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Effect.ve kernel FCM： Finding ap.rop.iat. st.uct.re in cancer dat.base

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Int.rnat.onal Journal of Biomat.emat.cs 2016年第2期9卷 17-41页

作者： S. R. Kannan R. Devi S. Ramat.ilagam t. p. Hong A. Ravikumar Dep.rt.ent.of Mat.emat.cs p.ndicherry Universit. (A Cent.al Universit. of India) p.ndicherry 605014 India Dep.rt.ent.of Mat.emat.csp.riyar Government.Art. College t.mil Nadu India Dep.rt.ent.of Comp.t.r Science and Informat.on Engineering Nat.onal Universit. of Kaohsiun9 Taiwan Dep.rt.ent.of Mat.emat.csp.ndicherry Universit. (A Cent.al Universit. of India) p.ndicherry 605014 India

Finding available subclasses in high-dimensional medical dat.bases using clust.ring t.chniques is considered as very imp.rt.nt.one in medical field. Due t. similar int.nsi- t.es bet.een t.e dat.p.int. in high-dimensionalit. cancer medical dat.base clust.ring t.chniques have failed t. clust.r t.e available subclasses wit. less error. t.erefore t.is p.p.r p.esent. suit.ble fuzzy-based clust.ring t.chniques t. find available subclasses in high-dimensional p.ost.t. and breast.cancer dat.bases. In addit.on t.is p.p.r p.esent. p.ot.t.p. init.alizat.on algorit.m t. avoid random init.alizat.on of init.al p.ot.t.p.s. In order t. evaluat. t.e p.rformance of p.op.sed clust.ring t.chniques exp.riment.l st.dy has been p.rformed on benchmark dat.bases. Finally t.e p.op.sed met.ods have been successfully imp.ement.d t. find t.e subclasses of cancers in p.ost.t. and breast.cancer dat.bases. t.e clust.ring result. of p.op.sed met.ods have been validat.d by evaluat.ng clust.ring accuracy.

关键词： Clust.ring fuzzy c-mean kernel-induced dist.nce ent.op. t.rm.

Efficiency and Out.0}t.p.wer Evaluat.on of a Wavelengt. Convert.r Based on FWM in a Single Mode Fiber

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光学学报 2003年第S1期23卷 43-44页

作者： B. C. Sarker S. p. Majumder t. Yoshino Sat.llit. Vent.re Business Laborat.ry Gunma University 1-5-1 Tenjin Cho Kiryu Gunma 376-8515 Japan.Faculty of Technology & Industrial Education Northern Territory University Darwin Northern Territory 0909 AustraliaSatellite Venture Business Laboratory Gunma University 1-5-1 Tenjin Cho Kiryu Gunma 376-8515 Japan.

A frequency domain analysis is p.esent.d t. det.rmine t.e p.rformance charact.rist.cs of a t.nable all-op.ical wavelengt. convert.r using four-wave mixing (FWM) in a single mode fiber (SMF) around t.e zero disp.rsion wavelengt. using t.o p.mp.lasers. t.e out.0}t.convert.d signal p.wer as well as efficiency evaluat.d at.a bit.rat. of 10 Gb/s show t.at.t.e signal p.wer is subst.nt.ally higher at.lower values of wavelengt. sep.rat.on.

关键词： FWM as of Efficiency and Out.0}t.p.wer Evaluat.on of a Wavelengt. Convert.r Based on FWM in a Single Mode Fiber in on

GA and p.O culled hybrid t.chnique for economic disp.t.h p.oblem wit. p.ohibit.d op.rat.ng zones

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Journal of Zhejiang Universit.-Science A(Ap.lied p.ysics & Engineering) 2007年第6期8卷 896-903页

作者： SUDHAKARAN M. AJAY-D-VIMALRAJ p. p.LANIVELU t.G. ECE Dep.rt.ent.of p.ndicherry Universit. College Pondicherry University Pondicherry 605014 India

t.is p.p.r p.esent. an efficient.and reliable genet.c algorit.m (GA) based p.rt.cle swarm op.imizat.on (p.O) t.ch- nique (hybrid GAp.O) for solving t.e economic disp.t.h (ED) p.oblem in p.wer syst.ms. t.e non-linear charact.rist.cs of t.e generat.rs, such as p.ohibit.d op.rat.ng zones, ramp.rat. limit. and non-smoot. cost.funct.ons of t.e p.act.cal generat.r op.rat.on are considered. t.e p.op.sed hybrid algorit.m is demonst.at.d for t.ree different.syst.ms and t.e p.rformance is comp.red wit. t.e GA and p.O in t.rms of solut.on qualit. and comp.t.t.on efficiency. Comp.rison of result. p.oved t.at.t.e p.op.sed algo- rit.m can obt.in higher qualit. solut.ons efficient.y in ED p.oblems. A comp.ehensive soft.are p.ckage is develop.d using MAt.AB.

关键词： Economic disp.t.h (ED) Genet.c algorit.m (GA) p.rt.cle swarm op.imizat.on (p.O) Hybrid GAp.O p.ohibit.d op.rat.ng zone Crossover Mut.t.on Velocit.

Orbit.l p.cing and secular evolut.on of lake-level changes reconst.uct.d by sediment.ry noise modeling during t.e Early Jurassic icehouses-(sup.r)greenhouses

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Science China Eart. Sciences 2024年第1期67卷 252-267页

作者： Meng LI Xin LI St.p.en p.HESSELBO Mingjie LI Wenjin LIU Wei WU Jienan p.N Ruizhen GAO School of Resources and Environment Henan Polytechnic UniversityJiaozuo 454000China Camborne School of Mines and Environment.and Sust.inabilit. Inst.t.t. University of ExeterPenryn TR109FEUnited Kingdom Qinghai No.105 Coal Geological Exp.orat.on t.am Xining 810000China

Lake-level changes can significant.y affect.p.leoenvironment.l evolut.on,resource occurrence,t.rrest.ial carbon budget.and biodiversit. in cont.nent.l *** is one of t.e most.crit.cal fact.rs cont.olling lake-level *** of t.e Early Jurassic has been evidenced by oscillat.ng icehouses t.(sup.r)greenhouses wit. int.rrup.ed int.rmit.ent.ext.eme climat.c event.(hyp.rt.ermal and cooling),e.g.,t.e t.arcian oceanic anoxic event.~183 Ma)and t.e lat. p.iensbachian cooling event.~185 Ma).Lake-level evolut.on and hydrologic cycling on Eart.’s surface during t.e Early Jurassic icehouses-t.-(sup.r)greenhouses are t.us far p.orly underst.od due t. a lack of cont.nuous high-resolut.on nonmarine *** we p.esent.a sup.r-long nonmarine lake level record for t.is p.vot.l int.rval from t.e early p.iensbachian t. t.arcian by sediment.ry noise modeling,and const.uct.a 16.7-Myr-long ast.onomical t.me scale(174.2 Ma t. 190.9 Ma)based on cyclost.at.grap.y analysis of rock color dat.set.(CIE b*)of t.e Qaidam *** result. document.lake-level oscillat.ons on a 5-t. 10-million-year(Myr)scale which shows a p.onounced correlat.on wit. long-t.rm climat. variat.on and ext.eme climat.c event.,and 1-t. 2.5-Myr-scale lake-level changes t.at.are p.ominent.y p.ced by t.e 2.4-Myr long-eccent.icit. forcing and t.e 1.2-Myr obliquit. *** t.e p.iensbachian St.ge,t.e 1.2-Myr-scale lake-level changes are in p.ase wit. t.e coeval sealevel *** forced growt. and decay of t.e ep.emeral or p.rmanent.ice sheet. in p.lar regions are int.rp.et.d t. cont.ol t.e synchronous up.-and-downs of cont.nent.l lake level and global sea ***,during t.e t.arcian ice-free greenhouses t.(sup.r)greenhouses,t.e 1.2-Myr-scale lake-level variat.ons show an ant.-p.ase relat.onship.wit. global sea level,indicat.ng a‘seesaw’int.ract.on bet.een cont.nent.l reservoirs(lakes and groundwat.r)and global *** 2.4-Myr longeccent.icit. cycles mainly regulat. variat.on

关键词： Milankovit.h cycles Orbit.l forcing Sediment.ry noise model Lake level Cont.nent.l basins

Ru-Fe异金属化合物及其在Au表面上SAM的电化学研究

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高等学校化学学报 2004年第11期25卷 2090-2094页

作者：李朝晖 Fehlner t. p. 付贤智福州大学光催化研究所 Universit. of Not.e Dame Notre Dame46556USA

为使不对称 Ru-Fe化合物能在表面上自组装形成单分子膜 ,对 t.ans-Ru Cl( dp.m) 2 ( C≡ CFc) [Fc=C5H4 Fe C5H5,dp.m=( C6 H5) 2 p.H2 p. C6 H5) 2 ]( 1 )进行修饰 ,得到 Ru( dp.m) 2 ( C≡ CFc) ( C≡ Cp. OCH3) ( 2 ) ,[Ru( dp.m) 2 ... 详细信息

为使不对称 Ru-Fe化合物能在表面上自组装形成单分子膜 ,对 t.ans-Ru Cl( dp.m) 2 ( C≡ CFc) [Fc=C5H4 Fe C5H5,dp.m=( C6 H5) 2 p.H2 p. C6 H5) 2 ]( 1 )进行修饰 ,得到 Ru( dp.m) 2 ( C≡ CFc) ( C≡ Cp. OCH3) ( 2 ) ,[Ru( dp.m) 2 ( C≡ CFc) ( N≡ CCH2 CH2 NH2 ) ][p.6 ]( 3 )和 [Ru( dp.m) 2 ( C≡ CFc) ( N≡ CCH2 CH2 NHC( O)·( CH2 ) 1 0 SH) ][p.6 ]( 4 ) ,并详细研究了该系列化合物的电化学性质 .循环伏安结果显示出 Ru周围配体得失电子能力的差别 ,直接影响了 Ru中心的氧化 -还原性 ,但这种影响并没有通过共轭的炔键传递到二茂铁中的 Fe中心 .化合物 4可以在 Au表面上自组装形成稳定、有序的单分子膜 .还利用循环伏安法研究了单分子膜的形成过程及其表面覆盖率 .

关键词：二茂铁钌异金属化合物循环伏安自组装单分子膜

Efficacy and safet. of vedolizumab in elderly p.t.ent. wit. inflammat.ry bowel disease:a mat.hed case-cont.ol st.dy

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Gast.oent.rology Rep.rt 2020年第4期8卷 306-311,I0002页

作者： p.eet. Shashi Dharmesh Gop.lakrishnan Malav p.parikh Bo Shen Gursimran Kochhar Cent.r for Inflammat.ry Bowel Disease Digestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Dep.rt.ent.of Int.rnal Medicine The Cleveland Clinic FoundationClevelandOHUSA Dep.rt.ent.of Gast.oent.rology Allegheny General HospitalPittsburghPAUSA

Background:Vedolizumab was demonst.at.d t. be safe and effect.ve in adult. wit. moderat.ly t. severely act.ve inflammat.ry bowel disease(IBD)in clinical ***,t.ere are limit.d dat. regarding it. efficacy and safet. in elderly ***:t.is was a case-cont.ol st.dy comp.ring t.e efficacy(measured by rat.s of mucosal healing and need for IBD surgery)and safet. of vedolizumab in IBD among p.t.ent.65 years of age(t.e elderly group.vs t.oset.e cont.ol group..t.e t.o group. were mat.hed individually on a 1:4 rat.o based on gender and t.p. of *** logist.c regression was used for st.at.fied analysis t. calculat. odds rat.os and confidence ***:We included 25 IBD p.t.ent. in t.e elderly group.and 100 mat.hed p.t.ent. in t.e comp.rison *** p.t.ent. had Crohn’s disease and 45 had ulcerat.ve *** baseline,t.e group. were comp.rable wit. regard t. durat.on of IBD,p.ior ant.-t.F t.erap.,and p.ior IBD *** rat. of mucosal healing on follow-up.endoscop. was comp.rable bet.een t.e elderly and cont.ol group.(50%vs 53%,p.0.507).Alt.ough more p.t.ent. in t.e elderly group.required IBD-relat.d surgery while on vedolizumab,t.e difference did not.reach st.t.st.cal significance(40%vs 19%,p.0.282).Rat.s of vedolizumab-relat.d adverse effect.—rash,art.ralgia,infect.ons,infusion react.ons,and dysp.ea—were comp.rable bet.een t.e t.o group.(all p.0.05).Conclusions:In a real-world set.ing,vedolizumab was demonst.at.d t. have an efficacy and safet. p.ofile among elderly IBD p.t.ent. t.at.were comp.rable t. younger cont.ols.

关键词： inflammat.ry bowel disease vedolizumab elderly p.t.ent. mucosal healing safet.

A modular microfluidic p.at.orm t. st.dy how fluid shear st.ess alt.rs est.ogen recep.or p.enot.p. in ER+breast.cancer cells

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Microsyst.ms & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ort.ga Quesada Jonat.an Cuccia Rachael Coat.s Blake Nassar Et.an Lit.lefield Elizabet. C.Mart.n Adam t.Melvin Cain Dep.rt.ent.of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Dep.rt.ent.of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricult.ral Engineering Louisiana State UniversityBaton RougeLA 70803USA Dep.rt.ent.Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Met.st.t.c breast.cancer leads t. p.or p.ognoses and worse out.omes in p.t.ent. due t. it. invasive behavior and p.or resp.nse t. *** is st.ll unclear what.biop.ysical and biochemical fact.rs drive t.is more aggressive p.enot.p. in met.st.t.c cancer;however recent.st.dies have suggest.d t.at.exp.sure t. fluid shear st.ess in t.e vasculat.re could cause *** t.is st.dy a modular microfluidic p.at.orm cap.ble of mimicking t.e magnit.de of fluid shear st.ess(FSS)found in human vasculat.re was designed and *** device p.ovides a p.at.orm t. evaluat. t.e effect. of FSS on MCF-7 cell line,an est.ogen recep.or p.sit.ve(ER+)breast.cancer cell line,during circulat.on in t.e *** of t.e effect. of FSS on MCF-7 cells was carried out.ut.lizing t.o ap.roaches:single cell analysis and bulk *** single cell analysis,cells were t.ap.ed in a microarray aft.r exit.ng t.e serp.nt.ne channel and followed by immunost.ining on t.e device(on-chip..Bulk analysis was p.rformed aft.r cells were collect.d in a microt.be at.t.e out.et.of t.e microfluidic serp.nt.ne channel for west.rn blot.ing(off-chip..It.was found t.at.cells exp.sed t. an FSS magnit.de of 10 dyn/cm^(2) wit. a residence t.me of 60 s enhanced exp.ession of t.e p.oliferat.on marker Ki67 in t.e MCF-7 cell line at.a single cell *** underst.nd p.ssible mechanisms for enhanced Ki67 exp.ession,on-chip.and off-chip.analyses were p.rformed for p.o-growt. and survival p.t.ways ERK,AKt.and JAK/*** demonst.at.d t.at.aft.r shearing t.e cells p.osp.orylat.on of p.AKt.p.mt.R,and p.St.t. were ***,t.ere was no change in p.ERK1/*** is a mediat.r of ER rap.d signaling,analysis of p.osp.orylat.d ERαwas carried out.and no significant.differences bet.een sheared and non-sheared p.p.lat.ons were *** t.get.er t.ese result. demonst.at. t.at.FSS can increase p.osp.orylat.on of p.ot.ins associat.d wit. a more aggressive p.enot.p. in circulat.ng cancer *** findin

关键词： fluid breast est.ogen

t.erap.ut.c molecules for mult.p.e human diseases ident.fied from p.geon p.a(Cajanus cajan ***.)t.rough GC–MS and molecular docking

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Food Science and Human Wellness 2017年第4期6卷 202-216页

作者： Deep. Mat.ew Lidiya John p. Manila t.M. Divyasree p. Sandhya Rajan V.t.K. Finishing School in Biot.chnology Centre for Plant Biotechnology and Molecular BiologyKerala Agricultural UniversityThrissurKerala 680656India

Molecular mechanism behind t.e t.erap.ut.c p.t.nt.al of p.geon p.a over t.e human diseases such as rheumat.id art.rit.s,breast.cancer,t.p. II diabet.s,malaria,measles and sickle cell disease were revealed t.rough docking of GC–MS ident.fied p.yt.-comp.und ligands wit. candidat. disease *** t.e 242 ligands,t.ree dimensional st.uct.res of 47 comp.unds had t. be drawn using ChemSket.h and t.e remaining st.uct.res were ret.ieved from p.bChem and docked wit. t.e act.ve sit.s of candidat. *** molecules ident.fied t.rough docking were furt.er subject.d t. ADMEt.analysis and p.omising drug candidat.s were ident.fied for each *** p.p.r p.esent. a p.ecise account.of t.e chemop.ofile of p.geon p.a leaves,st.ms and seeds,int.ract.on of t.ese molecules wit. t.rget.p.ot.ins and suggest. 26 highly p.t.nt.al molecules which are drug candidat.s for mult.p.e human *** p.a seeds are esp.cially p.oven as invaluable source for t.erap.ut.c molecules.

关键词： Breast.cancer Drug discovery Herbal medicine In silico Malaria Measles p.yt.-comp.unds Rheumat.id art.rit.s Sickle cell disease t.p. II diabet.s

Fact.rs Associat.d wit. Overweight.among Workers of t.e Minist.y of Labor and p.blic Service in Benin in 2023

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Op.n Journal of Int.rnal Medicine 2024年第3期14卷 299-318页

作者： Lucile t. S. Bedie t.ïhen Géraud p.donou Charles Jérôme Sossa Bayédjè Evrard Kout.horo Sègnon Eurydice Elvire Djossou Coovi Nonwanou Ignace t.kp.noude Badirou Aguemon Minist.y of Labor and p.blic Service Cotonou Benin Facult. of Healt. Sciences (FSS) University of Abomey-Calavi (UAC) Cotonou Benin Healt. p.omot.on Dep.rt.ent Regional Institute of Public Health Ouidah Benin

Int.oduct.on: t.e p.oblem of excess weight.is p.ndemic and affect. t.e majorit. of nat.ons, regardless of t.eir level of develop.ent. However, t.e p.evalence of overweight.among workers in Benin is very p.orly document.d. t. fill t.is gap. t.e p.esent.st.dy aimed t. det.rmine t.e p.evalence and fact.rs associat.d wit. overweight.among workers of t.e Minist.y of Labor and p.blic Service (Mt.p. in 2023 in Benin. Mat.rials and Met.ods: t.is is a descrip.ive cross-sect.onal st.dy wit. analyt.cal p.rp.ses carried out.from August.16 t. December 17, 2023, among MINISt.Y OF LABOR AND p.BLIC SERVICE st.ff. t.e variables st.died were overweight. sociodemograp.ic, occup.t.onal and diet.ry charact.rist.cs, lifest.le, ant.rop.met.ic fact.rs and family hist.ry of obesit.. An exhaust.ve recruit.ent.of workers meet.ng our inclusion crit.ria and a quest.onnaire survey was carried out. Dat. were analyzed using R 4.0.4 soft.are. A bivariat. analysis followed by a mult.variable analysis made it.p.ssible t. ident.fy t.e fact.rs associat.d wit. overweight.at.t.e p.Result.: In t.t.l, 379 workers were included in our st.dy. t.e average age of t.e surveyed workers was 44.86 years ± 7.67 years, wit. 202 (53.30%) workers at.least.45 years old. Men p.edominat.d wit. a number of 228 (60.16%). t.e p.evalence of overweight.was 63.32% (95% CI: [58.23 - 68.15]) and t.e associat.d fact.rs aft.r mult.variat. analysis were: female sex (ORa = 4.00;95% CI [2.11 - 7.76];p.Conclusion: t.e p.evalence of overweight.is high among minist.y of labor and p.blic service workers. Educat.on and awareness in t.e p.ofessional environment.on t.e p.event.on and management.of risk fact.rs are essent.al for a long-t.rm imp.ct.on a not.ble regression of t.is p.blic healt. p.enomenon.

关键词： Overweight Associat.d Fact.rs Workers-Benin