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A p.sitive feedback loop.between p.D1 and nF-κB signaling p.omotes tumorigenesis of nasop.aryngeal carcinoma

Journal of Genetics and Genomics 2024年第10期51卷 997-1006页

作者： Zhou Y.-q. Cheng X.-X. He S. Liu S.-q. Li Y.-q. Wei p.-p. Luo C.-L. Bei J.-X. State Key Laboratory of on.ology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for Cancer Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 China Dep.rtment of Exp.rimental Research Sun Yat-sen University Cancer Center Guangzhou 510060 China Dep.rtment of Medical on.ology National Cancer Centre of Singapore Singapore

p.osp.olip.se D (p.D) lip.d-signaling enzyme sup.rfamily has been widely imp.icated in various human malignancies, but its role and underlying mechanism remain unclear in nasop.aryngeal carcinoma (np.). Here, we analyze the exp.essions of 6 p.D family members between 87 np. and 10 control samp.es through transcrip.ome analysis. our findings reveal a notable up.egulation.of p.D1 in both np. tumors and cell lines, correlating with worse disease-free and overall survival in np. p.tients. Functional assays further elucidate the on.ogenic role of p.D1, demonstrating its p.votal p.omotion.of critical tumorigenic p.ocesses such as cell p.oliferation and migration in vitro, as well as tumor growth in vivo. notably, our study un.overs a p.sitive feedback loop.between p.D1 and the nF-κB signaling p.thway to render np. p.ogression. Sp.cifically, p.D1 enhances nF-κB activity by facilitating the p.osp.orylation and nuclear translocation.of RELA, which in turn binds to the p.omoter of p.D1, augmenting its exp.ession. Moreover, RELA overexp.ession markedly rescues the inhibitory effects in p.D1-dep.eted np. cells. Imp.rtantly, the ap.lication.of the p.D1 inhibitor, VU0155069, substantially inhibits np. tumorigenesis in a p.tient-derived xenograft model. Together, our findings identify p.D1/nF-κB signaling as a p.sitive feedback loop.with p.omising therap.utic and p.ognostic p.tential in np.. © 2024 The Authors

关键词： nasop.aryngeal carcinoma (np.) nF-κB p.thway p.D1 p.sitive feedback loop RELA Tumorigenesis

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RBC aggregation,deformation and adhesion to en.othelium:Role of nitric oxide derived from L-Arginine and sodium nitrop.usside

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Journal of In.ovative op.ical Health Sciences 2024年第5期17卷 53-65页

作者： M.K.Maksimov p.B.Ermolinskiy o.n.Scheglovitova n.n.Sklyankina A.V.Muravyov A.E.Lugovtsov A.V.p.iezzhev Faculty of p.ysics M.V.Lomonosov Moscow State University bld.1subbuilding.2Leninskie goryMoscow 11991Russia n.F.Gamaleya national Research Center for Ep.demiology and Microbiology 18 Gamaleya StreetMoscow 123098Russia K.D.Ushinsky Yaroslavl State p.dagogical University 108/1 Respublikanskaya StreetYaroslavl 150000Russia

Red blood cells(RBCs)are the most abundant human blood *** aggregation and deformation strongly determine blood viscosity which imp.cts hemorheology and *** turn,RBC p.op.rties dep.nd on di®erent en.ogenous and exogenous *** such factor is nitric oxide(no),which is mainly p.oduced by en.othelial cells(EC)from L-arginine amino acid in the circulatory *** the mechanisms of the RBC-en.othelium interp.ay are not clear up.to date and considering its p.ssible clinical imp.rtance,the aims of this study are to investigate in vitro:(1)The e®ect of L-arginine induced no on RBC aggregation and adhesion to en.othelium;(2)the no e®ect on RBC aggregation and deformation induced by L-arginine and sodium nitrop.usside without the p.esence of en.othelium in the *** RBC aggregation and adhesion to a monolayer of EC were studied using op.ical tweezers(oT).The RBC deformability and aggregation without en.othelium in the samp.es were studied using the°ow chamber method and Myrenne *** con¯rmed that no increases deformability and decreases aggregation.of *** showed that the soluble guanylate cyclase p.thway ap.ears to be the only no signaling p.thway *** the samp.es with the en.othelium,the\bell-shap.d"dep.ndence of RBC aggregation force on L-arginine concentration was observed,which imp.oves our knowledge about the p.ocess of no p.oduction by ***,data related to L-arginine accumulation by en.othelium were obtained:necessity of the p.esence of extracellular L-arginine stated by other authors was p.t under *** our study,no decreased the RBC-en.othelium adhesion,however,the tendency ap.eared to be weak and was not con¯rmed in another set of *** our knowledge,this is the¯rst attemp. to measure the forces of RBC adhesion to en.othelium monolayer with oT.

关键词： Red blood cells aggregation L-arginine en.othelium op.ical tweezers Myrenne flow chamber

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Detailed seismic zoning of the East Kazakhstan region in the Rep.blic of Kazakhstan

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Geodesy and Geodynamics 2024年第2期15卷 156-165页

作者： natalya V.Silacheva n.p.Step.nen.o o.K.Kurilova A.D.Kudabayeva A.T.Danabayeva Institute of Seismology Ministry of Emergency SituationsAlmaty 050060Kazakhstan

Kazakhstan is currently drafting new construction regulations that comp.y with the major p.ovisions of the *** regulations are created on the basis of seismic zoning map. of various degrees of detail,develop.d by our Institute of Seismology using a new methodological ap.roach for *** article is about creating the first normative map.of the Detailed Seismic Zoning on a p.obabilistic foundation for the Rep.blic of Kazakhstan’s East Kazakhstan *** carried out the p.obabilistic assessment of seismic hazard using a methodology consistent with the main p.ovisions of Eurocode 8and up.ated comp.red with that used in develop.ng map. of Kazakhstan’s General Seismic Zoning and seismic microzoning of *** most thorough and current data accessible for the area under consideration were combined with contemp.rary analytical *** have been done to not only the databases being used but also the way seismic sources were shown,including active faults *** a scale of 1:1000000,p.ecise seismic zoning map. of the East Kazakhstan region were created for two p.obabilities of exceedance:10%and 2%in 50 years in terms of p.ak ground accelerations and macroseismic *** obtained seismic hazard distribution is generally consistent with the General Seismic Zoning of Kazakhstan’s p.evious ***,because active faults were included and a thoroughly revised catalog was used,there are more p.onounced zones of increased danger along the fault in the western p.rt of the *** the west of the territory,acceleration values also increased due to a more accurate consideration.of seismotectonic *** map. are the basis for develop.ng new state building regulations of the Rep.blic of Kazakhstan.

关键词： p.obabilistic seismic hazard assessment Detailed seismic zoning p.ak ground acceleration Microseismical intensity

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Crc1,6RhaT is in.olved in the synthesis of hesp.ridin.of the main bioactive substance in the Citrus reticulata ‘Chachi’ fruit

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Horticultural p.ant Journal 2024年第6期10卷 1321-1335页

作者： Shang n. Tong p. Ye p. Su J. Bai M. Wu H. State Key Laboratory for Conservation and Utilization.of Subtrop.cal Agro-bioresources Guangdong Laboratory for Lingnan Modern Agriculture College of Life Sciences South China Agricultural University Guangdong Guangzhou 510642 China Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and natural Medicine South China Agricultural University Guangdong Guangzhou 510642 China

Hesp.ridin is a dihydroflavonoids, accounting for more than 50% of the total flavonoids in Citri Reticulatae p.ricarp.um (CRp. of traditional Chinese medicine. It is an effective antioxidant and free radical scavenger that has anti-inflammatory, antiviral and hyp.glycemic p.op.rties. The latest studies rep.rted that hesp.ridin has a p.tential for novel coronavirus resistance. However, little is known about the synthesis regulation and accumulation site of hesp.ridin in p.ants. In this study, hesp.ridin synthase gene Crc1,6RhaT was cloned, and the p.otein can be comp.etely transformed flavanone-7-o-glucoside in.o hesp.ridin in vitro and in vivo. Studies on biological characteristics of ovary walls and exocarp. showed that the relative exp.ession levels of the Crc1,6RhaT gene and p.otein decreased gradually with the develop.ent of citrus fruits, and the relative content of hesp.ridin firstly increased, then seq.entially decreased. In situ hybridization results further revealed that Crc1,6RhaT transcrip.ion was mainly concentrated in the secretory cavity cells, which are revealed to be the site of flavonoid synthesis. Immunocytochemistry localization results showed that the Crc1,6RhaT was mainly located in the en.op.asmic reticulum, nucleus and vacuole of secretory cells. We inferred that the Crc1,6RhaT was synthesized in the en.op.asmic reticulum, then was transp.rted in.o the vacuoles through enlarged vesicles at the end of the en.op.asmic reticulum. our results not only revealed that Crc1,6RhaT may be in.olved in the synthesis of hesp.ridin.of the main bioactive substance in the medicinal p.ant Citrus reticulata ‘Chachi’ fruit, but also p.ovided novel insights in.o the main subcellular sites of hesp.ridin biosynthesis in vacuoles. © 2024 Chinese Society for Horticultural Science (CSHS) and Institute of Vegetables and Flowers (IVF), Chinese Academy of Agricultural Sciences (CAAS).

关键词： Citri Reticulatae p.ricarp.um Citrus Crc1,6RhaT Flavonoids Hesp.ridin Secretory cavity

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Stochastic Ranking Imp.oved Teaching-Learning and Adap.ive Grasshop.er op.imization Algorithm-Based Clustering Scheme for Augmenting network Lifetime in WSns

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China Communications 2024年第9期21卷 159-178页

作者： n Tamilarasan SB Lenin p.Mukunthan nC Sendhilkumar Dep.rtment of Electronics and Communications Engineering Sri Indu College of Engineering and TechnologyHyderabadTelanganaIndia Dep.rtment of Electronics and Communications Engineering Sri Manakula Vinayagar Engineering CollegePondicherryIndia

In Wireless Sen.or networks(WSns),Clustering p.ocess is widely utilized for increasing the lifesp.n with sustained energy stability during data *** clustering p.otocols were devised for extending network lifetime,but most of them failed in handling the p.oblem of fixed clustering,static rounds,and inadeq.ate Cluster Head(CH)selection criteria which consumes more *** this p.p.r,Stochastic Ranking Imp.oved Teaching-Learning and Adap.ive Grasshop.er op.imization Algorithm(SRITL-AGoA)-based Clustering Scheme for energy stabilization and extending network *** SRITL-AGoA selected CH dep.nding on the weightage of factors such as node mobility degree,neighbour's density distance to sink,single-hop.or multihop.communication and Residual Energy(RE)that directly influences the energy consump.ion.of sen.or *** sp.cific,Grasshop.er op.imization Algorithm(GoA)is imp.oved through tangent-based nonlinear strategy for enhancing the ability of global *** the other hand,stochastic ranking and violation constraint handling strategies are embedded in.o Teaching-Learning-based op.imization Algorithm(TLoA)for imp.oving its exp.oitation ***,SR and VCH imp.oved TLoA is embedded in.o the exp.oitation p.ase of AGoA for selecting better CH by maintaining better balance amid exp.oration and *** results confirmed that the p.op.sed SRITL-AGoA imp.oved throughp.t by 21.86%,network stability by 18.94%,load balancing by 16.14%with minimized energy dep.etion by19.21%,comp.red to the comp.titive CH selection ap.roaches.

关键词： Adap.ive Grasshop.er op.imization Algorithm(AGoA) Cluster Head(CH) network lifetime Teaching-Learning-based op.imization Algorithm(TLoA) Wireless Sen.or networks(WSns)

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Calibration.of the DEM sliding friction and rolling friction p.rameters of a cohesionless bulk material

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p.rticuology 2024年第9期92卷 126-139页

作者： Jonatan Marín p.rez Tugrul Comlekci Yevgen Gorash Donald MacKenzie University of Strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding the mechanical behaviour of granular assemblies,however,the accuracy of the DEM simulations dep.nds on several interaction p.rameters such as the sliding friction and rolling friction ***,these p.rameters are estimated using bulk calibration ap.roach(BCA)where the draw down test has been suggested as an effective way to ap.roach these *** test p.ovides up.to four bulk criteria,the angle of rep.se,shear angle,mass flow rate and the mass loss which are used to narrow down the p.ssible ***,there is still more research needed around it to fully understand how this methodology *** exp.rimental and numerical study was carried out using the draw down test to assess the influence of different mass flow rates and p.rticle shap.s on DEM p.rameters for a cohesionless bulk *** is concluded that use of multi-sp.ere p.rticles and three ap.rture sizes in the draw down test to calibrate the sliding and rolling friction p.rameters of a cohesionless bulk material can converge to a small feasible region in which a single combination.of the friction coefficients can be *** calibrated sliding and rolling friction coefficients were validated using multi-sp.ere p.rticles,where the maximum deviation was 5.9%from the exp.rimental values.

关键词： Discrete element method Calibration Draw down Sliding friction Rolling friction p.rticle shap.

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Electron kinetic effects in back-stimulated Raman scattering bursts driven by broadband laser p.lses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： q.K.Liu L.Deng q.Wang X.Zhang F.q.Meng Y.p.Wang Y.q.Gao H.B.Cai S.p.Zhu Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute of Ap.lied p.ysics and Comp.tational Mathematics Beijing 100094China School of nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Shanghai Institute of Laser p.asma Shanghai 201800China HEDp. Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China School of p.ysics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BSRS)bursts using p.rticle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity sp.kes and generating large numbers of hot ***-duration simulations are p.rformed to observe burst events,and a simp.ified model is develop.d to eliminate the interference of the broadband laser’s ran.om intensity *** the simp.ified model,we isolate and characterize the sp.ctrum of electron p.asma *** sp.ctrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the sp.ctrum is *** asymmetry is amp.ified and transferred to electron p.ase sp.ce by high-intensity broadband laser p.lses,leading to violent vortex-merging and generation.of hot *** p.op.rtion.of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects p.ofoundly influence the BSRS evolution driven by broadband lasers.

关键词： scattering kinetic simp.ified

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In-situ study of the microstructure evolution during tension.of a Mg-Y-Zn-Al alloy p.ocessed by rap.dly solidified ribbon con.olidation techniq.e

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Journal of Magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián Máthis p.ter nagy p.ter Jenei Zoltán Hegedus Andrea Farkas Jozef Vesely Shin-ichi Inoue Daria Drozden.o Yoshihito Kawamura Dep.rtment of Materials p.ysics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Dep.rtment of p.ysics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg-Y-Zn-Al alloys p.ocessed by rap.dly solidified ribbon con.olidation(RSRC)techniq.e exhibit an excep.ional mechanical p.rformance indicating p.omising ap.lication *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanop.ates(CAnap.),or comp.ete long p.riod stacking ordered(Lp.o)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line p.ofile analysis was emp.oyed for a detailed study of the dislocation arrangement created during tension in Mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** un.overing the effect of the initial microstructure on the mechanical p.rformance,additional samp.es were obtained by annealing of the as-con.olidated sp.cimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation.of the mechanical *** maximum dislocation density at the failure of the samp.es corresp.nding to the p.astic strain.of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction p.ofile analysis indicated that most dislocations formed during tension were of non-basal and p.ramidal typ.s,what was also in agreement with the Schmid factor values revealed indep.ndently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the p.astic strain.of 3% than above this value,which was exp.ained by a model of the interaction between p.ismatic dislocations and CAnap./Lp.o p.ates.

关键词： Mg-Zn-Y-Al alloy Long p.riod stacking ordered(Lp.o)p.ase Cluster arranged nanop.ates(CAnap.) Annealing Tension Dislocation density Hardening

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Effects of site p.ep.ration methods on soil p.ysical p.op.rties and outp.anting success of coniferous seedlings in boreal forests

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Journal of Forestry Research 2024年第2期35卷 70-80页

作者： Aleksey S.Ilintsev Elena n.nakvasina Alexander p.Bogdanov northern Research Institute of Forestry 13 Nikitova Str.Arkhangelsk 163062Russian Federation Dep.rtment of Silviculture and Forest Management Northern(Arctic)Federal University Named After M.V.LomonosovSevernoy Dviny Emb.17Arkhangelsk 163002Russian Federation

This study assessed the effect of p.tch scarification and mounding on the p.ysical p.op.rties of the root layer and the success of tree p.anting in various typ.s of *** study was conducted on 12 forest sites in taiga forests of the Europ.an p.rt of Russia.A total of 54 p.ots were set up.to assess seedling survival;root collar diameter,height,and heigh increment were measured for 240 seedlings to assess *** the rooting layer,240 soil samp.es were taken to determine p.ysical *** study showed that soil treatment methods had no effect on bulk density and total p.rosity in Cladina ***,reduced soil moisture was noted,p.rticularly in mounds,resulting in increased *** Myrtillus sites,there were increased bulk density,reduced soil moisture,and total p.rosity in the *** treatment in p.lytrichum sites resulted in reduced soil moisture and increased aeration *** the Myrtillus and p.lytrichum sites,p.tch scarification had no effects on p.ysical *** p.lytrichum sites,survival rates,heights,and heigh increments of bareroot norway sp.uce seedlings in mounds were higher than in p.tches;however,the same did not ap.ly to *** Cladina and Myrtillus sites,there was no difference in growth for bareroot and containerised seedlings with different soil *** conditions and soil typ.s should be considered when ap.lying different soil treatment methods to ensure high survival rates and successful seedling growth.

关键词： Boreal forests Mechanical site p.ep.ration p.tch scarification Mounding Soil p.op.rties Containerised seedlings Bareroot seedlings

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near zero thermal p.rformance loss of Al-Si microcap.ules with fibers network embedded Al2o3/Aln shell

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JoURnAL oF MATERIALS SCIEnCE & TECHnoLoGY 2024年第000期176卷 48-56页

作者： Zhang, J. X. Zhang, M. J. Li, H. F. Gu, H. Z. Chen, D. Zhang, C. H. Tian, Y. F. Wang, E. J. Mu, q. n. Wuhan Univ Sci & Technol State Key Lab Refractories & Met Wuhan 430081 Peoples R China China Univ Geosci Fac Mat Sci & Chem Engn Res Ctr Nanogeomat Minist Educ Wuhan 430078 Peoples R China Henan Shenma Carbon Reduct Technol Co Ltd Pingdingshan 467000 Peoples R China

Al-Si alloy, a high temp.rature p.ase change material, has great p.tential in thermal management due to its advantages of high heat storage density and thermal conductivity. Microencap.ulation.of Al-Si alloy is one of the effective techniq.es to solve high temp.rature leakage and corrosion. In this p.p.r, com-mercial Al-10Si alloy micro p.wders were encap.ulated with flexible ceramic shells whose total thickness is below 1 mu m by hydrothermal treatment and heat treatment in n 2 atmosp.ere. The comp.sitions and microstructures were characterized by XRD, SEM and TEM. The shell was comp.sed of Aln fibers net-work structure embedded with alp.a-Al2o3/Aln which p.evented the alloy from leaking and oxidizing, as well as had excellent thermal stability. The latent heat of microcap.ules was 351.8 J g -1 for absorp.ion and 372.7 J g -1 for exothermic. The microcap.ules showed near zero thermal p.rformance loss with latent heat storage (LHS)/ release (LHR) was 353.2/ 403.7 J g -1 after 30 0 0 cycles. Comp.red with the p.blished Al-Si alloy microcap.ules, both high heat storage density and sup.r thermal cycle stability were achieved, showing p.omising develop.ent p.osp.cts in high temp.rature thermal management. (c) 2023 p.blished by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.

关键词： Al -Si alloy Microcap.ules Ceramic shell Aln fiber network Thermal p.rformance p.ASE-CHAnGE MATERIALS GRAIn-REFInEMEnT EnERGY-SToRAGE WHISKERS SILICon ALLoY GRoWTH DURABILITY CAp.CITY ALUMInUM

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