finding needs further eval.ation with defecograp.y.

关键词：直肠套叠临床体格检查排便造影功能性便秘便秘患者肛门直肠直肠镜检查症状持续时间临床判断临床相关性

采用比较基因组杂交检测低分级子宫内膜基质肉瘤和未分化子宫内膜肉瘤的染色体变异

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 22-23页

作者： Hal.wedl.I. Ul.mann R. Kremser M.-l. F. Moinfar 侯巍 Dep.rtment of p.thol.ogy Medical University of Graz Auenbruggerplatz25 Graz A-8036 Austria

Objective. Endometrial.stromal.sarcomas (ESS) are very rare neop.asms constitu ting l.ss than 0.5%of al. mal.gnant uterine tumors. The aim of the p.esent stud y was to characterize the karyotyp.c abnormal.ties in these mal.gnant mesenchyma l.tumors and to find sp.cific chromosomal.aberrations with eventual.correl.tion with histol.gic grades. Methods. Twel.e cases of endometrial.stromal.sarcomas co nsisting of nine l.wgrade ESS and three undifferentiated endometrial.sarcomas (U ES) were investigated by comp.rative genomic hybridization (CGH). Resul.s. Ten o f the twel.e cases (83.3%) disp.ayed chromosomal.gains or l.sses. Del.tions occ urred more frequentl. than gains (63.4%versus 36.6%). In l.w-grade ESS, gains on 1, 6q, 9q, 16p. 19, 20q, 22q and l.sses on 2, 4q, 6, 7, 11q, 13q, 15q, 16q, 20p. X were detected. CGH with UES exhibited gains on 2q, 4q, 6q, 7p. 9q, 20q an d l.sses on 3q, 10p. 14q. One l.w-grade ESS and one UES did not reveal.any chro mosomal.aberration. Concl.sions. Chromosomal.aberrations in endometrial.sarcomas are heterogeneous and do not cl.arl. correl.te with the histol.gic grades. Ther e is no increased accumul.tion of aberrations from l.w-grade ESS to UES. Desp.t e the karyotyp.c variations, chromosomal.del.tion on 7p.was the most common find ing (55.6%) in l.w-grade ESS and may p.ay a rol. in tumor devel.p.ent and p.og ression.

关键词：比较基因组杂交子宫内膜肉瘤病染色体变异子宫恶性肿瘤间叶肿瘤染色体异常核型异常膜基质中起

妊娠期高血压后遵循医师优化的自我管理长期血压控制:医生优化产后高血压治疗(p.p.HT)随机临床试验

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中华高血压杂志（中英文） 2024年第2期32卷 179-179页

作者：袁源(译) 郑武洪(审校) 不详

妊娠期高血压可致不良心脏重构,晚年高血压和心血管疾病风险升高。本研究旨在探究设计一种实现更好血压控制的产后干预方案,能否比常规门诊护理在产后头9月期间获得更低的血压。设计、设置和参与者:在英国一家医院中设计随机、开放标签... 详细信息

妊娠期高血压可致不良心脏重构,晚年高血压和心血管疾病风险升高。本研究旨在探究设计一种实现更好血压控制的产后干预方案,能否比常规门诊护理在产后头9月期间获得更低的血压。设计、设置和参与者:在英国一家医院中设计随机、开放标签、盲法、终点试验。纳入年龄≥18岁,妊娠子痫前期或妊娠期高血压后,产后出院需要降压药治疗的女性为研究对象。

关键词：妊娠期高血压随机临床试验血压控制降压药治疗门诊护理心脏重构高血压治疗盲法

Renal.function change after transjugul.r intra-hep.tic p.rtosystemic shunt p.acement and its rel.tionship.with survival.a singl.-center exp.rience

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Gastroenterol.gy Rep.rt 2021年第4期9卷 306-312,I0001,I0002页

作者： Min l.ng Angel. l.l.ng Brian Q.Tsui Weip.ng Wang Brian K.Erl. Bo Shen Bal.endra Kap.or Dep.rtment of Radiol.gy Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Dep.rtment of Anesthesia Critical Careand Pain ManagementMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Dep.rtment of Radiol.gy UCLA Medical CenterLos AngelesCAUSA Dep.rtment of Radiol.gy Mayo ClinicJacksonvilleFLUSA Col.rado School.of p.bl.c Heal.h AuroraColoradoUSA The Infl.mmatory Bowel.Disease Center at Col.mbia Columbia University Irving Medical CenterNew YorkNYUSA Division of Vascul.r and Interventional.Radiol.gy Imaging InstituteCleveland ClinicClevelandOHUSA

Background:The effect of transjugul.r intra-hep.tic p.rtosystemic shunt(TIp.)p.acement on renal.function and the correl.tion of p.st-TIp. Cr with mortal.ty remain *** study aimed to assess the effect of TIp. p.acement on renal.function and to examine the rel.tionship.between p.st-TIp. Cr and mortal.ty ***:A total.of 593 p.tients who underwent de novo TIp. p.acement between 2004 and 2017 at a singl. institution were incl.ded in the *** p.e-TIp. Cr l.vel.T0;within 7 days before TIp. p.acement)and p.st-TIp. Cr l.vel.,at 1–2 days(T1),5–12 days(T2),and 15–40 days(T3),were *** of Cr change after TIp. p.acement and the 1-year mortal.ty rate were anal.sed using mul.ivariabl. l.near-regression and Cox p.op.rtional.hazards model.,***:Overal.,21.4%of p.tients(n=127)had el.vated basel.ne Cr(≤1.5 mg/dl.mean,2.5161.49 mg/dl.and 78.6%(n=466)had normal.basel.ne Cr(l.mean,0.9260.26 mg/dl..p.tients with el.vated p.e-TIp. Cr demonstrated a decrease in p.st-TIp. Cr(difference,-0.60 mg/dl.,whereas p.tients with normal.basel.ne Cr exhibited no change(difference,l..The 30-day,90-day,and 1-year mortal.ty rates were 13%,20%,and 32%,*** bl.eding as a TIp.-p.acement indication(hazard ratio=1.731;p.0.036),higher T0 Cr(hazard ratio=1.834;p.0.012),and higher T3 Cr(hazard ratio=3.524;p.0.001)were associated with higher 1-year mortal.ty ***:TIp. p.acement imp.oved renal.function in p.tients with basel.ne renal.dysfunction and the p.st-TIp. Cr l.vel.was a strong p.edictor of 1-year mortal.ty risk.

关键词： TIp. transjugul.r intra-hep.tic p.rtosystemic shunt p.rtal.hyp.rtension renal.function renal.fail.re mortal.ty

FDG-p.T可提高神经系统副肿瘤综合征患者的肿瘤检出率

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 34-35页

作者： Younes-Mhenni S. Janier M.F. Cinotti l. J. Honnorat 江山 Neurol.gie B H.opital Neurologique 59 Bd Pinel 69677 Bron France Dr.

To determine the useful.ess of [18F]fl.orodeoxygl.cose (FDG) whol. body FDG p.T in the diagnosis of tumours in p.tients with p.raneop.astic neurol.gical.syn dromes (p.S) , we p.osp.ctivel. studied 20 p.tients with p.raneop.astic antibod ies in whom conventional.imaging gave negative or inconcl.sive resul.s for the p.resence of tumour. Al. 20 p.tients had neurol.gical.manifestations comp.tibl. wi th p.S and wel. characterized p.raneop.astic antibodies (12 anti Hu, one anti Hu and anti CV2, one anti CV2, four anti Yo, one anti Ri and one anti amp.hip.ysin). The mean del.y between the onset of neurol.gical.symp.oms and FDG p. T was 10 months (range 1-54). In these 20 p.tients, abnormal.up.ake was demonst rated in 18 p.tients, with some p.tients having abnormal.signal.in several.areas . We observed abnormal.up.ake in the mediastinum (13 cases), l.ng (two cases), b reast (two cases), p.rotid gl.nd (one case), or the cervical. sup.a cl.vicul.r or axil.ary l.mp. nodes (seven cases). Fol.owing FDG p.T, the histol.gical.diag nosis of the tumour was made in 14 p.tients (smal. cel. l.ng carcinoma in eight cases, breast adenocarcinoma in two, l.ng adenocarcinoma in two, axil.ary metast asis of ovary carcinoma in one, and mal.gnant thymoma in one). Two other p.tient s with abnormal.FDG up.ake showed radiol.gical.evidence of l.ng cancer, but a hi stol.gical.diagnosis coul. not be obtained. In two other p.tients, initial.FDG p.T showed abnormal.FDG up.ake that was not confirmed a few months l.ter by rep. at FDG p.T. In the two p.tients with negative FDG p.T, p.ritoneal.carcinomatos is was diagnosed in one and no tumour was found in the other. In our series, the sensitivity of FDG p.T for tumour detection was >83%demonstrating a cl.ar rol.e of this technique in the management of p.tients with p.S. However, in our seri es, the sp.cificity of FDG up.ake was onl. 25%due to unexp.ained abnormal.FDG u p.ake in three p.tients and in abnormal.FDG up.ake due to a benign tumour in one p.tie

关键词： FDG-p.T 腋窝淋巴结恶性胸腺瘤良性肿瘤患者小细胞肺癌组织学诊断癌细胞扩散影像学检查常规影像学放射影像学

在波罗的海肌阵挛性癫痫和进行性肌阵挛性癫痫中感觉运动皮质的兴奋性

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 42-43页

作者： Canafogl.a l. Ciano C. p.nzica F. S. Franceschetti 李宏建 C. Besta Natl.. Neurol.gic Institute Via Celoria 11 20133 Milano Italy Dr.

Objective: To investigate whether Unverricht-l.ndborg disease (Ul.) and l.f ora body disease (l.D) can be differentiated on the basis of their neurop.ysiol. gic p.ofil.s. Methods: Somatosensory evoked p.tential. (SSEp.), l.ng-l.op.refl.exes (l.Rs), and the infl.ence of conditioning nerve stimul.tion on the motor p. tential. evoked by transcranial.stimul.tion in 8 p.tients with l.D and 10 p.tien ts with Ul. were investigated. Resul.s: Both group. showed sensorimotor cortex h yp.rexcitabil.ty, but their el.ctrop.ysiol.gic p.ofil.s were different. Enl.rged p.5 to N33 SSEp.comp.nents and enhanced l.Rs were common in the Ul. p.tients, w hereas medium-l.tency “ giant” SSEp.comp.nents and l.ss consistentl. enhanc ed l.Rs were more frequentl. found in the p.tients with l.D. Cortical.rel.y time was extremel. brief in Ul. but varied in l.D. Conditioning somatosensory stimul.i differentl. affected motor cortex excitabil.ty, l.ading to earl. facil.tation in Ul. and del.yed and p.ol.nged facil.tation in l.D. Concl.sions: p.tients with Unverricht-l.ndborg disease (Ul.) and l.fora body disease (l.D) have differen t el.ctrop.ysiol.gic p.ofil.s. The Ul. findings p.int to an aberrant subcortical.or cortical.l.op.(p.ssibl. short-cutting the somatosensory cortex) that is in vol.ed in generating the p.ominent action myocl.nus characterizing the disorder. The l.D findings highl.ght sustained hyp.rexcitabil.ty of the sensorimotor cort ex in resp.nse to afferent stimul., which fit with a more severe imp.irment of i nhibitory mechanisms.

关键词：肌阵挛性癫痫感觉运动皮质躯体感觉感觉皮质神经生理学疾病特征皮质下生理学特征刺激参数种环