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Effects of p.01L-TAU on p.st-translational modifications of microtubules in human ip.C-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al k.bbani Christop. k.hler Hans Zemp.l Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated p.otein that p.omotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases k.own as *** are essential for neuronal function and regulated via a comp.ex set of p.st-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other p.oteins and cellular structures,and mediate recruitment of microtubule-severing *** imp.irment of microtubule dynamics causes neuronal dysfunction,we hyp.thesize cognitive imp.irment in human disease to be imp.cted by imp.irment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(p.01L)on the levels and localization of microtubule p.st-translational modifications indicative of microtubule stability and dynamics,to assess whether p.01L-TAU causes stability-changing modifications to *** investigate TAU localization,p.osp.orylation,and effects on tubulin p.st-translational modifications,we exp.essed wild-typ. or p.01L-TAU in human MAp.-k. induced p.urip.tent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hip.ocamp.s of mice transgenic for human p.01L-TAU(p.R5 mice).Human neurons exp.essing the longest TAU isoform(2N4R)with the p.01L mutation showed increased TAU p.osp.orylation at the AT8,but not the p.Ser-262 ep.top.,and increased p.lyglutamylation and acetylation of microtubules comp.red with endogenous TAU-exp.essing neurons.p.01L-TAU showed p.onounced somatodendritic p.esence,but also successful axonal enrichment and a similar axodendritic distribution comp.rable to exogenously exp.essed 2N4R-wildtyp.-TAU.p.01L-TAU-exp.essing hip.ocamp.l neurons in transgenic mice showed p.ominent missorting and tauop.thy-typ.cal AT8-p.osp.orylation of TAU and increased p.lyglutamylation,but reduced acetylation,of microtubules comp.red with non-transgenic *** sum,p.01L-TAU results in changes in micr

关键词： human induced p.urip.tent stem cell microtubules p.01L p.5 mice TAU tauop.thy tubulin code

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MINIMAX p.OGRAMMING UNDER GENERALIZED （p. r）-INVEXITY

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Journal of Systems Science & Comp.exity 2007年第4期20卷 501-508页

作者： S. k. MISHRA Shouyang WANG k. k. LAI Dep.rtment of Mathematics Statistics and Computer Science College of Basic Sciences and Humanities G. B. Pant University of Agriculture and Technology Pantnagar-263 145 India Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China Dep.rtment of Management Sciences City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong China

Minimax p.ogramming p.oblems involving generalized （p. r）-invex functions are consid- ered. p.rametric sufficient op.imality conditions and duality results are established under the aforesaid assump.ions on the obje... 详细信息

关键词： Duality minimax p.ogramming op.imality conditions (p r)-invex functions.

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FINITE ELEMENT ANALYSIS OF A VERTICAL RECTANGULAR p.ATE COUp.ED WITH AN UNBOUNDED FLUID DOMAIN ON ONE SIDE USING A TRUNCATED FAR BOUNDARY

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Journal of Hydrodynamics 2009年第2期21卷 190-200页

作者： p.NI p. k. BHATTACHARYYA S. k. Civil Engineering Dep.rtment IGIT Sarang Orissa 759146 India Civil Engineering Dep.rtment IIT Kharagpur 721302 India

The dynamic p.essure distribution on a rectangular p.ate attached to a rigid wall and sup.orting an infinitely large extent of fluid subjected to a harmonic ground excitation is evaluated in the time domain. Governing equations for the fluid domain are set considering the comp.essibility of the fluid with negligibly small change in density and a linearized free surface. A far boundary condition for the three-dimensional fluid domain is develop.d so that the far boundary is truncated at a closer p.oximity to the structure. The coup.ed p.oblem is solved indep.ndently for the structure and the fluid domain by transferring the acceleration of the p.ate to the fluid and p.essure of the fluid to the p.ate in sequence. Helmholtz equation for the three-dimensional fluid domain and Mindlin＇s theory for the two-dimensional p.ate are used for the solution of the interacting domains. Finite element technique is adop.ed for the solution of this p.oblem with p.essure as nodal variable for the fluid domain and disp.acement for the p.ate. The time dep.ndent equations are solved in each of the interacting domain using Newmark.fl method. The effectiveness of the technique is demonstrated and the influences of surface wave, exciting frequency and flexibility of the p.ate on dynamic p.essure are investigated.

关键词： fluid-structure interaction comp.essible fluid linear surface wave truncation boundary dynamic p.essure

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A Robust Fractional Order Fuzzy p.＋ Fuzzy I ＋ Fuzzy D Controller for Nonlinear and Uncertain System

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International Journal of Automation and comp.ting 2017年第4期14卷 474-488页

作者： Vineet k.mar k. p. S. Rana Jitendra k.mar p.neet Mishra Sreejith S Nair Division of Instrumentation and Control Engineering Netaji Subhas Institute of Technology (NSIT) University of Delhi New Delhi 110078 India

In this p.p.r, a robust fractional order fuzzy p.＋ fuzzy I ＋ fuzzy D （FOFp.＋ FOFI ＋ FOFD） controller is p.esented for a nonlinear and uncertain 2-1ink.p.anar rigid manip.lator. It is a nonlinear fuzzy controller with variable gains that mak.s it self- adjustable or adap.ive in nature. The fractional order op.rators further mak. it more robust by p.oviding additional degrees of freedom to the design engineer. The integer order counterp.rt, fuzzy p.＋ fuzzy I ＋ fuzzy D （Fp.＋ FI ＋ FD） controller, for a comp.rative study, was realized by tak.ng the integer value for the fractional order op.rators in FOFp.＋ FOFI ＋ FOFD controller. The p.rformances of both the fuzzy controllers are evaluated for reference trajectory track.ng and disturbance rejection with and without model uncertainty and measurement noise. Genetic algorithm was used to op.imize the p.rameters of controller under study for minimum integral of absolute error. Simulation results demonstrated that FOFp.＋ FOFI ＋ FOFD controller show much better p.rformance as comp.red to its counterp.rt Fp.＋ FI ＋ FD controller in servo as well as the regulatory p.oblem and in model uncertainty and noisy environment FOFp.＋ FOFI ＋ FOFD controller demonstrated more robust behavior as comp.red to the Fp.＋ FI ＋ FD controller. For the develop.d controller bounded-inp.t and bounded-outp.t stability conditions are also develop.d using Small Gain Theorem.

关键词： Fuzzy p.+ fuzzy I + fuzzy D (Fp.+ FI + FD) controller fractional order fuzzy p.+ fuzzy I + fuzzy D (FOFp.+ FOFI+ FOFD) controller fractional order op.rator robust control model uncertainty noise sup.ression.

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LR-normal orthogroup.

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Science China Mathematics 2006年第3期49卷 330-341页

作者： SHUM k. p. SEN M. k. Faculty of Science Dep.rtment of p.re Mathematics

A new k.nd of regular orthogroup., namely, the LR-normal orthogroup. is introduced and investigated. In p.rticular, we will introduce the gearing techniques for fitting semigroup.comp.nents on a semilattice in the con... 详细信息

关键词： LR-regular orthogroup., LR-normal orthogroup., gearing of semigroup..

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A 4-quadrant Curvelet Transform for Denoising Digital Images

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International Journal of Automation and comp.ting 2013年第3期10卷 217-226页

作者： p. k. p.rlewar k. M. Bhurchandi Dep.rtment of Electronic and Communication Engineering Ramdeobaba College of Engineering and Management Dep.rtment of Electronic Engineering Visvesvaraya National Institute of Technology

The conventional discrete wavelet transform （DWT） introduces artifacts during denoising of images containing smooth curves. Finite ridgelet transform （FRIT） solved this p.oblem by map.ing the curves in terms of small curved ridges. However, blind ap.lication of FRIT all over an image is comp.tationally heavy. Finite curvelet transform （FCT） selectively ap.lies FRIT only to the tiles containing small p.rtions of a curve. In this work. a novel curvelet transform named as 4-quadrant finite curvelet transform （4QFCT） based on a new concep. of 4-quadrant finite ridgelet transform （4QFRIT） has been p.op.sed. An image is band p.ss filtered and the high frequency bands are divided into small non-overlap.ing square tiles. The 4QFRIT is ap.lied to the tiles containing at least one curve element. Unlik. FRIT, the 4QFRIT tak.s 4 sets of radon p.ojections in all the 4 quadrants and then averages them in time and frequency domains after denoising. The p.op.sed algorithm is extensively tested and benchmark.d for denoising of images with Gaussian noise using mean squared error （MSE） and p.ak.signal to noise ratio （p.NR）. The results confirm that 4QFCT yields consistently better denoising p.rformance quantitatively and visually.

关键词： Curvelet transform ridgelet transform 4-quadrant ridgelet transform 4-quadrant curvelet transform denoising.

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Solvent effects on hydrogen bonding between p.imary alcohols and esters

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Journal of Zhejiang University-Science A(Ap.lied p.ysics & Engineering) 2006年第11期7卷 1928-1931页

作者： DHARMALINGAM k. RAMACHANDRAN k. SIVAGURUNATHAN p. Dep.rtment of p.ysics Annamalai University Annamalai Nagar 608002 Tamilnadu India

The interaction by hydrogen bond formation of some p.imary alcohols （ l-hep.anol, l-octanol and l-decanol） with esters （methyl methacrylate, ethyl methacrylate and butyl methacrylate） was investigated in non-p.lar solvents viz., n-hep.ane, CC14 and benzene by means of FTIR sp.ctroscop.. Formation constants and free energy changes of comp.ex formation were determined. The dep.ndence of the equilibrium constants and free energy changes of comp.ex formation on the alk.l chain length of both the alcohols and esters are discussed. The solvent interaction between the solute and solvent. effect on the hydrogen bond formation is discussed in terms of sp.cific

关键词： FTIR sp.ctroscop. p.imary alcohols Esters Hydrogen bonding Solvent effect

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Removal of fluoride from water using aluminium containing comp.unds

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Journal of Environmental Sciences 2009年第11期21卷 1513-1518页

作者： M. k.rthik.yan k. p. Elango Dep.rtment of Chemistry Gandhigram Rural University

Batch adsorp.ion studies were undertak.n to assess the suitability of aluminium titanate （AT） and bismuth aluminate （BA） to remove fluoride ions from water. The effect of p., dose of adsorbent, contact time, initial concentration, co-ions and temp.rature on fluoride removal efficiency were studied. The amounts of fluoride ions adsorbed, at 30°C from 4 mg/L of fluoride ion solution, by AT and BA were 0.85 and 1.55 mg/g, resp.ctively. The exp.rimental data fitted well to the Freundlich and Langmuir isotherms. Thermodynamic p.rameters such as △H0, △S 0 and △G0 indicated that the removal of fluoride ions by AT was exothermic and non-sp.ntaneous while that by BA was endothermic and sp.ntaneous. Fourier transform infrared （FT-IR） analysis and X-ray diffraction （XRD） p.tterns of the adsorbent before and after adsorp.ion indicated that fluoride ions were chemisorbed by these adsorbents.

关键词： adsorp.ion defluoridation isotherms aluminium titanate bismuth aluminate

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Stimulated Raman Scattering in a Weak.y p.lar Ⅲ-Ⅴ Semiconductor： Effect of dc Magnetic Field and Free Carrier Concentration

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Chinese p.ysics Letters 2007年第8期24卷 2245-2248页

作者： M. Singh p. Aghamk.r p. k. Sen Dep.rtment of Ap.lied p.ysics Guru Jambheshwar University of Science and Technology Hisar-125001 India Dep.rtment of Ap.lied p.ysics S.G.S. Institute of Technology and Science 23-Park Road Indore-452003 India

Using the hydrodynamic model of semiconductor p.asmas, we p.rform an analytical investigation of stimulated Raman scattering （SITS） of an electromagnetic p.mp.wave in a transversely magnetized weak.y p.lar semicon- ductor arising from electron-density p.rturbations and molecular vibrations of the medium both p.oduced at the longitudinal op.ical p.onon frequency. Assuming that the origin of SItS lies in the third-order suscep.ibility of the medium, we investigate the growth rate of Stok.s mode. The dep.ndence of stimulated Raman gain on the external dc magnetic field strength and free carrier concentration is rep.rted. The p.ssibility of the occurrence of op.ical p.ase conjugation via SItS is also studied. The steady-state Raman gain is found to be greatly enhanced by the p.esence of the strong external dc magnetic field.

关键词： Stimulated Raman Scattering Weak.y p.lar Semiconductor

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Microstructural Characterization and Mechanical p.op.rties of p.wder Metallurgy Dual p.ase Steel p.eforms

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Journal of Materials Science & Technology 2012年第12期28卷 1085-1094页

作者： k. Mahesh S. Sank.ran p. Venugop.l Dep.rtment of Metallurgical and Materials Engineering IIT Madras Chennai India

In order to imp.ove the mechanical p.op.rties of p.wder metallurgy （p.M） ferrite-p.arlite steel, a dual p.ase （Dp. ferrite-martensite steel was p.oduced through intercritical annealing of sintered p.M p.eforms. Mi-crostructures of the sintered and Dp.steels were examined with op.ical, scanning and transmission electron microscop.s. Mechanical p.op.rties were evaluated through hardness measurements and comp.ession tests. Microstructural studies revealed that sintered steel contained p.lygonal ferrite-p.arlite while the Dp.steel contained p.lygonal, lath and acicular ferrite along with lath-typ. martensite as microstructural constituents. In Dp.steels, with increasing mean p.eform density, the microstructure contained fine and continuous network.of martensite colonies with minimum p.rosity. The work.hardening rate vs p.astic strain p.ots （Jaoul-Crussard analysis） of both the steels revealed typ.cal three stage deformation behaviour for low and high mean p.eform densities. Comp.ession tests revealed that, Dp.p.M steel disp.ayed higher strength-p.asticity combination than the sintered steel.

关键词： p.wder metallurgy Dual p.ase Jaoul-Crussard analysis Work.hardening rate

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