检索结果-南通市图书馆

Analysis of the variability of auditory brainstem resp.nse comp.nents through linear regression

Journal of Biomedical Science and Engineering 2012年第9期5卷 517-525页

作者： Kheline F. p. Naves Adriano A. p.reira Slawomir J. Nasuto Ieda p. C. russo Adriano O. Andrade Catholic University of Sao p.ulo Sao Paulo Brazil Cybernetic Intelligence Research Group School of Systems Engineering University of Reading Reading UK Laboratory of Biomedical Engineering Faculty of Electrical Engineering Federal University of Uberlandia Uberlandia Brazil

The analysis of the Auditory Brainstem Resp.nse (ABR) is of fundamental imp.rtance to the investigation of the auditory system behavior, though its interp.etation has a subjective nature because of the manual p.ocess emp.oyed in its study and the clinical exp.rience required for its analysis. When analyzing the ABR, clinicians are often interested in the identification of ABR signal comp.nents referred to as Jewett waves. In p.rticular, the detection and study of the time when these waves occur (i.e., the wave latency) is a p.actical tool for the diagnosis of disorders affecting the auditory system. In this context, the aim of this research is to comp.re ABR manual/visual analysis p.ovided by different examiners. Methods: The ABR data were collected from 10 normal-hearing subjects (5 men and 5 women, from 20 to 52 years). A total of 160 data samp.es were analyzed and a p.ir- wise comp.rison between four distinct examiners was executed. We carried out a statistical study aiming to identify significant differences between assessments p.ovided by the examiners. For this, we used Linear Regression in conjunction with Bootstrap. as a method for evaluating the relation between the resp.nses given by the examiners. Results: The analysis suggests agreement among examiners however reveals differences between assessments of the variability of the waves. We quantified the magnitude of the obtained wave latency differences and 18% of the investigated waves p.esented substantial differences (large and moderate) and of these 3.79% were considered not accep.able for the clinical p.actice. Conclusions: Our results characterize the variability of the manual analysis of ABR data and the necessity of establishing unified standards and p.otocols for the analysis of these data. These results may also contribute to the validation and develop.ent of automatic systems that are emp.oyed in the early diagnosis of hearing loss.

关键词： Auditory Brainstem Resp.nse Hearing Loss Linear Regression

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

p.edicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Recep.or Agonism and Related Toxicity Mechanisms

引用

Environment & Health 2024年第7期2卷 474-485页

作者： Nada J.Daood Daniel p.russo Elena Chung Xuebin Qin Hao Zhu p.edicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Recep.or Agonism and Related Toxicity Mechanisms Dep.rtment of Chemistry and Biochemistry Rowan UniversityGlassboroNew Jersey 08028United States Center for Biomedical Informatics and Genomics Tulane University School of MedicineNew OrleansLouisiana 70112United States Tulane National p.imate Research Center Tulane University School of MedicineCovingtonLouisiana 70433United States

Comp.tational modeling has emerged as a time-saving and cost-effective alternative to traditional animal testing for assessing chemicals for their p.tential ***,few comp.tational modeling studies for immunotoxicity were rep.rted,with few models available for p.edicting toxicants due to the lack of training data and the comp.ex mechanisms of *** this study,we emp.oyed a data-driven quantitative structure–activity relationship.QSAR)modeling workflow to extensively enlarge the limited training data by revealing multip.e targets involved in *** this end,a p.obe data set of 6,341 chemicals was obtained from a high-throughp.t screening(HTS)assay testing for the activation of the aryl hydrocarbon recep.or(AhR)signaling p.thway,a key event leading to *** this p.obe data set against p.bChem yielded 3,183 assays with testing results for varying p.op.rtions of these 6,341 comp.unds.100 assays were selected to develop.QSAR models based on their correlations to AhR *** individual QSAR models were built for each assay using combinations of four machine-learning algorithms and three molecular fingerp.ints.5-fold cross-validation of the resulting models showed good p.edictivity(average CCR=0.73).A total of 20 assays were further selected based on QSAR model p.rformance,and their resulting QSAR models showed good p.edictivity of p.tential immunotoxicants from external *** study p.ovides a comp.tational modeling strategy that can utilize large p.blic toxicity data sets for modeling immunotoxicity and other toxicity endp.ints,which have limited training data and comp.icated toxicity mechanisms.

关键词： Immunotoxicity QSAR Machine learning Aryl hydrocarbon recep.or Data mining

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Activating Ru in the p.ramidal sites of Ru_(2)p.typ. structures with earth-abundant transition metals for achieving extremely high HER activity while minimizing noble metal content

引用

Carbon Energy 2024年第9期6卷 80-92页

作者： Sayed M.El-Refaei p.trícia A.russo Thorsten Schultz Zhe-Ning Chen p.trick Amsalem Norbert Koch Nicola p.nna Dep.rtment of Chemistry and the Center for the Science of Materials Berlin Humboldt-Universität zu BerlinBerlinGermany Max-p.anck-Institut für Chemische Energiekonversion Mülheim an der RuhrGermany Institut für p.ysik and Center for the Science of Materials Berlin Humboldt-Universität zu BerlinBerlinGermany Helmholtz-Zentrum Berlin für Materialien und Energie GmbH BerlinGermany State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouChina

Rational design of efficient p.-universal hydrogen evolution reaction catalysts to enable large-scale hydrogen p.oduction via electrochemical water sp.itting is of great significance,yet a challenging ***,Ru atoms in the Ru_(2)p.structure were rep.aced with M=Co,Ni,or Mo to p.oduce M_(2-x)Ru_(x)p.*** metals show strong site p.eference,with Co and Ni occup.ing the tetrahedral sites and Ru the square p.ramidal sites of the CoRup.and NiRup.Ru_(2)p.typ. *** p.esence of Co or Ni in the tetrahedral sites leads to charge redistribution for Ru and,according to density functional theory calculations,a significant increase in the Ru d-band *** a result,the intrinsic activity of CoRup.and NiRup.increases considerably comp.red to Ru_(2)p.in both acidic and alkaline *** effect is not observed for MoRup.in which Mo p.efers to occup. the p.ramidal *** p.rticular,CoRup.shows state-of-the-art activity,outp.rforming Ru_(2)p.with p.-like activity in 0.5 M H_(2)SO_(4)(η10=12.3 mV;η100=52 mV;turnover frequency(TOF)=4.7 s^(-1)).It remains extraordinarily active in alkaline conditions(η10=12.9 mV;η100=43.5 mV)with a TOF of 4.5 s^(-1),which is 4x higher than that of Ru_(2)p.and 10x that of p./*** increase in the Co content does not lead to drastic loss of activity,esp.cially in alkaline medium,where,for examp.e,the TOF of Co_(1.9)Ru_(0.1)p.remains comp.rable to that of Ru_(2)p.and higher than that of p./C,highlighting the viability of the adop.ed ap.roach to p.ep.re cost-efficient catalysts.

关键词： electrocatalysis ruthenium p.osp.ide transition metal p.osp.onates

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Lighting up.aggregate emission of p.rylene diimide by leveraging p.lymerization-mediated through-sp.ce charge transfer and π-π stacking

引用

Science China Chemistry 2024年

作者： Suiying Ye Désirée Füglistaller Tian Tian Anjay Manian Sudhir Kumar Celine Nardo Andrew J.Christofferson Salvy p.russo Chih-Jen Shih Jean-Christop.e Leroux Yinyin Bao Institute of p.armaceutical Sciences Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 3 Institute for Chemical and Bioengineering Department of Chemistry and Applied Biosciences ETH Zurich Vladimir-Prelog-Weg 1-5 ARC Centre of Excellence in Exciton Science School of Science RMIT University School of Science STEM College RMIT University

The molecular engineering of fluorescent organic/p.lymeric materials, sp.cifically those emitting in the deep.red to near-infrared sp.ctrum, is vital for advancements in op.oelectronics and biomedicine. p.rylene diimide(p.I), a well-known fluorescent scaffold, offers high thermal and p.otop.ysical stability but suffers from fluorescence quenching in solid or aggregate states due to intense π-π interactions. To mitigate this, simp.e and versatile methods for strong p.I aggregate emission without extensive synthetic demands are highly desirable but still lacking. Here, we rep.rt a straightforward strategy to enhance the solid-state emission of p.I by introducing certain degree of through-sp.ce charge transfer(TSCT) via controlled radical p.lymerization,which can efficiently distort the typ.cal face-to-face p.I stacking, enabling greatly enhanced deep.red emission. This is achieved by growing electron-donating star-shap. styrenic(co)p.lymers from a multidirectional electron-accep.ing p.I initiator. The incorp.ration of p.lycyclic aromatic monomers further shifted the emission into the near-infrared region, albeit with a reduced intensity. Overall, the emission of the p.I-based TSCT p.lymers can be systematically manip.lated by leveraging the balance between p.I stacking and the TSCT degree, as confirmed by both exp.rimental study and theoretical calculations. Our ap.roach circumvents comp.ex synthetic p.ocedures, offering highly emissive materials with large Stokes shifts and showing broad p.tential for op.oelectronic technology.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Intrap.aque injections of hyaluronic acid for the treatment of stable-p.ase p.yronie’s disease:a retrosp.ctive single-center exp.rience

引用

Asian Journal of Andrology 2024年第3期26卷 268-271页

作者： Simone Cilio Roberto La Rocca Giusep.e Celentano Claudio Marino Massimiliano Creta Gianluigi Califano Celeste Manfredi Giorgio Ivan russo Afonso Morgado Marco Falcone Marco Cap.ce YAU Working Group.Sexual and Rep.oductive Health Dep.rtment of Neurosciences Reproductive Sciences and OdontostomatologyUrology UnitUniversity of Naples“Federico II”Naples 80131Italy Urology Unit Department of WomenChild and General and Specialized Surgery“Luigi Vanvitelli”UniversityNaples 80131Italy Urology Section Department of SurgeryUniversityof CataniaCatania 95131Italy Dep.rtment of Urology Centro Hospitalar Universitário São JoãoPorto 4200-319Portugal Urology Clinic-A.O.U.“Cittàdella Salute edella Scienza”-Molinette Hosp.tal University of TurinTurin 10100Italy 不详

p.yronie’s disease(p.)is a condition of p.nile connective tissue affecting up.to 10%of men *** the comp.exity ofits management,nonsurgical treatments,such as intrap.aque injections,are gaining *** current literature shows dataon the efficacy of intrap.aque injections of hyaluronic acid(HA)mainly in acute-p.ase ***,data on injections of HA instable-p.ase p. are *** for this retrosp.ctive study were derived from a p.osp.ctively maintained database of p.ivatep.tients p.esenting at a p.ivate medical p.actice affiliated to the University of Nap.es“Federico II”(Nap.es,Italy)with stable-p.asep. between January 2020 and March *** underwent a standard p.otocol of three injections,each administered at atwo-week *** the intervals,p.tients p.rformed vacuum device therap.,p.nile stretching,and modeling *** comp.led the p.yronie’s Disease Questionnaire(p.Q)and Global Assessment of p.yronie’s Disease(GAp.)at baselineand 2 weeks after the third injection.A p.nile Dop.ler ultrasound was p.rformed 2 weeks after the last injection to record thefinal ***,we recruited 62 p.tients with stable-p.ase p. and a mean(±standard deviation[s.d.])curvature of52.7°(±9.7°).After 6 weeks,eight(12.9%)p.tients did not exp.rience any curvature *** remaining 54 p.tientshad a final mean(±s.d.)curvature of 40.3°(±9.1°)with p.0.001,comp.red to that before *** found imp.ovement inall p.Q domains(all p.0.01),and 50(80.6%)p.tients rep.rted subjective imp.ovement of the p.nile curvature according to *** conclusion,we demonstrated that after three injections of HA administered according to the adop.ed p.otocol,p.tientswith stable-p.ase p. could exp.rience significant imp.ovements in p.nile curvature,and p.ysical and p.ychological consequencesof the disease without significantly relevant side effects.

关键词： hyaluronic acid intrap.aque injection p.yronie’s disease stable-p.ase therap.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Janus structure p.otocatalyst having widely tunable electronic and op.ical p.op.rties with strain engineering

引用

Journal of Materials Science & Technology 2023年第24期155卷 142-147页

作者： Sri Kasi Matta Ting Liao Salvy p.russo Center for Comp.tational Sciences University of Tsukuba Japan ARC Centre of Excellence in Exciton Science School of Science RMIT University Melbourne 3000 Australia School of Mech. Medical & Process Engineering Queensland University of Technology Gardens Point Campus Brisbane Queensland Australia

p.otoelectrochemical water sp.itting using solar energy,generating oxygen and hydrogen is one of the clean fuel p.oduction *** by surface-dep.ndent characteristics of Janus structures,a newly designed Janus monolayer Silicon p.osp.orous Arsenide(Sip.s)was analyzed with Density Functional Theory(DFT)*** exchange-correlation functional(HSE06)combined with Wannier90-based analysis for electronic and op.ical p.op.rties of Sip.s reveals that it can act as a *** show an indirect bandgap.of 1.88 eV,absorbing visible light range is 350 to 500 *** p.onon sp.ctrum confirms dynamic *** exciton binding energy is comp.ted with GW/BSE *** electronic band edge p.sitions are at-5.75 and-4.43 eV,p.rfectly straddling the water redox *** the strain ap.lication modifies the bandgap.and also non-homogenously widens the absorp.ion band.A novel range of p.otocatalyst designs with Group.IV-V elements with great p.omise for water-sp.itting,p.otovoltaic,and narrow bandgap.semiconductor(op.oelectronics)ap.lications may be feasible.

关键词： Solar water-sp.itting Janus structure Density functional theory Strain engineering Op.ical and electronic p.op.rty tuning Op.oelectronic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肾细胞癌:MR成像评估肌肉静脉分支受侵的价值

引用

国际医学放射学杂志 2013年第4期 369-369页

作者： C.A. Karlo p.L.D. p.olo O.F. Donati p. russo S. Tickoo H. Hricak 周丹 Dep.rtment of Radiology Memorial Sloan -Kettering Cancer Center 1275 York Ave Radiology Academic OfficesRoom C278 New York NY 10065

目的在MRT2加权成像上测量肿瘤-肾窦间距,观察肾窦脂肪受侵,评估两者作为肌肉静脉分支受侵(MVBI)肾细胞癌(RCC)病人预测因子的诊断效能与观察者间一致性。材料与方法本项回顾性研究经机构审查委员会批准,免除知情同意书并符合HIp.A标准... 详细信息

目的在MRT2加权成像上测量肿瘤-肾窦间距,观察肾窦脂肪受侵,评估两者作为肌肉静脉分支受侵(MVBI)肾细胞癌(RCC)病人预测因子的诊断效能与观察者间一致性。材料与方法本项回顾性研究经机构审查委员会批准,免除知情同意书并符合HIp.A标准。连续的186例病人行术前MR检查,确定了188个RCC。在不知晓组织病理学信息的情况下,2名影像医生分别独立地在横断面和冠状面MR T2加权成像上测量肿瘤-肾窦间距并评估肾窦脂肪的受侵程度。计算其诊断效能与观察者间一致性(组内相关系数,Cohen κ)。最终以组织病理诊断作为参考标准。结果组织病理检查显示35%(66/188)的肿瘤发生MVBI。所有发生MVBI的肿瘤其肿瘤-肾窦间距为0。所有肾窦脂肪受侵的肿瘤均发生MVBI。肾窦脂肪受侵检出的敏感度和特异度分别为100%(95%CI:92%～100%)和94%(95%CI:89%～98%)。没有肾窦脂肪受侵且肿瘤-肾窦间距为0的21%(18/86)病例发生MVBI。观察者之间定量(同类相关系数=0.92;95%CI:0.89～0.94)和定性(κ=0.89;95%CI:0.81～0.96)评估一致性良好。结论在MR T2加权成像中,肿瘤-肾窦间距测量与肾窦脂肪受侵的评估可排除RCC病人肌肉静脉分支受侵。

关键词：受侵脂肪肾窦静脉分支肾细胞癌 MR

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tunable electrochemistry of gold-silver alloy nanoshells

引用

Nano Research 2018年第12期11卷 6336-6345页

作者： Lorenzo russo Victor p.ntes Arben Merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and BISTCampus UABBellaterra08193BarcelonaSpain Universitat Autonoma de Barcelona (UAB) Campus UABBellaterra08193BarcelonaSpain Vail d'Hebron Institut de Recerca (VHIR) 08035BarcelonaSpain Institucio Catalana de Recerca i Estudis Avancats (ICREA) P Llub Companys 2308010BarcelonaSpain

The widesp.ead and increasing interest in enhancing biosensing technologies by increasing their sensitivities and lowering their costs has led to the exp.oration and ap.lication of comp.ex nanomaterials as signal transducers and enhancers. In this work, the electrochemical p.op.rties of monodisp.rsed AuAg alloy nanoshells (NSs) with finely tunable morp.ology, comp.sition, and size are studied to assess their p.tential as electroactive labels. The controlled corrosion of their silver content, caused by the oxidizing character of dissolved oxygen and chlorides of the electrolyte, allows the generation of a rep.oducible electrochemical signal that is easily measurable through voltammetric techniques. Remarkably, the underp.tential dep.sition of dissolved Agp.+p. catalyzed on AuAg NS surfaces is observed and its dep.ndence on the nanop.rticle morp.ology, size, and elemental comp.sition is studied, revealing a strong correlation between the relative amounts of the two metals. The highest catalytic activity is found at Au/Ag ratios higher than ≈ 10, showing how the synergy between both metals is necessary to trigger the enhancement of Agp.+p. reduction. The ability of AuAg NSs to generate an electrocatalytic current without the need for any strong acid makes them an extremely p.omising material for biosensing ap.lications.

关键词： Au nanoshells nanop.rticles surface chemistry underp.tential dep.sition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine learning-based discovery of vibrationally stable materials

引用

np. Comp.tational Materials 2023年第1期9卷 2304-2309页

作者： Sherif Abdulkader Tawfik Mahad Rashid Sunil Gup.a Salvy p.russo Tiffany R.Walsh Svetha Venkatesh Institute for Frontier Materials Deakin UniversityGeelongVIC 3216Australia ARC Centre of Excellence in Exciton Science RMIT UniversityMelbourneVIC 3001Australia Ap.lied Artificial Intelligence Institute(A2I2) Deakin UniversityGeelongVIC 3216Australia Chemical and Quantum p.ysics School of ScienceRMIT UniversityMelbourneVIC 3001Australia

The identification of the ground state p.ases of a chemical sp.ce in the convex hull analysis is a key determinant of the synthesizability of *** material databases have been instrumental in exp.oring one asp.ct of the synthesizability of many materials,namely thermodynamic ***,the vibrational stability,which is another asp.ct of synthesizability,of new materials is not *** first p.incip.es ap.roaches to calculate the vibrational sp.ctra of materials in online material databases is comp.tationally ***,a dataset of vibrational stability for~3100 materials is used to train a machine learning classifier that can accurately distinguish between vibrationally stable and unstable *** classifier has the p.tential to be further develop.d as an essential filtering tool for online material databases that can inform the material science community of the vibrational stability or instability of the materials queried in convex hulls.

关键词： materials stability vibrational

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis, p.op.rties and p.tential Ap.lications of p.rous Grap.ene: A Review

引用

Nano-Micro Letters 2013年第4期5卷 260-273页

作者： p.ola russo Anming Hu Giusep.e Comp.gnini Dep.rtment of Mechanical and Mechatronics Engineering University of Waterloo Dip.rtimento di Scienze Chimiche Università degli Studi di Catania Institute of Laser Technology Beijing University of Technology

Since the discovery of grap.ene, many efforts have been done to modify the grap.ene structure for integrating this novel material to nanoelectronics, fuel cells, energy storage devices and in many other ap.lications. This leads to the p.oduction of different typ.s of grap.ene-based materials, which p.ssess p.op.rties different from those of p.re grap.ene. p.rous grap.ene is an examp.e of this typ. of materials. It can be considered as a grap.ene sheet with some holes/p.res within the atomic p.ane. Due to its sp.ngy structure, p.rous grap.ene can have p.tential ap.lications as membranes for molecular sieving, energy storage comp.nents and in nanoelectronics. In this review, we p.esent the recent p.ogress in the synthesis of p.rous grap.ene. The p.op.rties and the p.tential ap.lications of this new material are also discussed.

关键词： Grap.ene p.rous grap.ene Gas sep.ration Energy storage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：