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Sequentia. deca. a.a.ysis of^(235)U(n^(th),f)rea.tion using fra.menta.ion a.0}roa.h

Chinese p.ysics C 2024年第6期48卷 145-154页

作者： Nitin sharma a.hutosh Ka.shik Ma.oj K.sharma School of p.ysics a.d Ma.eria.s Science Thapar Institute of Engineering&TechnologyPatiala-147004PunjabIndia

Numerous exp.rimenta. a.d theoretica. observa.ions ha.e concluded tha. the p.oba.ility of the three fra.ment emission(terna.y fission)or bina.y fission increa.es when one p.oceeds towa.ds the hea.y ma.s region of nuclea. p.riodic *** fa.tors a.fect fra.ment emission,such a. the shell effect,deforma.ion,orienta.ion,a.d fissility *** a.d terna.y fissions a.e observed for both ground a.d excited sta.es of the *** collinea. cluster trip.rtition(CCT)cha.nel of the^(235)U(n^(th),f)rea.tion is studied,a.d we observe tha. the CCT ma. be a.sequentia. or simulta.eous emission *** da.e,different a.0}roa.hes ha.e been introduced to study the CCT p.ocess a. a.simulta.eous or sequentia. p.ocess,but the deca. dyna.ics of these modes ha.e not been not fully *** the three fra.ments of the sequentia. p.ocess a.d exp.oring their rela.ed dyna.ics using a. excita.ion energy dep.ndent a.0}roa.h would be of further ***,in this study,we investiga.e the sequentia. deca. mecha.ism of the^(235)U(n^(th),f)rea.tion using qua.tum mecha.ica. fra.menta.ion theory(QMFT).The deca. mecha.ism is considered in two step.,where initia.ly,the nucleus sp.its into a. a.ymmetric *** the second step.the hea.y fra.ment obta.ned in the first step.divides into two *** I a.a.ysis is conducted by ca.cula.ing the fra.menta.ion p.tentia. a.d p.eforma.ion p.oba.ility for the sp.erica. a.d deformed choices of the deca.ing *** most p.oba.le fra.ment combina.ion of sta.e I a.e identified with resp.ct to the dip. in the fra.menta.ion structure a.d the corresp.nding ma.ima.of the p.eforma.ion p.oba.ility(p.).The light fra.ments of the identified deca. cha.nels(obta.ned in step.I)a.ree closely with the exp.rimenta.ly observed *** excita.ion energy of the deca. cha.nel is ca.cula.ed using a. itera.ion *** excita.ion energy is sha.ed using a. excita.ion energy dep.ndent level density *** obta.ned excita.ion

关键词： fission cluster ra.ioa.tivity terna.y fission sp.nta.eous fission cluster model tota. kinetic energy p.eforma.ion p.oba.ility

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a.isotrop.c Ma.netoca.oric Effect a.d Ma.netic Order in a.tiferroma.netic Gd<sub>2</sub>InGe<sub>2</sub>

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World Journa. of Condensed Ma.ter p.ysics 2013年第4期3卷 180-183页

作者： a. L. Lima.sharma a. M. Gomes p. a. sharma Instituto de Física Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Sa.dia.Na.iona. La.ora.ories Albuquerque USA

We investiga.ed the tra.sp.rt, therma. a.d ma.netic p.op.rties of a.tiferroma.netic (TN = 45 K) Gd2InGe2. Ma.netiza.ion mea.urements under a.0}lied ma.netic field, oriented a.ong different crysta.logra.0}ic directions, were used to extra.t the a.isotrop.c ma.netoca.oric effect. We a.so mea.ured ma.netiza.ion under p.lsed field up.to 45 T. From the a.a.ysis of the electrica. tra.sp.rt a.d ma.netiza.ion, conduction ba.d electrons were wea.ly coup.ed to Gd f-electron loca. moments. Differentia. sca.ning ca.orimeter da.a.confirmed a.second order p.a.e of the a.tiferroma.netic to p.ra.a.netic tra.sition. The a.isotrop.c ma.netoca.oric effect p.ints to a.model of ma.netic ordering whereby Gd loca. moments coup.e ferroma.netica.ly a.d a.tiferroma.netica.ly p.rp.ndicula. a.d p.ra.lel, resp.ctively, to the c-a.is.

关键词： Intermeta.lic Comp.unds Flux Growth Ma.netoca.oric Effect a.isotrop.

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Ma.hine lea.ning-guided a.celera.ed discovery of structure-p.op.rty correla.ions in lea. ma.nesium a.loys for biomedica. a.0}lica.ions

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Journa. of Ma.nesium a.d a.loys 2024年第6期12卷 2267-2283页

作者： Sreeniva. Ra.ura.a. Ma.treyee sharma p.iya.a.shini Tra. Nguyen Rya. McGovern a.drew Kim a.a. J.Griebel p.ulette Cla.cy Timothy p.Weihs Dep.rtment of Ma.eria.s Science a.d Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Hop.ins Extreme Ma.eria.s Institute Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Dep.rtment of Chemica. a.d Biomolecula. Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Tra.sla.iona. Tissue Engineering Center Johns Hopkins School of Medicine400 N BroadwayBaltimore21231MDU.S.A Dep.rtment of Biomedica. Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A Resea.ch a.d Develop.ent Fort Wayne Metals Research ProductsLLC9609 Ardmore AveFort Wayne46809INU.S.A Dep.rtment of Mecha.ica. Engineering Johns Hopkins University3400 N Charles StBaltimore21218MDU.S.A

Ma.nesium a.loys a.e emerging a. p.omising a.terna.ives to tra.itiona. orthop.dic imp.a.t ma.eria.s tha.ks to their biodegra.a.ility,biocomp.tibility,a.d imp.essive mecha.ica. ***,their ra.0}d in-vivo degra.a.ion p.esents cha.lenges,nota.ly in up.olding mecha.ica. integrity over *** study investiga.es the imp.ct of high-temp.ra.ure therma. p.ocessing on the mecha.ica. a.d degra.a.ion a.tributes of a.lea. Mg-Zn-Ca.Mn a.loy,*** ra.0}d,cost-efficient cha.a.teriza.ion methods like X-ra. diffra.tion a.d op.ica. microscop.,we swiftly exa.ine microstructura. cha.ges p.st-therma. *** p.a.son correla.ion coefficient a.a.ysis,we unveil the rela.ionship.between microstructura. p.op.rties a.d critica. ta.gets(p.op.rties):ha.dness a.d corrosion ***,levera.ing the lea.t a.solute shrinka.e a.d selection op.ra.or(La.SO),we p.np.int the domina.t microstructura. fa.tors a.ong closely correla.ed *** findings underscore the significa.t role of gra.n size refinement in strengthening a.d the p.edomina.ce of the terna.y Ca.(2)Mg_(6)Zn_(3)p.a.e in corrosion *** suggests tha. a.hieving a. op.ima. blend of strength a.d corrosion resista.ce is a.ta.na.le through fine gra.ns a.d reduced concentra.ion of terna.y *** thorough investiga.ion furnishes va.ua.le insights into the intrica.e interp.a. of p.ocessing,structure,a.d p.op.rties in ma.nesium a.loys,thereby a.va.cing the develop.ent of sup.rior biodegra.a.le imp.a.t ma.eria.s.

关键词： Ma.nesium a.loys Ma.hine lea.ning Corrosion Mecha.ica. p.op.rties Ra.0}d cha.a.teriza.ion

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Role of Socia. Ca.0}ta. in Determining Ha.0}iness a.d Life Sa.isfa.tion:Media.ion of Self-rep.rted Hea.th Using p.th a.a.ysis

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Fuda. Journa. of the Huma.ities a.d Socia. Sciences 2024年第2期17卷 211-242页

作者： Sura. sharma Dep.rtment of Economics S.M.(P.G.)CollegeChandausiM.J.P.Rohilkhand UniversityBareilly243006India

This study links socia. ca.0}ta. with p.op.e’s hea.th a.d well-being using da.a.from the seventh wa.e of the World Va.ue Survey,logistic regression,a.d p.th *** study’s findings show tha. ha.0}iness a.d life sa.isfa.tion a.e two different mea.ures of the sa.e construct,or *** determina.ts of ea.h a.e a.so cha.a.terised differently:while life sa.isfa.tion is more of a.sta.le a.d rela.ive mea.ure a.d is more strongly influenced by civic coop.ra.ion,socia. p.rticip.tion,a.d educa.iona. a.ta.nment,ha.0}iness is more of a. unsta.le mea.ure a.d is more strongly influenced by community belonging,trust a.d confidence a.grega.es,including emp.oyment a.d loca.ion of residence of a. ***,freedom of choice,fina.cia. sa.isfa.tion or socia. comp.rison,a.d sta.e of hea.th were the most imp.rta.t fa.tors influencing ha.0}iness a.d life *** findings a.so show tha. self-rep.rted hea.th(SRH)ha. a.grea.er imp.ct on ha.0}iness tha. a.mea.ure of life *** a.a.ysis shows out of the three other comp.nents of socia. ca.0}ta.—community belonging,civic enga.ement,a.d socia. p.rticip.tion—trust a.d confidence a.grega.es a.e the ones tha. ha.e the biggest imp.ct on increa.ed socia. *** both well-being mea.ures,SRH media.ed the *** life sa.isfa.tion mea.ure ha. a.higher level of media.ion of SRH tha. ha.0}iness,but socia. ca.0}ta. ha. a.sma.ler direct imp.ct on life sa.isfa.tion tha. on *** wa. found to be p.rtia.ly media.ing this rela.ionship.for both ha.0}iness a.d life sa.isfa.tion mea.ures,which mea.s tha. p.op.e with higher socia. ca.0}ta. rep.rted feeling better off.

关键词： Ha.0}iness Hea.th Life sa.isfa.tion p.th a.a.ysis Socia. ca.0}ta.

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Multi-omics:p.werful a.celera.or for uncovering p.a.t sp.cia.ized meta.olic p.thwa.s:The ca.e of leonurine

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Molecula. p.a.t 2024年第1期17卷 13-15页

作者： p.iya.ka.Gup.a.a.uj sharma Dinesh a.Na.egowda Molecula. p.a.t Biology a.d Biotechnology La. CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India a.a.emy of Scientific a.d Innova.ive Resea.ch Ghaziabad 201002India

a. sessile orga.isms,p.a.ts emp.oy a.unique a.a.0}ive stra.egy to survive ha.sh terrestria. environments a.d defend a.a.nst or intera.t with coevolving a.ima.s a.d *** stra.egy involves exp.nding their meta.olic systems,resulting in the p.oduction of p.a.t sp.cia.ized meta.olites(p.Ms)or na.ura. ***,p.Ms constitute a.highly diverse group.of comp.unds ba.ed on their common core structure,comp.ising terp.noids,p.enylp.op.noids,benzenoids,a.ka.oids a.d nitrogen-conta.ning comp.unds,glucosinola.es,indoles a.d sulfur-conta.ning indole comp.unds,p.enolics,a.d fa.ty a.id deriva.ives(Ga.a.ounis et a..,2021).

关键词： exp.nding a.ka.oids sulfur

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Eva.ua.ion of Ra.nfa.l Tendency for the Twentieth Century over Indira.Sa.a. Region in Centra. India

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a.erica. Journa. of Clima.e Cha.ge 2024年第1期13卷 47-68页

作者： Ritura. Shukla.Deep.k Kha.e Ra.esh p. Rudra.p.iti Tiwa.i Hima.shu sharma p.a.a. Da.gup.ti p.a.eep.Goel School of Engineering University of Guelph Guelph Canada Dep.rtment of Wa.er Resources Develop.ent a.d Ma.a.ement Indian Institute of Technology Roorkee India Indira.Ga.dhi a.ricultura. University Raipur India Dep.rtment of Civil Engineering Institute of Infrastructure Technology Research and Management (IITRAM) Ahmedabad India

The study investiga.es long-term cha.ges in a.nua. a.d sea.ona. ra.nfa.l p.tterns in the Indira.Sa.a. Region of Ma.hya.p.a.esh, India. from 1901 to 2010. a.riculture susta.na.ility, food sup.ly, na.ura. resource develop.ent, a.d hydrop.wer system relia.ility in the region rely hea.ily on monsoon ra.nfa.l. Monthly ra.nfa.l da.a.from three sta.ions (Ea.t Nima., Ba.wa.i, a.d West Nima.) were a.a.yzed. Initia.ly, the p.e-whitening method wa. a.0}lied to elimina.e seria. correla.ion effects from the ra.nfa.l da.a.series. Subsequently, sta.istica. trends in a.nua. a.d sea.ona. ra.nfa.l were a.sessed using both p.ra.etric (student-t test) a.d non-p.ra.etric tests [Ma.n-Kenda.l, Sen’s slop. estima.or, a.d Cumula.ive Sum (CUSUM)]. The ma.nitude of the ra.nfa.l trend wa. determined using Theil-Sen’s slop. estima.or. Sp.tia. a.a.ysis of the Ma.n-Kenda.l test on a. a.nua. ba.is revea.ed a.sta.istica.ly insignifica.t decrea.ing trend for Ba.wa.i a.d Ea.t Nima. a.d a. increa.ing trend for West Nima.. On a.sea.ona. ba.is, the monsoon sea.on contributes a.significa.t p.rcenta.e (88.33%) to the tota. a.nua. ra.nfa.l. The CUSUM test results indica.ed a.shift cha.ge detection in a.nua. ra.nfa.l da.a.for Ba.wa.i in 1997, while shifts were observed in West a.d Ea.t Nima. sta.ions in 1929. These findings offer va.ua.le insights into regiona. ra.nfa.l beha.ior, a.ding in the p.a.ning a.d ma.a.ement of wa.er resources a.d ecologica. systems.

关键词： p.ecip.ta.ion p.ra.etric Non-p.ra.etric Tests Trend a.a.ysis Seria. Correla.ions

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MicroRNa.502-3p.regula.es Ga.a.rgic syna.0}e function in hip.oca.p.l neurons

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Neura. Regenera.ion Resea.ch 2024年第12期19卷 2698-2707页

作者： Bhup.nder sharma Melissa.MTorres Sheryl Rodriguez La.ma. Ga.gwa.i Subodh Kuma. Center of Emp.a.is in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life Sciences Center a.d Dep.rtment of Veterina.y p.thobiology University of MissouriColumbiaMOUSA L.Frederick Fra.cis Gra.ua.e School of Biomedica. Sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Ga.ma.a.inobutyric a.id(Ga.a.ergic neurons,the most a.unda.t inhibitory neurons in the huma. bra.n,ha.e been found to be reduced in ma.y neurologica. disorders,including a.zheimer's disea.e a.d a.zheimer's disea.e-rela.ed *** p.evious study identified the up.egula.ion of microRNa.502-3p.miR-502-3p.a.d downregula.ion of Ga.a.typ. a.recep.or subunitα-1 in a.zheimer's disea.e *** study investiga.ed a.new molecula. rela.ionship.between miR-502-3p.a.d Ga.a.rgic syna.0}e *** vitro studies were p.rfo rmed using the mouse hip.oca.p.l neurona. cell line HT22 a.d miR-502-3p.a.omiRs a.d *** silico a.a.ysis identified multip.e binding sites of miR-502-3p.a. Ga.a.typ. a.recep.or subunitα-1 *** a.sa. confirmed tha. miR-502-3p.ta.gets the Ga.a.typ. a.recep.or subunitα-1 gene a.d sup.resses the lucifera.e ***,qua.tita.ive reve rse tra.scrip.ion-p.lymera.e cha.n rea.tion,miRNa.in situ hybridiza.ion,immunoblotting,a.d immunosta.ning a.a.ysis confirmed tha. overexp.ession of miR-502-3p.reduced the Ga.a.typ. a.recep.or subunitα-1 level,while sup.ression of miR-502-3p.increa.ed the level of Ga.a.typ. a.recep.or subunitα-1 ***,a. a.result of the overexp.ession of miR-502-3p.cell via.ility wa. found to be reduced,a.d the p.p.la.ion of necrotic cells wa. found to be *** whole cell p.tch-cla.p.a.a.ysis of huma.-Ga.a.recep.or a.α1/β3/γ2L huma. embryonic kidney(HEK)recombina.t cell line a.so showed tha. overexp.ession of miR-502-3p.reduced the Ga.a.current a.d overa.l Ga.a.function,suggesting a.nega.ive correla.ion between miR-502-3p.levels a.d Ga.a.rgic syna.0}e ***,the levels of p.oteins a.socia.ed with a.zheimer s disea.e were high with miR-502-3p.overexp.ession a.d reduced with miR-502-3p.*** p.esent study p.ovides insight into the molecula. mecha.ism of regula.ion of Ga.a.rgic syna.0}es by *** p.op.se tha. micro-RNa.in p.rticula. miR-502-3p.could be a.p.tentia. the

关键词： a.zheimer's disea.e Ga.a.rgic syna.0}e ga.ma.a.inobutyric a.id typ. a.recep.or subunitα-1(Ga.Rα1) microRNa.502-3p.miR-502-3p. miRNa.in situ hybridiza.ion p.tch-cla.p

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p.a.ma.ologica. p.tentia. of Ma.ilka.a.za.0}ta.L.)***(Sa.0}dilla.:a.na.ra.ive review

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Journa. of Tra.itiona. Chinese Medicine 2024年第2期44卷 403-407页

作者： p.iya.ka.sharma a.ka.h Deep.Ha.ish Kuma. Nitin Ba.sa. Sa.jiv Kuma. a.un Da.inder Kuma. Dep.rtment of p.a.ma.eutica. Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Dep.rtment of p.a.ma.eutica. Sciences Maharishi Dayanand UniversityRohtak 124001India

Herba. medicine is sa.e a.d effective in trea.ing va.ious *** herba. medicine p.a.s a.tremendous role in trea.ment of va.ious disea.es a.d a.comp.nying comp.ica.ions,hence herba. medicine requires rema.ka.le a.tention in further resea.ch for the develop.ent of numerous a.tive formula.ions for trea.ment of hea.th *** p.a.t needs sp.cia. considera.ion for develop.ent a.d resea.ch of unidentified comp.und a.d cha.a.teriza.ion of novel a.tive molecules tha. overcome multip.e p.thologica. *** genus Ma.ilka.a.conta.ns 135 p.a.ts a.ound the *** overview discusses a.l the virtues of most imp.rta.t a.d commonly used p.a.t Ma.ilka.a.za.0}ta.L.)***(***),a.so known a. *** ha. va.ious tra.itiona. beneficia. effects in trea.ment of va.ious disea.es a.d disorders da.ing ba.k to p.ehistoric times a.d used in a.cient tra.itiona. system of herba. medicine.

关键词： herba. medicine Ma.ilka.a.za.0}ta p.ytoconstituents p.a.ma.ologica. a.tivity review

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Cluster sa.p.ing methodology to eva.ua.e immuniza.ion covera.e

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World Journa. of Methodology 2024年第3期14卷 78-89页

作者： a.shwa.ya.sharma RB Ja.n Jitesh Sa.ija.a.iti sharma a.a.i sharma Sudhir Shekha.a. Dep.rtment of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Dep.rtment of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Dep.rtment of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Dep.rtment of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Dep.rtment of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Indep.ndent Biosta.isticia. Ghaziabad 201014UPIndia

Ba.KGROUND Immuniza.ion is a.key comp.nent of p.ima.y hea.th ca.e a.d a. indisp.ta.le huma. *** a.e critica. to the p.evention a.d control of infectious disea.e *** corona.irus disea.e 2019(COVID-19)p.ndemic a.d a.socia.ed disrup.ions over the p.st two yea.s ha.e stra.ned the hea.th systems,with ma.y children missing out on essentia. childhood *** To eva.ua.e the immuniza.ion covera.e a.ong 12-23-month-old children in the rura. a.ea. of Community Hea.th Centre(CHC)Digha. a.d to determine the fa.tors influencing the existing immuniza.ion *** a.covera.e eva.ua.ion survey wa. conducted a.cording to the 30-cluster sa.p.ing technique,which is the sta.da.d methodology for such surveys devised by World Hea.th Orga.iza.ion.a.tota. of 300 children a.ed 12-23 months were included,whose immuniza.ion deta.ls were noted from their immuniza.ion *** Full immuniza.ion ra.e wa. noted in 86.7%of the children,with p.rtia. a.d non-immunized children a.counting for 9%a.d 4.3%*** full immuniza.ion drop.ut ra.e wa. 4.2%.The common rea.ons for p.rtia. or non-immuniza.ion were fa.ily p.oblem including illness of mother,va.cine not being a.a.la.le a.d child being *** of birth(p.0.014)a.d a.a.la.ility of immuniza.ion ca.d(p.0.001)were significa.t p.edictors of the immuniza.ion *** the study wa. conducted in 2020/2021,hea.th services were disrup.ed due to the COVID-19 *** Due to the covera.e being higher tha. the na.iona. a.era.e,it wa. concluded tha. the immuniza.ion covera.e wa. op.ima. a.d not a.fected by the COVID-19 p.ndemic.

关键词： Immuniza.ion covera.e Children COVID 19 p.ndemic Va.cines Fa.ily hea.th Routine immuniza.ion

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Molecula. insights into clinica. tria.s for immune checkp.int inhibitors in colorecta. ca.cer:Unra.elling cha.lenges a.d future directions

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World Journa. of Ga.troenterology 2024年第13期30卷 1815-1835页

作者： Sa.a.tha.sharma Na.esh Singh a.ita.a.med Turk Isa.ella.Wa. a.sha. Guttikonda.Julia.Lily Dong Xinna.Zha.g Ma.eusz Op.rcha. Dep.rtment of Medica. a.d Molecula. Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hema.ology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin a.d Bren Simon Comp.ehensive Ca.cer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorecta. ca.cer(CRC)is a.comp.ex disea.e with diverse etiologies a.d clinica. *** considera.le p.ogress in develop.ent of CRC thera.0}utics,cha.lenges rema.n rega.ding the dia.nosis a.d ma.a.ement of a.va.ced sta.e meta.ta.ic CRC(mCRC).In p.rticula.,the five-yea. surviva. ra.e is very low since mCRC is currently ra.ely *** the p.st deca.e,ca.cer trea.ment ha. significa.tly imp.oved with the introduction of ca.cer immunothera.0}es,sp.cifica.ly immune checkp.int *** a.med a. blocking immune checkp.ints such a. p.-1,p.-L1,a.d CTLa.4 ta.get inhibitory p.thwa.s of the immune system,a.d thereby enha.ce a.ti-tumor *** thera.0}es thus ha.e shown p.omising results in ma.y clinica. tria.s a.one or in *** effica.y a.d sa.ety of immunothera.0},either a.one or in combina.ion with CRC,ha.e been investiga.ed in severa. clinica. *** tria.s,including KEYNOTE-164 a.d CheckMa.e 142,ha.e led to Food a.d Drug a.ministra.ion a.0}rova. of the p.-1 inhibitors p.mbrolizuma. a.d nivoluma.,resp.ctively,for the trea.ment of p.tients with unresecta.le or meta.ta.ic microsa.ellite insta.ility-high or deficient misma.ch rep.ir ***,these drugs benefit only a.sma.l p.rcenta.e of p.tients,with the benefits of immunothera.0} rema.ning elusive for the va.t ma.ority of CRC *** this end,p.ima.y a.d seconda.y resista.ce to immunothera.0} rema.ns a.significa.t issue,a.d further resea.ch is necessa.y to op.imize the use of immunothera.0} in CRC a.d identify bioma.kers to p.edict the *** review p.ovides a.comp.ehensive overview of the clinica. tria.s involving immune checkp.int inhibitors in *** underlying ra.iona.e,cha.lenges fa.ed,a.d p.tentia. future step. to imp.ove the p.ognosis a.d enha.ce the likelihood of successful tria.s in this field a.e discussed.

关键词： Colorecta. ca.cer Immune checkp.int inhibitors Clinica. tria.s Immunothera.0} Microsa.ellite insta.ility Microsa.ellite sta.ility DNa.misma.ch rep.ir

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