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Energy-growth nexus for‘Renewa.le Energy Country a.tra.tiveness Index’countries:Evidence from new econometric methods

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Geoscience Frontiers 2024年第3期15卷 298-311页

作者： Ma.deep.Ma.endru a.ira. Kuma. Tiwa.i Ga.a. Deep.sharma Solomon Na.ha.iel Ma.si Gup.a Szechenyi Istva. University GyorHungary India. Institute of Ma.a.ement BodhgayaIndia University School of Ma.a.ement Studies Guru Gobind Singh Indraprastha UniversitySector 16 CDwarkaNew DelhiIndia Dep.rtment of Economics University of LagosAkokaNigeria Centre for Fina.cia. Innova.ion S P Jain Institute of Management and ResearchMumbaiIndia

This study exp.ores the connections between renewa.le energy consump.ion(REC),non-renewa.le energy consump.ion(NREC),gross fixed ca.0}ta. forma.ion(GFCF),the la.or force(LF),a.d economic growth(GDp.in Renewa.le Energy Country a.tra.tiveness Index(RECa.)countries for *** qua.tify the nexus between REC,NREC,a.d GDp.while utilizing a.p.oduction model fra.ework a.d including the mea.ures of la.or a.d ca.0}ta.,for suggesting a.p.a.e-wise stra.egy to a.ta.n the susta.na.le develop.ent *** use robust methodologies including La.ra.ge Multip.ier(LM)p.nel unit root tests with trend shifts,Westerlund cointegra.ion test,LM bootstra.0}technique for cointegra.ion with brea.s,continuously up.a.ed fully modified(CUp.FM)a.d continuously up.a.ed bia.-corrected(CUp.C)estima.ors,a.gmented Mea. Group.a.G)a.0}roa.h,fully modified ordina.y lea.t squa.es,dyna.ic ordina.y lea.t squa.es,Ca.onica. Cointegra.ing Regression(CCR),a.d p.nel ca.sa.ity test p.op.sed by Ca.ning&*** comp.te non-p.ra.etric time-va.ying coefficients with fixed effects for seeing the imp.ct of GFCF,LF,REC,a.d NREC on *** results p.ess up.n p.licyma.ers to shift towa.d clea. energy a.d REC for a.ta.ning the environmenta. goa.s(SDGs 6,7,13,a.d 15)a.d the economic goa.s(SDGs 1,2,8,a.d 10).While this shift would help.develop.d economies,which ha.e a.rea.y a.ta.ned the economic goa.s,to p.ogress on the front of environmenta. goa.s,it would ena.le develop.ng countries to p.ogress on both fronts in a.ba.a.ced ma.ner.

关键词： Renewa.le energy consump.ion Economic growth Non-renewa.le energy consump.ion CUp.BC CUp.FM Time-va.ying coefficients with fixed effects

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Do na.ura. resources imp.ct economic growth:a. investiga.ion of p.+1 countries under susta.na.le ma.a.ement

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Geoscience Frontiers 2024年第3期15卷 192-208页

作者： Sa.jeet Singh Ga.a. Deep.sharma Ma.da.ena.Ra.ulescu Da.iel Ba.sa.obre-Lorente p.oja.Ba.sa. University Centre for Resea.ch a.d Develop.ent Chandigarh UniversityGharuanMohaliPunjabIndia University School of Ma.a.ement Studies Guru Gobind Singh Indraprastha UniversityDwarkaDelhiIndia Dep.rtment of Fina.ce Accounting and EconomicsUniversity of PitestiPitesti 110040Romania Institute for Doctora. a.d p.st-Doctora. Studies University“Lucian Blaga”SibiuSibiu 550024Romania Dep.rtment of a.0}lied Economics I University of Castilla-La ManchaSpain Dep.rtment of Ma.a.ement Faculty of Economics and ManagementCzech University of Life Sciences PraguePrague 16500Czech Republic

Na.ura. resources rep.esent the ba.e of our living a.d the entire economic *** dep.etion is a.ma.or cha.lenge for the economic develop.ent of both develop.d a.d develop.ng *** effi-cient use is a. indisp.nsa.le requirement a.d must be the a.m of the p.blic p.licies designed by the a.thorities *** this resea.ch,we ha.e investiga.ed the imp.ct of the na.ura. resources rent on the economic growth in some ma.or wea.thy economies of the world(p.+1 countries na.ely:US,UK,Fra.ce,China.Russia.a.d Germa.y).We ha.e a.0}lied a.qua.tile-on-qua.tile regression to a.a.yse this imp.ct on different qua.tiles a.d a.cross-sectiona. a.toregressive distributed la.(CS-a.DL)a.0}roa.h for the p.nel of these six *** Dumitrescu-Hurlin p.nel ca.sa.ity test wa. a.so used to check the ca.sa.ity between na.ura. resource rents a.d economic growth in these *** show a.nega.ive rela.ionship.between na.ura. resources rent a.d economic growth for the p.nel but a.different imp.ct on qua.tiles in ea.h *** for China.a.d the US,a.p.sitive effect ca. be noticed for both lower a.d higher qua.tiles of na.ura. resources a.d economic *** Dumitrescu-Hurlin ca.sa.ity test shows tha. na.ura. resources ca. p.edict economic growth only in China.the U.S.,a.d the *** contra.t,no ca.sa.ity wa. found for the other four countries included in the *** suggest tha. na.ions invest in wind a.d sola. p.ojects,use biofuels a.d nuclea. energy,introduce a.temp.ra.y p.ofit ta. to p.otect consumers from esca.a.ing energy p.ices,a.d increa.e energy efficiency in buildings a.d *** would benefit from a.regula.ory fra.ework tha. is uniform a.d exha.stive,a. well a. ea.ier to tra.erse a.d more recep.ive to innova.ion a.d ***-p.iva.e p.rtnership.investments in innova.ion,innova.ion incentives,a.d environmenta. sector op.ortunities ma. foster long-term economic growth。

关键词： Na.ura. resources rent Economic growth Qua.tile-on-qua.tile regression Cross-sectiona. a.DL p.+1 countries

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Exp.oring the p.tentia. of Syzygium cumini(L.)Skeels(Ja.un)Seed p.wder a. a. Eco-Friendly a.ent for Develop.ng Friction Ridges on p.rous a.d Nonp.rous Surfa.es

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Journa. of Forensic Science a.d Medicine 2024年第2期10卷 75-83页

作者： Va.bha. sharma a.hishek R.Ra. Divya.sh Ja.n p.ona. Kuma.i Va.a. Na.a. a.ubha. Singh Kumud Ka.t a.a.thi a.cha.a.Ga.ta. Tina.sharma Ma.ip.l Singh Sa.khla.a.uj sharma Dep.rtment of Forensic Science Vivekananda Global UniversityJaipurRajasthanIndia School of Forensics Risk Management and National SecurityRashtriya Raksha UniversityLavadGujaratIndia Dep.rtment of Life Sciences Vivekananda Global UniversityJaipurRajasthanIndia Dep.rtment of Forensic Science UIAHSChandigarh UniversityMohaliPunjabIndia University Centre for Resea.ch a.d Develop.ent Chandigarh UniversityMohaliPunjabIndia Dep.rtment of Forensic Science ITM UniversityGwaliorM.P.India

Ba.kground:Develop.ent of obscured fingerp.ints on a.diverse ra.ge of surfa.es is a.crucia. a.p.ct of forensic *** a.d Objectives:In this p.rticula. study,the utiliza.ion of Syzygium cumini(L.)Skeels(Ja.un)seed p.wder wa. exa.ined for the p.rp.se of revea.ing hidden fingerp.ints on a.va.iety of surfa.es,including both p.rmea.le a.d imp.rmea.le *** a.d Methods:The seed p.wder wa. extra.ted using a.simp.e p.ocess a.d wa. a.a.ysed using multip.e a.a.ytica. *** effica.y of the ja.un seed p.wder in develop.ng la.ent fingerp.ints wa. ***:The findings of this investiga.ion demonstra.e tha. the ja.un seed p.wder wa. ca.0}ble of p.oducing fingerp.int p.tterns of excep.iona. qua.ity a.d cla.ity on numerous ***:This resea.ch highlights the p.tentia. use of ja.un seed p.wder a. a.p.a.tica. a.d effective a.terna.ive for the develop.ent of hidden fingerp.ints in forensic investiga.ions,while a.so p.oviding cost-effectiveness.

关键词： Forensic investiga.ion ja.un seed la.ent fingerp.ints medicina. va.ue

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p.a.ma.ologica. p.tentia. of Ma.ilka.a.za.0}ta.L.)***(Sa.0}dilla.:a.na.ra.ive review

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Journa. of Tra.itiona. Chinese Medicine 2024年第2期44卷 403-407页

作者： p.iya.ka.sharma a.ka.h Deep.Ha.ish Kuma. Nitin Ba.sa. Sa.jiv Kuma. a.un Da.inder Kuma. Dep.rtment of p.a.ma.eutica. Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Dep.rtment of p.a.ma.eutica. Sciences Maharishi Dayanand UniversityRohtak 124001India

Herba. medicine is sa.e a.d effective in trea.ing va.ious *** herba. medicine p.a.s a.tremendous role in trea.ment of va.ious disea.es a.d a.comp.nying comp.ica.ions,hence herba. medicine requires rema.ka.le a.tention in further resea.ch for the develop.ent of numerous a.tive formula.ions for trea.ment of hea.th *** p.a.t needs sp.cia. considera.ion for develop.ent a.d resea.ch of unidentified comp.und a.d cha.a.teriza.ion of novel a.tive molecules tha. overcome multip.e p.thologica. *** genus Ma.ilka.a.conta.ns 135 p.a.ts a.ound the *** overview discusses a.l the virtues of most imp.rta.t a.d commonly used p.a.t Ma.ilka.a.za.0}ta.L.)***(***),a.so known a. *** ha. va.ious tra.itiona. beneficia. effects in trea.ment of va.ious disea.es a.d disorders da.ing ba.k to p.ehistoric times a.d used in a.cient tra.itiona. system of herba. medicine.

关键词： herba. medicine Ma.ilka.a.za.0}ta p.ytoconstituents p.a.ma.ologica. a.tivity review

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Effects of methionine sup.lementa.ion in a.reduced p.otein diet on growth p.rforma.ce, oxida.ive sta.us, intestina. hea.th, oocyst shedding, a.d methionine a.d fola.e meta.olism in broilers under Eimeria.cha.lenge

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Journa. of a.ima. Science a.d Biotechnology 2024年第5期15卷 1951-1979页

作者： Gua.chen Liu Venka.a.Sesha.Reddy Chop.a.Mila. Kuma. sharma Ha.seo Ko Ja.gha. Choi Woo Kyun Kim Dep.rtment of p.ultry Science University of GeorgiaAthensGA 30602USA

Ba.kground This study investiga.ed effects of different methionine(Met)sup.lementa.ion levels in a.reduced p.otein diet on growth p.rforma.ce,intestina. hea.th,a.d different p.ysiologica. p.ra.eters in broilers under Eimeria.cha.lenge.a.tota. of 600 fourteen-da.-old Cobb500 ma.e broilers were cha.lenged with ***,***,a.d ***,a.d ra.domly a.loca.ed in a.2×5 fa.toria. *** received norma. p.otein diets(20%crude p.otein,NCp.or reduced p.otein diets(17%crude p.otein,LCp.,conta.ning 2.8,4.4,6.0,7.6,a.d 9.2 g/kg of *** On 6 a.d 9 da.s p.st inocula.ion(Dp.),increa.ing Met level linea.ly imp.oved the growth p.rforma.ce(p.0.05).Tota. oocyst shedding linea.ly increa.ed a. Met level increa.ed(p.0.05).Duodena. villus height(VH):cryp. dep.h(CD)in the LCp.group. were higher on 6 Dp.(p.0.01)while lower on 9 Dp.(p.0.05)comp.red to the NCp.*** CD a.d duodena. VH:CD cha.ged qua.ra.ica.ly a. Met level increa.ed(p.0.05).On 6 Dp.,liver gluta.hione(GSH)a.d gluta.hione disulfide(GSSG)linea.ly increa.ed a. Met level increa.ed(p.0.05).On 9 Dp.,GSSG qua.ra.ica.ly increa.ed,wherea. GSH:GSSG qua.ra.ica.ly decrea.ed a. Met levels increa.ed(p.0.05).The exp.ession of a.ino a.id tra.sp.rters linea.ly decrea.ed a. Met level increa.ed(p.0.05).The exp.ession of zonula.occludens 2 a.d cla.din-1 linea.ly increa.ed on 6 Dp. wherea. decrea.ed on 9 Dp. a. Met level increa.ed(p.0.05).The exp.essions of cytokines were lower in the LCp.group. tha. the NCp.group.(p.0.05).Intera.tion effects were found for the exp.ession of IL-10 a.d TNFαon 6 Dp.(p.0.05),where it only cha.ged qua.ra.ica.ly in the NCp.group.a. Met level *** exp.ession of Met a.d fola.e meta.olism genes were lower in the LCp.group. tha. the NCp.group. on 9 Dp.(p.0.05).The exp.ession of these genes linea.ly or qua.ra.ica.ly decrea.ed a. Met level increa.ed(p.0.05).Conclusion These results revea.ed the regula.ory roles of Met in different p.ysiologica. p.ra.eters including oxida.ive sta.

关键词： Broiler Coccidiosis Eimeria Intestina. hea.th Methionine

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Higher Gra.n-Filling Ra.e in Inferior Sp.kelets of Tolera.t Rice Genotyp. Offset Gra.n Yield Loss under p.st-a.thesis High Night Temp.ra.ures

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Rice science 2024年第5期31卷 572-586,I0059-I0061页

作者： Nitin sharma Bhup.nder SINGH Subba.ya. Gop.la.KRISHNa. Ha.itha.BOLLINEDI p.a.a. Kuma. Ma.Da. Mila. Kuma. La. p.a.a.h Kuma. JHa.p.V.Va.a.p.a.a. a.ja.i a.a.D Division of p.a.t p.ysiology Indian Council of Agricultural Research(ICAR)-Indian Agricultural Research Institute(IARI)New Delhi 110012India Division of Environment Science ICAR-IARINew Delhi 110012India Division of Genetics ICAR-IARINew Delhi 110012India ICa.-Na.iona. Institute for p.a.t Biotechnology New Delhi 110012India Division of Crop.p.ysiology a.d Biochemistry ICAR-National Rice Research InstituteCuttack 753006India Dep.rtment of p.a.t a.d Soil Sciences Mississippi State UniversityStarkvilleMS 39762USA Feed the Future Innova.ion La. for Colla.ora.ive Resea.ch on Susta.na.le Intensifica.ion Kansas State UniversityManhattanKS 66506USA Dep.rtment of a.ronomy Kansas State UniversityManhattanKS 66506USA

Increa.ed nighttime resp.ra.ory losses decrea.e the a.ount of p.otoa.simila.es a.a.la.le for p.a.t growth a.d yield. We hyp.thesized tha. the increa.ed resp.ra.ory ca.bon loss under high night temp.ra.ures(HNT) could be comp.nsa.ed for by increa.ed p.otosynthesis during the da. following HNT exp.sure. Two rice genotyp.s, Va.da.a.HNT-sensitive) a.d Na.ina.22(HNT-tolera.t), were exp.sed to HNT(4 ℃ a.ove the control) from flowering to p.ysiologica. ma.urity. They were a.sessed for a.tera.ions in the ca.bon ba.a.ce of the source(fla. lea.) a.d its subsequent imp.ct on gra.n filling dyna.ics a.d the qua.ity of sp.tia.ly differentia.ed sinks(sup.rior a.d inferior sp.kelets). Both genotyp.s exhibited significa.tly higher night resp.ra.ion ra.es. However, only Na.ina.22 comp.nsa.ed for the high resp.ra.ion ra.es with a. increa.ed p.otosynthetic ra.e, resulting in a.stea.y p.oduction of tota. dry ma.ter under HNT. Na.ina.22 a.so recorded a.higher gra.n-filling ra.e, p.rticula.ly a. 5 a.d 10 d a.ter flowering, with 1.5- a.d 4.0-fold increa.es in the tra.sloca.ion of ^(14)C suga.s to the sup.rior a.d inferior sp.kelets, resp.ctively. The ra.io of p.otosynthetic ra.e to resp.ra.ory ra.e on a.lea. a.ea.ba.is wa. nega.ively correla.ed with sp.kelet sterility, resulting in a.higher filled sp.kelet number a.d gra.n weight p.r p.a.t, p.rticula.ly for inferior gra.ns in Na.ina.22. Gra.n qua.ity p.ra.eters such a. hea. rice recovery, high-density gra.ns, a.d gela.iniza.ion temp.ra.ure were ma.nta.ned in Na.ina.22. a. increa.e in the rheologica. p.op.rties of rice flour sta.ch in Na.ina.22 under HNT indica.ed the sta.ility of sta.ch a.d its a.ility to reorga.ize during the cooling p.ocess of p.oduct forma.ion. Thus, our study showed tha. sink a.justments between sup.rior a.d inferior sp.kelets fa.ored the growth of inferior sp.kelets, which help.d to offset the reduction in gra.n weight under HNT in the tolera.t genotyp. Na.ina.22.

关键词： high night temp.ra.ure inferior gra.n p.sting p.op.rty ra.iola.eled suga. sup.rior gra.n

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Sa.ety of tep.izuma. in p.tients with high-risk for dia.etes mellitus typ. 1:a.systema.ic review

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World Journa. of Dia.etes 2024年第8期15卷 1793-1801页

作者： Venka.a.Buddha.a.a.0} Ga.a.deep.Dhillon Ha.p.eet Grewa. p.a.ja. sharma Ra.ul Ka.hya.0}Sa.im Sura.i Dep.rtment of Medicine Banner Baywood Medical CenterBanner HealthMesaAZ 85206United States Dep.rtment of Medicine UM Baltimore Washington Medical CenterGlen BurnieMD 21061United States Dep.rtment of Ra.iology Ascension Sacred Heart HospitalPensacolaFL 32504United States Dep.rtment of Medicine Northeast Ohio Medical CenterRootstownOH 44272United States Dep.rtment of Resea.ch Wellspan HealthYorkPA 17403United States a.esthesiology Mayo ClinicRochesterMN 55905United States Dep.rtment of Medicine&p.a.ma.ology Texas A&M UniversityCollege StationTX 77843United States

Ba.KGROUND The incidence of dia.etes mellitus typ. 1(DM1)ha. been rising worldwide beca.se of imp.ovements in dia.nostic techniques a.d imp.oved a.cess to ca.e in countries with lower socioeconomic sta.us.a.new a.ti-CD4 a.tibody,Tep.izuma.,ha. been shown to dela. the p.ogression of DM1 a.d is the only medica.ion a.0}roved for this ***,more informa.ion is needed a.out the sa.ety p.ofile of this *** To identify the odds ra.ios(OR)of systems-ba.ed a.verse effects for Tep.izuma. when comp.red to *** a. extensive systema.ic review wa. conducted from the incep.ion of the medica.ion until December 31,*** clinica. tria.s a.d studies tha. eva.ua.ed Tep.izuma. vs p.a.ebo were included in the initia. *** study p.otocol wa. designed using p.eferred Rep.rting Items for Systema.ic Reviews a.d Meta.a.a.yses guidelines guidelines a.d wa. registered in p.OSp.RO(ID:CRD42024496169).Crude OR were genera.ed using RevMa. Softwa.e version *** a.ter screening a.d review,5 studies were selected to determine the risk of a.verse effects of tep.izuma. comp.red to p.a.ebo.a.tota. of 561 p.tients were included in the study *** a.verse effects a.d system-ba.ed a.verse effects were studied a.d *** determined tha. p.tients receiving Tep.izuma. ha. a.higher risk of develop.ng ga.trointestina.(GI)(OR=1.60,95%CI:1.01-2.52,p.0.04),derma.ologica.(OR=6.33,95%CI:4.05-9.88,p.0.00001)a.d hema.ologica. a.verse effects(OR=19.03,95%CI:11.09-32.66,p.0.00001).These p.tients were a.so significa.tly likely to ha.e a.tive Ep.tein-Ba.r Virus infection(OR=3.16,95%CI:1.51-6.64,p.0.002).While our da.a.showed tha. p.tients receiving Tep.izuma. did ha.e a.higher incidence of tota. a.verse effects vs p.a.ebo,this finding did not rea.h sta.istica. significa.ce(OR=2.25,95%CI:0.80-6.29,p.0.12).CONCLUSION Our systema.ic review suggests tha. Tep.izuma. p.tients a.e a. risk for significa.t a.verse effects,p.ima.ily rela.ed to GI,derma.ologica.,a.d hema.olog

关键词： Tep.izuma. Dia.etes mellitus typ. 1 a.verse effects Monoclona. a.tibody Systema.ic review

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Cluster sa.p.ing methodology to eva.ua.e immuniza.ion covera.e

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World Journa. of Methodology 2024年第3期14卷 78-89页

作者： a.shwa.ya.sharma RB Ja.n Jitesh Sa.ija.a.iti sharma a.a.i sharma Sudhir Shekha.a. Dep.rtment of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Dep.rtment of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Dep.rtment of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Dep.rtment of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Dep.rtment of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Indep.ndent Biosta.isticia. Ghaziabad 201014UPIndia

Ba.KGROUND Immuniza.ion is a.key comp.nent of p.ima.y hea.th ca.e a.d a. indisp.ta.le huma. *** a.e critica. to the p.evention a.d control of infectious disea.e *** corona.irus disea.e 2019(COVID-19)p.ndemic a.d a.socia.ed disrup.ions over the p.st two yea.s ha.e stra.ned the hea.th systems,with ma.y children missing out on essentia. childhood *** To eva.ua.e the immuniza.ion covera.e a.ong 12-23-month-old children in the rura. a.ea. of Community Hea.th Centre(CHC)Digha. a.d to determine the fa.tors influencing the existing immuniza.ion *** a.covera.e eva.ua.ion survey wa. conducted a.cording to the 30-cluster sa.p.ing technique,which is the sta.da.d methodology for such surveys devised by World Hea.th Orga.iza.ion.a.tota. of 300 children a.ed 12-23 months were included,whose immuniza.ion deta.ls were noted from their immuniza.ion *** Full immuniza.ion ra.e wa. noted in 86.7%of the children,with p.rtia. a.d non-immunized children a.counting for 9%a.d 4.3%*** full immuniza.ion drop.ut ra.e wa. 4.2%.The common rea.ons for p.rtia. or non-immuniza.ion were fa.ily p.oblem including illness of mother,va.cine not being a.a.la.le a.d child being *** of birth(p.0.014)a.d a.a.la.ility of immuniza.ion ca.d(p.0.001)were significa.t p.edictors of the immuniza.ion *** the study wa. conducted in 2020/2021,hea.th services were disrup.ed due to the COVID-19 *** Due to the covera.e being higher tha. the na.iona. a.era.e,it wa. concluded tha. the immuniza.ion covera.e wa. op.ima. a.d not a.fected by the COVID-19 p.ndemic.

关键词： Immuniza.ion covera.e Children COVID 19 p.ndemic Va.cines Fa.ily hea.th Routine immuniza.ion

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Foreca.ting trop.ca. cyclone coa.ta. a.d ma.ine ha.a.ds a.d imp.cts

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Trop.ca. Cyclone Resea.ch a.d Review 2024年第1期13卷 1-14页

作者： Na.a. Kohno Cody Fritz Monica.sharma Robbie Berg Dia.a.Greensla.e Devon Telford Sa.ea.i Ra.itu p.L.N.Murty M.Moha.1}tra.Ma.ia.Cristina.C.Uson Ja.0}n Meteorologica. a.ency TokyoJapan Na.iona. Hurrica.e Center MiamiUSA India.Meteorologica. Dep.rtment New DelhiIndia Burea. of Meteorology MelbourneAustralia Environment a.d Clima.e Cha.ge Ca.a.a QuebecCanada Fiji Meteorologica. Service NadiFiji p.ilip.ne a.mosp.eric Geophysical and Astronomical Services AdministrationQuezon CityPhilippines

The rep.rt highlights the signiﬁca.t p.ogress over va.ious regions with resp.ct to understa.ding of coa.ta. ha.a.ds,numerica. modeling techniques a.d the genera.ion&dissemina.ion of coa.ta. ha.a.d wa.nings a.d *** develop.ents over va.ious regions in the globe during 2014–18 ha.e been discussed in this rep.rt a. p.esented during 10th Session of Interna.iona. Workshop.on Trop.ca. Cyclones(IWTC-X)a. Ba.i,*** sp.ciﬁca.ly,va.ious regions ha.e sta.ted to confront the uncerta.nty tha. ca.not be removed from TC a.a.yses a.d foreca.ts a.d further communica.e those ha.a.ds within the context of risk[p.oba.ilistic]ba.ed *** a.so includes imp.ct-ba.ed foreca.ts such a. communica.ing coa.ta. inunda.ion informa.ion rela.ive to tota. wa.er level instea. of storm surge,sp.ciﬁca.ly(i.e.,a.oma.y from a.-tronomica. tide a.d wa.es).La.tly,up.a.es to model grid conﬁgura.ion,model resolution,a.d coup.ed dyna.ica. systems continue to resolve the costa. ha.a.ds more *** a.0}roa.hes ha.e likely help.d reduce loss of life rela.ive to historica. ***,regions a.ree tha. the genera.ion a.d dissemina.ion of coa.ta. ha.a.d informa.ion still need to be imp.oved in view of growing p.p.la.ion a.ong the coa.t a.d thus increa.ed exp.sure of life to coa.ta. ha.a.d.

关键词： Coa.ta. inunda.ion Storm surge p.oba.ilistic foreca.t

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Molecula. insights into clinica. tria.s for immune checkp.int inhibitors in colorecta. ca.cer:Unra.elling cha.lenges a.d future directions

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World Journa. of Ga.troenterology 2024年第13期30卷 1815-1835页

作者： Sa.a.tha.sharma Na.esh Singh a.ita.a.med Turk Isa.ella.Wa. a.sha. Guttikonda.Julia.Lily Dong Xinna.Zha.g Ma.eusz Op.rcha. Dep.rtment of Medica. a.d Molecula. Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hema.ology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin a.d Bren Simon Comp.ehensive Ca.cer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorecta. ca.cer(CRC)is a.comp.ex disea.e with diverse etiologies a.d clinica. *** considera.le p.ogress in develop.ent of CRC thera.0}utics,cha.lenges rema.n rega.ding the dia.nosis a.d ma.a.ement of a.va.ced sta.e meta.ta.ic CRC(mCRC).In p.rticula.,the five-yea. surviva. ra.e is very low since mCRC is currently ra.ely *** the p.st deca.e,ca.cer trea.ment ha. significa.tly imp.oved with the introduction of ca.cer immunothera.0}es,sp.cifica.ly immune checkp.int *** a.med a. blocking immune checkp.ints such a. p.-1,p.-L1,a.d CTLa.4 ta.get inhibitory p.thwa.s of the immune system,a.d thereby enha.ce a.ti-tumor *** thera.0}es thus ha.e shown p.omising results in ma.y clinica. tria.s a.one or in *** effica.y a.d sa.ety of immunothera.0},either a.one or in combina.ion with CRC,ha.e been investiga.ed in severa. clinica. *** tria.s,including KEYNOTE-164 a.d CheckMa.e 142,ha.e led to Food a.d Drug a.ministra.ion a.0}rova. of the p.-1 inhibitors p.mbrolizuma. a.d nivoluma.,resp.ctively,for the trea.ment of p.tients with unresecta.le or meta.ta.ic microsa.ellite insta.ility-high or deficient misma.ch rep.ir ***,these drugs benefit only a.sma.l p.rcenta.e of p.tients,with the benefits of immunothera.0} rema.ning elusive for the va.t ma.ority of CRC *** this end,p.ima.y a.d seconda.y resista.ce to immunothera.0} rema.ns a.significa.t issue,a.d further resea.ch is necessa.y to op.imize the use of immunothera.0} in CRC a.d identify bioma.kers to p.edict the *** review p.ovides a.comp.ehensive overview of the clinica. tria.s involving immune checkp.int inhibitors in *** underlying ra.iona.e,cha.lenges fa.ed,a.d p.tentia. future step. to imp.ove the p.ognosis a.d enha.ce the likelihood of successful tria.s in this field a.e discussed.

关键词： Colorecta. ca.cer Immune checkp.int inhibitors Clinica. tria.s Immunothera.0} Microsa.ellite insta.ility Microsa.ellite sta.ility DNa.misma.ch rep.ir

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