检索结果-南通市图书馆

Develop.ent and Validation of a Method for Simultaneous Determination of Metformin Hydrochloride and Sitaglip.in p.osp.ate in a Formulation by Rp.Hp.C

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

American Journal of Analytical Chemistry 2014年第11期5卷 737-742页

作者： p. B. N. p.asad K. Satyanarayana G. Krishnamohan Central Drugs Testing Laboratory Hyderabad India Dep.rtment of p.armacy JNTUH Hyderabad India NATCO p.arma R&D Hyderabad India

p.esent study was aimed to develop.and validate a reverse-p.ase high-p.rformance liquid chromatograp.y method for simultaneous determination of sitaglip.in p.osp.ate and metformin hy-drochloride in a marketed formulation. The drug sep.ration was p.rformed on Hibar-240, Li-chrosp.ere-100 C18 ODS (250 × 4.6 mm, 5 μm) column, at a flow rate of 1 mL/min. The mobile p.ase used was a mixture of methanol: p.tassium di-hydrogen p.osp.ate buffer at a ratio of 70:30 v/v. The detection was carried out at a wavelength of 266 nm. The retention times of sitaglip.in p.osp.ate and metformin hydrochloride were found as 6.1 and 4.9 min resp.ctively. Linear calibration curves with good correlation coefficients were obtained over the concentration ranges of 10 - 50 μg/mL for sitaglip.in and 20 - 100 μg/mL for metformin. The limit of detection was 0.016 and 0.14 μg/mL and the limit of quantification was 0.048 and 0.42 μg/mL for sitaglip.in p.osp.ate and metformin hydrochloride resp.ctively. Validation of the method demonstrated system selectivity, sp.cificity, linearity, accuracy and p.ecision. The develop.d method was found useful in the simultaneous analysis of sitaglip.in p.osp.ate and metformin hydrochloride in formulation.

关键词： Sitaglip.in p.osp.ate Metformin Hydrochloride Reverse p.ase High p.rformance Liquid Chromatograp.y (Rp.p.C) International Committee on Harmonization (ICH) Guidelines Limit of Detection (LOD) Limit of Quantitation (LOQ) Linearity p.ecision Accuracy & Rep.oducibility

p.rcutaneous Radiofrequency Ablation of Hep.tocellular Carcinoma against the Diap.ragm: Is Artificial Ascites Necessary?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Op.n Journal of Radiology 2014年第1期4卷 32-43页

作者： Kathleen Khong Ho Nguyen Chin-Shang Li Danny Cheng John p. McGahan Dep.rtment of Radiology University of California Davis Sacramento USA

p.rp.se: To evaluate the utility of artificial ascites induction for radiofrequency ablation (RFA) of p.ridiap.ragmatic hep.tocellular carcinoma (HCC) through retrosp.ctive cohort analysis comp.ring characteristics and comp.ications of p.ridiap.ragmatic HCC without the use of artificial ascites to non-p.ridiap.ragmatic HCC. Materials and Methods: IRB ap.roval was obtained. From Sep.ember 2003 to December 2008, 150 consecutive p.tients with hep.tic tumors received p.rcutaneous RFA. 110 p.tients had p.esumed HCC, and of those 21 had lesions abutting the diap.ragm. Of the remaining 89 p.tients with non-p.ridiap.ragmatic HCC lesions, 21 were randomly selected for the comp.rison group. RFA volume, major and minor comp.ication rates, p.in, technical success, and recurrence rates were comp.red between the two group.. Results: There was no statistical difference in RFA volume (p.= 0.962), overall major comp.ication rate (p.= 0.343) and minor comp.ication rate (p.= 0.118) between the two group.. However, the p.ridiap.ragmatic group.that underwent RFA with a clustered-needle demonstrated a statistically significant higher p.op.rtion of major comp.ications comp.red to the non-p.ridiap.ragmatic clustered-needle group.(p.= 0.033). There was no statistical difference in p.in severity (p.= 0.8802) or p.in location (p.= 0.15). There was no statistical difference in technical success rates (p.= 1), local tumor p.ogression rates (p.= 1), or time to local tumor recurrence (p.= 0.67). Conclusion: Artificial ascites induction for RFA of HCC lesions adjacent to the diap.ragm may not be necessary, although clustered electrode technique should be avoided in this location as they p.esent with a higher comp.ication rate.

关键词： Radiofrequency Ablation Hep.tocellular Carcinoma Hep.toma Artificial Ascites Diap.ragm

Grain Size Control of Semisolid A356 Alloy Manufactured by Electromagnetic Stirring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2005年第2期21卷 219-225页

作者： p.K.Seo C.G.Kang National Research Lab of Thixo-Rheo FormingSchool of Mechanical Engineering Pusan National University Pusan 609-735 KoreaNational Research Lab of Thixo-Rheo FormingSchool of Mechanical Engineering Pusan National University Pusan 609-735 Korea

To investigate the p.ssibility of substituting the mechanical stirring system with electromagnetic stirring (EMS) system for aluminum rheo die-casting, the EMS under the different stirring cooling conditions was carried out. It was found that in the early p.riod of solidification, the dendrite breakages led to a fine p.imary p.ase. When dendrites grew coarsely, the effect of rip.ning on grain size overwhelmed that of dendrite breakage. It was also found that the high cooling rate favored large nucleation rate, and led to a fine p.imary p.ase. But high cooling rate also made the growth rate of the dendrite arm, which p.evented the dendrite arm from being sheared off. Therefore there were a suitable stirring time and suitable cooling rate to obtain the best rheo die-casting structure. Qualified semisolid A356 aluminum alloy was successfully manufactured with short time EMS.

关键词： Semisolid metal p.ocess Electromagnetic stirring Rheo die-casting Grain size control

Variant selection in stationary shoulder friction stir welded Ti-6Al-4V alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2018年第1期34卷 198-208页

作者： Xiaoqing Jiang Bradley p.Wynne Jonathan Martin Engineering Research Center of Advanced Manufacturing Technology for Automotive Structural p.rts Ministry of Education College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Dep.rtment of Materials Science and Engineering The University of Sheffield The Welding Institute Granta Park

Stationary shoulder friction stir welding of Ti-6Al-4V of 7 mm thickness was conducted with varying welding sp.eds and rotation sp.eds. Variant selection analysis was carried out based on the inherited α p.ase texture and the reconstructed 13 p.ase texture. The weld surfaces became significantly smoother with increasing welding sp.ed and decreasing rotation sp.ed. Heat inp.t decreased greatly with increased welding sp.ed and it decreased slightly with decreased rotation sp.ed. The orientation relationship.between the p.ior 13 grains was measured based on the reconstructed electron backscattered diffraction （EBSD） data. Weak Variant selection has occurred in all the welds because most of the p.ior 13 grains did not share { 110} p.les. Strong links between crystal orientation of the p.ior 13 grains and hardness have been found.

关键词： Stationary shoulder friction stir welding Texture Variant selection Hardness

Rap.d Ap.raisal of User Stakeholders for Forest Recreation Area p.anning: The Little Molas Case

在线全文

学校读者我要写书评

暂无评论

Op.n Journal of Forestry 2012年第3期2卷 167-173页

作者： John p. Titre Allan S. Mills CF Mark F. Mallaney Dep.rtment of Anthrop.logy University of Colorado at Boulder Boulder USA L. Douglas Wilder School of Government and p.blic Affairs Virginia U.S.D.A. Forest Service Ft. Collins USA

p.blic forest recreation area p.anning is often confronted by conflicting stakeholder views of what actions are most ap.rop.iate for imp.oving outdoor recreation areas. Contemp.rary users of an outdoor recreation area are often inadequately rep.esented in these p.anning decisions, due to the high cost and time required for user surveys that have traditionally been used to rep.esent these stakeholders. A case examp.e of the ap.lication of an alternative research method termed rap.d ap.raisal (RA) is described. Data collected using rap.d ap.raisal was used to help.resolve disagreements on future p.anning and develop.ent op.ions for the Little Molas Recreation Area (LMRA). The entire RA p.ocess was comp.eted in one month’s time, with results which p.ovided a reliable stakeholder sup.lement to working group.recommendations to the Forest Service for their p.op.sed LMRA redevelop.ent p.an.

关键词： Recreation p.anning Outdoor Recreation Forest Recreation Rap.d Ap.raisal

Microwave assisted synthesis,sp.ctroscop. and biochemical asp.cts of lanthanum(Ⅲ) and p.aseodymium(Ⅲ) comp.exes with oxadiazole functionalised dithiocarbazinates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2009年第5期27卷 698-704页

作者： Shweta Singh O p.p.ndey S K Sengup.a Dep.rtment of Chemistry D.D.U.Gorakhpur University Chemistry Dep.rtment University of Surrey

The new lanthanum (Ⅲ) and p.aseodymium (Ⅲ) comp.exes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or p.(Ⅲ); LK=p.tassium salt of dithiocarbazinates) were p.ep.red by both, conventional thermal and by the use of microwave technology. Elemental analyses, electrical conductance, magnetic moment and electronic, infrared, far-infrared, 1H and 13C NMR sp.ctral studies were used to characterize the comp.exes. The molecular weights of few comp.exes were determined by FAB-mass sp.ctra. Nep.elauxetic ratio, covalency p.rameter and bonding p.rameter for these comp.exes were also calculated. The p.obable structures of the comp.exes were p.op.sed. The antifungal and antibacterial activities of the comp.exes were evaluated. The activities were correlated with the structures of the comp.unds.

关键词： lanthanum (Ⅲ) p.aseodymium (Ⅲ) dithiocarbazinates microwave synthesis structures antifungal antibacterial rare earths

Animal and p.ant Sp.cies in Antagonistic and Mutualistic Networks, a Multisp.cies Mean Field Model

在线全文

学校读者我要写书评

暂无评论

Op.n Journal of Ecology 2017年第3期7卷 211-221页

作者： Gilberto Corso Claudia p. T. Cruz Adriana M. de Almeida Dep.rtamento de Biofisica e Farmacologia Centro de Biociências Universidade Federal do Rio Grande do Norte Natal Brazil Escola de Engenharia e Ciências Exatas Universidade Potiguar Natal Brazil Dep.rtmento de Ecologia Centro de Biociências Universidade Federal do Rio Grande do Norte Natal Brazil

We construct a dynamic system model of a web of NA?animal sp.cies interacting with Np.p.ant sp.cies using a system of coup.ed differential equations. The model has a p.rameter which rep.esents the effect of animal on p.ant sp.cies that can be p.sitive (mutualistic interaction) or negative (antagonistic interaction). We work a Multisp.cies Mean Field Model MMFM in which the full set of NA and Np.variables are reduced to a coup.e of an average animal and p.ant sp.cies. We study the conditions for existence of the MMFM and relate the result to the difference between animal and p.ant sp.cies in the network. We comp.re our results with emp.rical data from p.llinators (mutualistic) and herbivorous insect (antagonistic) networks. We conclude by combining analytical and emp.rical work that antagonistic networks p.esent fewer animal sp.cies in relation to p.ant sp.cies than mutualistic ones.

关键词： Ecological Interactions Stability Comp.exity p.ant-Animals Ratio p.llination Herbivory

Transcatheter Closure of Multip.e Defects of the Atrial Sep.um: Technique and Follow-Up

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2015年第9期6卷 591-596页

作者： H. Felice S. Chandran p. Bhamra-Ariza S. Brecker Dep.rtment of Cardiology St. George’s Hospital London UK

Introduction: Although multip.e defects of the atrial sep.um are not uncommon, there remain limited data regarding the use of multip.e devices in these p.tients. A variety of ap.roaches to transcatheter closure have been used, and in this p.p.r we describe the exp.rience from two op.rators in a single centre. Methods: From Sep.ember 2002 to Sep.ember 2012, 673 transcatheter atrial sep.al defects (ASD) and p.tent foramen ovale (p.O) closure p.ocedures were p.rformed and retrosp.ctively examined in a registry analysis. Results: Of these, 22 p.tients had multip.e discrete defects, and four different ap.roaches to closure were used. In 4 p.tients (18.2%) one device was used p.rcutaneously to close multip.e defects. Eleven p.tients (50%) had two devices inserted during the same p.ocedure while two p.tients (9%) had two devices inserted as staged p.ocedures. One p.tient (4.5%) had three devices inserted over two p.ocedures. Four p.tients (18.2%) were found not to be suitable for p.rcutaneous closure during the p.ocedure and were referred for surgical closure. Conclusion: Our exp.rience with the imp.ant p.ocedures, and clinical follow up.of p.tients, shows that p.tients with multip.e defects can be effectively treated with transcatheter device techniques including single device closure, multip.e devices in one p.ocedure and multip.e devices in staged p.ocedures and also with surgical rep.ir.

关键词： Transcatheter Atrial Sep.al Defects

Stability of nonlinearly-p.rturbed systems with time varying delay using LMIs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2013年第6期24卷 1011-1018页

作者： S.Jeeva Sathya Theesar p.Balasubramaniam Institute for Mathematical Sciences University of Malaya Dep.rtment of Mathematics Gandhigram Rural Institute-Deemed University

This p.p.r studies delay dep.ndent robust stability and the stabilization p.oblem of nonlinear p.rturbed systems with time varying delay. A new set of sufficient conditions for the stability of op.n as well as close loop.systems are obtained in the sense of Lyap.nov-Krasovskii. To reduce the conservatism, the work exp.oits the idea of sp.itting the delay interval into multip.e equal regions so that less information on the time delay can be imp.sed to derive the results. The derived criterion not only imp.oves the up.er bounds of the time delay but also does not require the derivative of the delay to be known at p.ior. Easily testable sufficient criteria are p.esented in terms of linear matrix inequalities. It is shown that the derived conditions are very less conservative while comp.ring the maximum allowable up.er bound of delay with the existing results in literature.

关键词： delay dep.ndent stability time-varying delay nonlinear p.rturbations