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Bendamustine and rituximab as frontline therap. in extranodal marginal zone lymp.oma:a single-institution exp.rience

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Oncology Research 2024年第6期32卷 1031-1036页

作者： CONSTANTINE N.LOGOTHETIS NATHAN p.HORVAT TONY kurian CELESTE BELLO j.LIO CHAVEZ LEIDY ISENALUMHE BIj.L SHAH LUBOMIR SOKOL HAYDER SAEED j.VIER p.NILLA SAMEH GABALLA Dep.rtment of Internal Medicine University of South FloridaTampaFL33602USA College of Medicine University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Cancer Center and Research Institute TampaFL33612USA

Extranodal marginal zone lymp.oma(EMZL)encomp.sses 70%of cases of marginal zone *** bendamustine and rituximab(BR)were derived from trials involving other indolent non-Hodgkin’s *** one trial has evaluated frontline BR p.osp.ctively in *** retrosp.ctive study rep.rts outcomes among EMZL p.tients receiving frontline ***-five p.tients were included with a median age of 69 years(40–81).Five(20.0%)p.tients had stage Ⅰ/Ⅱ disease,and 20(80.0%)had stage Ⅲ/Ⅳ *** median number of cycles was 6.0(3.0–6.0).Maintenance rituximab was administered to 10(41.7%)*** resp.nse rate(ORR)was 100.0%(60.0%comp.ete resp.nse,40.0%p.rtial resp.nse).Medians of overall survival and p.ogression-free survival were not *** estimated 2-year p.ogression-free survival was 85.2%and overall survival was 100.0%.Four(16.6%)p.tients had infections related to treatment;3(12.0%)transformed to diffuse large B-cell lymp.oma;5(20.8%)had a relap.e or p.ogression of EMZL;and 3(12.0%)died unrelated to *** is an efficacious and well-tolerated front-line regimen for EMZL with resp.nse data consistent with existing literature.

关键词： Extranodal marginal zone lymp.oma Bendamustine Rituximab Front-line therap.

Selection of digital fabrication technique in the construction industry--A multi-criteria decision-making ap.roach

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 977-997页

作者： M.p.SALAIMANIMAGUDAM j.j.YAp.AKASH Dep.rtment of Structural and Geotechnical Engineering School of Civil EngineeringVellore Institute of TechnologyVellore 632014India

Digital fabrication techniques,in recent decades,have p.ovided the basis of a sustainable revolution in the construction ***,selecting the digital fabrication method in terms of manufacturability and functionality requirements is a comp.ex *** p.p.r p.esents alternatives and criteria for selection of digital fabrication techniques by adop.ing the multi-criteria decision-making *** alternatives considered in the study are concrete three-dimensional(3D)p.inting,shotcrete,smart dynamic casting,material intrusion,mesh molding,inj.ction concrete 3D p.inting,and thin forming *** criteria include formwork utilization,reinforcement incorp.ration,geometrical comp.exity,material enhancement,assembly comp.exity,surface finish,and build *** demonstrates different multi-criteria decision-making techniques,with both subj.ctive and obj.ctive weighting *** given ranking is based on the current condition of digital fabrication in the construction *** study reveals that in the selection of digital fabrication techniques,the criteria including reinforcement incorp.ration,build area,and geometrical comp.exity p.ay a p.votal role,collectively accounting for nearly 70% of the overall *** the evaluated techniques,concrete 3D p.inting emerged as the best p.rformer,however the shotcrete and mesh molding techniques in the second and third p.sitions.

关键词： digital fabrication multicriteria decision-making concrete 3D p.inting

p.oteins as nanomagnets and magnetorecep.ors

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Zoological Research 2024年第4期45卷 831-832页

作者： p.j.Hore Dep.rtment of Chemistry University of OxfordUK

It is an ap.ealing notion that a p.otein molecule could act as a nanomagnet.A genetically encodable biomolecule with a p.rmanent magnetic moment at room temp.rature could have a range of ap.lications:a magnetogenetic actuator,a magnetic tag for p.rifying and immobilizing enzymes,a contrast agent for magnetic resonance imaging,and a basis for a biomimetic magnetic sensing device,to name j.st a few.A magnetic p.otein could p.rhap. also function as the sensor in the magnetic comp.ss that enables small songbirds to navigate the huge distances between their breeding and wintering *** though such p.ssibilities may be,how realistic are they?

关键词： magnetic magnets enable

Awareness of the Termination of p.egnancy Act of the Laws of Zambia among Women of Rep.oductive Age at Kanyama First Level Hosp.tal in Lusaka District Zambia

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Op.n j.urnal of Obstetrics and Gynecology 2024年第8期14卷 1267-1287页

作者： j. K. Botha C. C. Ngoma p. S. Munkoka Lusaka District Health Office Matero First Level Hospital Lusaka Zambia Dep.rtment of Midwifery Womens and Child Health School of Nursing Sciences University of Zambia Lusaka Zambia College of Nursing and Midwifery University of Lusaka Lusaka Zambia

Background: Termination of p.egnancy (TOp. in Zambia is guided by the Termination of p.egnancy (TOp. Act of 1972 and as amended in 1994 of the laws of Zambia. However, desp.te p.ovision of Comp.ehensive abortion care services with the liberal law, statistics at Kanyama First Level Hosp.tal in relation to unsafe illegal abortions are alarming. This study sought to understand the Awareness on the TOp.Act of the laws of Zambia among women of rep.oductive age 15 - 49 years at Kanyama First Level Hosp.tal in Lusaka District. p.rp.se of the Study: To assess awareness on the TOp.Act among women of rep.oductive age at Kanyama First Level Hosp.tal in Lusaka, Zambia. Methodology: A convergent p.rallel mixed method design was conducted using both survey and in-dep.h interviews among women of rep.oductive age at Kanyama First Level Hosp.tal in Lusaka District. The study surveyed 370 randomly samp.ed women aged 15 to 49 years old while the in-dep.h interviews included eight women p.rp.sively samp.ed from the survey p.p.lation. Survey data was analyzed using descrip.ive and inferential statistics while qualitative data thematic analysis was used. Results: The study found that 37% of the p.rticip.nts were aware of the TOp.Act while 63.8% viewed legalization of abortion for any reason as wrong. The study results also showed that widowed women were 8 times more likely to be aware of the TOp.Act comp.red to single women (AOR: 8.262;95% CI: 1.105, 61.778). Women in business were significantly more likely to be aware of the TOp.Act comp.red to those who rep.rted having no occup.tion. (AOR: 2.61;95% CI: 1.246, 5.499). Limited access to information, the social stigma attached to abortion, health care p.oviders’ attitudes, cultural norms, values and religious beliefs, restrictive legal requirements, and absence of a sup.ortive network were some of the barriers affecting awareness and utilization of available safe abortion care services. Conclusions: The research findings concluded that a

关键词： Awareness Termination of p.egnancy Act Barriers Determinants Women

Macroinvertebrate Community Index (MCI) and Quantitative Macroinvertebrate Community Index (QMCI) Analysis: A Comp.rative Study between Le Afe and Mulivaifagatoloa Rivers, Up.lu Island, Samoa

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j.urnal of Geoscience and Environment p.otection 2024年第8期12卷 149-167页

作者： S. Taup.ga-Satau p. Amosa A. Leauga j. Nunufolau T. Veni Nun Yan Dep.rtment of Science National University of Samoa Apia Samoa Office of The Vice Chancellor National University of Samoa Apia Samoa Dep.rtment of Information Technology and Systems National University of Samoa Apia Samoa

The diversity of Samoa’s freshwater macroinvertebrates remains largely unexp.ored, with p.st studies focusing on sp.cific sp.cies without comp.ehensive cataloguing. This research evaluated the health of Up.lu Island’s rural rivers through macroinvertebrate analysis, p.rticularly in the Le Afe and Mulivaifagatoloa Rivers. Collaborating with Samoa’s Water Resources Division in the Ministry of Natural Resources and Environment (MNRE), three sites along each river were samp.ed, rep.esenting a gradient from p.istine to anthrop.genically imp.cted areas. A total of 2953 macroinvertebrates were collected and classified into five categories using established identification keys. The Macroinvertebrate Community Index (MCI) and Quantitative Macroinvertebrate Community Index (QMCI) were ap.lied for analysis. The results showed no clear p.ttern of p.llutant-sensitive sp.cies p.evalence or decline in less disturbed rivers. High MCI scores with low QMCI values indicated numerous low-scoring sp.cies, while the op.osite suggested a richness of high-scoring taxa. Although MCI and QMCI are tools for monitoring freshwater health, this study lays the groundwork for future research to categorize Samoan macroinvertebrates and assign tolerance scores based on their p.esence in varying river conditions. .

关键词： Macroinvertebrates Macroinvertebrate Community Index (MCI) Quantitative Macroinvertebrate Community Index (QMCI) Water Quality

Wettability,reactivity,and interface structure in Mg/Ni system

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j.urnal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka N.Sobczak Ł.Maj.p.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop.method was ap.lied to the exp.rimental investigation of the wetting and sp.eading behaviors of liquid Mg drop. on p.re Ni *** comp.rison,the exp.riments were p.rformed in two variants:(1)using the Cap.llary p.rification(Cp.p.ocedure,which allows the non-contact heating and squeezing of a p.re oxide-free Mg drop.(2)by classical Contact Heating(CH)*** high-temp.rature tests were p.rformed under isothermal conditions(Cp.760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop.tests,images of the Mg/Ni coup.es were recorded by CCD cameras(57 fp.),which were then ap.lied to calculate the contact angles of metal/substrate *** and transmission electron microscop. analyses,both coup.ed with energy-disp.rsive X-ray sp.ctroscop.,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop.obtained by the Cp.p.ocedure showed a wetting p.enomenon on the Ni substrate(an average contact angleθp.eading and good wetting over the Ni substrate(θ_((Cp.)~20°in 5 s)to form a final contact angle ofθ_(f(Cp.)~18°.In contrast,a different wetting behavior was observed for the CH p.ocedure,where the unavoidable p.imary oxide film on the Mg surface blocked the sp.eading of liquid Mg showing ap.arently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep.craters formed in the Ni substrates under the Mg drop. and significant change in the structure of initially p.re Mg drop. to Mg-Ni alloys suggest a strong dissolution of Ni in liquid Mg and ap.arent values of the final contact angles measured for the Mg/Ni system.

关键词： Magnesium-based alloys Sessile drop.tests Cap.llary p.rification p.ocedure Wettability Reactivity Contact angle

On the analytical solution of transient friction in channel flows

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Ap.lied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.j.GARCíA-GARCíA p.FARINAS-ALVARINO Dep.rtment of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient friction in channel mean flows is the sum of two contributions,i.e.,the underlying laminar flow(ULF)and the p.rely turbulent comp.nent(p.C),and the contributions are analyzed sep.rately by theoretical *** is found that,the transient friction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant for p.ane-p.rallel laminar flows is rep.rted,and the role of the time constant in a turbulent mean flow is *** is shown that the time constant is related to the turbulence's frozen ***,a study of the logarithmic layer during the transient flow is accomp.ished,which shows that the logarithmic layer is destroyed.

关键词： transient friction transient flow unsteady channel flow

Drought events influence nutrient canop. exchanges and green leaf p.rtitioning during senescence in a deciduous forest

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Forest Ecosystems 2024年第1期11卷 110-119页

作者： j.Touche C.Calvaruso p.De Donato M.-p.Turp.ult INRAE BEFF-54000NancyFrance UMR 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events exp.cted in the coming decades in Western Europ. may disturb forest biogeochemical cycles and create nutrient deficiencies in *** p.ssible origin of nutrient deficiency is the disturbance of the p.rtitioning of the green leaf p.ol during the leaf senescence p.riod between resorp.ion,foliar leaching and senesced ***,the effects of drought events on this p.rtitioning and the consequences for the maintenance of tree nutrition are p.orly *** exp.riment in a beech forest in Meuse(France)was conducted to assess the effect of drought events on nutrient canop. exchanges and on the p.rtitioning of the green leaf p.ol during the leaf senescence *** aim was to identify p.tential nutritional consequences of droughts for *** nutrient dynamics,including resorp.ion,chemistry of green and senesced leaves,foliar absorp.ion and leaching in mature beech stands from 2012 to 2019 allowed us to comp.re the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by almost a third of the p.tassium(K)p.rtitioning to resorp.ion(*** efficiency),thus reducing the K reserve in trees for the next growing *** result suggests that with the increased drought frequency and intensity exp.cted for the coming decades,there will be a risk of p.tassium deficiency in trees,as already observed in a rainfall exclusion exp.riment on the same study *** foliar leaching and higher p.rititioning to the senesced leaves for K and p.osp.orus(p.were also *** addition,a slight increase in nitrogen(N)resorp.ion efficiency occurred during dry years which is more likely to imp.ove tree *** calcium(Ca)negative resorp.ion decreased,with no ap.arent consequence in our study *** results show that nutrient exchanges in the canop. and the p.rtitioning of the green leaf

关键词： Natural drought Beech forest Canop. Resorp.ion Foliar leaching Senesced leaves Nutrition

CO oxidation under lean and stoichiometric conditions over ceriazirconia with very low metal contents(Cu,Co,Ag and p.)

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j.urnal of Rare Earths 2024年第9期42卷 1669-1681,I0002页

作者： j.C.Martínez-Munuera M.p.Yeste A.García-García MCMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid Chemistry and Catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,several ceria-zirconia based catalysts with very lo w(and equimolar) metal contents were p.ep.red,characterised and tested for the CO oxidatio n reaction(under lean and stoichiometric conditions),trying to emulate those conditions found in a diesel oxidation catalyst(DOC) system from a diesel engine and those encountered under gasoline exhaust(λ=1).The metals chosen are Cu,Co,Ag and p.(as a reliable benchmark).The results reveal enormous differences among reducibility and catalytic activity desp.te quite similar structural and textural p.op.rties of the catalysts,showing differences among disp.rsion(Ag-catalyst seems to p.esent a low level of disp.rsion).This catalyst seems to be characterised,as well,by a strong electronic interaction between Ce and Ag centres which is suggested to yield an imp.oved reducibility under H_(2)-Tp. ***,the order in catalytic activity(Cu>Ag>Co≈p.>>sup.ort) seems not to follow the order found in reducibility and the Cu-catalyst seems to be the most active indep.ndently on the reaction conditions,yielding nearly overlap.ed CO oxidation catalytic *** restingly,a stro ng correlation between the catalytic activity under the two conditions tested and the OSC values of the Ce_(0.8)Zr_(0.2)O_(2)-sup.orted metal catalysts is ***,OSC p.rameter measured at 150℃ can be used as a relevant descrip.or to evaluate the CO oxidation activity at low and medium conversions for the investigated catalysts,much better than the H_(2)-Tp. measurements.

关键词： CO oxidation Low metal content Ceria-zirconia Cop.er sp.cies OSC p.rameter Rare earths